Ntawm cov kab mob uas tuaj yeem txo txoj sia nyob ntev thiab cuam tshuam rau nws qhov ua tau zoo, cov hlab ntsha ntawm cov hlab ntsha tuaj yeem sib nrug. Nws maj mam thiab maj mam cuam tshuam rau cov hlab ntsha, hlwb, ob lub raum thiab myocardium. Hauv cov theem pib, nws nyuaj rau tus neeg mob kom paub txog tus kab mob, vim nws tshwm sim nws tus kheej tsis muaj kev tsis txaus siab.
Tom qab lawv tshwm sim, thiab tus neeg mob sau tseg tias nws cov ntshav siab ntau dua li qub. Qhov teeb meem no yuav tsum tau pib ntawm kev kho tshuaj pharmacological, uas yog ua tau nrog kev siv 5 chav kawm ntawm cov tshuaj. Thiab "Ramipril" yog qhov zoo tshaj plaws ntawm lawv, lav qhov tshwm sim hauv kev kho mob monotherapy lossis ua ib feem ntawm kev kho mob sib xyaw ua ke.
Cov yam ntxwv ntawm cov tshuaj
"Ramipril", analogues ntawm cov tshuaj, nrog rau cov tshuaj complex yog cov tshuaj tiv thaiv kab mob siab. Ramipril nws tus kheej yog ib qho khoom xyaw uas muaj nyob hauv ntau cov tshuaj. Nws yog ib qho ACE inhibitor uas tuaj yeem thaiv cov enzyme thiab txo cov ntshav siab. Nws tuaj yeem txhim kho qhov kev cia siab ntawm cov kab mob hauv cov neeg laus.
Nyob hauv chaw kho mobCov kev tshawb fawb tau pom tias ramiprilat, lub zog metabolite ntawm Ramipril, inhibits angiotensin-hloov enzyme ntau zog. Vim li no, Ramipril, analogues thiab cov tshuaj complex yog cov tshuaj ntawm kev xaiv rau kev tswj ntshav siab.
Analogues
Txij li cov tshuaj muaj peev xwm tiv thaiv ACE thiab pab tswj cov ntshav siab, cov tshuaj "Ramipril" analogues muaj ntau heev. Tag nrho cov ntawm lawv tau ua tiav zoo siv hauv kev kho mob ntshav siab. Ntxiv mus, thawj ramipril yog cov tshuaj "Tritace". Tag nrho cov seem yog nws cov generics, cov hauj lwm zoo uas yuav tsum tau muab piv nrog nws. Kev pom zoo rau kev muag yuav tsum tau lees paub los ntawm bioequivalence rau Tritace.
Tam sim no, cov npe ntawm cov analogues yog raws li nram no: Amprilan, Vasolong, Dilaprel, Korpril, Pyramil, Ramepress, Ramigamma, Ramicardia, Tritace, Hartil . Ramipril kuj yog tsim los ntawm Lavxias teb sab tuam txhab TatkhimPharmPreparaty, Biokom thiab Severnaya Zvezda. Cov khoom tom kawg yog hu ua Ramipril SZ.
qauv dosages thiab complex npaj
Cov tshuaj tiv thaiv kab mob ntshav siab Ramipril yog ib qho yooj yim rau koob thiab noj. Nws txoj haujlwm tso cai rau peb paub qhov txawv ntawm peb qhov kev siv tshuaj ntau npaum li cas. Cov no yog 2.5 mg, 10 thiab 5 mg. Cov ntsiav tshuaj ntawm qhov loj no tau noj ob zaug ib hnub. Tseem muaj cov tshuaj complex uas muaj ramipril thiab hydrochlorothiazide: Amprilan ND, Amprilan NL, Vasolong N, Remazid, Triapin, Tritace Plus, Hartil D, Egipress. Ntawm no, tus nqi ntawm ramipril yog li ntawm 2.5 mg mus rau 10, thiab koob tshuaj hydrochlorothiazide yog los ntawm 12.5 txog 25 mg hauv ib ntsiav tshuaj.
qeb thib ob ntawm kev npaj nyuaj yog kev sib xyaw ntawm Ramipril thiab calcium antagonist Amlodipine. Ib qho piv txwv ntawm cov tshuaj yog Egipress, uas muaj nyob rau hauv ob koob tshuaj: 10 mg ntawm ramipril thiab 5 mg ntawm amlodipine, nrog rau ntawm ib koob ntawm 10/10 mg. Ntxiv rau qhov kev sib xyaw ua ke no, muaj lwm yam tshuaj uas muaj ACE inhibitor Ramipril thiab calcium antagonist Felodipine. Qhov no yog Triapin, uas muaj 2.5 mg ntawm ramipril thiab 2.5 mg ntawm felodipine.
Cov lus qhia rau kev siv
Ntxiv nrog rau cov lus pom zoo ntawm tus kws kho mob, tus neeg mob yuav tsum coj mus rau hauv tus account cov lus qhia rau kev siv. Nws muaj cov ntaub ntawv hais txog kev qhia, kev mob tshwm sim, koob tshuaj thiab kev tswj hwm kev tswj hwm, contraindications thiab ceev faj. Kuj tseem txuas nrog cov tshuaj "Ramipril" cov lus qhia rau kev siv piav qhia qhov xav tau kom tsis txhob haus cawv hauv kev kho mob ntshav siab.
Kev qhia
"Ramipril", analogues ntawm cov tshuaj thiab generics "Tritace" yog qhia ntawm:
- qhov tseem ceeb hypertension;
- ua ib feem ntawm txoj kev kho ntau hom kev kho mob ntevplawv tsis ua hauj lwm;
- mob ntshav qab zib thiab lwm yam kev kho mob lossis subclinical nephropathy tsis cuam tshuam nrog lub raum hlab ntsha stenosis;
- nrog cov tsos mob ntawm arterial hypertension;
- rau kev tiv thaiv ntawm myocardial infarction, txo qis kev tuag ntawm cov neeg mob uas muaj kab mob plawv, thiab kev kho mob ntshav siab nrog rau tag nrho cov hlab plawv.
Qhov taw qhia tseem ceeb yog arterial hypertension. Qhov no yog kab mob feem ntau ntawm cov hnub nyoog nruab nrab thiab laus uas yuav tsum tau kho. Tsis tas li ntawd, cov tshuaj "Ramipril" lossis lwm ACE inhibitor yuav tsum tau muab rau cov neeg mob thawj 2-9 hnub txij li lub sijhawm mob hnyav tshaj plaws ntawm myocardial infarction. Qhov koob tshuaj ntawm cov tshuaj yuav tsum yog qhov siab tshaj plaws zam txawm tias thaum tus neeg mob tsis raug kev txom nyem los ntawm kub siab. Qhov no yog vim muaj zog cardioprotective los ntawm ACE inhibitors.
YContraindications
Cov tshuaj "Ramipril SZ" yuav tsum tsis txhob siv yog tias muaj keeb kwm ntawm angioedema rau ib qho analogue ntawm cov tshuaj, nrog rau cov tshuaj tsis haum uas tau tsim los ntawm kev txais tos. Kev teem caij yog contraindicated nyob rau hauv lub xub ntiag ntawm hemodynamically stenosis ntawm cov hlab ntsha ntawm ob sab. Yog hais tias tus mob stenosis yog unilateral thiab ob lub raum ua haujlwm ib txwm nyob hauv tus neeg mob, ces qhov kev teem caij raug tso cai nrog ceev faj thiab nyob rau hauv kev tswj ntawm GFR.
Cov tshuaj "Ramipril" (5 mg lossis muaj nyob rau hauv lwm yam tshuaj) tsis yog siv rau hypotension qis dua 90 mm Hg. Art. Tsis tas li ntawd, cov tshuaj yuav tsum tsis txhob siv rau hemodynamicQhov tseem ceeb stenosis ntawm lub aortic los yog mitral valve, nrog obstructive hypertrophic cardiomyopathy, thawj hyperaldosteronism, mob raum tsis ua hauj lwm nrog creatinine clearance (GFR) tsawg dua 20 ml / min.
Cov lus qhia rau kev siv txuas nrog cov tshuaj "Ramipril" (tsis muaj qhov sib piv ntawm cov ntaub ntawv no) muaj qhov qhia txog kev siv tshuaj tsis zoo thaum cev xeeb tub thiab lactation. Nws kuj tseem siv tsis tau rau kev siv tshuaj rau menyuam yaus. Hnub nyoog qis dua 18 xyoo, kev kho mob tsuas yog txwv thiab tsis tuaj yeem lees paub kev nyab xeeb.
Kev noj tshuaj
Daim ntawv tseem ceeb ntawm Ramipril yog cov ntsiav tshuaj. Hauv cov tshuaj ntsiav, nws tsis tshua muaj. Qhov pom zoo pib koob tshuaj yog 1.25 mg. Qhov tsawg tshaj plaws ntawm cov tshuaj yog 2.5 mg, uas yuam kom nws muab faib ua ob. Lub xub ntiag ntawm kab ntawm cov ntsiav tshuaj ua kom yooj yim.
Rau txhua hom ntshav siab, thawj koob tshuaj yog 1.25 mg ib hnub ib zaug. Tom qab ntawd, nrog kev ua siab ntev, koob tshuaj maj mam muab ob npaug. Kev txhaj tshuaj titration yog nqa tawm kom txog thaum lub ntsuas ntshav siab stabilizes. Cov txheej txheem rau kev kho mob ntshav siab yog cov ntshav siab tas li uas tsis tshua nce siab thaum so.
Kev Tiv Thaiv
Cov tshuaj yuav tsum tau noj nyob rau hauv kev tswj hwm, tshwj xeeb tshaj yog thaum xub thawj. Nws yog ib qho tseem ceeb uas systolic ntshav siab poob qis dua 90 mm. ua rt. Art. Thaum ntshav siab poob qis dua qib no, nws raug nquahu kom nrhiav kev pab ntawm cov neeg ua haujlwm kho mob. Los ntawmTxhawm rau tiv thaiv kev poob ntawm cov ntshav siab, nws tsis pom zoo kom siv Ramipril ua ke nrog nitrates, chav kawm I antiarrhythmics (Procainamide) thiab alpha-1 blockers (Alfuzosin, Tamsulosin).
Cov tshuaj yuav tsum tau noj tsis tu ncua thiab nyiam dua tib lub sijhawm. Qhov no tso cai rau kev hloov pauv ntawm renin-angiotensin-aldosterone system, uas tswj cov ntshav siab. Tsis tas li ntawd, tsis txhob hla cov tshuaj, uas tuaj yeem tshwm sim hauv kev kub ntxhov hnyav. Kev tshem tawm sai sai tuaj yeem ua rau mob stroke, qhov txaus ntshai uas nce ntxiv rau lub sijhawm no.
Kev tshuaj xyuas cov neeg mob txog tshuaj
Tritace thiab nws cov generics yog cov tshuaj zoo uas tswj cov ntshav siab zoo. Txog niaj hnub no, cov tshuaj no yog cov tshuaj tiv thaiv kab mob siab tshaj plaws. Vim qhov no, cov neeg mob tshuaj xyuas txog nws feem ntau yog qhov zoo. Lawv qhia tias nws yog ib qho tshuaj txhim khu kev qha thiab muaj zog uas tswj cov ntshav siab zoo. Kev tshuaj xyuas cov neeg mob yav dhau los tau noj lwm yam tshuaj hauv pab pawg no yog qhov tseem ceeb tshwj xeeb.
Cov neeg mob tau tshaj tawm qee qhov kev cuam tshuam tsis zoo cuam tshuam nrog kev lom. Cov qib siab ntawm kev sib raug zoo rau ACE, nrog rau kev siv tshuaj tsawg, ua rau muaj kev cuam tshuam ntau ntawm cov teebmeem metabolic uas muaj feem cuam tshuam nrog kev siv tas li. Nws yog ib qho tseem ceeb uas tus naj npawb ntawm cov teeb meem tawm tsam keeb kwm yav dhau ntawm kev siv tas li ntawm "Ramipril" txo qis. Txawm li cas los xij, lawv qhov kev tshem tawm tiav tsis tuaj yeem ua tau nrog kev kho mob monotherapy.
Tshaj tawm cov kws kho mob txog tshuaj
Hypertension statistics yog kev nyuaj siab. Nws lees paub qhov tseem ceeb ntawm tus kab mob no rau cov tshuaj niaj hnub. Nws tseem yog ib qho tseem ceeb uas pathology txo qis lub neej expectancy. Hypertension tshwm sim vim yog overproduction ntawm renin, uas ua rau kom cov angiotensin nyob rau hauv cov ntshav. Inhibition ntawm cov enzyme no ua rau txo qis hauv siab. Qhov no yog qhov tsim nyog los tiv thaiv kab mob sclerosis ntawm phab ntsa vascular thiab cov tsos ntawm cov teeb meem loj heev ntawm kev kub siab.
Raws li tau pom hauv kev tshawb fawb soj ntsuam rov qab, ntau qhov atrial fibrillations thiab cov kab mob ntawm lub plawv tuaj yeem tshwm sim tom qab tus neeg mob tau kub siab rau qee lub sijhawm. Yog li ntawd, qhov tseem ceeb ntawm nws txoj kev kho mob yog loj heev. Thiab tseem ceeb tshaj, nws yog lub peev xwm los tshem tawm cov kab mob ua tsaug rau cov tshuaj ntawm ACE inhibitor pawg. Ntawm lawv, "Ramipril" yog tam sim no muaj zog thiab ua tau zoo tshaj plaws.
Kev tshuaj xyuas cov kws kho mob txog nws ua pov thawj nws cov txiaj ntsig. Cov tshuaj yog ib qho yooj yim mus use, muaj ob peb phiv thiab zoo heev. Txawm li cas los xij, txawm tias cov khoom zoo li no, nws yuav tsis txaus los kho mob ntshav siab. Qhov no yog yuav luag 40-50% ntawm qhov chaw kho mob.
Lawv xav tau kev sib xyaw ua ke uas muaj ACE inhibitor, diuretic, calcium antagonist, thiab qee zaum beta blocker. Raws li angiotensin-hloov enzyme inhibitor, Ramipril yog qhov zoo. Yog li ntawd, nws tuaj yeem coj nws qhov chaw hauv kev kho mob ntshav siab thaum twg nws tso cai. Txawm hais tias ntau tus neeg mob yuav pom nws qhov tsis zoo, nws qhov sib piv siabnqi.
