Xyoo 1962, thaum thawj cov tshuaj muaj zog hauv chav kawm no tshwm sim, tsis muaj leej twg kwv yees qhov kev vam meej rau lawv. Lawv tau tsim los ua kev kho mob rau cov kab mob urinary, tab sis tom qab ntawd lawv tau los ua cov tshuaj tua kab mob nrov tshaj plaws. Hauv kev xyaum kho mob, pab pawg tshuaj no tau pib siv zog tsuas yog hauv 80s ntawm lub xyoo pua XX. Thiab niaj hnub no cov tshuaj tua kab mob fluoroquinolones tsuas yog qhov tseem ceeb hauv kev kho cov kab mob ua pa. Nyob rau thaj tsam ntawm Russia, kev faib thoob ntiaj teb ntawm cov tshuaj tua kab mob los ntawm tiam neeg yog nrov. Tab sis, hmoov tsis, qhov kev faib tshuaj no tsis tso cai rau peb txheeb xyuas lawv cov tshuaj muaj pes tsawg leeg thiab spectrum ntawm kev ua. Yog li ntawd, feem ntau lawv tham txog fluoroquinolones (cov tshuaj tua kab mob), hais txog 2 pawg - qub thiab tshiab.
Tshuaj cais tawm
Cov tshuaj ntawm pab pawg qub suav nrog Ofloxacin, Enoxacin, Ciprofloxacin thiab lwm yam. Cov tshuaj tua kab mob tshiab yog Sparfloxacin, Clinafloxacin, Moxifloxacin. Txawm li cas los xij, qee cov tshuaj tsim tawm tsis raug tsim tawm lawm, raws li cov kws tshawb fawb tau tshawb pom cov kev mob tshwm sim loj.thaum thov lawv.
Kev siv tshuaj tua kab mob
Cov tshuaj no ib txwm siv rau cov kab mob ntawm cov zis, kab mob hauv plab thiab cov kab mob sib deev. Hmoov tsis zoo, fluoroquinolones tsis tshua siv los kho cov kab mob ua pa, txawm hais tias lawv tuaj yeem cuam tshuam qee yam kab mob.
Cov nyhuv ntawm tshuaj
Cov tshuaj tua kab mob fluoroquinolones tau nqus tau zoo los ntawm txoj hnyuv thiab muaj ntau tshaj plaws hauv cov ntaub so ntswg 3 teev tom qab siv. Yog tias koj noj zaub mov tib lub sijhawm, kev nqus dej yuav qeeb me ntsis, tab sis qhov kev txiav txim yuav ua haujlwm zoo li qub. Cov txheej txheem ntawm kev txiav txim ntawm cov tshuaj yog inhibit DNA gyrase thiab topoisomerase IV ntawm microbes, yog li tsis muaj kev cuam tshuam nrog lwm cov tshuaj tua kab mob. Cov tshuaj tua kab mob no tau siv dav hauv gynecology (cov kab mob ntawm cov poj niam cev xeeb tub), tshwj xeeb tshaj yog rau cov kab mob ntawm lub plab hnyuv siab raum, uas tshwm sim vim muaj zog ntawm cov kab mob nkag mus rau hauv qhov chaw mos. Nws raug pom zoo kom noj quinolones ntawm lub plab khoob, txawm hais tias nws kuj tseem siv tau tom qab noj mov.
Side effects
Tshuaj tua kab mob Fluoroquinolones tau txais txiaj ntsig zoo los ntawm kev txhaj tshuaj ntawm qhov ncauj thiab cov hlab ntsha. Kev phiv tshuaj tsis tshua muaj, tab sis yog tias lawv tshwm sim, lawv feem ntau cuam tshuam rau kev ua haujlwm ntawm lub plab zom mov thiab kev ua haujlwm ntawm lub paj hlwb. xeev siab, ntuav, mob taub hau,kiv taub hau, convulsions, nervousness. Feem ntau, cov tshuaj tua kab mob no yog cov yam ntxwv ntawm cov tshuaj pharmacokinetic zoo heev.
theem tseem ceeb ntawm kev ua ntawm fluoroquinolones
- Kev nkag mus ntawm daim nyias nyias mus rau hauv lub cell.
- Inhibition ntawm enzyme DNA gyrase.
- YDNA biosynthesis.
- Kev puas tsuaj ntawm cell division algorithm.
- Hloov cov qauv ntawm tes.
- Cell death.
Cov tshuaj tua kab mob no tau siv dav hauv cov tshuaj, thiab yog siv kom raug, tuaj yeem pab txhawb kev noj qab haus huv tib neeg.
