Ntau lub sij hawm tib neeg tau sim nrhiav tshuaj kho mob qog noj ntshav. Ntau qhov kev sim kom kov yeej tus kab mob no tsis muaj tseeb, tab sis kev tshawb fawb txuas ntxiv mus. Yog li, cov kws tshawb fawb tau tshawb pom tias nws muaj txiaj ntsig zoo tiv thaiv kab mob txaus ntshai los tswj txhua lub zog ntawm lub cev tiv thaiv kab mob. Immunologists-oncologists niaj hnub ua haujlwm rau qhov no. Qhov no yog li cas ib txoj kev kho mob qog noj ntshav tshwm sim - cytokine therapy. Nws yog dab tsi, peb yuav xav txog ntxiv. Nws yog qhov nthuav kom paub tias qhov kev tshuaj xyuas txog txoj kev kho no yog dab tsi.
Cia siab rau txoj kev cawm seej
Hauv Moscow muaj lub chaw kho mob qog noj ntshav tshiab - lub tsev kho mob rau oncoimmunology thiab cytokine therapy. Ntawm no cov kws kho mob siv cov txheej txheem tshiab tshaj plaws hauv kev kho mob qog noj ntshav. Cov txheej txheem ib txwm siv xws li tshuaj tua kab mob, xov tooj cua thiab phais yog siv hauv tsev kho mob ua ke nrog kev kho cytokine. Oncologists-immunologists tau tsim ib txoj kev tshwj xeeb ntawm kev kho mob uas tsis yog ib leeg noj qab haus huvlub cell tsis raug kev txom nyem, thaum cov qog nqaij hlav cancer raug rhuav tshem nrog tsawg kawg ntawm cov kev mob tshwm sim. Txoj kev kho no hu ua "cytokine therapy". Nws yog ua tsaug rau txoj kev tshawb fawb ntawm oncoimmunology uas qhov tshwj xeeb ntawm kev kho tus kab mob no tau tshwm sim.
Dab tsi yog oncoimmunology raws li?
Nyob hauv peb lub cev txhua lub zog tau tso tseg kom nws tus kheej tuaj yeem tiv thaiv kab mob thiab qog. Lub hauv paus ntsiab lus tseem ceeb ntawm oncoimmunology yog stimulation ntawm lub cev tiv thaiv cov qog. Cov kws tshawb fawb tau pom tias tag nrho cov qog nqaij hlav malignant nrog rau lub cev tiv thaiv kab mob tsawg heev. Peb lub cev tiv thaiv kab mob yog tsim los ntawm:
- ntau cov qe ntshav, cov ntaub so ntswg (macrophages, T hlwb, B hlwb, dendritic hlwb, thiab lwm yam);
- cov tshuaj soluble nyob rau hauv qhov chaw intercellular, uas xa cov cim ntawm lub xov tooj mus rau ntawm tes thiab ua ib qho kev ua haujlwm.
Tom qab kev tshawb fawb ntxaws txog kev ua ntawm mononuclear phagocytes, nws tau pom tias lawv ua lub luag haujlwm ntawm kev tiv thaiv, muaj peev xwm nqus thiab zom cov khoom txawv teb chaws. Tsis tas li ntawd, cov hlwb no tau koom nrog ntau yam kev tiv thaiv kab mob hauv lub cev.
Nyob rau hauv cov tshuaj tiv thaiv inflammatory, phagocytes pab tua o, ua haujlwm tiv thaiv. Nws yog cov hlwb uas tsim cov protein uas, raws li nws tau muab tawm, muaj peev xwm xa cov cim qhia ntawm qib intercellular thiab cuam tshuam cov hlwb los ntawm receptors.
Lawv muaj zog los tawm tsam cov qog sib txawv. Clinic ntawm oncoimmunology thiab cytokine therapy nyob rau hauvMoscow tab tom ua haujlwm siv txoj kev tshwj xeeb no los tawm tsam mob qog noj ntshav. Cov kws kho mob tau tswj kom qhib lub zog sab hauv ntawm lub cev los tua cov qog. Txoj kev no hu ua cytokine therapy. Cia wb mus saib seb nws yog dab tsi.
"Cytokine therapy" txhais li cas?
Ua ntej tshaj plaws, nws tsim nyog hais tias lub npe ntawm txoj kev los ntawm lub npe ntawm cytokine proteins, ua tsaug rau qhov nws tau los tawm tsam cov qog. Kev kho mob siv cytokines hu ua "cytokine therapy". Nws yog dab tsi, hom proteins txawv txawv?
Cytokines yog cov proteins uas tsim tawm hauv cov ntshav, tiv thaiv kab mob thiab lwm yam kab mob hauv lub cev, lawv nqa tawm kev xa tawm ntawm cov teeb liab kho thiab muaj peev xwm cuam tshuam cov hlwb los ntawm receptors. Nws yog kev kho cytokine uas yog ib qho tseem ceeb heev rau kev tswj xyuas qhov tsis tu ncua thiab kev tswj tus kheej ntawm lub cev nyob rau hauv lub xeev ntawm ib txwm lossis pathological txawv txav. Cytokines rhuav tshem cov qog hlwb nkaus xwb, thaum tsis cuam tshuam rau cov neeg noj qab haus huv. Lawv kuj muaj cov nyhuv immunostimulatory. Raws li lawv qhov kev ua, cytokines tuaj yeem muab faib ua ntau pawg:
- Lawv qhib kev loj hlob thiab tsim cov qe ntshav hluas.
- Tiv thaiv lub cev los ntawm kab mob thiab kab mob los ntawm kev cuam tshuam cov macrophage thiab granulocyte cells.
- Txhawb kev loj hlob, ua kom thiab sib txawv ntawm cov lymphocytes paub tab.
- Ua kom muaj cytotoxic macrophages thiab ntuj tua cov hlwb.
Cytokines yog siv ob qho tib si rau kev kuaj xyuas cov kab mob thiab kev kho mob, nrog rautiv thaiv kab mob.
Raws li cov haujlwm ntawm cov hlwb, peb tuaj yeem hais txog qhov zoo ntawm kev kho cytokine.
Cov txiaj ntsig zoo ntawm kev kho cytokine
Kev kho cytokine hauv oncology yog dab tsi? Nws tuaj yeem xaus lus los ntawm kev kawm txog qhov kev kho cytokine muaj txiaj ntsig rau lub cev ntawm tus neeg mob.
Cia saib ob peb yam zoo thaum siv cytokine kho:
- Kev xaiv cuam tshuam rau cov qog hlwb thiab metastases.
- Qhov tseem ceeb hauv kev ua tau zoo ntawm cov tshuaj khomob.
- Tiv thaiv kev sib kis ntawm metastases thiab qog rov ua dua.
- Kev txo qis hauv cov kev mob tshwm sim ntawm cov tshuaj khomob, txo cov tshuaj lom.
- Kev kho thiab tiv thaiv kab mob sib kis thaum kho.
- Tsis muaj tshuaj lom thiab siv tau rau cov neeg mob uas muaj kab mob hnyav.
- Yuav siv tau nrog lossis tsis siv tshuaj khomob.
Kev paub txog cov yam zoo no, peb tuaj yeem xav tias tsuas yog kev tshuaj xyuas zoo nkaus xwb txog cov txheej txheem xws li kev kho cytokine hauv kev kho cov kab mob oncological.
keeb kwm me ntsis
Cytokine therapy rau kev kho mob qog noj ntshav tau siv rau hauv ntiaj teb kev coj ua ntev heev. Txawm li cas los xij, cov tshuaj thaum ntxov muaj tshuaj lom heev thiab ua rau muaj ntau yam kev mob tshwm sim, uas feem ntau ua rau cov txiaj ntsig zoo li no. Yog li, hauv Asmeskas thiab Europe, lawv pib siv cov tshuaj TNF-alpha (mob necrosis factor) rov qab rau xyoo 80s. Nws tuaj yeem siv tau yog tias nws tuaj yeem cais lub cev los ntawm cov dav davntshav ntws vim nws toxicity ntau heev. Cov tshuaj yog siv los ntawm lub tshuab plawv-lub ntsws nkaus xwb nyob rau hauv lub cev uas muaj cov txheej txheem qog kom txo tau qhov tshwm sim ntawm kev phiv tshuaj.
Muaj tshuaj siv tau ntev thiab ua tau zoo, cov tshuaj no yog ob pawg:
- Interferons-alpha ("Intron", "Reaferon", thiab lwm yam).
- Interleukins (IL-2).
Cov tshuaj no tsuas yog siv tau rau kev kho mob ntawm daim tawv nqaij melanoma thiab mob raum. Tab sis cov kws kho mob tseem tab tom nrhiav kev kho mob uas tuaj yeem kov yeej tus kab mob phem no.
Hauv tebchaws Russia, lub tsev kho mob ntawm oncoimmunology thiab cytokine therapy hauv Moscow siv cov tshuaj tshiab.
Tshuaj rau kev kho cytokine
Xyoo 1990, cov tshuaj "Refnot" tau tsim nyob rau hauv Russia, uas tam sim no siv. Nws tau tsim los ntawm Tus Kws Kho Mob ntawm Kev Tshawb Fawb Kev Tshawb Fawb, Tus Tswv Cuab ntawm International Academy ntawm Social Sciences V. A. Shmelev. Cov cuab yeej tau ua tiav dhau los ntawm kev sim tshuaj thiab txij li xyoo 2009 tau pom zoo siv los kho ntau hom qog. Nws muaj ntau qhov zoo dua li cov tshuaj uas tau tso tawm dhau los:
- Tshuaj tshuaj muaj tshuaj tsawg, kwv yees li 100 npaug.
- Ua ncaj qha rau cov qog nqaij hlav cancer los ntawm cov receptors ntawm lawv qhov chaw.
- Endothelial hlwb thiab lymphocytes tau qhib, ua rau qog necrosis.
- Cov ntshav rau cov qog txo qis, tus neeg sawv cev tuaj yeem nkag mus rau hauv nws qhov chaw thiab rhuav tshem nws.
- Cov tshuaj nce cov tshuaj tiv thaiv kab mob ntawm cov tshuaj interferon recombinant los ntawm 1000 zaug.
- Txhawj xeebKev ua tau zoo ntawm kev kho mob tsis tu ncua.
- Txhawb kev ua haujlwm ntawm cov tshuaj tua kab mob ntuj, nrog rau cov tshuaj tiv thaiv kab mob.
- Kev txo qis tus nqi rov qab los ntawm cov neeg mob kho.
- Zoo siab ntev.
- No side effects.
- Txhim kho tus mob ntawm tus neeg mob.
Raws li tau hais ua ntej, TNF-alpha yog tshuaj lom heev thiab tsuas yog cuam tshuam rau thawj qhov chaw qog.
Lwm cov tshuaj uas siv tau zoo heev thiab siv hauv kev kho cytokine yog Ingaron. Nws tau tsim los ntawm cov tshuaj "Interferon-gamma". Cov tshuaj "Ingaron" tuaj yeem thaiv kev tsim cov kab mob sib kis thiab kab mob RNA thiab DNA.
Sau npe xyoo 2005 thiab siv rau kev kho thiab tiv thaiv cov kab mob xws li:
- kab mob siab B thiab C.
- AIDS thiab HIV.
- Pulmonary tuberculosis.
- Kab mob tshwm sim los ntawm tib neeg papillomavirus.
- YChlamydia urogenital.
- Cancer.
Thiab tseem txhawm rau tiv thaiv cov teeb meem hauv kev kho mob granulomatosis.
Rau kev kho thiab tiv thaiv kab mob ua pa nyuaj, mob khaub thuas, cov tshuaj Ingaron yog siv los kho cov mucous daim nyias nyias.
Nyob rau hauv kev kho cov qog, Ingaron zoo activates lub receptors ntawm cov qog nqaij hlav cancer, uas yog ces cuam tshuam los ntawm Refnot. Yog li ntawd, kev siv ob yam tshuaj no ua ke tau zoo hauv kev kho cytokine.
Kev ua ntawm Ingaron yog raws li hauv qab no:
- Tswj kev kis tus kab mob RNA thiab DNA hauvcells.
- Tsis tso cai rau cov kab mob hauv nruab nrog cev, kab mob, cov kab mob kis mus.
- Npaum macrophage kev ua haujlwm.
- Increases natural killer cell act.
- Restores lub ntuj phenotype ntawm cov hlwb puas.
- Slows down the growth of cancer cells.
- Tua qee hom mob qog noj ntshav ntawm qib cellular.
- Tsawg kev loj hlob ntawm cov hlab ntsha.
- Tshwj xeeb txwv tsis pub cov qog loj hlob.
- Txuag ntshav siab.
- txo qis lipoprotein.
Kev Npaj "Refnot" thiab "Ingaron" tau ua tiav siv ua ke hauv kev kho cytokine. Kev kho mob nrog txoj kev no yog ua los ntawm lub tsev kho mob ntawm oncoimmunology thiab cytokine therapy nyob rau hauv Moscow.
Leej twg tuaj yeem tau txais txiaj ntsig los ntawm kev kho cytokine?
Kev tshawb fawb tau pom tias ib lub lis piam ua ntej kev kho mob, kev kho cytokine yuav txo qis cov kev mob tshwm sim lom. Kev txuas ntxiv ntawm kev kho cytokine tom qab siv tshuaj khomob yuav tiv thaiv lub cev los ntawm kev txhim kho kev kis kab mob, nce kev tiv thaiv kab mob. Nyob rau hauv rooj plaub no, kev kho mob yuav ua rau kom muaj txiaj ntsig zoo.
Txoj kev kho cytokine yog siv los kho cov qog xws li:
- Cervical and uterine cancer.
- Cov qog mis.
- Mesothelioma.
- mob ntsws cancer.
- Oncology ntawm lub plab, me thiab cov hnyuv loj.
- Tomors ntawm pancreas.
- Kidney Cancer.
- Ovary.
- Npaj.
- Brain cancer.
- Malignant qog ntawm txoj hlab pas.
- Sarcomas ntawm cov pob txha thiab cov nqaij mos.
- Glioma.
- Tshuaj ntawm lub paj hlwb.
- daim tawv nqaij mob cancer, melanoma.
Cytokine therapy rau granulosa cell hlav kuj ua tau rau kev tiv thaiv thiab kho.
Leej twg tsis haum rau kev kho cytokine?
Vim tias cov tshuaj rau kev kho cytokine tsis muaj kev phiv, lawv tuaj yeem siv tau los ntawm txhua tus neeg. Txawm li cas los xij, muaj ib pawg ntawm cov neeg uas qhov kev kho mob no yog contraindicated:
- Cov poj niam cev xeeb tub.
- lub sijhawm pub mis niam.
- Nyob rau hauv lub xub ntiag ntawm intolerance rau cov constituent tshuaj, uas yog heev tsawg.
- kab mob autoimmune.
Ntau hom mob qog noj ntshav tuaj yeem kho nrog cytokine therapy, peb tau tham txog lawv ua ntej, tab sis cov qog thyroid tseem tsis tuaj yeem suav nrog lawv tus lej, txij li kev npaj interferon muaj txiaj ntsig zoo rau nws cov ntaub so ntswg thiab kev ua haujlwm. Tej zaum yuav ua rau kev puas tsuaj ntawm tes thiab cuam tshuam nws txoj haujlwm. Cytokines tseem ceeb heev rau kev txhim kho cov kab mob autoimmune, nrog rau cov thyroid caj pas. Qhov kev vam khom no tseem tsis tau nkag siab tag nrho. Kev kho cytokine puas pab tus neeg mob qog noj ntshav nrog AIT? Nws tseem ntxov dhau los tham txog nws. Txij li txoj kev kho cytokine suav nrog cov tshuaj interferon "Ingaron".
Kev kho mob tsuas yog sau los ntawm tus kws kho mob oncologist.
Side effects
Raws li tau hais dhau los, tsis muaj qhov tshwm sim tsis zoo. Txawm li cas los xij, thaum noj cov tshuaj "Refnot" nyob rau hauv tsawg zaus, muaj qhov kub thiab txias los ntawm 1-2 degrees. Hauv qhov no, nws raug nquahu kom noj Ibuprofen lossis Indomethacin. Qhov no yuav tsis cuam tshuam rau cov tshuaj.
Cytokinotherapy kho tshuaj xyuas
Tau kawg, Kuv xav paub cov lus teb los ntawm cov neeg mob uas tau ntsib txoj kev kho cytokinotherapy.
Muab hais tias txoj kev kho mob no yog siv nyob rau hauv Russia tsis ntev los no thiab tsuas yog lub tsev kho mob ntawm oncoimmunology thiab cytokine therapy nyob rau hauv Moscow deals nrog qhov no, tsis muaj ntau heev tshuaj xyuas. Cov neeg muaj lus nug ntau txog cov tshuaj tshiab, vim tias muaj ntau qhov kev dag ntxias hauv cheeb tsam no, thiab cov tshuaj zoo li no tsis pheej yig. Txawm li cas los xij, muaj cov tshuaj xyuas uas tsim nyog tau txais kev saib xyuas.
Piv txwv li, ib tug txiv neej tau kuaj pom tias mob qog noj ntshav prostate theem 4. Kev kho phais raug tsis kam lees. Peb tig mus rau lub tsev kho mob, nws tau thov kom mus kawm ib txoj kev kho mob nrog cytokine therapy ua ke nrog hormonal therapy. Raws li qhov tshwm sim - txo qis hauv cov qog, tsis muaj metastases. Raws li koj tuaj yeem pom, kev kho cytokine hauv theem 4 mob qog noj ntshav muab cov txiaj ntsig zoo thiab kev cia siab rau kev rov zoo. Thiab qhov no tsis yog ib qho xwm txheej cais.
Ib tug tub hluas tau kuaj mob qog noj ntshav. Peb kawm tau tias muaj ib lub tsev kho mob rau oncoimmunology thiab cytokine therapy. Cov kws kho mob tau ncua kev ua haujlwm thiab muab tshuaj khomob nrog kev kho cytokine. Tau muaj qhov zoo sib xws. Cov qog tau txo qis hauv qhov loj me, kev kho mobtxuas ntxiv.
Poj niam kuaj mob cancer mis. Hauv qhov chaw mob qog noj ntshav ntawm qhov chaw nyob, lawv tau hais kom ua haujlwm. Tom qab hu rau lub tsev kho mob ntawm oncoimmunology thiab cytokine therapy, kev kho mob tau sau tseg. Tshuaj kho mob ua ke nrog cytokines kov yeej tus kab mob, lub mis tau txais kev cawmdim.
Oncoimmunology thiab cytokine therapy yog tas li tau kawm thiab tsim, thiab cov txiaj ntsig zoo ntawm kev kho mob tsuas yog pov thawj tias kev tawm tsam mob qog noj ntshav yog txoj hauv kev. Kev kho Cytokine ua rau nws tuaj yeem nres tus kab mob, tiv thaiv kom tsis txhob muaj kev loj hlob, thiab lub sijhawm ntxiv no yuav tsum tau siv los nrhiav cov tshuaj uas tuaj yeem kov yeej tus kab mob phem no. Oncoimmunology thiab cytokine therapy tau txais tsuas yog kev tshuaj xyuas zoo, uas qhia txog qhov ua tau zoo ntawm thaj chaw no hauv kev kho cov qog.
Kev tshuaj xyuas txog tsev kho mob hauv Moscow
Lub tsev kho mob ntawm oncoimmunology thiab cytokine therapy nyob rau hauv Moscow tsuas yog tau txais kev tshuaj xyuas zoo xwb. Cov neeg sau txog kev coj zoo thiab kev paub ntawm cov neeg ua haujlwm. Muaj peev xwm muab kev txhawb nqa ncaj ncees, qhib rau lub nthwv dej zoo thiab kev ntseeg hauv qhov zoo tshaj plaws. Muaj ntau qhov kev tshuaj xyuas uas tau hais tias cov kws kho mob tuaj yeem sau tshuaj kho mob rau cov neeg mob mob qog noj ntshav theem 4, thaum cov chaw kho mob qog noj ntshav tau tsis kam lees cov neeg mob li no.
Tseem muaj ntau zaj dab neeg uas cov kws kho mob tau pab cawm lub cev cuam tshuam thiab zam kev phais. Tag nrho cov no hais txog kev ua haujlwm siab thiab npaj txhij los pab. Nws yog ib qho tseem ceeb heev uas yuav tsum paub tam sim no tias muaj txoj hauv kev zoo li no.kev kho mob, zoo li kev kho cytokine, nws yog dab tsi thiab cov txiaj ntsig tau ua tiav yog tias siv. Qhov no yuav ua rau muaj kev cia siab rau ntau tus neeg. Qhov tseem ceeb yog sib ntaus sib tua thiab ntseeg qhov zoo tshaj plaws.
