Cov ntsuas (raws li kev cai) ntawm cov protein hauv cov ntshav raug ntsuas hauv kev kuaj mob ntawm ntau tus kab mob pathological. Cov txiaj ntsig tau ua kom tau txais cov ntaub ntawv ntxaws ntxaws ntawm tus neeg mob txoj kev noj qab haus huv feem ntau thiab cov yam ntxwv ntawm kev ua haujlwm ntawm tus kheej lub cev thiab lub cev. Yog tias tsim nyog, kev kawm tag nrho cov protein lossis kev sim txuas ntxiv, suav nrog kev txiav txim siab ntawm cov ntsiab lus ntawm cov protein ntau, yuav raug sau tseg.
hom tshuaj ntsuam xyuas ntshav protein
Kev txiav txim siab tus nqi ntawm cov ntshav protein yog qhov qhia tseem ceeb. Muaj ntau ntau hom kev tshawb fawb. Feem ntau cov kws kho mob tau tshuaj xyuas yog albumin, homocysteine, hemoglobin, tag nrho cov protein (txiav txim siab hauv cov ntshav lossis zis, nrog rau lwm yam ntsuas), C-reactive, alpha, beta thiab gamma globulins, ferritin, rheumatoid factor, myoglobin, ceruloplasmin thiab lwm. Ib qho ntawm cov kev tshawb fawb yooj yim tshaj plaws yog ntshav biochemistry, uas tso cai rau koj los txiav txim siab qhov concentration ntawm C-reactive protein thiab albumin. Cov txiaj ntsig yog qhov tsim nyog rau kev kuaj mob ntawm daim siab thiab lub raum kab mob, kab mobCov txheej txheem metabolic, kab mob, kab mob oncological, txiav txim siab txog kev noj qab haus huv ntawm tus neeg mob tom qab hlawv. Kev suav cov ntshav ua tiav (CBC) tso cai rau koj los ntsuas qhov concentration ntawm hemoglobin, sib txawv ntawm cov ntsuas uas qhia tias muaj ntshav qab zib, protein metabolism tsis txaus lossis los ntshav sab hauv.
YBiochemical tsom xam: tag nrho cov protein
Kev kuaj ntshav rau cov protein (cov qauv hauv qab no) tso cai rau koj los txiav txim siab qhov concentration ntawm cov protein molecules hauv ntshav plasma. Qhov ntsuas no qhia txog lub peev xwm ntawm lub cev, lub peev xwm los teb sai thiab tsim nyog rau txhua qhov kev ua txhaum cai, vim tias cov proteins yog ib yam khoom siv hauv tsev uas tuav cov ntsiab lus ntawm cov hlwb thiab cov ntaub so ntswg. Nrog rau qhov tsis muaj protein ntau, txhua lub cev lossis lub cev ua haujlwm tsis zoo hauv cov qauv thiab cov qauv. Cov protein yog sawv cev los ntawm ntau hom sib txawv: fibrinogen, piv txwv li, ua rau cov txheej txheem coagulation, thiab cov globulin feem cuam tshuam kev tiv thaiv.
Indications for analysis
Kev tsom xam rau tag nrho cov protein hauv cov ntshav (tus qauv lossis pathology yog txiav txim siab los ntawm kev kuaj mob, tus neeg mob tsuas yog xav pub ntshav xwb) yog muab rau txhua lub hnub nyoog rau qee qhov kev qhia, suav nrog cov menyuam mos thiab cov menyuam mos ntxov ntxov. Indications yog suspicion ntawm metabolic ntshawv siab, muaj cov kab mob los yog foci ntawm o, kab mob ntawm lub siab thiab ob lub raum, thiab oncological kab mob. Tus kws kho mob tuaj yeem sau tshuaj ntsuam xyuas tom qab muaj qhov kub hnyiab los yog thaum muaj zaub mov tsis txaus. Lub ntsiab lus ntawm commonCov ntshav protein tuaj yeem raug txiav txim nrog rau lwm yam kev sim ua ib feem ntawm kev tshuaj ntsuam xyuas kev noj qab haus huv.
Cov khoom tseem ceeb ntawm tag nrho cov protein
Tag nrho cov protein nyob rau hauv cov ntshav (tus qauv rau cov txiv neej thiab cov poj niam yog me ntsis, tab sis txawv, nyob ntawm seb tsis yog ntawm poj niam txiv neej, hnub nyoog thiab tus mob ntawm lub cev, tab sis kuj nyob rau hauv cov kev qhia tshwj xeeb hauv kev kawm) muaj ntau yam. Thaum txoj kev tshawb no, qhov concentration ntawm albumins, globulins thiab fibrinogen yog txiav txim siab. Albumins tsim cov protein ntau. Cov ntsiab lus no muab tag nrho cov kev xav tau ntawm lub cev los tswj cov qauv thiab kev sib txuas ntawm cov hlwb tshiab. Globulins yog tsim nyog rau kev tsim cov tshuaj tiv thaiv kab mob, suav nrog cov tshuaj tiv thaiv thiab immunoglobulin, inflammatory mediators, C-reactive protein, thiab lwm yam. Fibrinogen yog lub luag haujlwm rau cov txheej txheem ntawm cov ntshav txhaws.
Norm of tag nrho cov ntshav protein
Cov qib protein ib txwm yuav txawv ntawm cov poj niam thiab txiv neej. Feem ntau, qhov ntau ntawm cov txheej txheem sab saud thiab qis dua yog qhov dav heev. Nyob rau hauv sib piv rau tag nrho cov protein, tus qauv yog 64-84 g / l. Nyob ntawm seb hom protein ntau hauv cov ntshav, cov qauv yog raws li hauv qab no: albumins - 35-55 g / l, fibrinogen - 2-5 units ntawm cov khoom ib liter. Globulins tsuas yog txiav txim los ntawm cov feem, nyob ntawm qhov xav tau, tsis muaj qhov tseem ceeb. Rau cov menyuam yaus ntawm thawj lub hlis ntawm lub neej, qhov ntsuas yog 48-73 g / l, thaum thawj xyoo - 42-72 g / l, txog tsib xyoos - 61-75 g / d, thaum hluas - 58-76 g /l.
Cov qauv ntawm cov protein hauv cov ntshav tau tso cainyob rau hauv cov poj niam, nws yog me ntsis txo (los ntawm 10%) piv nrog rau cov cim qhia nyob rau hauv cov neeg sawv cev ntawm cov poj niam muaj zog ntawm tib lub hnub nyoog. Qhov no yog vim qhov kev xav tau siab ntawm lub cev ntawm cov poj niam hauv cov protein, vim tias cov khoom siv nquag siv rau kev tsim cov tshuaj hormones kev sib deev. Tsis tas li ntawd, cov khoom hluavtaws ntawm daim siab ntawm cov poj niam yog qis dua li cov txiv neej.
Ib qho kev hloov pauv ntau dua ntawm tus nqi tshwm sim thaum cev xeeb tub. Tsis pub dhau qhov ib txwm muaj - txo qis mus txog 30% piv nrog cov ntsuas dav dav. Cov txiaj ntsig zoo li no yog qhov tshwm sim ntawm qhov xav tau ntawm lub cev ntawm leej niam leej niam nyob rau hauv cov khoom siv rau kev sib txuas ntawm cov tshuaj hormones ntawm cov qog endocrine, kev loj hlob raws sij hawm thiab kev loj hlob ntawm tus me nyuam hauv plab tag nrho, qhov nce hauv cov ntshav plasma vim yog khaws cia ntau dhau. Cov kua dej hauv qhov chaw vascular.
tag nrho cov ntshav protein: pathology
Pathological hloov pauv ntawm tus nqi ntawm cov protein hauv cov ntshav hauv cov txiv neej thiab poj niam tuaj yeem sawv cev los ntawm ob qho tib si txo qis thiab nce qhov concentration ntawm cov khoom. Thawj qhov kev xaiv yog ntau dua nyob rau hauv kev kho mob, tab sis yog tsawg dua. Ib qho tseem ceeb ntawm kev sib txawv ntawm cov qauv no tsis tshua kuaj pom, tab sis yog tus yam ntxwv ntawm lub voj voog nqaim ntawm cov kab mob loj.
Ua rau muaj cov protein ntau
Kev nce ntawm tag nrho cov protein hauv cov ntshav biochemistry qhia tias hyperproteinemia. Cov xwm txheej no yog ib txwm muaj rau:
- lub cev qhuav dej vim yog pathological redistribution ntawm cov kua nruab nrab ntawm cov ntaub so ntswg thiab vascular qhov chaw nyob rau hauv sepsis, kab mob los yogkev npam;
- nce synthesis ntawm cov tshuaj tiv thaiv thaum lub sij hawm tsim cov tshuaj tiv thaiv kab mob tom qab kev qhia txog cov tshuaj tiv thaiv lossis cov kab mob sib kis tsis ntev los no (feem ntau yog qhov sib txawv me ntsis ntawm cov qauv);
- ntau tus kab mob myeloma (qib ntawm tag nrho cov protein ntau nce ntxiv vim muaj cov protein ntau txawv txav, xws li Bence-Jones protein);
- DIC-tus kab mob tawm tsam keeb kwm yav dhau los ntawm ntau yam mob (feem ntau yog qhov tseem ceeb) thiab qaug cawv - qhov mob no yog tus cwj pwm los ntawm kev ua tsis zoo ntawm cov ntshav txhaws thiab tsim ntau cov hlab ntshav.
Ua kom muaj protein ntau tsawg
Txo cov qib protein hauv cov ntshav qis dua li qub yog hu ua hypoproteinemia. Qhov no yuav qhia tau cov xwm txheej hauv qab no:
- protein deficiency vim tsis noj zaub mov los yog qaug zog ntawm lub cev;
- kab mob siab, xws li cirrhosis, viral thiab toxic hepatitis;
- mob ntshav qab zib;
- kab mob HIV lossis lwm yam kab mob autoimmune;
- nce cov protein ntau hauv cov zis nrog cov proteinuria hnyav lossis kab mob raum tsis tau them nyiaj;
- kab mob ntawm txoj hnyuv thiab plab nrog malabsorption ntawm cov as-ham;
- zais cia thiab enzymatic deficiency hauv tus mob pancreatitis ntev;
- endocrine pathologies, tshwj xeeb yog hypothyroidism;
- mob hnyav anemia thiab los ntshav hnyav;
- nce qib ntawm cov kab mob oncological, metastasis.
Kev txo qis qis qis ntawm cov protein hauv cov ntshav yog ib qho kev ceeb toom, qhiahais txog kev hloov pauv pathological hauv lub cev. Yog li ntawd, nrog rau cov txiaj ntsig uas dhau mus dhau qhov kev txwv qis ntawm cov qauv, nws yuav tsum tau kuaj xyuas ntxiv txhawm rau txhawm rau txhawm rau paub qhov laj thawj ntawm qhov sib txawv thiab pib kho kom tsim nyog.
Acute theem C-reactive protein
C-reactive protein yuav siv sij hawm ib feem ntawm lub cev tiv thaiv kab mob. Hauv cov txheej txheem inflammatory, qhov ntsuas no nce ib qho ntawm thawj. Hauv thawj plaub teev, nws cov concentration hauv cov ntshav nce ntau zaus, thiab tom qab plaub caug-yim teev nws tuaj yeem dhau qhov kev cai los ntawm ib txhiab zaus. Qhov siab tshaj plaws tau pom nrog cov kab mob, nrog rau cov kab mob C-reactive protein nyob rau hauv cov ntshav (tus qauv yog qhia hauv qab no) nce mus rau tsis ntau tshaj 40 mg / l.
ntsuas ntsuas ntshav
C-reactive protein (C-RP) hauv cov ntshav yog txiav txim siab thaum kuaj pom cov txheej txheem inflammatory, kev kuaj mob sib txawv ntawm tus kab mob thiab kab mob, ua ntej thiab tom qab phais, txiav txim siab xav tau tshuaj tua kab mob thiab ob peb hnub tom qab pib ntawm kev kho mob nrog cov tshuaj zoo sib xws, nrog kev mob ntev ntawm cov pob qij txha, cov qog nqaij hlav o, ua npaws. Kev ntsuas C-reactive protein yog xav tau rau txhua yam mob hnyav thiab kab mob, nrog rau cov txheej txheem mob ntev.
Norm of C-reactive protein nyob rau hauv cov ntshav
Nquag, cov ntsiab lus ntawm C-reactive protein ntau txog 5 mg / l raug tso cai, hauv qee qhov chaw kuaj mob (qhov tshwm simnyob ntawm cov reagent siv) - 10 mg / l. Thaum cev xeeb tub, tus nqi nce mus txog 20 units ib liter, thiab hauv cov menyuam yug tshiab, tus nqi tuaj yeem muaj li ntawm 0 txog 15 mg / l. Rau cov menyuam mos, tus qauv yog nce txog 10 mg / l. Tom qab kev tawm dag zog lub cev hnyav, qhov ntsuas tuaj yeem nce mus rau 60 mg / l yam tsis muaj kev noj qab haus huv tsis zoo, thiab cov qauv rau cov neeg haus luam yeeb txawv ntawm 0 txog 20 units ib liter ntawm cov khoom siv roj ntsha. Cov qauv ntawm C-reactive protein tsis yog txiav txim los ntawm thoob ntiaj teb cov qauv kev kho mob, vim nws muaj zog nyob ntawm cov reagents thiab cov txheej txheem ntawm kev soj ntsuam.
C-reactive protein: tsom xam nta
Ib qho tseem ceeb, qib C-reactive protein ib txwm yuav tsis txwv qhov muaj me me lossis qib qis qis nrog lub cev tiv thaiv kab mob tsawg. Qhov no yog pom, piv txwv li, nyob rau hauv ulcerative colitis. Tab sis kev tshawb fawb tseem tsim nyog los ntsuas cov txheej txheem hauv dynamics. Cov qib ntawm kev nce hauv cov ntsuas sib raug rau cov haujlwm ntawm cov txheej txheem inflammatory, tab sis tsis qhia nws qhov chaw. Yog li, C-RP yuav nce siab nyob rau hauv ob qhov mob plab hnyuv thiab cov pos hniav.
Transcript of S-RB tsom xam
Protein nyob rau hauv cov ntshav los ntawm tus qauv yuav txawv nyob rau hauv ntau yam mob. Yog li, nce qib C-RP tuaj yeem ua rau muaj kab mob sib kis, kab mob sib txuas thiab lwm yam kab mob:
- nce mus rau 100 mg / l qhia tias muaj cov kab mob o (colitis, nephritis, mob ntsws);
- C-RP siab dua 200-300 mg / l - sepsis thiab kab mob dav dav,uas tuaj yeem cuam tshuam ntau lub cev ib zaug;
- nce mus rau 50 mg / l - kab mob kis tau (raws li cov txiaj ntsig ntawm kev tshuaj ntsuam, mob ntsws ntawm tus kab mob tuaj yeem paub qhov txawv ntawm tus kab mob ntsws);
- C-RP hauv qaum ntshav 10-20 mg / l - kab mob hauv lub cev, txog 50 units ib liter - sepsis, meningitis;
- nce ntau dua 100 mg / l - meningitis ntawm cov kab mob hauv paus chiv keeb, 20-60 units ib liter - tuberculous, qis dua 20 mg / l lossis nyob rau hauv ib txwm muaj - kab mob;
- hauv rheumatoid mob caj dab, mob rheumatic kub taub hau, mob caj dab psoriatic thiab polymyalgia rheumatica (mob mob ntev), siab C-RP qhia txog qhov mob hnyav;
- nrog myocardial infarction, qog, mob leukemia, tom qab kev phais mob (ob leeg nrog thiab tsis muaj teeb meem), qhov mob ntawm lub plab zom mov, qhov ntsuas yuav nyob rau hauv qhov qub lossis nce me ntsis (txog 20 units ib liter);
- mob pancreatitis, C-RP hauv cov ntshav siab tshaj 100 mg / l (qhov mob hnyav dua, qib protein ntau dua), yog tias qhov ntsuas tsis zoo, koj yuav tsum tau saib xyuas cov teeb meem.
C-reactive protein nyob rau hauv cov ntshav nce thiab poob sai heev, yog li nws yog ib qho tseem ceeb qhia rau kev txiav txim siab tus neeg mob tus mob.
