Tam sim no, kev kho tshuaj hormone rau mob qog noj ntshav yog ib txoj hauv kev zoo tshaj plaws ntawm kev kho cov neoplasms uas nyob ntawm cov keeb kwm hormonal ntawm tus neeg mob. Hoob no feem ntau hu ua tshuaj tiv thaiv estrogen, txij li lub luag haujlwm tseem ceeb ntawm txoj haujlwm tshuaj yog txo qis cov tshuaj estrogen ntawm cov kab mob atypical cellular.
Nws puas pab tau?
Ua ntej sau tshuaj hormone kho mob cancer mis, nws yog ib qho tseem ceeb kom ua tib zoo tshuaj xyuas tus neeg mob. Los ntawm cov ntaub ntawv kho mob nws tau paub tias cov tshuaj hormonal tuaj yeem ua tiav cov txiaj ntsig zoo hauv kwv yees li 75% ntawm cov xwm txheej. Qhov no yog vim lub nuances ntawm pathological formations nyob rau hauv cov poj niam lub mis: lub ntsiab feem pua ntawm cov qog nyob ntawm lub keeb kwm hormonal. Kev xaiv ntawm kev kho mob yog nqa tawm raws li lub nuances ntawm tus kab mob, qhov dav ntawm lub cev, kev sib kis ntawm cov txheej txheem. Ib txoj hauv kev tshwj xeeb yog xav tau thaum lub sij hawm cev xeeb tub. Thaum xaiv ib qho kev kho mob, tus kws kho mob soj ntsuam seb cov qog loj hlob li cas, qhov txheej txheem pathological hnyav npaum li cas.
Kev xaiv txoj cai rau kev siv cov tshuaj hormones kho mob qog noj ntshav hauv ib kis yog lub luag haujlwm ntawm tus kws kho mob ua qhov teeb meem. Lub luag haujlwm ntawm tus neeg mob yog ua tib zoo ua raws li tag nrho cov lus pom zoo, ua raws li cov lus qhia thiab lub sijhawm ntawm kev noj tshuaj. Yog tias qhov kev xav tau zoo tsis raug saib xyuas, txawm tias cov cuab yeej niaj hnub thiab cov txheej txheem feem ntau yuav tsis ua haujlwm.
Thaum twg yuav pab tau?
Kev kho tshuaj hormonal rau kev mob qog noj ntshav mis tau raug sau tseg yog tias tus kab mob ua haujlwm raws li qhov xwm txheej tsis cuam tshuam, nws yuav tsum txo qis qhov kev pheej hmoo ntawm kev rov tshwm sim ntawm cov kab mob. Yog tias tus neeg mob tau txais kev phais mob, kev kho mob hluav taws xob lossis tshuaj lom neeg, nrog rau kev sib xyaw ua ke, cov tshuaj hormonal tuaj yeem txo qhov kev pheej hmoo ntawm kev rov qab los, tsim kom muaj lub hom phiaj tshiab ntawm cell degeneration.
Nrog rau qhov muaj feem ntau ntawm kev tsim mob qog noj ntshav, chav kawm hormonal tuaj yeem raug sau ua ib txoj hauv kev tiv thaiv kab mob. Nrog rau cov txheej txheem mob qog noj ntshav, cov tshuaj hormonal raug siv los txo qhov loj ntawm qhov chaw mob. Cov tshuaj hormonal siv rau kev mob qog noj ntshav mis yog siv dav hauv kev kho mob nyuaj nrog metastasis.
Nws puas tsim nyog?
Cov kws kho mob feem ntau hu rau kev kho tshuaj hormonal rau cov thyroid cancer lossis mob qog noj ntshav mis yog hom kev pov hwm xaiv. Hoob no ntawm kev kho mob yog siv ua ke nrog cov kev pab cuam tseem ceeb ntawm kev phais, hluav taws xob,kev kho mob. Tag nrho cov ntawm lawv, txawm tias thaum sib xyaw ua ke, tsis tuaj yeem lav 100% txoj hauv kev ntawm kev ua tiav tiav yam tsis muaj kev rov tshwm sim yav tom ntej. Kev kho hormonal pab kho kev ua haujlwm ntawm lub cev tag nrho, inhibits kev nruj ntawm cov tshuaj estrogen. Cov tshuaj no tuaj yeem pom muaj txiaj ntsig zoo tsuas yog tias cov txheej txheem qog nyob ntawm keeb kwm hormonal.
Yuav kom nkag siab tias kev kho tshuaj hormone ntau npaum li cas yog qhov tsim nyog nyob rau hauv ib rooj plaub tshwj xeeb rau mob qog noj ntshav tom qab phais lossis ua ntej kev cuam tshuam, tus neeg mob tus mob tau ua tib zoo tshuaj xyuas siv cov cuab yeej siv niaj hnub no. Txhawm rau tswj tus neeg mob thaum lub sijhawm kawm hormonal, koj yuav tsum tau siv tshuaj tua kab mob thiab tshuaj los ntawm qeb ntawm kws khomob.
Ntau yam thiab hom
Muaj peb hom kev kawm tseem ceeb: prophylactic, curative thiab neoadjuvant. Kev kho tshuaj hormone rau mob qog noj ntshav tom qab phais yog ib txoj hauv kev tiv thaiv. Lawv xyaum qhov no tom qab ib chav kawm ntawm hluav taws xob, kev kho mob qog noj ntshav nrog tshuaj. Lub luag haujlwm tseem ceeb yog los tiv thaiv qhov rov tshwm sim ntawm tus kab mob. Lub sijhawm ntawm chav kawm txawv ntawm tsib xyoos mus rau kaum xyoo. Feem ntau, cov neeg mob tau txais cov tshuaj uas inhibit aromatase, nrog rau Tamoxifen.
Neoadjuvant kev kho mob txhawm rau txhim kho kev kho mob. Nws yog xyaum ua ntej cov txheej txheem phais, hluav taws xob. Lub sijhawm ntawm qhov kev zov me nyuam yog los ntawm ib lub hlis twg mus txog ib nrab ntawm ib xyoos. Yog tias cov txiaj ntsig tau ua tiav tiav, cov chav kawm tuaj yeem txuas ntxiv mus rau lub sijhawm ntev -piv txwv li, rau 2 xyoos. Hormone therapy rau neoadjuvant mis cancer yog qhia kom txo qhov loj ntawm kev tsim, kho ntawm metastases. Qhov kev zov me nyuam tso cai rau koj los ua kom yooj yim rau kev ua haujlwm yav tom ntej, txo nws cov ntim, ua rau kom muaj txoj sia nyob thiab qhov tsis tuaj yeem tshwm sim yav tom ntej. Kev kho Hormonal pab ntsuas qhov rhiab heev ntawm cov hlwb txawv txav rau kev kho cytostatic, nrog rau xyuas seb cov tshuaj siv tau zoo npaum li cas. Raws li qhov tshwm sim ntawm cov chav kawm neoadjuvant, kwv yees li 80% ntawm cov neeg mob, cov neoplasm ua me me, hauv 15% muaj kev tshem tawm morphological.
Kev kho mob: ntev lossis luv?
Yog tias tus txheej txheem yog dav dav, tus neeg mob tus mob tsis tso cai rau kev phais mob, qhia txog kev kho mob nrog tshuaj hormonal. Nws kuj raug sau tseg yog tias metastases pom nyob rau hauv cov hlab ntsws, daim siab, tus neeg mob yog ib tug hluas nkauj. Cov kev kho mob zoo sib xws yog qhia nyob rau hauv cov kauj ruam remission.
Kev txiav txim siab seb cov tshuaj twg yog qhov zoo tshaj plaws rau kev kho cov tshuaj hormones rau mob qog noj ntshav, tus kws kho mob tshwj xeeb ntsuas ntau yam. Coj mus rau hauv tus account hom hormonal ntawm neoplasm, cov xwm txheej ntawm tus neeg mob (qeb kev xeeb tub, menopause). Thaum xaiv ib chav kawm ntawm kev kho mob, nws yog ib qho tsim nyog los sau cov ntaub ntawv hais txog kev ntsuas yav dhau los thiab lawv cov txiaj ntsig, txhawm rau txheeb xyuas cov kab mob somatic. Txhawm rau xaiv qhov kev pab cuam zoo tshaj plaws, theem ntawm tus kab mob thiab qhov yuav rov qab los tau raug coj mus rau hauv tus account.
xwm txheej thiab hnub nyoog
Kev kho tshuaj Hormone rau premenopausal, menopausal, hluas cancer misHnub nyoog yog qhov sib txawv kiag li. Kev xaiv cov tshuaj yog ib txwm ua raws li kev nyab xeeb ntawm kev coj khaub ncaws. Yog tias lub voj voog tsis tu ncua, lub xeev yog premenopausal, nws tau qhia tias yuav tsum siv tamoxifen txoj haujlwm tsib xyoos, yog tias tus kab mob nyob rau theem pib. Tsis tas li ntawd, kev tshem tawm ntawm zes qe menyuam yog qhia. Tom qab lawv tshem tawm, los yog inhibit qhov kev ua haujlwm ntawm lub cev, cov tshuaj uas inhibit aromatase yuav tsum tau siv.
Nyob rau theem ntawm menopause, thaum cev xeeb tub thiab tom qab nws, koj yuav tsum xub xa tus neeg mob mus rau kev phais, sau ntawv rau kev siv hluav taws xob, tshuaj kho mob. Tom qab ntawd, tus neeg mob tau txais cov tshuaj uas inhibit aromatase. Yog hais tias, txawm tias ua ntej qhov pib ntawm lub cev tsis muaj zog, tus poj niam siv Tamoxifen rau tsib xyoos, cov tshuaj tau hloov mus rau Femara. Yog tias kev siv "Tamoxifen" tau nrog los ntawm kev tsim cov txheej txheem qog nqaij hlav tshiab lossis rov tshwm sim ntawm rooj plaub, cov tshuaj tau hloov nrog aromatase inhibitors.
Muaj peev xwm rov qab los vim yog siv cov aromatase inhibitors. Hauv qhov no, cov tshuaj tau hloov mus rau Tamoxifen. Muaj lwm txoj hauv kev yog Faslodex lossis lwm yam tshuaj zoo sib xws. Feem ntau, "Anastrozole". Hormone kho mob cancer mis yog kho raws li lub cev cov lus teb, kev vam meej, regression.
Yam kab mob, kawm
Muab cov txheej txheem benign, malignant qog. Hauv thawj hom kev tsim, qhov tshwm sim ntawm malignancy ntawm cov qog tseem nyob. Cov chav kawm kho mob tau sau tseg rau tus mob no tsuas yog Tamoxifen xwb. ATHauv kev xyaum kho mob, tus neeg sawv cev no yog siv yog tias kuaj pom tus kab mob ductal.
Nyob rau hauv rooj plaub HER2-zoo, raws li pom tau los ntawm kev tshuaj xyuas kev kho mob, kev kho tshuaj hormone rau kev mob qog noj ntshav mis muab cov txiaj ntsig zoo tshaj yog tias koj xaiv cov tshuaj aromatase-suppressing. Lawv raug coj mus rau yog tias Tamoxifen tsis muab qhov xav tau.
Tamoxifen
Means belongs rau chav kawm ntawm antiestrogen. Ib zaug nyob rau hauv tus neeg mob lub cev, lub active tivthaiv tiv thaiv cov tshuaj tiv thaiv ntawm combining estrogen, atypical cellular lug; pathological formations tsis tuaj yeem nce ntxiv. Cov kev kho mob muab qhov zoo tshaj plaws los yog siv nyob rau hauv lub active reproductive lub sij hawm tiv thaiv keeb kwm ntawm kev coj khaub ncaws ruaj khov, nyob rau hauv thawj theem ntawm pathology. Raws li kev tshuaj xyuas, kev kho tshuaj hormone rau kev mob qog noj ntshav mis siv Tamoxifen tau txais txiaj ntsig zoo los ntawm cov neeg mob, txawm tias cov kev mob tshwm sim tsis tuaj yeem zam.
Ntawm kev muag khoom koj tuaj yeem nrhiav daim ntawv ntsiav tshuaj, nthuav tawm hauv khw muag tshuaj raws li lub npe "Tamoxifen-Nolvadex". Nws tau raug pom tias qee cov neeg mob thaum lub sijhawm kho mob tau yws yws ntawm qhov chaw mos tawm los yog ntau dhau dryness ntawm mucous daim nyias nyias ntawm thaj chaw no. Nws muaj peev xwm ua kom cov hws qog. Qee zaum cov neeg mob hnyav dua, lwm tus tau txhawj xeeb txog hyperemia ntawm daim tawv nqaij.
Aromatase inhibitors
Cov nyiaj no inhibit tsim cov tshuaj estrogen hauv poj niam lub cev. Lawv raug pom zoo kom siv tom qab menopause, thaum cev xeeb tub thiab tom qab nws. Los ntawm kev siv tshuaj kho mob, muaj ntau qhov xwm txheej ntawm kev kho mob ntawm pathology hauv nqe lus nug, siv Aromasin,"Femaru". Cov lus teb zoo heev tuaj yeem pom ntawm cov tshuaj "Arimidex". Txhua yam tshuaj uas tau hais los no tau raug sau tseg hauv ib qho xwm txheej tshwj xeeb. Piv txwv li, yog tias cov qog hlwb tau raug tshem tawm, thiab cov kab mob tau raug kho thaum ntxov, Arimidex yuav ua tau zoo tshaj plaws.
"Aromasin" yog qhia thaum pib ntawm kev loj hlob ntawm tus kab mob malignant. Nws raug sau tseg rau cov neeg mob uas tau siv Tamoxifen rau xyoo. "Femara" kuj tsim nyog yog tias tus kab mob no tau tsim ntxov, tus neeg mob twb tau phais lawm. Femara raug tshuaj yog tias tus neeg mob tau siv Tamoxifen tau tsib xyoos lossis ntau dua.
Cov kev mob tshwm sim ntawm kev kho tshuaj hormone rau mob qog noj ntshav nrog aromatase-inhibiting compounds yog tsawg. Hauv ib feem me me ntawm cov neeg mob, cov neeg mob hnov mob, cov pob qij txha teb nrog kev tsis xis nyob thiab mob. Qhuav ntawm qhov chaw mos mucosa yog ua tau. Kev siv tshuaj ntev ntev tuaj yeem ua rau lub cev tsis muaj zog. Txhawm rau tiv thaiv qhov tshwm sim tsis zoo, chav kawm kho mob nyuaj yog ntxiv nrog calcium, calciferol.
Goserelin
Qhov no yog cov tshuaj hluavtaws zoo ib yam li LHRH ua rau poj niam lub cev. Cov tshuaj yog ib txwm tswj kev ua haujlwm ntawm lub caj pas pituitary. Nyob rau hauv nws cov cawv, tus naj npawb ntawm cov tshuaj hormonal generated txo. Nws tau raug tsim los hais tias raws li cov chav kawm kho mob tiav, cov haujlwm ntawm lub caj pas pituitary tsis tsuas yog rov qab mus rau qhov qub, tab sis ua siab dua. Qhov kev kho kom zoo tshaj plaws yognoj "Goserelin" rau ob peb lub hlis, tom qab uas tus neeg mob raug xa mus rau oophorectomy. Kev tshem tawm ntawm zes qe menyuam yog ua tau los ntawm hluav taws xob lossis ua ib feem ntawm kev phais.
Cov kev mob tshwm sim ntawm kev kho tshuaj hormone rau mob qog noj ntshav thaum siv "Goserelin" suav nrog kev ua kom tsis muaj zog ntawm kev sib raug zoo, ua kom tawv nqaij. Qee tus tsis txaus siab ntawm kev ua haujlwm ntawm cov qog hws ntau ntxiv, lwm tus tau ntsib nrog kev poob qis hauv kev tawm tsam. Tej zaum yuav mob taub hau.
Cov tshuaj yog txhaj tshuaj nruj me ntsis. Cov txheej txheem yog rov ua txhua hli, muab txhaj rau hauv phab ntsa ntawm lub plab kab noj hniav, nyob rau hauv qis.
Kev kho mob thiab nws qhov tshwm sim
Hormone therapy muaj ntau yam zoo thiab zoo, tab sis tsis muaj qhov tsis zoo. Qhov nruab nrab, txhua tus neeg mob thib ob tau ntsib nrog qee qhov tsis zoo ntawm qhov kev kawm. Qee tus ua hnyav dua, lwm tus nco ntsoov dryness ntawm qhov chaw mos mucosa, lwm tus raug kev txom nyem los ntawm edema, tawm hws. Tawm tsam keeb kwm yav dhau los ntawm kev kho mob, menopause yuav tuaj ua ntej. Nrog rau qib siab ntawm qhov tshwm sim, kev kho hormonal tuaj yeem ua rau muaj kev nyuaj siab-kev xav. Cov neeg mob ua rau lub siab hloov pauv.
"Tamoxifen", tam sim no nquag siv hauv kev kho mob qog noj ntshav, tuaj yeem ua rau cov ntshav txhaws. Tawm tsam keeb kwm yav dhau los ntawm nws txoj kev siv, kev pheej hmoo ntawm kev xeeb tub yav tom ntej nce ntxiv, nrog rau kev pheej hmoo ntawm cov txheej txheem qog nqaij hlav hauv tsev menyuam. Aromatase inhibitors, yog li txo qis cov tshuaj estrogen hauvlub cev, tuaj yeem ua rau pob txha thiab pob txha ntawm cov cholesterol hauv cov hlab ntsha. Tawm tsam keeb kwm ntawm lawv qhov kev noj haus, qhov kev pheej hmoo ntawm kev mob plab hnyuv nce ntxiv.
Yog tias txoj kev kho mob nrog cov tsos mob tsis zoo, koj txhawj xeeb txog kev phiv, koj yuav tsum hu rau koj tus kws kho mob. Raws li txoj cai, cov nyiaj raug muab tso tseg, chav kawm raug hloov kho, xaiv cov qauv kev nyab xeeb thiab zoo dua.
Txhua Hnub thiab Kev Kho Mob: Txoj Cai Khoom Noj
Yog tias kuaj pom cov qog ua haujlwm hormone, koj yuav tsum ua tib zoo xav txog koj txoj kev ua neej, suav nrog kev npaj zaub mov. Kev noj zaub mov kom raug yog tus yuam sij rau kev noj qab haus huv, txo qhov kev pheej hmoo ntawm kev nce qib ntawm pathology. Nrog mob qog noj ntshav, nws yog ib qho tsim nyog yuav tsum muaj kev noj zaub mov kom zoo uas muab lub cev nrog cov vitamins tsim nyog, cov ntsiab lus tsis tuaj yeem hloov pauv. Koj yuav tsum noj ntau zaus, me me.
Cov ntawv qhia zaub mov yuav tsum muaj ntau yam ci, muaj yeeb yuj, vitamin-nplua nuj zaub mov - taub dag, txiv lws suav, cranberries. Cov neeg mob tau txais txiaj ntsig los ntawm cereals - bran thiab hom qoob mog. Cov ntawv qhia zaub mov yuav tsum muaj xim av, xim av. Cov ntsiab lus calorie yog txiav txim siab los ntawm kev ntsuas qhov hnyav ntawm tus neeg mob. Nrog rau qhov hnyav dhau los ntawm kev noj zaub mov, qhov ntsuas no yuav tsum tau kho. Tsiaj cov rog, yog tias ua tau, tshem tawm lossis txo lawv cov concentration, hloov cov roj zaub. Cov khoom noj muaj txiaj ntsig zoo tshaj plaws uas muaj calciferol, calcium, tab sis cov khoom noj uas muaj phytoestrogens raug txwv.
