Nyob rau hauv tsab xov xwm, peb yuav xav txog cov xwm txheej uas Eufillin siv intramuscularly.
Qhov no yog ib qho bronchodilator. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov kev daws teeb meem thiab cov ntsiav tshuaj, tab sis nyob rau hauv dab tsi rooj plaub thiab nyob rau hauv dab tsi ntau npaum li cas siv nws yog ib lo lus nug nyuaj. Nws nyob ntawm qhov hnyav ntawm tus kab mob pathological, kev kuaj mob ntawm tus neeg mob, nws lub hnub nyoog, kev qhia thiab contraindications. Ntau tus neeg txaus siab: Puas yog nws muaj peev xwm txhaj tshuaj "Eufillin" intramuscularly lossis intravenously, lossis nws puas zoo dua los siv cov ntsiav tshuaj? Cov kws tshaj lij muaj kev xav tias los ntawm kev txhaj tshuaj intramuscular, cov tshuaj sai sai nkag mus rau hauv cov hlab ntsha thiab cov nyhuv kho tau tshwm sim hauv ob peb feeb. Qhov no qhia tau hais tias muaj xwm txheej ceev thiab muaj mob hnyav. Nyob rau hauv cov ntaub ntawv ntawm qhov nruab nrab thiab me me qhov hnyav ntawm cov kab mob, cov tshuaj yog muab los ntawm qhov ncauj.
Pharmacologicalkhoom
Cov tshuaj bronchodilator yog PDE inhibitor. Cov tshuaj nquag yog theophylline ethylenediamine ntsev (uas ua rau kom nqus tau thiab ua kom yooj yim solubility). Nws muaj cov nyhuv bronchodilatory, uas yog vim muaj kev cuam tshuam ncaj qha rau ntawm cov leeg nqaij ntawm cov hlab ntsha hauv lub ntsws thiab lub ntsws. Nws ntseeg tau tias cov nyhuv no yog tshwm sim los ntawm kev xaiv inhibition ntawm kev ua haujlwm ntawm PDEs tshwj xeeb, uas ua rau muaj kev nce hauv intracellular concentrations ntawm cAMP. Cov txiaj ntsig ntawm kev sim ntsuas hauv vitro tau pom tias isoenzymes ntawm 3rd thiab 4th hom ua lub luag haujlwm tseem ceeb. Kev cuam tshuam ntawm kev ua haujlwm ntawm cov isoenzymes no tuaj yeem ua rau qee qhov kev mob tshwm sim ntawm aminophylline (theophylline), tshwj xeeb yog ntuav, tachycardia thiab arterial hypotension. Blocks purine (adenosine) receptors, uas tej zaum yuav yog ib qho ntawm feem cuam tshuam rau bronchi.
Ntau tus neeg xav paub yog tias Eufillin tuaj yeem siv tau rau hauv lub cev. Xav paub ntau ntxiv hauv qab no.
Txo cov pa cua hyperreactivity cuam tshuam nrog lub sijhawm lig cov tshuaj tiv thaiv raug ntxias los ntawm kev nqus cov tshuaj tsis haum los ntawm cov txheej txheem ntawm kev tsis paub txog etiology uas tsis cuam tshuam nrog PDE tsuj lossis thaiv ntawm adenosine raug. Kuj tseem muaj cov ntaub ntawv hais tias aminophylline nce tus lej thiab kev ua haujlwm ntawm T-suppressors hauv cov ntshav peripheral.
Cov tshuaj ua kom cov mucociliary tshem tawm, txhim kho kev ua haujlwm ntawm cov leeg intercostal thiab ua pa, ua kom cov leeg nqaij ntawm diaphragm thiab qhov chaw ua pa, ua rau nws nce.rhiab heev rau carbon dioxide molecules thiab normalizes alveolar ventilation, uas thaum kawg ua rau ib tug txo nyob rau hauv lub zaus thiab hnyav ntawm apnea tawm tsam. Los ntawm normalizing ua pa ua haujlwm, cov tshuaj no yuav pab kom cov ntshav saturate oxygen thiab txo cov concentration ntawm carbon dioxide. Ua kom lub ntsws ua pa hauv hypokalemia.
Ntxiv rau, cov tshuaj no muaj cov txiaj ntsig zoo rau kev ua haujlwm ntawm lub plawv, ua kom lub plawv dhia ntau zaus, ua kom cov ntshav ntws hauv cov hlab ntsha thiab ua rau qhov xav tau oxygen hauv cov leeg nqaij. Nws txo cov suab nrov ntawm cov phab ntsa vascular (feem ntau ntawm daim tawv nqaij, lub hlwb thiab lub raum hlab ntsha), muaj cov nyhuv peripheral venodilating, txo cov hlab ntsha hauv lub ntsws, thiab txo cov ntshav siab hauv cov hlab ntsws. Txhim kho lub raum cov ntshav khiav, muaj cov nyhuv me me diuretic.
nthuav tawm cov kab mob biliary extrahepatic, stabilizes cov qauv ntawm mast cell membrane, slows cia tso tawm cov neeg kho kom haum xeeb uas provoke kev loj hlob ntawm kev tsis haum tshuaj thiab platelet aggregation (inhibits lub activation yam PgE2α thiab platelets), tsub kom qhov kev tiv thaiv ntawm erythrocytes rau cov kev hloov hauv cov qauv (normalizes lub rheological zog ntawm cov ntshav), txo cov kev pheej hmoo ntawm thrombosis thiab normalizes cov txheej txheem ntawm microcirculation, muaj ib tug tocolytic khoom, tsub kom lub acidity ntawm gastric kua txiv. Hauv cov koob tshuaj ntau, nws muaj cov nyhuv epilepogenic.
Cov lus qhia rau kev siv "Eufyllin" intramuscularly yoglees paub.
Pharmacokinetic zog
Aminophylline yog metabolized hauv tib neeg lub cev ntawm lub cev pH kom tso tawm dawb theophylline. Cov cuab yeej bronchodilating tau tshwm sim ntawm qhov concentration ntawm theophylline hauv cov ntshav hauv thaj tsam ntawm 10-20 μg / ml. Cov concentration ntau dua 20 mg / ml yog suav tias yog tshuaj lom. Cov nyhuv excitatory ntawm qhov chaw ua pa yog pom tau tias qis dua - 5-10 mcg / ml.
Kev khi ntawm lub ntsiab lus tseem ceeb rau plasma proteins yog kwv yees li 40%; Hauv cov menyuam yug tshiab, nrog rau cov neeg laus uas muaj qee qhov pathologies, qib ntawm kev khi raug txo. Hauv cov neeg laus, cov ntshav plasma protein khi yog kwv yees li 60%, hauv cov menyuam yug tshiab - 36%, hauv cov neeg mob ntshav siab - 36%. Cov khoom no dhau los ntawm cov placenta (theem hauv cov ntshav ntawm tus menyuam hauv plab me ntsis siab dua hauv cov ntshav ntawm leej niam) thiab mus rau hauv niam cov kua mis.
Theophylline yog metabolized hauv daim siab nrog kev koom tes ntawm qee cov cytochrome P450 isoenzymes, qhov tseem ceeb tshaj plaws yog CYP1A2. Nrog kev hloov pauv hauv metabolic, 1,3-dimethyluric acid yog tsim, nrog rau 3-methylxanthine thiab 1-methyluric acid. Cov metabolites no tau tawm los ntawm cov zis. Hauv cov neeg mob laus, kwv yees li 10% ntawm cov khoom tseem ceeb raug tshem tawm tsis hloov pauv. Hauv cov menyuam yug tshiab, ib feem tseem ceeb yog tawm hauv daim ntawv ntawm caffeine (vim qhov tsis paub qab hau ntawm txoj hauv kev ntawm nws cov metabolism hauv qab), hauv daim ntawv tsis hloov pauv - kwv yees li 50%.
Qhov sib txawv ntawm tus kheej muaj zog hauv cov kab mob siab metabolictheophylline yog suav hais tias yog lub ntsiab ua rau muaj kev hloov pauv hauv kev tshem tawm, ntshav siab, ib nrab-lub neej. Hepatic metabolism yog cuam tshuam los ntawm yam xws li kev haus luam yeeb, hnub nyoog, kev nyiam noj zaub mov, kab mob, thiab kev siv tshuaj sib xyaw ua ke.
Ib nrab-lub neej ntawm theophylline hauv cov neeg mob tsis haus luam yeeb nrog mob ntsws asthma uas yuav luag tsis muaj kev hloov pauv hauv lwm lub cev thiab lub cev yog 6-12 teev, hauv cov neeg haus luam yeeb - 4-5 teev, hauv cov menyuam yaus - 1-5 teev, nyob rau hauv lub sij hawm neonatal thiab cov me nyuam ntxov ntxov - 10-45 teev. Qhov no ncua sij hawm nce nyob rau hauv cov neeg laus thiab cov neeg uas muaj kab mob siab los yog lub plawv tsis ua hauj lwm.
Kev tshem tawm txo qis hauv kev ua txhaum ntawm daim siab ua haujlwm, lub plawv tsis ua haujlwm, pulmonary edema, haus dej cawv ntev, COPD. Ethylenediamine tsis cuam tshuam rau cov tshuaj pharmacokinetic ntawm theophylline.
Puas yog nws tuaj yeem siv "Eufillin" intramuscularly, nws yog ib qho tseem ceeb kom paub ua ntej.
Kev sib sau thiab tso tawm daim ntawv
Cov khoom xyaw tseem ceeb ntawm cov tshuaj yog aminophylline. Nws yog ua tsaug rau nws hais tias tag nrho cov pharmacological kev ua ntawm cov tshuaj yog tiav. Rau kev tswj hwm intramuscular, nws yog tsim nyob rau hauv daim ntawv ntawm ampoules. Cov tshuaj muaj pes tsawg leeg (concentration 24 mg / ml) suav nrog cov khoom tseem ceeb thiab cov khoom pabcuam - dej rau kev txhaj tshuaj. Ampoule muaj 5 lossis 10 ml ntawm cov tshuaj kho mob.
Cov lus qhia rau cov tshuaj
Tshuaj "Eufillin" intramuscularlyyog tshuaj rau cov kab mob hauv qab no:
- mob hawb pob (raws li kev kho mob ntxiv).
- Apnea in the neonatal period.
- Sab laug ventricular tsis ua haujlwm nrog bronchospasm thiab ua tsis taus pa ua haujlwm ntawm Cheyne-Stokes hom (raws li ib feem ntawm kev kho mob nyuaj).
- Edematous Syndrome ntawm lub raum xwm ntawm keeb kwm.
- kab mob Ischemic cerebrovascular (raws li ib feem ntawm txoj kev kho), mob plawv thiab mob ntev (raws li ib feem ntawm kev kho mob ua ke).
- Broncho-obstructive syndrome ntawm ntau yam etiologies (xws li COPD, bronchial hawb pob, pulmonary emphysema, chronic obstructive bronchitis), nce siab hauv pulmonary ncig, apnea, cor pulmonale.
Cov lus qhia rau kev siv
Yuav siv li cas raws li cov lus qhia "Eufillin" hauv ampoules - intramuscularly lossis intravenously?
hom kev xaiv ntawm cov tshuaj no yog tus kheej, nyob ntawm lub hnub nyoog, qhov qhia tau, qhov xwm txheej kho mob, muaj kev quav tshuaj nicotine.
Nyob rau hauv cov xwm txheej uas xav tau kev saib xyuas xwm txheej ceev, cov neeg laus tau pom tias siv "Eupyllin" intramuscularly hauv ib koob tshuaj. Yog tias tus neeg mob tau noj theophylline yav dhau los, qhov koob tshuaj ntawm aminophylline yuav tsum tau muab faib ua ib nrab.
Dab tsi ntxiv cov lus qhia rau kev siv "Eufillin" hauv ampoules intramuscularly qhia rau peb?
YContraindications
Txhaj tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv hauv qab no:
- hypersensitivity rauaminophylline thiab lwm yam xanthine derivatives;
- angina;
- myocardial infarction nyob rau theem mob;
- mob plawv tsis ua hauj lwm;
- extrasystole;
- paroxysmal tachycardia;
- pulmonary edema;
- mob ntshav siab ntshav siab / mob ntshav siab;
- vascular atherosclerosis;
- hemorrhagic stroke;
- muaj keeb kwm ntawm kev los ntshav tam sim;
- ntshav hauv cov ntaub so ntswg ntawm retina;
- peptic ulcer ntawm theem ntawm exacerbation;
- mob vwm;
- nce kev qaug dab peg;
- gastroesophageal reflux (GER);
- tsis tswj hwm hypothyroidism;
- Ythyrotoxicosis;
- porphyria;
- sepsis;
- mob siab lossis mob raum.
Txhua tus tuaj yeem txhaj "Eufillin" intramuscularly?
Vim qhov muaj feem cuam tshuam, nws tsis pom zoo kom siv cov tshuaj hauv cov menyuam yaus hnub nyoog qis dua 14 xyoos. Hauv cov menyuam yaus hnub nyoog qis dua 3 xyoos, cov tshuaj no tsuas yog siv tau thaum muaj xwm txheej ceev, tsis pub dhau 14 hnub.
kev tawm tsam tsis zoo
Raws li cov lus qhia rau kev siv, Eufillin intramuscularly tuaj yeem ua rau muaj ntau yam tsis zoo, suav nrog cov hauv qab no:
- Nervous system: nyob tsis tswm, kiv taub hau, tshee, pw tsaug zog, convulsions.
- Cov kab mob plawv: lub plawv tsis sib xws, palpitations, mob hauv plawv,tachycardia, txo cov ntshav siab, ntau yam arrhythmias, cardialgia, nce cov tsos mob ntawm angina pectoris.
- Digestive system: gastroesophageal reflux, xeev siab, kub hnyiab, ntuav, raws plab, exacerbation ntawm peptic rwj; Nrog rau kev siv ntev, anorexia tuaj yeem tshwm sim.
- Us system: hematuria, albuminuria.
- Kev ua xua tshwm sim: daim tawv nqaij ua pob khaus thiab khaus khaus, febrile syndrome.
- Metabolism: Hypoglycemia (tsis tshua muaj).
- Cov tshuaj tiv thaiv hauv zos: hyperemia, induration, mob ntawm qhov chaw txhaj tshuaj.
- Lwm cov kev mob tshwm sim: tachypnea, mob hauv siab, lub ntsej muag tawm, albuminuria, hematuria, nce diuresis, tawm hws ntau dhau.
Puas tuaj yeem "Eufillin" hauv ampoules siv intramuscularly thaum cev xeeb tub thiab lactation? Xav paub ntxiv.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj hla cov placenta, thiab yog li ntawd kev siv aminophylline thaum cev xeeb tub tuaj yeem ua rau muaj kev tsim cov qib txaus ntshai ntawm cov tshuaj nquag thiab caffeine hauv cov ntshav ntawm tus menyuam mos. Cov menyuam yaus uas nws niam tau txais aminophylline thaum cev xeeb tub yuav tsum tau saib xyuas kev kho mob ntawm qhov tshwm sim ntawm kev qaug cawv hauv thawj hnub ntawm lub neej.
Theophylline yog tawm hauv cov kua mis. Thaum siv cov tshuaj thaum lactation, kev ntxhov siab ntau dhau ntawm tus menyuam yuav tshwm sim. Hauv qhov no, kev siv cov tshuaj no thaum cev xeeb tub thiab lactationTej zaum yuav raug sau tseg tsuas yog nyob rau hauv cov xwm txheej uas qhov txiaj ntsig ntawm kev kho rau leej niam tshaj qhov muaj feem cuam tshuam rau tus menyuam.
Special Recommendations
Nrog ceev faj, Eupyllin tus neeg saib xyuas kev kho mob yog siv intramuscularly raws li cov lus qhia rau kev mob plawv tsis txaus (angina pectoris, mob theem ntawm infarction), obstructive hypertrophic cardiomyopathy, dav atherosclerosis, ceev ventricular extrasystole, siab convulsive npaj siab, siab los yog Lub raum tsis ua haujlwm, tsis ntev los no los ntshav los ntawm lub plab zom mov, nrog peptic ulcer, tswj tsis tau hypothyroidism lossis thyrotoxicosis, nrog ua npaws ntev, prostatic hypertrophy, gastroesophageal reflux, hauv cov neeg laus thiab cov menyuam yaus.
Kev hloov tshuaj Aminophylline yuav tsim nyog thaum lub plawv tsis ua haujlwm, lub siab ua haujlwm tsis zoo, ua npaws, haus dej cawv ntev ntev, SARS. Kev txo koob tshuaj yuav tsum tau rau cov neeg mob laus.
Aminophylline tsis siv ib txhij nrog lwm cov xanthine derivatives. Thaum lub sijhawm kho, kev siv cov khoom uas muaj xanthine derivatives yuav tsum raug zam. Nrog ceev faj, cov tshuaj yog siv ib txhij nrog purine derivatives thiab anticoagulants. Kev siv ua ke nrog cov piam thaj thiab beta-blockers yuav tsum zam.
Puas muaj peev xwm txhaj "Eufillin" intramuscularly, tam sim no paub.
Reviews
Kev tshuaj xyuas txog cov khoom siv tshuaj nome ntsis, txij li feem ntau nws tsuas yog siv nyob rau hauv qhov chaw nyob ruaj khov. Txawm li cas los xij, cov neeg mob taw qhia rau qee qhov xwm txheej ntawm kev sau tshuaj rau kev siv hauv tsev hauv bronchial hawb pob, tshwj xeeb yog thaum muaj tus kab mob no tshwm sim.
Kev tshuaj xyuas qhia tias cov tshuaj muaj txiaj ntsig zoo, tshem tawm cov tsos mob ntawm tus neeg mob sai sai, pab ua pa thiab tau txais kev kho mob rau obstructive bronchitis thiab qee lub plawv pathologies.
Muaj ntau cov kev mob tshwm sim los ntawm kev siv Eufillin hauv kev txhaj tshuaj intramuscular raws li cov lus qhia. Cov neeg mob uas tau txais cov tshuaj nco ntsoov tias li ntawm 15 feeb tom qab thov, lawv tau xeev siab, thiab qee zaum txawm ntuav. Kuj tseem muaj qhov qhia tias kiv taub hau hnyav, cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb.
Peb tau tshuaj xyuas cov lus qhia rau "Eufillin". Nws yog muab tshuaj intramuscularly nyob rau hauv cov ntaub ntawv loj ntawm pathologies.
