Cov tshuaj tsis haum - lub ntsiab lus tseem ceeb heev, tshwj xeeb tshaj yog rau cov niam txiv. Tom qab tag nrho, txhua txhua xyoo tus xov tooj ntawm thiaj li hu ua "allergy sufferers" yog tas li nce. Yog li ntawd, niaj hnub no peb yuav xav txog nyob rau hauv kom meej cov tshuaj "Clarotadine". Cov lus qhia rau kev siv yuav pib peb tshuaj xyuas cov tshuaj no. Peb xav kom koj paub koj tus kheej nrog nws ua ntej siv nws. Koj tuaj yeem yuav Clarotadine ntawm txhua lub tsev muag tshuaj hauv koj lub nroog thiab tsis muaj daim ntawv xaj.
Thaum thov
Cov tshuaj no tuaj yeem siv rau kev ua xua kab mob, Quincke's edema, urticaria (mob ntev, nrog rau idiopathic). Cov tshuaj "Klarotadin" kuj tseem siv tau nyob rau lub sijhawm xyoo puag ncig lossis raws caij nyoog rhinitis; nrog pseudo-allergic cov tshuaj tiv thaiv uas tshwm sim los ntawm kev tso tawmhistamine; cov tshuaj tiv thaiv rau tom ntawm ntau yam kab; nrog rau khaus dermatoses. Cov npe yuav raug ntxiv.
Yuav ua li cas hauv
Cia peb pib xav txog cov tshuaj "Clarotadine" syrup. Cov lus qhia rau kev siv nws yuav muab hauv qab no. Dosage - 5 mg / 5 ml. Loratodine (active ingredient) ib milligram ib milliliter ntawm syrup. Excipients: propylene glycol, qab zib, benzoic acid, ethyl cawv, citric acid, tropeolin, purified dej, zaub mov flavors.
Tso tawm hauv lub raj mis tsaus nti, lub peev xwm ntawm ib puas milliliters. Lub raj mis no yog nyob rau hauv ib lub thawv ntawv cardboard. Cov khoom siv kuj suav nrog rab diav ntsuas tshwj xeeb.
Tam sim no xav txog cov tshuaj Clarotadine. Ib ntsiav tshuaj muaj kaum milligrams ntawm loratodine. Ntawm cov excipients - MCC, mis nyuj qab zib, calcium stearate, glycolate, sodium starch. Muab tso rau hauv hlwv, txhua qhov muaj xya lossis kaum daim. Cov thawv ntawv tuaj yeem muaj los ntawm ib mus rau peb pob ntawm cov ntaub ntawv.
Pharmacodynamics
Cov tshuaj no yog cov tshuaj H1-antihistamine uas tsis muaj anticholinergic thiab lub hauv paus ua haujlwm. Nws pib ua haujlwm li ntawm ib nrab teev tom qab siv thiab siv tau thoob plaws hnub. Nws yog ib qho tseem ceeb uas kev siv cov tshuaj no mus ntev tsis muaj kev tiv thaiv rau nws. Nws yuav tsum raug sau tseg tias cov tshuaj loratodin, nrog rau nws cov metabolites, tsis tuaj yeem nkag mus rau BBB.
YPharmacokinetics
Dab tsiRaws li deb li kev txaus siab, thaum noj qhov ncauj ntawm cov koob tshuaj pom zoo los ntawm cov chaw tsim khoom, lub ntsiab lus tseem ceeb ntawm loratodine yog sai thiab tag nrho absorbed rau hauv lub circulatory system los ntawm txoj hnyuv. Concentrations uas twb txiav txim tau tshwm sim nyob rau hauv cov ntshav plasma kaum tsib feeb tom qab noj. Raws li lub sijhawm kom ncav cuag Cmax hauv cov ntshav ntawm loratodine, nws nyob ntawm ib teev thiab plaub caug feeb mus rau ob teev thiab peb caug feeb.
Tab sis lub sijhawm kom ncav cuag Cmax ntawm nws cov metabolite nquag yog yuav luag peb teev. Nws tsuas yog tsim nyog nco ntsoov tias kev siv ib txhij ntawm cov khoom noj nrog rau cov tshuaj tuaj yeem ua rau qeeb ntawm kev ua tiav ntawm Cmax ntawm loratodine, nrog rau nws cov metabolite hauv plasma, los ntawm ib teev. Hauv qhov no, Cmax ntawm cov tshuaj no yuav nyob twj ywm tsis hloov, thiab zaub mov tsis tuaj yeem cuam tshuam qhov tshwm sim hauv ib txoj kev.
Tam sim no hais txog cov neeg laus. "Clarotadine" (cov lus qhia rau kev siv sau ntawv) lawv tuaj yeem noj yam tsis muaj kev tshwj xeeb tshwj xeeb txog hnub nyoog. Cia li nco ntsoov tias lub sijhawm kom ncav cuag Cmax nce los ntawm ib teev thiab ib nrab, tsis zoo li cov tub ntxhais hluas. Hais txog kev puas tsuaj rau lub siab cawv, nyob ntawm qhov hnyav ntawm tus kab mob no, lub sij hawm kom ncav cuag Cmax kuj nce.
Hauv cov ntshav ntshav, cov ntsiab lus ntawm loratodine nrog nws cov metabolite nquag nce mus txog qib nyob ruaj khov hauv cov neeg mob feem ntau hnub thib tsib tom qab kev tswj hwm. Thiab kev sib txuas nrog plasma proteins yog 97%.
YMetabolism
Nyob rau hauv daim siab, cov tshuaj nquagLoratodine yog metabolized rau cov nquag metabolite descarboethoxyloratadine. Qhov no yog vim qhov kev ua ntawm cytochrome P450 isoenzyme CYP3A4. Qhov cuam tshuam ntawm CYP2D6 isoenzyme ntawm cytochrome P450 kuj muaj qhov cuam tshuam, txawm tias tsawg dua. Lub xub ntiag ntawm kectonazole, uas yog CYP3A4 inhibitor, tso cai rau loratodine hloov mus rau descarboethoxyloratadine. Qhov no tshwm sim vim qhov cuam tshuam ntawm CYP2D6.
Derivation
Cov tshuaj "Clarotadine" raug tso tawm (cov lus qhia rau kev siv kuj hais txog qhov no) los ntawm ob lub raum, thiab nrog rau cov kua tsib. Qhov nruab nrab T1 / 2 ntawm cov tshuaj loratadine yog yim teev thiab nees nkaum feeb (qhov ntau yuav yog los ntawm peb mus rau nees nkaum teev). Raws li rau cov nquag metabolite, nws qhov nruab nrab yog nees nkaum yim teev (ntau tuaj yeem yog los ntawm rau teev thiab plaub caug feeb mus rau peb caug-xya teev).
Mean decaboethoxyloratadine yog kaum xya teev thiab peb caug feeb (ntau txog kaum ib txog peb caug yim teev). Yog tias peb tab tom tham txog kev puas tsuaj rau daim siab nrog cawv, ces T1 / 2 yuav nce ntxiv nrog rau qhov nce ntawm qhov mob hnyav. Tab sis nyob rau hauv cov neeg mob uas lub raum tsis ua hauj lwm, nrog rau cov uas tau txais hemodialysis, cov pharmacokinetics tsis hloov ntau.
Kev cev xeeb tub
Cov poj niam cev xeeb tub yuav tsum tsis txhob noj cov tshuaj no, vim tias "Clarotadine" rau cov menyuam yaus hauv plab tuaj yeem ua rau muaj kev phom sij. Yog tias muaj kev xav tau siv cov tshuaj no los ntawm tus niam laus, cesnws yuav tsum tsis txhob pub mis niam kom txog thaum kho tiav.
YContraindications
Zoo li lwm yam tshuaj, nws muaj contraindications thiab "Klarotadin". Cov lus qhia rau kev siv hais tias cov tshuaj no yuav tsum tsis txhob siv yog tias tus neeg mob muaj hypersensitivity rau ib yam ntawm cov tshuaj no. Cev xeeb tub thiab lactation kuj yog qhov xwm txheej uas qhov kev kho no tsis raug sau lossis noj. Cov neeg mob uas lub siab tsis ua haujlwm yuav tsum tau noj Clarotadine nrog ceev faj.
Side effects
Tam sim no nws tsim nyog tham txog yuav ua li cas cov tshuaj no tuaj yeem cuam tshuam rau tib neeg lub cev. Tej zaum yuav muaj kev tshwm sim ntawm ib qho teeb meem ntawm lub paj hlwb, xws li ntxhov siab vim, asthenia, hyperkinesia, ntxhov siab nyob rau hauv ib tug me nyuam, tsaug zog, tshee, parasthesia, kev nyuaj siab thiab amnesia. Subcutaneous rog, nrog rau daim tawv nqaij, yuav hnov mob rau cov khoom ntawm cov tshuaj nrog dermatitis.
Yog tias peb tham txog cov kab mob genitourinary, tom qab ntawd ntawm nws feem yuav muaj kev hloov pauv ntawm cov zis, tus neeg mob yuav hnov mob tso zis, uas yuav ua rau mob. Vaginitis, dysmenorrhea, thiab menorrhagia kuj tuaj yeem tshwm sim.
Kev ua txhaum cai kuj tuaj yeem ua tau los ntawm cov kab mob endocrine. Qhov hnyav yuav nce, tus neeg mob yuav nqhis dej, thiab nws kuj tuaj yeem tawm hws ntau dua. Cov kab mob musculoskeletal kuj tuaj yeem raug qee yamua txhaum cai hauv lawv txoj haujlwm. Cov no yog spasms ntawm calf nqaij, thiab myalgia, thiab arthralgia.
Lub plab zom mov tuaj yeem raug kev txom nyem. Distortions ntawm saj, raws plab los yog cem quav, anorexia, gastritis, dyspepsia, nce qab los noj mov, flatulence thiab stomatitis - tag nrho cov no tuaj yeem tshwm sim nrog qee qhov tshwm sim thaum siv Clarotadine.
Nyob rau qhov tsis ua haujlwm thiab ua pa. Kev ua txhaum cai yuav tshwm sim nyob rau hauv daim ntawv ntawm bronchospasm, hnoos, sinusitis, thiab dryness ntawm mucous daim nyias nyias nyob rau hauv lub qhov ntswg. Conjunctivitis tuaj yeem txhim kho, pom kev tsis pom kev, mob pob ntseg thiab qhov muag tshwm. Cov kab mob plawv kuj raug rau cov kev mob tshwm sim, uas tuaj yeem tshwm sim raws li lub plawv dhia, nce ntshav siab, thiab txo qis ntshav siab.
Muaj ntau zaus ntawm kev tsis haum tshuaj, tshwm sim hauv daim ntawv ntawm angioedema, khaus, urticaria thiab photosensitivity. Mob nraub qaum, kub taub hau, dysphonia, mob hauv siab, ua daus no, blepharospasm, thiab mob mis kuj tuaj yeem tshwm sim.
Raws li koj tuaj yeem pom, cov kev mob tshwm sim tuaj yeem loj heev, yog li tsis txhob hnov qab txog nws. Tus kws kho mob qhov kev sab laj yuav tsum muaj ob qho tib si ua ntej thawj koob tshuaj, thiab yog tias pom pom cov teeb meem saum toj no.
Syrup thiab ntsiav tshuaj "Klarotadin" los ntawm dab tsi - txheeb nws tawm. Tam sim no cia peb tham txog yuav ua li cas coj nws. Cov tshuaj no yog npaj rau kev siv sab hauv. Cov menyuam yaus hnub nyoog tshaj kaum ob, thiabQhov pom zoo noj txhua hnub rau cov neeg laus yog kaum milligrams. Qhov no yog ob scoops ntawm kua syrup los yog ib ntsiav tshuaj. Tab sis rau cov menyuam yaus hnub nyoog ob txog rau kaum ob xyoos, nws lub cev hnyav dua li peb caug kilograms, nws raug nquahu kom noj tsib milligrams. Qhov no yog ib tug daus los yog ib nrab ib ntsiav tshuaj. Cov koob tshuaj txhua hnub yuav tsum tsis txhob tshaj qhov ntsuas no. Yog tias qhov hnyav ntau tshaj peb caug kilograms, ces qhov koob tshuaj yuav zoo ib yam li cov neeg laus.
Ntau tshaj
Yog tias koj tsis ua raws li cov lus pom zoo thiab noj tshuaj ntau, cov neeg laus yuav ntsib cov tsos mob uas tam sim no tau teev tseg. Cov no yog tachycardia, mob taub hau thiab tsaug zog. Thiab hauv cov menyuam yaus uas hnyav dua li peb caug kilograms, kev noj ntau dhau yuav ua rau lub plawv dhia, nrog rau cov tsos mob extrapyramidal.
Yog tus neeg mob tso cai noj tshuaj ntau dhau, yuav tsum tau mus ntsib kws kho mob tam sim ntawd. Kev saib xyuas kuj yuav tsum tau ua kom ntseeg tau tias cov tshuaj raug tshem tawm ntawm txoj hnyuv thiab txo qhov nqus. Qhov no yog ua los ntawm inducing ntuav, gastric lavage, thiab siv activated charcoal. Yog tias tsim nyog, kev kho mob tuaj yeem ua tiav. Nws yuav tsum nco ntsoov tias cov tshuaj nquag loratadine tsis tuaj yeem raug tshem tawm ntawm lub cev los ntawm hemodialysis. Kuj tsis muaj ntaub ntawv hais txog kev tshem tawm ntawm cov khoom no thaum lub sij hawm kho peritoneal.
Kev sib tham nrog lwm yam tshuaj
Yog tias koj siv "Clarotadine" hauv koob tshuaj kho mob, kev ua kom muaj zog nrog dej cawv tsis yognrhiav pom. Thiab thaum siv cov tshuaj no nrog tshuaj tua kab mob xws li Cimetidine, Erythromycin thiab Ketoconazole, plasma concentration ntawm loratodine yuav nce. Qhov tshwm sim no tsis tau tshwm sim nyob rau hauv ib txoj kev, thiab kuj tsis muaj kev cuam tshuam rau lub electrocardiogram.
Muaj pov thawj tias inducers ntawm microsomal oxidation, uas suav nrog ethanol, phenytoin, barbiturates, rifampicin, zixorin, tricyclic antidepressants, phenylbutazone, tuaj yeem txo cov txiaj ntsig ntawm cov tshuaj no.
Cov lus qhia tshwj xeeb
Cov neeg mob uas raug kev txom nyem los ntawm kev ua haujlwm tsis zoo ntawm lub siab, thiab leej twg muaj lub raum tsis txaus (glomerular filtration rate tsawg dua peb caug ml / min), qhov pom zoo thawj koob tshuaj Clarotadine yuav tsum tsis pub tshaj kaum milligrams (qhov no yog ib ntsiav tshuaj lossis ob zaug. ntsuas diav ntawm syrup) nyob rau hauv ob hnub. Tsis tas li, tsis txhob muab cov tshuaj no rau cov menyuam yaus hnub nyoog qis dua ob xyoos.
Txhua tus neeg uas pib noj cov tshuaj no yuav tsum tsis kam rau tag nrho lub sijhawm ntawm kev kho mob los ntawm kev koom nrog txhua yam kev ua ub no uas yuav tsum tau ua kom muaj kev xav ntau ntxiv, nrog rau kev ceev ntawm kev xav ntawm psychomotor.
Analogues
Nws yog qhov ncaj ncees hais tias Clarotadine tsis yog ib qho ntawm nws hom. Muaj cov analogues ob qho tib si ntawm cov tshuaj hauv tsev thiab txawv teb chaws. Ib tug ncaj ncees txawv teb chaws "kwv tij" yogtshuaj "Claritin". Nws cov khoom yuav luag zoo ib yam li cov tshuaj saum toj no Clarotadine. Nqe yog qhov sib txawv loj. Cov tshuaj txawv teb chaws yog kim dua. Hauv tsev muaj tus nqi nyob ntawm qhov kev teeb tsa. Yog, ib pob ntawm 7. yuav raug nqi txog 100 rubles, 10 x 3 cell contour packs - kwv yees li 270 rubles, thiab 100 ml syrup - txog 135 rubles.
Peb yuav tsis tham txog qhov no yog qhov zoo dua rau kev siv - Clarotadine lossis Claritin. Qhov no yog qhov teeb meem ntawm tus kheej rau txhua tus, thiab koj yuav tsum txiav txim siab rau koj tus kheej seb puas yuav yuav cov tshuaj pheej yig hauv tsev, lossis muab kev nyiam rau tus nqi kim txawv teb chaws. Tab sis nws yog tsim nyog sau cia tias rau tag nrho cov xyoo no cov tshuaj "Clarotadine" tau ua pov thawj nws tus kheej zoo heev. Tib lub sijhawm, analogues tshwm sim txhua hnub.
Txawm li cas los xij, ua ntej koj pib noj cov tshuaj no, thiab ntau ntxiv thaum muab tshuaj rau cov menyuam yaus, nco ntsoov nrog koj tus kws kho mob tham. Qhov no yuav tiv thaiv koj ntawm qhov tshwm sim tsis zoo uas yuav tshwm sim los ntawm kev tsis haum tshuaj, kev siv tsis raug lossis kev siv tshuaj ntau dhau. Koj yuav tsum nco ntsoov tias cov txiaj ntsig zoo li no tuaj yeem tsim teeb meem loj rau koj txoj kev noj qab haus huv, kev noj qab haus huv ntawm koj cov menyuam, thiab koj lub neej.
