Xav txog cov lus qhia rau kev siv thiab contraindications "Indapamide". Nws yog cov tshuaj uas muaj vasodilatory, diuretic thiab hypotensive zog. Nws yog tsim los ntawm ntau lub tuam txhab txawv teb chaws thiab Lavxias teb sab kws tshuaj: Teva (Israel), PRANAPHARM LLC, Valenta Pharmaceuticals OJSC (Russia), German STADA Artsneimittel, Hemofarm (Serbia thiab Montenegro), Ukrainian JSC Stoma.
Kev sib sau thiab tso tawm daim ntawv
Peb yuav tham txog contraindications thiab kev phiv ntawm Indapamide hauv qab no. Nyob rau hauv lub meantime, cia saib seb dab tsi nyob rau hauv cov tshuaj muaj pes tsawg leeg.
Nws los ntawm ntau hom:
- Cov tshuaj ntsiav uas ntim rau hauv cov hlwv ntawm 5, 6, 7, 10, 30 pcs. los yog hauv jars ntawm 10, 20, 30, 40, 50, 100 pieces
- Long-acting film-coated tablets - in blister packs of 10 pcs. los yog 30 pcs. hauv txhab nyiaj.
- Cov ntsiav tshuajnrog hloov kho - nyob rau hauv blister blister pob ntawm 10 thiab 14 pcs.
Cov tshuaj no muaj cov khoom nquag - indapamide. Cov khoom pabcuam ntawm cov tshuaj ntsiav yog: magnesium stearate, microcrystalline cellulose. Cov tshuaj ntxiv hauv cov tshuaj muaj pes tsawg leeg: hypromellose, lactose monohydrate, magnesium stearate, colloidal anhydrous silicon dioxide, polyethylene glycol, croscarmellose sodium, crospovidone, povidone K30, talc, sodium lauryl sulfate. Contraindications "Indapamide" yog ib qho tseem ceeb kom paub ua ntej.
Pharmacological action
Qhov no yog sulfonamide derivative, thiab nws cov tshuaj pharmacological zoo ib yam li thiazide diuretics. Cov tshuaj no yog tus yam ntxwv los ntawm diuretic thiab saluretic teebmeem ntawm qhov mob hnyav, vim qhov kev poob qis hauv kev nqus ntawm sodium, chlorine thiab, rau qee qhov, potassium thiab magnesium ions nyob rau hauv cov tubules ze ntawm ob lub raum thiab cortical cheeb tsam ntawm lub distal tubule. lub nephron.
Tus neeg sawv cev tshuaj no tuaj yeem txo cov suab nrov ntawm cov leeg leeg leeg, muaj cov cuab yeej vasodilating, thiab tseem muab kev txo qis hauv cov kab mob peripheral vascular tsis kam. Cov kev ua ntawm cov tshuaj no yog vim qhov txo qis ntawm cov phab ntsa vascular mus rau norepinephrine thiab angiotensin II, kev cuam tshuam ntawm calcium tam sim no hauv cov hlwb ntawm cov hlab ntsha du, thiab kev ua kom muaj zog ntawm prostaglandin E2, uas yog tus cwj pwm los ntawm vasodilating khoom.
Thaum siv tshuaj "Indapamide" pomtxo qis ntawm sab laug ventricular hypertrophy hauv plawv. Cov tshuaj muaj antihypertensive zog thaum noj nyob rau hauv ntau npaum uas tsis muaj ib tug tseem ceeb diuretic nyhuv. Rau thiazide-zoo li thiab thiazide diuretics, tom qab nce ib koob tshuaj, qhov tsim ntawm lub toj siab hauv cov nyhuv kho yog tus yam ntxwv, thaum qhov kev mob tshwm sim tsis zoo tseem nce ntxiv. Yog li ntawd, nws tsis pom zoo kom nce koob tshuaj yog tias qhov txiaj ntsig zoo tsis ua tiav thaum lub sijhawm kho ntawm cov tshuaj pom zoo. Thiab, tau kawg, koj yuav tsum nco ntsoov txog contraindications ntawm Indapamide ntsiav tshuaj, uas tau piav qhia hauv qab no.
Cov lus qhia rau kev siv
Tshuaj yog muab rau kev kho mob ntshav siab. Tsis txhob siv cov tshuaj no yam tsis tau sab laj nrog kws kho mob.
Daim ntawv teev cov Indapamide contraindications
Lub xub ntiag ntawm cov kab mob hauv qab no yuav tsum tau qhia rau tus kws kho mob. Cov kab mob hauv qab no yuav tsum raug sau tseg raws li contraindications rau Indapamide:
- raum tsis ua haujlwm (mob daim ntawv, nyob rau theem ntawm anuria);
- galactosemia;
- hypokalemia;
- mob siab tsis ua haujlwm (suav nrog encephalopathy);
- poob qabzib / galactose absorption, lactose intolerance;
- kev tswj hwm nrog tshuaj uas ncua sijhawm QT;
- rhiab heev rau cov tshuaj muaj pes tsawg leeg, nrog rau lwm yam sulfonamide derivatives;
- hnub nyoog qis dua 18 xyoo (kev ua tau zoo thiab kev nyab xeeb ntawm kev sivcov tshuaj rau hnub nyoog no tsis tau tsim).
Siv nrog saib xyuas
Feem ntau, cov contraindications ntawm "Indapamide" yuav tsum nruj me ntsis soj ntsuam. Ntxiv nrog rau cov tseem ceeb, kuj muaj cov txheeb ze. Cov tshuaj yuav tsum tau siv ceev faj nyob rau hauv cov xwm txheej hauv qab no:
- nrog rau kev ua haujlwm ntawm lub siab lossis lub raum;
- nrog ntshav qab zib mellitus (decompensation stage);
- nrog hyperuricemia (yog tias nrog gout thiab urate nephrolithiasis);
- ua txhaum dej lossis electrolyte tshuav;
- nrog hyperparathyroidism, nrog nce QT ntu ntawm ECG;
- people ntawm cov tshuaj tiv thaiv arrhythmic.
Cov lus qhia rau kev siv
Yog tias tsis muaj contraindications rau Indapamide ntsiav tshuaj, ces koj yuav tsum nyeem cov lus qhia ua ntej noj lawv. Cov tshuaj no yog noj thaum sawv ntxov, ib zaug, ntxuav nrog kua thiab tsis zom. Kev noj tshuaj txhua hnub - 1 pc. (nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog kev hloov kho los yog kev ua haujlwm ntev, nrog rau cov tshuaj ntsiav). Yog tias tom qab 1-2 lub hlis ntawm kev siv cov tshuaj, qhov tsim nyog kho cov nyhuv tsis pom, nws tsis pom zoo kom nce cov tshuaj ntau npaum li cas (vim muaj kev pheej hmoo siab ntawm cov kev mob tshwm sim yam tsis tau txhim kho cov nyhuv antihypertensive). Nyob rau hauv tas li ntawd, nws yog ntshaw kom suav nrog lwm yam tshuaj antihypertensive uas tsis yog diuretics nyob rau hauv cov tshuaj regimen.
Thaum noj ob yam tshuaj sib txawv, tsis tas yuavkho koob tshuaj. Yog tias contraindications raug coj mus rau hauv tus account thiab cov lus qhia "Indapamide" tau kawm kom raug, ces qhov tshwm sim ntawm kev tsim cov tshuaj tiv thaiv tsis zoo yuav tsawg dua.
Side effects
Thaum lub sijhawm kho nrog cov tshuaj no, qee qhov kev mob tshwm sim tuaj yeem tshwm sim:
- Lub plawv thiab cov hlab ntsha: orthostatic hypotension, ECG abnormalities (hypokalemia), arrhythmia, palpitations.
- CNS: asthenia, nervousness, cephalgia, kiv taub hau, tsaug zog, pw tsaug zog cuam tshuam, kev nyuaj siab, vertigo, malaise, qaug zog, qaug zog heev, nqaij spasm, nro, chim siab, ntxhov siab vim.
- digestive system: mob plab, qhov ncauj qhuav, xeev siab, anorexia, gastralgia, ntuav, cem quav, raws plab, muaj peev xwm ua rau mob siab encephalopathy thiab pancreatitis.
- Ytso zis: nquag kis kab mob, nocturia, polyuria. Tab sis, ntawm chav kawm, contraindications thiab phiv ntawm Indapamide tsis yog ib txwm cuam tshuam. Qee zaum, cov tshuaj raug tso cai noj, tab sis nws tseem ua rau muaj kev cuam tshuam tsis zoo hauv lub cev.
- Cov kab mob ua pa: pharyngitis, sinusitis, rhinitis, hnoos.
- Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, pob txha pob txha aplasia thiab hemolytic type anemia.
- kuaj ntsuas: hyperuricemia, hypercalcemia, hypokalemia, hyponatremia, hyperglycemia, hypochloremia, nce nitrogen thiab plasma urea, hypercreatininemia, glycosuria.
- Cov tshuaj tsis haum: pob khaus, hemorrhagic vasculitis, khaus. Urticaria.
- Lwm yam tshwm sim ntawm pathological: exacerbation ntawm lupus erythematosus.
Cov tsos mob ntau dhau
Nws yog ib qho tseem ceeb tsis tsuas yog coj mus rau hauv tus account lub contraindications rau kev siv "Indapamide", tab sis kuj nruj me ntsis saib xyuas cov tshuaj. Nws muaj peev xwm txiav txim siab txog kev txhim kho cov tshuaj overdose ntawm lub xeev los ntawm cov cim xws li oliguria lossis polyuria mus txog rau anuria (raws li qhov tshwm sim ntawm hypovolemia), txo qis hauv siab, dej thiab electrolyte hloov pauv (hyponatremia, hypokalemia), kev nyuaj siab ntawm kev ua pa. center, tsaug zog, lethargy, tsis meej pem, convulsive qaug dab peg, kiv taub hau, xeev siab, ntuav. Hepatic coma tuaj yeem tshwm sim hauv cov neeg mob cirrhosis ntawm daim siab. Raws li kev kho mob, kev kho mob tau pom zoo (pas plab lavage, noj sorbents, ntsuas kom normalize dej thiab electrolyte tshuav).
Special Recommendations
Indapamide cov lus qhia thiab contraindications tau piav qhia meej hauv cov lus qhia. Cov neeg mob laus thiab cov neeg noj glycosides thiab laxatives tiv thaiv keeb kwm yav dhau ntawm hyperaldosteronism tau qhia kom saib xyuas cov ntsiab lus ntawm creatinine thiab potassium ions tsis tu ncua. Thaum kho nrog Indapamide, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam cov ntsiab lus ntawm magnesium, sodium thiab potassium ions hauv ntshav (vim muaj peev xwm tsim cov kab mob electrolyte), cov seem nitrogen, qabzib, uric acid, thiab pH qib. Kev tshawb fawb thawj zaug ntawm cov tshuaj potassium yog nqa tawm hauv thawj lub lim tiam ntawm kev kho mob. RauCov pawg uas muaj kev pheej hmoo siab kuj suav nrog cov neeg uas muaj lub sijhawm QT ntev ntawm ECG (hom kab mob los yog tsim tawm tsam keeb kwm yav dhau los ntawm qee cov txheej txheem pathological).
Cov neeg mob ntshav siab (feem ntau nrog edema lossis ascites, uas cuam tshuam nrog qhov tshwm sim ntawm metabolic alkalosis, uas ua rau mob siab rau daim siab encephalopathy), CAD, plawv tsis ua haujlwm, thiab cov neeg laus yuav tsum tau saib xyuas kom zoo. Hypercalcemia uas tsim thaum siv cov tshuaj yuav qhia tau tias yav dhau los tsis tau kuaj pom hyperparathyroidism.
Ntxiv rau, nws raug pom zoo kom tswj cov piam thaj hauv cov neeg mob ntshav qab zib. Lub cev qhuav dej tseem ceeb tuaj yeem ua rau mob raum tsis ua haujlwm (txo glomerular pom tus nqi). Cov neeg mob yuav tsum tau them nyiaj rau qhov poob dej hauv lub cev thiab tswj kev ua haujlwm ntawm lub raum thaum pib ntawm kev ntsuas kho.
Cov tshuaj "Indapamide" tuaj yeem muab cov txiaj ntsig zoo hauv kev siv tshuaj tua kab mob. Nyob rau hauv cov ntaub ntawv ntawm hyponatremia thiab arterial hypertension, 3 hnub ua ntej pib siv cov angiotensin-hloov enzyme inhibitors, diuretics yuav tsum tau cuam tshuam los yog thawj zaug angiotensin-hloov enzyme inhibitors yuav tsum tau siv nyob rau hauv me me npaum li cas. Sulfonamide derivatives tuaj yeem ua rau muaj qhov exacerbation ntawm lupus erythematosus. Qee qhov xwm txheej, cov xwm txheej ntawm tus kheej cuam tshuam nrog kev hloov ntshav siab tuaj yeem ua tau thaum kho, suav nrog thaum lwm cov tshuaj tiv thaiv hypertensive suav nrog hauv kev kho mob. ATVim li ntawd, kev muaj peev xwm tsav tsheb thiab ua cov haujlwm uas yuav tsum tau ua kom muaj zog yuav raug txo.
Tshuaj rau lactation thiab cev xeeb tub
Kev siv cov khoom kho mob "Indapamide" thaum cev xeeb tub tsis pom zoo, vim nws cov kev tswj hwm tuaj yeem ua rau fetoplacental ischemia, uas tuaj yeem ua rau kev loj hlob ntawm tus menyuam hauv plab. Txij li thaum lub ntsiab tseem ceeb ntawm cov tshuaj nkag mus rau hauv niam cov kua mis, nws yuav tsum tsis txhob muab tshuaj thaum lactation. Yog tias tsim nyog los noj cov tshuaj los ntawm cov neeg mob laus, kev pub niam mis yuav tsum raug ncua. Nws yog qhov zoo dua los sau cov ntaub ntawv hais txog contraindications thiab kev phiv ntawm Indapamide ua ntej.
Kev Sib Tham Tshuaj
Thaum siv ua ke nrog lwm cov tshuaj, cov teebmeem tsis zoo yuav tshwm sim:
- mob plawv glycosides ntxiv rau cov tshuaj laxatives, saluretics, tetracosactide, amphotericin B, gluco- thiab mineralocorticoids: nce kev pheej hmoo ntawm hypokalemia thiab digitalis intoxication;
- astemizole, erythromycin, pentamidine, terfenadine, vincamine, sultopride, chav kawm I A antiarrhythmic tshuaj (quinidine, disopyramide) thiab chav kawm III (amiodarone, sotalol): torsade de pointes arrhythmia;
- tshuaj tiv thaiv kab mob nonsteroidal, tetracosactide, glucocorticosteroids, sympathomimetics: txo qis hauv cov khoom hypotensive;
- tricyclic (imipramine) tshuaj tiv thaiv kev ntxhov siab thiab tshuaj tiv thaiv kev puas siab puas ntsws: nce cov teebmeem hypotensivethiab ua rau muaj feem ntau ntawm orthostatic hypotension;
- calcium npaj: qhov yuav tshwm sim ntawm hypercalcemia;
- Metformin: yuav ua rau muaj cov tsos mob ntawm lactic acidosis;
- cyclosporine: kev pheej hmoo ntawm hypercreatininemia;
- koob tshuaj iodine-muaj cov tshuaj sib txawv: kev pheej hmoo ntawm kev tsim lub raum tsis ua haujlwm thiab lub cev qhuav dej (nws raug pom zoo kom rov qab ua kua dej ua ntej kev qhia txog cov tshuaj muaj iodine);
- angiotensin-hloov pauv enzyme inhibitors: kev pheej hmoo ntawm kev tsim lub raum tsis ua haujlwm thiab cov hlab ntsha hypotension (tshwj xeeb yog kuaj pom lub raum hlab ntsha stenosis);
- baclofen: nce hypotensive nyhuv;
- indirect anticoagulants (coumarin lossis indandione derivatives): kev tawm tsam ntawm lawv cov txiaj ntsig (kho tshuaj yuav tsum tau);
- potassium-sparing diuretics: tshwm sim ntawm hyper- lossis hypokalemia;
- non-depolarizing cov leeg so kom txaus: thaiv kev sib kis ntawm neuromuscular uas txhim kho nyob rau hauv lawv lub zog nce.
Cov tshuaj "Indapamide" nce qhov concentration ntawm lithium ions hauv plasma (inhibition ntawm urinary excretion), thiab lithium, tig, muaj cov nyhuv nephrotoxic.
Analogues
Ntawm cov analogues ntawm tus kws tshuaj "Indapamide" nws yuav tsum raug sau tseg:
- Indapamid Retard.
- Indapamid-Teva.
- "Arifon Retard".
- Indapamid MV Shtada.
- Ionic.
- Indap.
- Tenzar.
- Lorvas.
- Indapen.
- Indopress.
- "Acrylamide".
- Y"Hydrochlorothiazide".
- YCyclomethiazide.
- Oxodoline.
Price
Ntawm qhov nruab nrab, tus nqi ntawm kev npaj kho mob "Indapamide" hauv daim ntawv tshuaj ntsiav txawv ntawm 22 txog 30 rubles (30 daim ib pob). Tus nqi ntawm cov ntsiav tshuaj ntev ntev yog kwv yees li 90-140 rubles (30 pcs.). Hloov kho cov ntsiav tshuaj raug nqi kwv yees li 100‒107 rubles (30 pcs.).
Qhia seb yog Indapamide Retard 1.5 mg muaj cov tshuaj contraindications.
Means sib txawv
Ntxiv rau cov tshuaj classic Indapamide, ntawm lub rhawv ntawm cov khw muag tshuaj koj tuaj yeem pom cov tshuaj Indapamide Retard, 1.5 mg. Cov nyiaj no muaj tib lub ntsiab lus tseem ceeb thiab muaj cov lus qhia zoo ib yam rau kev siv. Raws li rau contraindications thiab phiv, Indapamide Retard muaj raws nraim tib yam li cov pa pa.
Txawm li cas los xij, qee txoj hauv kev cov tshuaj no txawv, thiab qhov sib txawv tshaj plaws yog cov chaw tsim khoom sib txawv. Lwm qhov sib txawv ntawm cov tshuaj yog cov txheej txheem ntawm kev tso tawm ntawm cov khoom tseem ceeb. Ib nrab-lub neej ntawm cov tshuaj kuj txawv, thiab nyob rau hauv view ntawm qhov no, lub tom kawg muaj ib tug ntev lub neej.
Tshuaj xyuas ntawm contraindications thiab kev phiv ntawm "Indapamide"
Tsis yog cov neeg mob uas tau muab tshuaj Indapamide nkaus xwb, tab sis kuj yog cov kws kho mob tshwj xeeb uas hais tias cov tshuaj no yuav tsum tsis txhob noj.ywj siab, tsis muaj kws kho mob cov tshuaj. Qhov no yog vim lub fact tias nyob rau hauv cov kev kho mob ntawm kub siab nws yog tsim nyog los xyuas kom meej tus kab mob, xaiv qhov zoo npaum li cas, thiab txo qhov yuav tshwm sim ntawm qhov tshwm sim tsis zoo, uas nyob rau hauv cov ntaub ntawv ntawm cov tshuaj no yuav loj heev. Cov kws kho mob kuj tau taw qhia tias yog nws muaj peev xwm sau tau lwm txoj kev kho mob siab dua, nws yog qhov zoo dua tsis txhob siv cov tshuaj no.
Cov neeg mob uas tau siv tshuaj "Indapamide", hauv kev tshuaj xyuas nco ntsoov tias hauv thawj theem ntawm kev kho mob, nws yuav luag ib txwm ua rau muaj kev phiv. Cov no yog cov kab mob digestive thiab kev hloov pauv hauv kev ua haujlwm ntawm lub paj hlwb, uas yog qhov tshwm sim ntawm kiv taub hau, tsaug zog, qaug zog thiab qaug zog. Ntau tus neeg tau ntsib kev mob taub hau ntau zaus thaum noj Indapamide. Cov neeg mob feem ntau muaj teeb meem dyspeptic thiab quav quav. Cov nyhuv kho, raws li cov neeg mob, tau ua tiav feem ntau thaum noj tshuaj.
Peb tau tshuaj xyuas cov lus qhia, qhia thiab contraindications ntawm Indapamide.
