Lub sij hawm tsis nyob twj ywm, thiab txhua yam kev lom neeg ntawm lub neej hauv ntiaj teb raug hloov pauv loj. Cov txheej txheem kev laus uas tshwm sim los txiav txim siab qhov tshwm sim ntawm kev tsis txaus siab ntawm tus kheej lub cev thiab lwm tus, qhov tshwm sim ntawm kev ua pa nrawm thaum txav mus los, ua tsis taus pa luv, stooping posture thiab nruj ntawm kev txav. Tsis tas li ntawd, qhov pom kev tsis zoo.
Muaj ib lub tswv yim, uas, los ntawm txoj kev, yog heev, hais tias cov txheej txheem kev laus tsis yog ib yam dab tsi yuav tsum tau, tab sis kom qeeb yog yuav luag tsis yooj yim sua. Xib fwb Skulachev, uas nws lub qhov muag tee muaj ib qho txuj ci tseem ceeb tiag tiag, muaj qhov sib txawv ntawm qhov pom.
Tau kawg, kev laus yog txheej txheem ntuj tsim, tab sis vim li cas nws thiaj li tsis tuaj yeem qeeb? Kev laus tshwm sim rau ib qho laj thawj. Nyob rau hauv lub voj voog ntawm cov kws tshawb fawb koom nrog kev laus ntawm tib neeg lub cev, muaj kev xav zoo tias peb cov DNA saw muaj ib txoj haujlwm tshwj xeeb rau kev laus ntawm lub cev. Thaum ncav cuag ib lub hnub nyoog, qhov kev pab cuam no tau qhib, uas thaum kawg ua rau qhov kev zam tsis tau -tuag.
Qhov phom sij ntawm kev laus rau qhov muag yog dab tsi
Kev ua txhaum ntawm cov txheej txheem ntawm kev pom kev pom yog ib qho ntawm cov cim qhia ntawm kev laus. Tsis yog, tau kawg, koj tuaj yeem ntsib cov neeg uas muaj kev noj qab haus huv loj, uas txaus los ua kom muaj zog thiab tiv taus txhua yam kab mob ntawm lub hnub nyoog laus, tab sis yog tias ib tug neeg dheev poob nws qhov muag los yog nws deteriorates heev, ces txawm xws li ib tug " hero" dhau los ua kev tsis taus.
Feem ntau ntawm cov kab mob ophthalmic loj hlob qeeb qeeb dhau sijhawm. Nrog lub hnub nyoog, lub caj pas lacrimal ua haujlwm tsis zoo thiab tsis zoo, thiab qhov no ua rau txo qis hauv kev tsim khoom thiab tsim kua muag nws tus kheej. Qhov no tshwm sim tom qab muaj hnub nyoog 40, tab sis kuj tuaj yeem tshwm sim tom qab 30.
Yog li ntawd yog dab tsi? Nws yog ib qho tseem ceeb heev uas thaum muaj hnub nyoog lub qhov muag tiv thaiv zaj duab xis yuav thinner, corneal microtraumas thiab puas, inflammatory kab mob tshwm sim ntau thiab ntau zaus, qhov muag nkees tshwm sim sai. Nyob rau hauv lub neej yav tom ntej, xws li microchanges yog lub hauv paus rau txoj kev loj hlob ntawm ntau formidable kab mob, xws li cataracts, nce intraocular siab nrog rau txoj kev loj hlob ntawm glaucoma, degenerative hloov nyob rau hauv lub retina thiab optic paj hlwb tej zaum yuav pib nrog zuj zus tsis pom kev. Txawm li cas los xij, tsis txhob ntshai tias cov kab mob no tuaj yeem tshwm sim lawv tus kheej ib zaug. Lawv txoj kev loj hlob qeeb thiab maj mam.
Qhov no tau ua rau qhov tseeb tias xibfwb Skulachev txiav txim siab los tsim cov tee qhov muag. Kev tshuaj xyuastxog tam sim no qhov zoo tshaj plaws txog lawv. Qhov loj heev, yog tias tsis loj, tus naj npawb ntawm cov neeg mob ophthalmic tau muaj sijhawm los saib lub ntiaj teb dua nrog lub qhov muag pom tseeb yam tsis muaj kev phais. Thiab txhua yam ua tsaug rau qhov tseeb tias xibfwb Skulachev tau tsim qhov muag tee, tus nqi uas yog ntau tshaj li tus nqi pheej yig.
Mitochondrial yam antioxidants
Nyob hauv Moscow State University. Lomonosov, txij li xyoo 2005, ib txoj haujlwm tshawb fawb tau tsim los tsim cov tshuaj tsim los ua kom qeeb thiab ua kom cov txheej txheem kev laus qeeb. Raws li kev taw qhia nruj ntawm V. P. Skulachev, Academician ntawm Lavxias teb sab Academy of Sciences, biochemist uas tau kawm txog cov txheej txheem tshwm sim hauv mitochondria rau ntau tshaj plaub caug xyoo, ib hom tshiab ntawm cov tshuaj lom neeg lom neeg, mitochondrial hom antioxidants, tau tsim.
Hauv thawj cov kev tshawb fawb tom qab tsim cov tshuaj no, cov kws tshawb fawb pom tias mitochondrial antioxidants qeeb qeeb, thiab qee qhov kev hloov pauv, kev loj hlob ntawm qhov muag kab mob hauv cov tsiaj hauv kev sim. Ob peb xyoos tom qab ntawd, ntau txoj haujlwm tau ua tiav los ntawm kev tsim cov tshuaj tshiab raws li mitochondrial antioxidants, thiab xibfwb Skulachev tau qhia txog qhov muag tee nyob rau hauv lub npe "Vizomitin".
Cia peb saib ntawm ib qho ntawm thawj qhov cim ntawm qhov muag laus - hnub nyoog txog kev ua haujlwm tsis zoo ntawm lub caj pas lacrimal. Yuav ua li cas muaj hnub nyoog? Nrog lub hnub nyoog, muaj qhov txo qis hauv qhov ntau thiab zoo ntawm cov kua dej lacrimal thiab, vim li ntawd, kev loj hlob ntawm "qhov muag qhuav" syndrome. Nws tshwm sim nws tus kheej nrog qhov kev xav ntawm qhov tsis xis nyob hauv lub qhov muag, qhov kev xav ntawm cov xuab zeb lossis lub cev txawv teb chaws me me, thiab nrog rau cov kab mob maj mam zuj zus tuaj, yuav tshwm sim ntau thiab ntau dua.
Nco ntsoov tias cov tshuaj tiv thaiv kab mob cataract tam sim no muaj nyob rau hauv khw muag tshuaj hauv ntau qhov ntau. Tus naj npawb ntawm cov tshuaj tsom rau kev kho cov tsos mob tshwm sim nyob rau hauv "qhuav qhov muag" kuj loj, tab sis yuav luag tag nrho cov ntawm lawv (los yog feem ntau ntawm lawv) yog ib tug hluavtaws analogue ntawm tib neeg lacrimal kua. Lawv lub ntsiab qhov tsis zoo yog tias tus neeg mob yuav tsum tau siv cov tshuaj no los ntawm 10 mus rau 20-25 zaug hauv ib hnub, vim tias kev siv tsuas yog txhawm rau kho cov ntsiab lus ntawm cov kua muag hauv qhov muag.
Kev kuaj mob thiab kuaj mob
Cov tshuaj tshiab tshaj plaws "Vizomitin" radically txawv ntawm txoj cai ntawm kev ua los ntawm cov tshuaj zoo sib xws siv los kho qhov muag qhuav. Lawv ua raws li qhov ua rau ntawm tus kab mob, txhim kho kev ua haujlwm ntawm lub caj pas lacrimal thiab nres nws cov kev hloov pauv degenerative. Tsis tas li ntawd, cov tee no muaj cov txiaj ntsig zoo ib yam li cov tee cataract raws li cov kua muag cuav.
qhov xwm txheej no tsis yog ib nqe lus theoretical xwb, tab sis yog qhov tseeb tsim tiag. Xib fwb Skulachev kawm txog qhov muag tee nyob rau hauv txhua txoj kev uas ua tautsiaj txhu, thiab kuj tau ua qhov kev sim tshuaj ntawm cov tshuaj hauv ntau lub qhov muag: ntawm Department of Ophthalmology (Russian State Medical University) thiab ntawm Helmholtz Research Institute of Eye Diseases.
Cov txiaj ntsig los ntawm cov kev tshawb fawb no thiab kev sim tshuaj ntsuam xyuas tau txhawb nqa. Xib fwb Skulachev, uas nws lub qhov muag tee yog muag nyob rau hauv lub npe Vizomitin, hais tias lawv muaj ntau txoj kev zoo dua li cov tshuaj zoo sib xws siv los kho thiab tshem tawm cov tsos mob ntawm qhov muag qhuav. Ntxiv mus, nws tsim nyog sau cia tias tsis muaj kev phiv tshwm sim hauv cov neeg mob uas siv cov tshuaj no.
Raws li cov txiaj ntsig ntawm cov kev tshawb fawb no, cov tshuaj tau sau npe nrog Ministry of He alth thiab Social Development nyob rau lub Kaum Ob Hlis 2011 ua tus neeg sawv cev keratoprotective hu ua "Vizomitin", lossis Skulachev qhov muag tee. Hnub no mus yuav tshuaj qhov twg? Txij li thaum lub caij ntuj sov ntawm 2012, nws tau tshwm sim nyob rau hauv lub khw muag khoom network ntawm cov chaw muag tshuaj nyob rau hauv lub teb chaws.
Tau kawg, zoo li lwm yam tshuaj tshiab uas muaj cov khoom xyaw uas tsis paub yav dhau los, "Vizomitin" tsuas yog tso tawm los ntawm cov tshuaj. Puas muaj peev xwm yuav Skulachev qhov muag tee yam tsis muaj nws? Kuv tuaj yeem yuav lawv qhov twg yog tias tsis muaj tshuaj? Tsis txhob siv dag zog, tab sis tiv tauj koj tus kws kho mob ophthalmologist. Kev tso tawm ntawm cov tshuaj los ntawm cov tshuaj yuav tsum tsis txhob raug ntaus nqi rau qhov tsis zoo - qhov no feem ntau txiav txim siab nws lub hom phiaj tshuaj, uas, nyob rau hauv lem, implies ib tug zoo los ntawm daim ntawv thov.
Qhov kev tshawb pom tiag tiag tau uaXibfwb Skulachev. Qhov muag tee, tshuaj xyuas uas tsuas yog qhov zoo, yeej muaj txiaj ntsig zoo kawg nkaus. Ophthalmologists tsis tau tsuas yog nyob rau hauv Russia, tab sis thoob plaws lub ntiaj teb no ua raws li lawv cov kev siv thiab kev sim tshuaj. Cov rooj sib tham sib cais thiab cov rooj sib tham tau mob siab rau cov tshuaj no txhawm rau nthuav qhia cov ntaub ntawv rau txhua tus kws kho qhov muag.
Cia peb nyob hauv ntau yam ntawm cov tshuaj "Vizomitin". Cov lus qhia rau kev siv tuaj yeem muab cov ntaub ntawv nthuav dav.
Kev piav qhia
Cov khoom no yog ze li qhov tseeb, tej zaum muaj xim me ntsis lossis cov kua dej me me. Cov khoom xyaw nquag yog plastoquinonyldecyltriphenylphosphonium bromide, uas muaj 0.155 mcg hauv 1 ml ntawm cov tshuaj. Raws li excipients, benzalkonium chloride, hypromellose, sodium chloride, thiab lwm yam yog siv.
pharmacodynamic data
Plastoquinonyldecyltriphenylphosphonium bromide yog ib qho derivative ntawm plastoquinone, uas yog txuas mus rau triphenylphosphine residue los ntawm qhov hu ua linker saw. Raws li Dr. Skulachev, qhov muag tee (tus nqi rau lawv tsis siab vim yog cov txheeb ze cheapness ntawm synthesis ntawm no compound) nyob rau hauv nanomolar concentrations muaj peev xwm nthuav tawm cov tshuaj tiv thaiv kab mob siab heev nrog cov nyhuv stimulating siab ntawm cov txheej txheem tsim kua muag, nce lub cev. stability ntawm lub kua muag zaj duab xis tsim, thiab kujmuaj kev cuam tshuam rau cov txheej txheem epithelialization.
Pharmacokinetic data
Hnub no, nws tsim nyog hais tias kev tshawb fawb tshuaj pharmacokinetic tsis tau ua rau tib neeg. Raws li kev tshawb fawb preclinical ntawm cov tsiaj, kev faib tawm ntawm cov tshuaj nquag ntawm cov tee dej thoob plaws hauv lub cev tau sau tseg tsis pub dhau 2 hnub tom qab kev tswj hwm ntawm parenteral lossis qhov ncauj. Lub xub ntiag ntawm plastoquinonyldecyltriphenylphosphonium bromide tau sau tseg hauv qhov siab tshaj plaws nyob rau hauv cov ntaub so ntswg ntawm lub raum thiab daim siab, lub plawv 1 teev tom qab kev tswj hwm. Nws tau sau tseg tias cov khoom no tau degraded sai heev los ntawm enzymes thiab muaj peev xwm ntawm covalent bonds nrog cov proteins.
Cov lus qhia rau kev siv thiab contraindications
Skulachev's "Vizomitin" tee yog tshuaj rau "qhov muag qhuav" syndrome, muaj hnub nyoog hloov pauv hauv lub caj pas lacrimal, computer syndrome. Raws li qhov tseeb tias kev tshawb fawb tshawb fawb txog kev cuam tshuam ntawm cov tshuaj tseem tsis tu ncua, nws tseem pom zoo rau cataracts, glaucoma thiab txoj kev kho mob ntawm txhua yam kab mob hauv ophthalmology.
Raws li Vladimir Skulachev taw qhia, qhov muag tee yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hypersensitivity rau cov tshuaj, nrog rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Siv thaum cev xeeb tub thiab lactation
Tam sim no, tseem tsis tau muaj tag nrho, tsis muaj kev txwv, qhov muag tsis pom kev sim tshuaj hauv cov poj niam cev xeeb tub, nrog rau cov niam laus. Nws yog. Raws li qhov xwm txheej no, nws tsis pom zoo kom sau cov tshuaj thaum cev xeeb tub. Yog tias muaj qhov xav tau ceev ceev rau lub sijhawm teem caij rau lub sijhawm lactation, ces kev pub niam mis yuav tsum raug tso tseg.
Txoj kev thov thiab ntau npaum li cas ntawm cov tshuaj
Cov tshuaj yuav tsum tau muab tso rau hauv 1-2 tee rau hauv lub hnab ntim khoom ntawm lub qhov muag peb zaug ib hnub. Raws li qhov hnyav ntawm cov tsos mob thiab qhov hnyav ntawm chav kawm ntawm tus kab mob, lub sijhawm ntawm chav kho mob tuaj yeem teem caij rau tus kheej los ntawm tus kws kho mob tuaj koom.
Kev mob tshwm sim thiab kev noj tshuaj ntau dhau
Raws li cov txiaj ntsig ntawm kev tshawb fawb tshawb fawb, nrog rau kev soj ntsuam thiab kev sim tshuaj ntawm cov tshuaj, tsis muaj kev phiv tshwm sim, tab sis kev tsis haum tshuaj yuav tshwm sim. Tsis muaj cov ntaub ntawv hais txog kev siv tshuaj ntau dhau nrog kev siv tshuaj pleev ib ce.
Kev Sib Tham Tshuaj
Tsis muaj ntaub ntawv qhia txog kev cuam tshuam tshuaj nrog rau lwm pawg tshuaj. Yog tias xav tau kev siv tib lub sijhawm ntawm "Vizomitin" nrog rau lwm qhov muag te, lub sijhawm nruab nrab ntawm qhov muag yuav tsum yog tsawg kawg 5 feeb.
Cov lus qhia tshwj xeeb
Nyob rau hauv kev sim tshuaj ntawm cov tshuaj, cov ntaub ntawv tau txais tias "Vizomitin" muaj peev xwm ua rau muaj kev cuam tshuam rau lub sijhawm luv luv ntawm kev pabcuam nrog nws cov kev rov qab los tom ntej. Yog tias tom qab siv cov tshuaj muaj qhov muag tsis pom kev, koj yuav tsum tsis txhob tsav tsheb lossis cov txheej txheem, nrog rau kev ua ub ua no uas yuav tsum tau ua kom muaj kev saib xyuas ntxiv, kom txog rau thaum lub acuity rov qab los.saib.
Ib daim foos
Qhov muag dauv nrog cov ntsiab lus tseem ceeb ntawm 0.155 mcg / ml yog tsim nyob rau hauv tshwj xeeb 5 ml polyethylene fwj nrog stoppers - droppers thiab hau hau. Cov tshuaj tsuas yog tso tawm los ntawm cov tshuaj. Khaws qhov muag dauv ntawm qhov kub ntawm 2 txog 80C.
yuav tshuaj qhov twg
Y Koj tuaj yeem yuav Vizomitin tee, tus nqi uas tsis siab hnub no, yog tias koj muab piv nrog cov txiaj ntsig xav tau, yuav luag txhua lub tsev muag tshuaj hauv Russia. Qhov nruab nrab nqi nyob rau hauv Lavxias teb sab Federation ntawm tee yog hais txog 500 rubles. Cov nyhuv ntawm cov tshuaj tsuas yog colossal. Cov neeg coob coob tau pom tau meej thiab meej ua tsaug rau cov cuab yeej no. Raws li xibfwb Skulachev tau taw qhia, qhov muag tee, tus nqi uas pheej yig rau txhua tus, yuav muaj txiaj ntsig zoo rau cov neeg uas raug kev txom nyem los ntawm cov kab mob ophthalmic.
Tsis ntseeg, tom qab qee lub sijhawm, cov tsev kawm tshawb fawb yuav ua tiav cov kev tshawb fawb tag nrho ntawm Visomitin qhov muag tee, thiab tom qab ntawd, nrog rau qib siab ntawm qhov tshwm sim, cov sijhawm tshiab rau kev siv mitochondrial antioxidants yuav tshwm sim tsis yog hauv kev kho mob ntawm ophthalmology, tab sis kuj nyob rau lwm qhov chaw ntawm cov tshuaj.
Reviews about tshuaj
Ntau cov lus pov thawj los ntawm cov neeg uas tau siv Vizomitin qhov muag tee yog raws li lawv qhov kev ua. Cov neeg mob tau txaus siab tias cov tshuaj tsis tas yuav tsum tau instillation nquag, thiab nrog rau kev siv ntev, nws zaus.daim ntawv thov tuaj yeem raug txo kom tsawg ib zaug ib hnub. Raws li cov neeg siv khoom, qhov muag teeb meem yeej daws tau. Lawv nres blushing, nkees tsawg, puffiness disappears. Cov neeg mob tsis pom muaj qhov tshwm sim.
