Hnub no, Allopurinol yog cov tshuaj tseem ceeb (tseem ceeb thiab muaj cov tshuaj tiv thaiv kab mob) siv hauv kev kho mob ntawm cov kab mob xws li gout. Txhua tus neeg, ua ntej sim ua ib yam dab tsi tshiab, sim nrhiav cov ntaub ntawv muaj txiaj ntsig ntau li ntau tau. Yog li, peb xav kom nkag siab ntau ntxiv thaum nws tsim nyog siv Allopurinol. Cov lus teb los ntawm cov neeg mob thiab kws kho mob yuav raug nthuav tawm hauv peb cov ntaub ntawv, thiab koj tseem yuav kawm paub yuav ua li cas ntshai thaum noj cov tshuaj no.
tshuaj yam ntxwv ntawm cov tshuaj
"Allopurinol" belongs rau pab pawg ntawm cov tshuaj tiv thaiv kab mob gout. Cov khoom xyaw tseem ceeb yog allopurinol thiab nws cov nquag metabolite oxypurinol. Lawv cov teebmeem pharmacodynamic yog vim kev ua txhaum ntawm kev sib txuas ntawm uric acid nrog kev txhim kho ntawm cov nyhuv urostatic. Thaum kawg, qhov no ua rau txo qis hauv nws cov concentration los ntawmtom qab tawg ntawm urates.
Vim nws cov solubility zoo, Allopurinol muaj bioavailability siab. Cov tshuaj yog absorbed zoo nyob rau hauv lub lumen ntawm cov hnyuv. Nyob rau hauv lub plab, nws tsis nkag mus rau hauv lub systemic ncig. Lub xub ntiag nyob rau hauv cov ntshav plasma tau pom lawm ib nrab ib teev tom qab noj, thiab qhov siab tshaj plaws concentration yog pom tom qab 1.5 teev. Raws li, qhov siab tshaj plaws ntawm allopurinol metabolite, oxypurinol, tau pom peb teev tom qab kev tswj hwm qhov ncauj.
Cov tshuaj muaj ib nrab-lub neej ntev thiab yog li ntawd muaj peev xwm sib sau ua ke. Hauv cov neeg mob thaum pib ntawm kev kho mob, kev nce hauv cov concentration ntawm cov tshuaj yog pom, uas stabilizes tom qab ib mus rau ob lub lis piam ntawm kev kho mob. Vim lub sij hawm ntev excretion ntawm "Allopurinol" (kev tshuaj xyuas ntawm kws kho mob paub meej tias qhov no) tsis pom zoo rau siv los ntawm cov neeg uas muaj lub raum tsis ua hauj lwm. Hauv cov neeg mob uas khaws cia lub raum excretory muaj nuj nqi, kev sib sau tsis raug pom.
"Allopurinol": cov lus qhia rau kev siv
Kev tshuaj xyuas ntawm cov kws kho mob sau cov tshuaj no hais tias nws siv tau zoo tshaj plaws thiab raug cai rau cov neeg mob hyperuricemia (nce uric acid cov ntsiab lus hauv ib chav ntim ntawm cov ntshav) thaum:
- gouty mob caj dab (gout);
- kab mob urate ntawm thaj chaw urogenital (nephropathy, urolithiasis);
- ntshav qog noj ntshav;
- congenital anomalies ntawm enzymatic system.
Qee zaum nws ua tausau tshuaj rau cov me nyuam rau kev kho mob ntawm urate nephropathy, uas tshwm sim thaum lub sij hawm kho leukemia, nyob rau hauv cov kab mob congenital txuam nrog impaired metabolism ntawm uric acid, theem nrab hyperuricemia ntawm ntau yam keeb kwm.
Txoj kev siv tshuaj
Allopurinol ntsiav tshuaj (kev tshuaj xyuas ceeb toom ntawm kev ua raws li cov lus pom zoo thaum noj cov tshuaj) tau noj tom qab noj mov, lawv yuav tsum tsis txhob chew, tab sis ntawm qhov tsis sib xws, lawv qaug cawv tag nrho thiab ntxuav nrog tsawg kawg ib khob sov. dej.
Cov neeg noj cov tshuaj no yuav tsum tau saib xyuas lawv cov zaub mov, thiab yog tias muaj kev ua txhaum ntawm kev noj haus, nco ntsoov kho nws cov tshuaj, tab sis tsuas yog nyob rau hauv kev saib xyuas ntawm koj tus kws kho mob tshwj xeeb.
Cov koob tshuaj Allopurinol xav tau rau kev kho mob yog txiav txim siab nyob ntawm cov ntsiab lus ntawm uric acid hauv cov hlab ntsha. Raws li txoj cai, nws txawv ntawm 100 mus rau 300 mg rau ib koob ntawm Allopurinol. Cov lus teb los ntawm cov neeg mob thiab kws kho mob txog qhov koob tshuaj no yog qhov zoo, txij li cov tshuaj tau noj ib hnub nkaus xwb.
Kev kho mob gout pib nrog 100 mg ntawm cov tshuaj ib hnub ib zaug. Nyob rau hauv cov ntaub ntawv ntawm kev ua tau zoo tsis txaus thiab txo qis me ntsis ntawm qib ntawm uric acid, qhov koob tshuaj maj mam nce ntxiv (los ntawm 100 mg txhua ob mus rau peb lub lis piam), coj cov qib ntawm uric acid mus rau qib kho tau zoo nyob rau hauv kev tswj xyuas hauv chav kuaj. Hauv cov xwm txheej zoo li no, qhov nruab nrab ntau npaum li cas thiab koob tshuaj ntxiv yog los ntawm 200 txog 400 mg, txawm li cas los xij, hauv qee qhov xwm txheej, koob tshuaj.cov tshuaj tuaj yeem ncav cuag 800 mg. Hauv qhov no, nws muab faib ua ob peb zaug hauv ib hnub.
Thaum muab tshuaj rau cov neeg mob lub raum tsis txaus, nws yuav tsum tau tsom mus rau kev tshem tawm creatinine.
Contraindications rau kev teem caij ntawm "Allopurinol"
Cov tshuaj yog contraindicated rau siv rau cov neeg mob uas mob raum tsis txaus, nrog rau cov poj niam cev xeeb tub thiab lactating. Nws kuj tsis pom zoo kom sau cov tshuaj no rau cov neeg mob uas muaj kev tsis haum tshuaj lossis tsis haum rau ib lossis ntau yam ntawm cov tshuaj. Nws yog txwv tsis pub siv cov tshuaj nyob rau hauv cov neeg uas muaj ib tug ciam teb cov ntsiab lus ntawm uric acid nyob rau hauv cov ntshav plasma, txij li thaum nws txo tau tiav tiav los ntawm kev kho cov zaub mov.
"Allopurinol" phiv
Kev tshuaj xyuas ntawm cov neeg mob uas siv cov tshuaj no thawj zaug qhia tias feem ntau tuaj yeem ua rau tus kab mob hnyav dua thiab ua rau muaj cov tsos mob ntawm gout nrog qhov pib ntawm kev tawm tsam. Tab sis qhov tshwm sim no yog luv luv, thiab koj yuav tsum tsis txhob ntshai ntawm nws ntau npaum li kom tsis txhob kho. Tab sis thaum muaj pob khaus, tsis xis nyob, lossis cov tsos mob tshwm sim ntxov, koj yuav tsum qhia tus kws kho mob tam sim ntawd. Hauv qhov no, kev noj tshuaj "Allopurinol" yuav tsum raug tso tseg tam sim ntawd, thiab thaum cov tsos mob ploj mus, tus kws kho mob tuaj yeem rov sau cov tshuaj, tab sis ntawm qhov qis dua (pib ntawm 50 mg). Kev txais tos yuav tsum tau ua raws li kev saib xyuas ze ntawm tus kws kho mob uas tuaj koomthiab sib cais.
Ntawm cov kev phiv los ntawm lub paj hlwb thiab kev puas siab puas ntsws zog, kev nyuaj siab yuav tshwm sim. Nyob rau ib feem ntawm lub hematopoietic system, kev loj hlob ntawm kev nyuaj siab ntawm cov pob txha pob txha muaj nuj nqi nrog tshwm sim ntawm thrombocytopenia, aplastic anemia tsis tshua pom.
Thaum noj tshuaj, kev txhim kho ntawm cov kab mob metabolic hauv daim ntawv ntawm ntshav qab zib mellitus, nce qib ntawm fatty acids hauv cov ntshav plasma yog ua tau.
Los ntawm sab ntawm cov hlab plawv, kev loj hlob ntawm arterial hypertension, bradycardia yog ua tau.
Qhov tshwm sim ntawm qhov tshwm sim tsis zoo rau cov tshuaj no nce ntxiv thaum tus neeg mob lub raum tsis ua haujlwm.
Kev tso tawm thiab ntau npaum li cas
"Allopurinol" muaj nyob rau hauv daim ntawv ntsiav tshuaj (30 lossis 50 daim ib pob) ntawm qhov ntau npaum ntawm 100 thiab 300 mg ntawm cov khoom xyaw nquag hauv ib ntsiav tshuaj. Allopurinol Sandoz 300 yog tam sim no nyob rau hauv kev ua lag luam. Kev tshuaj xyuas txog nws yog qhov zoo, txij li cov tshuaj hauv qhov koob tshuaj no tsuas yog muab ib zaug ib hnub xwb, uas ua haujlwm tsis zoo rau kev hla cov tshuaj.
Tshuaj lom thiab tshuaj ntau dhau
Tshuaj lom yog qhov tsawg kawg nkaus, tab sis muaj cov xwm txheej ntawm ib koob ntawm 20 grams ntawm cov tshuaj. Cov tsos mob hauv qab no tau pom: kiv taub hau, ntuav, xeev siab, raws plab. Nrog rau lub raum tsis ua haujlwm thiab kev siv sijhawm ntev ntawm kev siv tshuaj ntau, cov tsos mob hnyav ntawm kev qaug cawv tau sau tseg hauv daim ntawv ua npaws, kab mob siab, exacerbation.lub raum tsis ua haujlwm.
Kev kho mob hnyav thiab tshuaj ntau dhau yog cov tsos mob, txhawm rau txhawm rau tshem tawm cov tshuaj hauv lub cev kom nrawm. Tsis muaj tshuaj tiv thaiv tshwj xeeb. Rau kev tshem tawm sai ntawm cov tshuaj los ntawm lub cev, txoj kev lim ntshav detoxification tau zoo.
Reviews
Muab qhov tseeb tias lub sijhawm ntawm cov tshuaj no hauv cov ntshav (hauv cov ntsiab lus txaus los muab cov txiaj ntsig kho mob) yog nyob rau nruab nrab ib lub lis piam, cov neeg mob gout yuav tsum siv Allopurinol yuav luag txhua lub neej. Kev tshuaj xyuas ntawm cov kws kho mob tsis paub meej: cov tshuaj tau ua pov thawj nws tus kheej zoo. Tab sis qhov no tsis yog "miracle ntsiav tshuaj" uas koj tuaj yeem haus thiab tsis nco qab txog tus kab mob. Gout yog ib txoj kev ua neej ntau dua li cov kab mob ntev. Tab sis nws yog Allopurinol uas pab tswj cov qib ntawm lactic acid thiab tiv thaiv tus kab mob exacerbation thiab nws cov kev loj hlob ntxiv.
Los ntawm qhov pom ntawm qhov yooj yim ntawm kev sau tshuaj Allopurinol, cov kws kho mob cov kev tshuaj xyuas kuj zoo, vim tias feem ntau tus neeg mob yuav tsum tau noj cov tshuaj ib hnub ib zaug. Qhov no txo qis txoj hauv kev ploj ntawm cov tshuaj thiab yog li ua kom cov txiaj ntsig ntawm kev kho.
Zoo kawg
Yog li, qhov kev kho mob tseem ceeb rau gout yog Allopurinol. Kev tshuaj xyuas ntawm cov kws kho mob tshwj xeeb thiab cov neeg mob noj cov tshuaj no yog qhov zoo, thiab qhov no dua ib zaug lees paub qhov ua tau zoo ntawm kev sivtshuaj nyob rau hauv kev kho mob ntawm gout thiab mob ntawm uric acid metabolism. Ua tsaug rau kev siv cov tshuaj no, ntau tus neeg mob tau txais kev cia siab los txo qhov mob ntshav qab zib.
