nce qib ntawm uric acid hauv tib neeg cov ntshav yog cais raws li hyperuricemia. Nws yog dab tsi? Qhov no yog qhov tshwm sim los ntawm kev tsis sib haum xeeb ntawm purine metabolism, feem ntau vim yog ib puag ncig (kev noj haus thiab lwm yam) thiab cov caj ces. Qhov no pathology nyiam mloog tom qab rov soj ntsuam cov kev tshawb fawb uas qhia nws qhov cuam tshuam rau cov kab mob plawv. Nws kuj tseem suav hais tias yog thawj biochemical kos npe ntawm gout. Hyperuricemia feem ntau yog asymptomatic thiab yog li tsis tau kuaj pom tam sim ntawd.
Thaum twg hyperuricemia tshwm sim?
Uric acid yog qhov khoom kawg ntawm cov metabolism hauv purine hauv paus. Tsim nyob rau hauv daim siab, nws yog tawm los ntawm lub cev nyob rau hauv cov zis. Kev nce hauv nws cov concentration hauv ntshav plasma qhia txog kev txhim kho ntawm qee yam kab mob pathological. Nws ua rauhyperuricemia. Nyob rau hauv cov ntaub ntawv ntawm qhov txo qis ntawm uric acid, hypouricemia tshwm sim. Nws qib ib txwm yog 360 μm / l hauv cov poj niam, thiab 400 μm / l hauv cov txiv neej. Tshaj dhau ntawm cov ntsuas no yuav tsum tau qhia meej ntawm cov laj thawj ua rau, qhov tshwm sim yog hyperuricemia. Nws yog dab tsi? Qhov no yog qhov tshwm sim ntawm kev tsim cov uric acid ntau dhau thiab ua rau lub raum tsis ua haujlwm, cov tsos mob tseem ceeb ntawm gout. Nws kuj tseem tuaj yeem ua pov thawj ntawm cov kab mob xws li lymphoma, leukemia, anemia vim tsis muaj vitamin B12, cov kab mob ntawm cov kab mob biliary, daim siab, ob lub raum, psoriasis, mob ntsws, preeclampsia, tuberculosis, ntshav qab zib mellitus, mob eczema.
Nyob rau hauv cov theem pib ntawm cov teeb meem ntawm purine metabolism, lub raum puas tsim, ua ntej ntawm kev tawm tsam ntawm gouty mob caj dab thiab lwm yam tsos mob. Qhov tseeb yog tias ob lub raum yog thawj zaug suav nrog hauv cov txheej txheem ntawm kev them nyiaj rau kev sib xyaw ua ke ntawm uric acid ntau dhau, ua rau kom cov kua dej tawm hauv lub cev, uas ua rau muaj kev pheej hmoo ntawm crystallization ntawm cov ntsev hauv lub raum. Kev tso tawm ntau ntxiv (tso tawm) ntawm uric acid muaj kev puas tsuaj rau cov tubules, interstitium ntawm ob lub raum, pab txhawb kev loj hlob ntawm cov kab mob xws li hyperuricosuria thiab hyperuricemia. Thawj qhov kev mob tshwm sim yog tshwm sim los ntawm kev nce siab ntawm uric acid hauv cov zis, uas yog tshwm sim los ntawm kev ua txhaum ntawm purine metabolism vim kev noj zaub mov tsis txaus, nplua nuj nyob hauv purine hauv paus, noj zaub mov muaj protein ntau, thiab haus cawv. Qhov thib ob yog kuaj pom los ntawm kev kuaj ntshav biochemical.
Type of hyperuricemia
Hyperuricemia yog thawj thiab theem nrab. Thawj yog feem ntau tshwm sim los ntawm thawj tus kab mob gout, tsev neeg caj ces anomaly ntawm purine metabolism (constitutional dyspurinism). Raws li cov laj thawj, nws tau muab faib ua peb hom:
- hom metabolic, vim qhov nce hauv kev sib txuas ntawm endogenous purines thiab tus cwj pwm los ntawm uricosuria siab thiab tus nqi ntawm kev ua kom huv ntawm cov nqaij mos thiab cov kua hauv lub cev (kev tshem tawm) ntawm uric acid;
- raum hom, tshwm sim los ntawm lub raum tsis ua haujlwm ntawm uric acid thiab tus cwj pwm los ntawm kev tshem tawm tsawg;
- hom sib xyaw, uas yog kev sib xyaw ua ke ntawm thawj ob yam xwm txheej, uas qhov uraturia txo qis lossis tsis dhau qhov kev cai, thiab kev tshem tawm tsis hloov pauv.
Symptoms of disease
Tsis ntev los no, hyperuricemia feem ntau kuaj tau thaum kuaj mob thaum pub ntshav rau kev tshuaj xyuas biochemical. "Nws yog dab tsi?" - thawj lo lus nug los ntawm cov neeg mob, txij li thaum lawv tsis pom muaj cov tsos mob ntawm tus kab mob. Tus kab mob, qhov tseeb, feem ntau dhau yuav luag asymptomatically.
Yuav ua li cas tsis muaj kev phom sij npaum li cas yog qhov tsis tau hais tawm hyperuricemia, cov tsos mob ntawm qhov twg, thiab thaum lawv tshwm sim, feem ntau tsis yog tshwj xeeb? Hauv cov menyuam yaus, tus mob no tuaj yeem tshwm sim los ntawm cem quav, mob plab, nocturnal enuresis, logoneurosis, tics, tawm hws ntau dhau. Cov tub ntxhais hluas feem ntau pom cov tsos mob ntawm hyperuricemia, xws li rog dhau, mob hauv thaj tsam lumbar, khaus hauv cov zis, biliary dyskinesia.txoj kev. Daim duab kho mob tuaj yeem nrog kev qaug cawv thiab asthenia. Hauv cov neeg laus, thaum ntxov ntawm kev loj hlob ntawm pathology, interstitial nephritis yog tsim. Nws muaj peev xwm hloov mus rau hauv theem nrab pyelonephritis nyob rau hauv kev cuam tshuam ntawm cov kab mob ntawm cov kab mob, tsim kom muaj txiaj ntsig zoo rau kev tsim cov pob zeb raum. Tsis tshua muaj tshwm sim yog urolithiasis, lossis nephrolithiasis. Raws li kev tsim cov pob zeb tso zis, cov teeb meem hauv qab no yuav tsum raug sau tseg: kev hloov pauv ntawm cov kua qaub ntawm cov zis, hypercalciuria, hyperoxaluria, hyperphosphaturia, hyperuricuria thiab hyperuricemia. Hyperuricemia feem ntau ua ke nrog ntau yam pathologies ntawm lub plab zom mov.
Risk Factor
Tus kab mob, tsim tawm tsam keeb kwm ntawm kev tsim cov uric acid nrawm dua, feem ntau tshwm sim los ntawm kev cuam tshuam ntawm cov xwm txheej xws li:
- kev koom tes ntawm purine hauv cov txheej txheem metabolic;
- raum tsis ua haujlwm;
- siab fructose hauv kev noj haus txhua hnub.
Ua rau hyperuricemia
Qhov laj thawj tseem ceeb ntawm tus mob no yog kev tsim txom ntawm cov khoom noj uas muaj purines, cov khoom noj muaj roj. Tsis muaj tsawg txaus ntshai yog kev tshaib kev nqhis, nrog rau cov ntaub so ntswg puas, neoplasms ntawm malignant xwm. tuaj yeem pab txhawb kev txhim kho cov kab mob hyperuricemia ntawm lymphatic system, ntshav.
Kev kho mob
Kev ua kom tsis zoo ntawm cov khoom pom thiab ua txhaum txoj haujlwm ntawm lub raum yog qhov ua rau ua rau muaj kev cuam tshuam xws li hyperuricemia. Tus mob no yog dab tsiPuas yog keeb kwm los yog tau txais? Cov kab mob kis tau feem ntau tshwm sim hauv cov neeg laus vim yog sclerosis ntawm lub raum hlab ntsha. Hyperuricemia kuj feem ntau yog tus khub ntawm cov kab mob xws li ntshav ntshav, mob eczema, acidosis, psoriasis, toxicosis thaum cev xeeb tub.
Thaum kuaj pom tias "hyperuricemia" raug tsim, kev kho mob raug sau raws li cov ntaub ntawv tau txais los ntawm kev sim kuaj thiab lwm yam kev kuaj ntxiv. Nws lub hauv paus yog kev noj haus. Cov khoom noj uas muaj cov purine derivatives tseem ceeb raug cais tawm ntawm tus neeg mob noj cov zaub mov, lossis lawv cov kev siv tau txo qis. Cov tshuaj muaj xws li uricosodepressor tshuaj, tshuaj nrog uricosuric txiav txim. Ib qho tseem ceeb ntawm kev kho mob yog qhov ua tiav ntawm cov tshuaj tiv thaiv alkaline tso zis. Kev noj tshuaj rau tus kheej tsis tuaj yeem lees txais, txawm tias kev noj zaub mov raug tsim raws li tus kheej txoj kev npaj los tiv thaiv ib qho ntawm cov teeb meem loj - gout.
