mob hawb pob yog thawj zaug hauv ntiaj teb ntawm cov kab mob cuam tshuam nrog kev ua haujlwm siab ntawm lub cev tiv thaiv kab mob. Rau nws txoj kev kho mob, ntau cov tshuaj tau tsim. Ib qho kev kho mob zoo li no yog Budesonide. Analogues ntawm cov tshuaj no kuj feem ntau siv los kho broncho-obstructive syndrome. Yog li cov tshuaj no yog dab tsi?
Budesonide yog dab tsi?
Cov tshuaj no yog nyob rau hauv pab pawg ntawm nqus tau glucocorticoids. Cov tshuaj no yog ib qho tshuaj sib xyaw ua ke ntawm cov tshuaj hormones synthesized hauv peb lub cev (hauv adrenal cortex). "Budesonide" cuam tshuam dab tsi?
Cov lus qhia rau kev siv cov tshuaj hais tias cov cuab yeej no pab ua kom cov beta-adrenergic receptors nyob rau hauv lub ntsws.
Ntxiv rau, cov tshuaj thaiv qhov kev ua ntawm inflammatory leukotrienes thiab prostaglandins, yog li tiv thaiv kev txhim kho ntawm cov txheej txheem inflammatory hauv bronchial mucosa.
Ua haujlwm tom qab noj txhua hnub rau ob peb hnub (feem ntau li 5-7 hnub).
Nws yog ib qho tshuaj tseem ceeb rau kev kho mob bronchial hawb pob thiab mob ntsws ntsws ntev. Thaum pib ntawm txoj kev loj hlob ntawm cov kab mob no tsis siv.
Budesonide cuam tshuam li cas rau cov hlwb?
Pharmacodynamics
Cov tshuaj, vim kev nqus pa, nqus tau zoo los ntawm lub ntsws (los ntawm qhov chaw ntawm qhov ntswg qhov ntswg nws xyaum tsis nkag mus rau hauv lub cev).
Qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav ntshav tau pom 45 feeb tom qab nws nqus tau. 85 feem pua ntawm tag nrho cov tshuaj tuaj yeem khi rau cov ntshav albumin, thaum tus so raug tshem tawm tsis hloov pauv.
Ua hauv siab. Nws tawm ntawm lub cev los ntawm txoj hnyuv (nrog rau cov kua tsib) thiab cov zis.
Nyob rau hauv cov neeg mob uas muaj pathology ntawm cov kabmob no, muaj cov tshuaj khaws cia ntev dua hauv cov ntshav, uas cuam tshuam nrog kev txhim kho ntawm cov teeb meem feem ntau thiab kev noj ntau dhau ntawm cov tshuaj hormones glucocorticoid.
Koj tuaj yeem siv cov tshuaj hauv daim ntawv ntsiav tshuaj rau kev kho mob ntawm cov kab mob collagenosis (txawm li cas los xij, tsuas yog 10 feem pua ntawm tag nrho cov tshuaj uas nkag mus rau hauv txoj hnyuv tuaj yeem muaj kev kho mob).
Nws kuj yog siv rau kev kho mob ntawm cov kab mob uas tsis yog mob ntawm lub qhov ntswg mucosa vim ua haujlwm ntev hauv zos.
Cov lus qhia rau kev siv
Thaum twg koj tuaj yeem xaiv tau"Budesonide"? Cov lus qhia rau kev siv teev cov kab mob tseem ceeb uas cov tshuaj no tuaj yeem siv tau:
- Bronchial hawb pob. Cov tshuaj tau txais koob meej vim nws cov tshuaj tiv thaiv kab mob thiab muaj peev xwm los cuam tshuam cov kev ua ntawm cov neeg kho mob inflammatory.
- Crohn's disease. Rau kev kho mob ntawm tus kab mob no, ib ntsiav tshuaj daim ntawv ntawm cov tshuaj yog siv. Cov tshuaj no tau raug sau tseg kom ua rau muaj kev tso tawm me me thiab nruab nrab ntawm tus kab mob.
- Kev kho mob rhinitis. Kev teem caij ntawm ib daim ntawv intranasal ntawm budesonide rau kev kho cov tsos mob ntawm hay fever thiab allergic rhinitis yog qhia. Ib qho tshuaj zoo heev rau kev kho tus kab mob no yog "Budesonide formoterol".
- Tiv thaiv kev rov tshwm sim ntawm qhov ntswg mucosal polyposis. Cov tshuaj yog siv nyob rau hauv thaum ntxov postoperative lub sij hawm. Hauv yuav luag 95 feem pua ntawm cov neeg mob, nws tiv thaiv kev rov txhim kho polyposis.
Cov kab mob uas tau teev tseg yog cov txheej txheem tseem ceeb uas "Budesonide" tau sau tseg.
Qee zaum cov tshuaj no yuav raug muab tshuaj los tiv thaiv kev txhim kho ntawm cov kab mob pulmonary. Cov xwm txheej no suav nrog cov neeg mob uas muaj kab mob ua haujlwm lossis ua haujlwm hauv kev ua haujlwm txaus ntshai. Tab sis nws yuav tsum nco ntsoov tias txawm tias siv tshuaj tiv thaiv, ib tus yuav tsum tsis txhob hnov qab txog kev siv tshuaj ceev faj, txwv tsis pub muaj teeb meem ntawm cov qog adrenal thiab glucocorticoid tshem tawm syndrome.
BNyob rau hauv dab tsi yog nws siv contraindicated?
YContraindications
Raws li cov txheej txheem thiab kab mob dab tsi yog txwv tsis pub siv "Budesonide"? Cov lus qhia rau kev siv tshuaj qhia txog cov kab mob hauv qab no:
- Ntau rhiab heev rau cov tshuaj lossis nws cov khoom. Kev loj hlob txaus ntshai ntawm angioedema.
- Daim ntawv ua haujlwm ntawm pulmonary tuberculosis.
- kab mob ua pa ntawm cov kab mob fungal.
- Cov txheej txheem kis mob hnyav hauv plab hnyuv.
- mob siab ua tsis taus pa.
- Cov me nyuam hnub nyoog.
Nrog rau tag nrho cov kab mob no, kev siv cov glucocorticoids raug txwv. Qhov no yog vim lub fact tias cov tshuaj yog exacerbates tus txheej txheem, los yog ua phem rau nws cov chav kawm. Hauv cov menyuam yaus, cov tshuaj no yuav tsum tsis txhob siv vim qhov tseeb tias lub cev tsim tawm ntawm glucocorticoid cov tshuaj hormones tuaj yeem cuam tshuam vim qhov ua tsis tiav ntawm adrenal cortex.
Tseem muaj qee qhov kev txwv raws li "Budesonide" yuav tsum tau muab tshuaj nrog ceev faj heev. Cov lus qhia rau kev siv ceeb toom tias cov neeg uas muaj ntshav siab, ntshav qab zib mellitus, pheochromocytoma, callous ulcer ntawm lub plab thiab duodenum yuav tsum tau siv kom zoo zoo.
Side effect
Tam sim no, tsis muaj tshuaj uas tsis tsim qhov no lossis qhov tshwm sim ntawd. Hmoov tsis zoo, "Budesonide" kuj yog ib qho tshuaj uas muaj ntau yam kev mob tshwm sim ntawm nws qhov kev ua.
YogYog tias "Budesonide" yog siv rau kev nqus pa, ces cov kev mob tshwm sim tseem ceeb ntawm nws txoj kev siv yuav yog kev hais lus tsis zoo (dysphonia), hoarseness, qhuav qhov ncauj, hnoos, kev loj hlob ntawm paradoxical bronchospasm.
Thaum noj qhov ncauj, kev nyuaj siab, kiv taub hau, chim siab yuav tshwm sim.
Cov kab mob plawv tuaj yeem teb rau cov lus qhia ntawm "Budesonide" nrog kev txhim kho vasculitis, nce ntshav siab, tachycardia.
Cov tshuaj kuj tseem tuaj yeem ua rau muaj kab mob hauv plab hnyuv - rwj, pancreatitis. Tsis tas li ntawd, nws txhawb txoj kev loj hlob ntawm cov kab mob dyspeptic.
Nws kuj ua rau tsis zoo rau lub cev musculoskeletal. Osteoporosis, myasthenia gravis, mob pob qij txha tuaj yeem tsim.
Cov kev mob tshwm sim hnyav tshaj plaws yog hypercortisolism syndrome. Nws tshwm sim vim qhov tseeb tias thaum lub sij hawm noj cov tshuaj glucocorticoids, synthesis ntawm tus kheej cov tshuaj hormones txo. Yog tias cov tshuaj corticoids tau siv ntev heev, cov qog adrenal tsuas tuaj yeem tso tseg cov tshuaj physiological, uas yuav cuam tshuam rau tus neeg mob txoj kev noj qab haus huv. Yog li ntawd nws yog ib qho tseem ceeb kom ua tib zoo tswj cov koob tshuaj ntawm cov tshuaj hormones uas tuaj, nrog rau kom tsis txhob noj lawv.
tshuaj tshuaj
Yuav tsum tau txhaj tshuaj Budesonide li cas?
Kev siv cov ntawv nqus pa ntawm "Budesonide" yog nyob ntawm qhov mob hnyav. Qhov koob tshuaj zoo tshaj rau tus neeg lausyog 200-800 mcg ib hnub twg. Qhov siab tshaj plaws txhua hnub koob tshuaj yuav tsum tsis pub tshaj 1.5 mg. Hauv cov menyuam yaus, cov tshuaj yog contraindicated rau kev siv, thiab nws cov analogues raug sau tseg raws li qhov hnyav ntawm qhov chaw kho mob.
Cov tshuaj hauv qhov ncauj yog siv 30-60 feeb ua ntej noj mov. Siv 3 mg 3 zaug ib hnub twg. Cov chav kawm ntawm kev kho mob nrog tshuaj qhov ncauj yog li 2 lub hlis. Kev rho tawm ntawm cov tshuaj yog nqa tawm maj mam txhawm rau txhawm rau tiv thaiv kev tshem tawm syndrome.
Budesonide Easyhaler feem ntau yog siv tshuaj intranasally. Nws koob tshuaj raug xaiv rau txhua tus neeg ib leeg, nyob ntawm qhov hnyav ntawm cov txheej txheem. Qhov nruab nrab, 2-3 tee ntawm cov tshuaj yog siv nyob rau hauv txhua lub qhov ntswg ob zaug ib hnub twg. Hauv cov menyuam yaus, daim ntawv ntawm cov tshuaj no yog contraindicated. Kev kho mob yog tsim los rau 2 lub lis piam.
Kev sib tham nrog lwm yam tshuaj
Qee cov tshuaj, thaum siv ua ke nrog Budesonide, tuaj yeem ua rau nws nqus tau. Cov tshuaj no suav nrog cytochrome P450 inhibitors. Piv txwv li, yog tias koj siv ib txhij "Budesonide" ("Pulmicort" - raws li ib qho analogue) thiab cov tshuaj xws li "Ketoconazole", "Erythromycin", nws muaj peev xwm maj mam tshem tawm cov glucocorticoid los ntawm cov ntshav, uas yog fraught nrog rau cov kab mob. kev loj hlob ntawm hormonal intoxication thiab cov tsos ntawm undesirable teebmeem ntawm cov tshuaj.
Parallel tau txais "Budesonide" thiab qee cov tshuaj diuretics ("Indap") pab txhawb kev txhim kho hypokalemia hauv tus neeg mob lub cev, uas yuav ua rau muaj kev cuam tshuam rau kev ua haujlwm ntawm lub plawv.
Qee cov tshuaj (piv txwv li, antacids - "Almagel"), thaum siv ib txhij nrog "Budesonide", muaj cov nyhuv antagonistic rau ib leeg, i.e. tsis txhob cia ib leeg los siv lawv txoj kev kho mob. Vim li no, nws raug nquahu kom siv cov tshuaj no tsawg kawg ob teev sib nrug (tsuas yog siv rau hauv daim ntawv ntawm qhov ncauj nkaus xwb).
Siv lub tshuab nqus pa
Vim tias cov tshuaj no tau tsim los kho cov kab mob ntawm cov kab mob ua pa, nws tsim nyog xav txog seb yuav muab tshuaj li cas.
Muaj ob peb hom tshuaj nqus tau pa, tab sis lawv cov kev siv feem ntau converges ntau txoj hauv kev.
Ua ntej, cov tshuaj no feem ntau yog siv los ntawm nebulizer. Cov cuab yeej no tso cai rau koj nkag mus rau ib qho tshuaj nruj me ntsis xaiv cov tshuaj mus rau hauv txoj kev ua pa. Ib qho kev noj cov hmoov rau kev nqus pa feem ntau yog txaus los tiv thaiv cov tsos mob ntawm mob hawb pob lossis COPD.
Rau lub hom phiaj no, "Budesonide-native" feem ntau yog siv. Cov tshuaj no yog patented los ntawm ib lub tuam txhab Lavxias teb sab. Nyob rau hauv nws cov muaj pes tsawg leeg, cov tshuaj yog ncua kev kawm ntawv (los yog hmoov) ntawm Budesonide. Lub cassette nrog cov tshuaj yog loaded rau hauv lub nebulizer, tom qab ntawd, ntawm kev tshoov siab, cov tshuaj nkag mus rau hauv lub bronchi thiab lub ntsws.
Qee cov tshuaj muaj nyob rau hauv daim ntawv ntawm aerosol, uas kuj muaj Budesonide. Lawv lub npe lag luam yuav txawv ntawm ib leeg, tab sis cov tshuaj nquag tseem yuav yog tib yam glucocorticoid. Yog tias koj noj cov tshuaj no, koj yuav tsum nco ntsoov qhov ntawdib koob tshuaj aerosol muaj 0.05 ml ntawm active budesonide (qhov no yog ib qho tseem ceeb uas yuav tsum paub kom tsis txhob ua rau overdose ntawm glucocorticoids).
Tus nqi tshuaj
Muab qhov loj ntawm lub khw muag tshuaj tam sim no, nws tsis yooj yim rau xaiv "Budesonide" rau kev nqus pa. Tus nqi rau nws thiab nws cov analogues yuav txawv, tab sis nws yuav tsum nco ntsoov tias txhua yam zoo ib yam, cov khoom tseem ceeb hauv lawv cov muaj pes tsawg leeg yuav yog budesonide. Tus nqi ntawm cov tshuaj tsuas yog nyob ntawm seb leej twg ua cov tshuaj thiab seb nws puas yog cov tshuaj uas muaj patented lossis generic.
Cov tshuaj yog yuav tshwj xeeb hauv khw muag tshuaj. "Budesonide" yuav raug nqi npaum li cas? Tus nqi rau nws thiab nws cov analogues yog nyob rau nruab nrab ntawm 300 txog 2000 rubles. Nws tag nrho yog nyob ntawm seb tus neeg tsim khoom yog leej twg, thiab hom twg ntawm kev tso tawm cov tshuaj. Piv txwv li, ib qho tshuaj xws li Benacort muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav nrog hmoov rau nqus tau pa. Qhov nruab nrab, nws raug nqi 400 rubles. Cov tshuaj Askiv yog kim dua. Piv txwv li, British-ua Budesonide Formoterol nqi nyob ib ncig ntawm 2,000 rubles, uas tsis yog pheej yig rau txhua leej txhua tus. Nws yooj yim dua los yuav cov tshuaj Slovenian, uas tsis txawv ntawm qhov ua tau zoo, tab sis pheej yig dua.
Cov kev tshawb fawb tau pom tias cov tshuaj kim dua yuav luag zoo li lawv cov peev nyiaj. Yog li ntawd, yam tshuaj twg yuav yog ib qho kev xaiv rau txhua tus, nyob ntawm seb lawv xav tau thiab muaj.
tshuaj tshuaj xyuas
Glucocorticoid tshuaj tau siv los ntawm ntau lub sijhawmcov neeg mob uas muaj kab mob plawv los yog mob hawb pob. Xyaum txhua tus neeg mob uas muaj hom mob hnyav ntawm ib qho ntawm cov kab mob uas tau teev tseg yog raug tshuaj Budesonide. Nws cov analogues nyob hauv lub xov tooj ntawm tes dav dav hauv kev sau npe tshuaj tiv thaiv cov kab mob no, yog li ntawd, lawv kuj tseem nyob ntawm lub rooj sib hais. Cov no yog cov tshuaj xws li, piv txwv li, "Apulein", "Benacap", "Buderin", twb tau hais saum toj no "Pulmicort" thiab "Benacort", thiab lwm yam.
Raws li ntau tus neeg mob, cov tshuaj no yog qhov zoo tshaj plaws hauv kev kho mob ntawm cov kab mob ua pa. Muaj ob peb tus neeg uas yuav tsis tau txais kev pab los ntawm ib qho kev nqus ntawm glucocorticoid lossis nws ua ke nrog beta-agonists.
Nrog rau kev siv tshuaj kom raug, nws tuaj yeem ua tiav qhov kev txhim kho tseem ceeb ntawm cov neeg mob zoo li no. Tam sim no, ntau tus tsuas tuaj yeem xav txog lub neej thiab kev ua haujlwm ib txwm tsis siv cov tshuaj no.
Txawm li cas los xij, txawm tias muaj ntau qhov kev tshuaj xyuas zoo, kuj tseem muaj qhov tsaus ntuj ntawm cov tshuaj xws li "Budesonide" - tus nqi.
Tau ntev heev tau muaj ib qho qauv ntawm cov tshuaj noj dawb tshuaj tiv thaiv kab mob hawb pob rau cov neeg mob xav tau. Txhua tus neeg mob tuaj yeem tuaj rau lub tsev muag tshuaj thiab, thaum nthuav tawm cov ntaub ntawv cuam tshuam, tau txais tshuaj dawb rau lawv tus kheej xav tau.
Tam sim no, qhov no kuj tau xyaum, txawm li cas los xij, cov neeg sib tw uas muaj cai tau txais cov tshuaj dawb no tau nqaim heev. Cov tshuaj no tam sim no muaj pub dawb xwb.tsuas yog rau cov neeg xiam oob qhab ntawm pawg 2 thiab 1, nrog rau cov menyuam yaus; lwm tus neeg raug yuam mus yuav tshuaj nrog lawv tus kheej cov nyiaj. Muab hais tias cov tshuaj xav tau ntau heev, tsis yog txhua tus neeg muaj peev xwm them taus qhov kev kho no.
