"Tubocurarine chloride" yog cov leeg nqaij so thiab muaj cov nyhuv peripheral. Cov lus qhia qhia tias nws muaj peev xwm thaiv cov kab mob neuromuscular.
Kev sib sau thiab tso tawm daim ntawv
Lub ntsiab ntawm cov tshuaj no yog tubocurarine chloride, uas muaj nyob rau hauv ib koob ntawm 0.01 g. Glycerol - 0.3 g thiab tshwj xeeb dej rau txhaj tshuaj yog ntxiv rau ntxiv tshuaj.
Cov khoom ntawm qhov concentration ntawm 1% yog nchuav rau hauv ampoules ntawm 1.5 ml. Tom qab ntawd lawv muab tso rau hauv pob ntawm 25 pieces. Tsis tas li, cov tshuaj tau muab tso rau hauv 10 ml vials, uas tau ntim rau hauv lub thawv ntawm 5 daim.
Pharmacological action
"Tubocurarine chloride" yog ib qho tsis muaj polarizing nqaij so uas tuaj yeem thaiv kev sib kis ntawm neuromuscular. Yog li, nws ua rau H-cholinergic receptors ntawm cov leeg pob txha. Cov nyhuv so kom maj mam nce mus txog qhov siab tshaj tom qab li 5 feeb.
Kev so ntawm cov leeg nqaij tshwm sim tas li. Nws tag nrho pib nrog cov ntiv tes ntawm sab sauv ceg, thiab tom qab ntawd cov leeg ntawm lub qhov muag, cov ceg qis, nraub qaum thiab diaphragm ua raws. Restoration ntawm lub suab tshwm sim nyob rau hauv qhov kev txiav txim rov qab thiabpib nrog cov leeg ntawm lub diaphragm.
Mechanism ntawm kev ua "Tubocurarine chloride" tso tawm histamine los ntawm cov ntaub so ntswg thiab tuaj yeem ua rau cov leeg nqaij hauv bronchi.
Cov lus qhia rau kev siv
Cov tshuaj no yog siv rau cov leeg nqaij so thaum tus neeg mob txuas nrog lub tshuab ua pa. Nws kuj raug sau tseg rau cov tshuaj pharmacological lossis hluav taws xob ua rau cov leeg mob thiab thaum kuaj mob myasthenia gravis.
Hauv traumatology, nws yog siv rau repositioning pob txha fragments thiab repositioning dislocations. Nyob rau hauv kev puas siab puas ntsws - rau kev tiv thaiv ntawm schizophrenia thiab nyob rau hauv kev kho mob ntawm qaug dab peg. Thiab nyob rau hauv neurology - nrog cov xwm txheej epilepticus thiab convulsions ntawm txawv keeb kwm.
YContraindications
Cov tshuaj yuav tsum tsis txhob siv nyob rau hauv cov ntaub ntawv ntawm ib tug neeg intolerance thiab hypersensitivity rau cov khoom uas muaj nyob rau hauv muaj pes tsawg leeg. Tsis tas li ntawd, "Tubocurarine chloride" tsis raug tshuaj rau cov neeg mob uas tsis txaus ntawm cov kab mob siab hauv lub raum tsis ua haujlwm thiab cov neeg laus.
Cov lus qhia rau kev siv
Qhov koob tshuaj yog nyob ntawm hom tshuaj loog uas yuav muab rau tus neeg mob. Cov lus qhia rau "Tubocurarine chloride" hais tias nws tau muab tso rau hauv cov hlab ntsha.
Nyob rau hauv cov neeg laus, cov tshuaj provokes ib ntus tuag tes tuag taw ntawm cov nqaij ntshiv ntawm cov hlab ntsha ntawm ib koob ntawm 16-26 mg. Txhawm rau kom ua tiav cov txiaj ntsig ntev, kev tswj hwm ntawm cov tshuaj tau rov ua dua nrog kev txo qis ntawm 2 lossis 1.5 zaug. Rau kev txiav tawm ntxov ntawm cov tshuaj, "Prozerin" yog siv.
Side effects
UCov neeg mob tom qab siv cov tshuaj, ua pob liab liab, o, o, vau, bronchospasm, tachycardia thiab txo qis hauv siab (arterial) tuaj yeem tshwm sim. Bradycardia, hypersalivation thiab ua xua tshwm sim vim yog kev ywj pheej ntawm histamine kuj tuaj yeem tsim. Tsawg dua yog mob plawv los yog arrhythmias.
Ntau tshaj
Yog tias siv tshuaj ntau dhau, cov leeg mob ntev yuav tshwm sim. Kev kho mob nyob rau hauv rooj plaub no yog ua los ntawm kev pab txhawb lub patency ntawm lub pa ib ntsuj av tau thiab kev taw qhia ntawm neostigmine los yog pyridostigmine rau hauv lub cev.
Cov lus piav qhia yuav tsum tau ua ntawm thawj cov tsos mob ntawm kev noj tshuaj ntau dhau.
Kev sib tham nrog lwm yam tshuaj
Kev ua tau zoo ntawm "Tubocurarine chloride" tsis muaj zog los ntawm qee yam tshuaj. Cov no suav nrog:
- acetylcholine;
- potassium;
- tshuaj anticholinesterase.
txias txias thiab hypothermia tuaj yeem txo qhov kis tau.
Tshuaj loog (s nqus tau pa), calcium ntsev, quinine, qee cov tshuaj tua kab mob (streptomycin, kanamycin, neomycin) thiab lwm cov leeg nqaij tuaj yeem txhim kho cov nyhuv. Tsis tas li, kev nce ntxiv tshwm sim nrog hypokalemia.
pab pawg kws tshuaj thiab cov lus qhia tshwj xeeb
"Tubocurarine chloride" yog hais txog cov tshuaj uas ua rau lub paj hlwb peripheral. Nws ua tsuas yog nyob rau thaj tsam ntawm cov hlab ntsha thiab cov hlab ntsha. Nws yog ib qho anti-depolarizing nqaij relaxant.
Siv cov tshuaj tsuas yog ib tus kws kho mob uas muaj kev paub txog kev siv cov leeg nqaij hauv cov mobKev npaj rau kev kho cov pa oxygen thiab ua pa hauv plab.
Lub neej txee thiab xa tawm los ntawm chaw muag tshuaj
Cov tshuaj no tsis tau muag hauv txhua lub tsev muag tshuaj thiab muag nruj me ntsis raws li daim ntawv tshuaj.
Khaws thiab thauj cov tshuaj nyob rau hauv qhov chaw txias thiab tiv thaiv los ntawm tshav ntuj. Txee lub neej - 5 xyoo.
Tom qab hnub tas sij hawm lossis yog tias qhov chaw cia tsis raug, siv cov khoom raug txwv.
Analogues
Cov tshuaj hauv qab no yog siv los hloov Tubocurarine Chloride:
- Amerizol;
- "Kukarin Asta";
- "Delakukarin";
- "Myostatin";
- "Tubokurine";
- YMiricin.
Cov npe analogues muaj tib yam kev ua haujlwm. Tab sis koj tuaj yeem hloov cov tshuaj tsuas yog tom qab sab laj nrog kws kho mob.
