Hauv kab lus no koj yuav kawm txhua yam txog Mirapex: yuav ua li cas hloov cov tshuaj no, nws yog dab tsi, contraindications rau kev siv, kev phiv, cov lus qhia tshwj xeeb rau nws siv. Cov tshuaj no tuaj yeem ua rau tus cwj pwm txawv txav thiab cuam tshuam rau tus neeg mob qhov kev xav. Yog li ntawd, ua ntej noj Mirapeks, cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm. Peb kuj tseem yuav tham txog kev sib raug zoo ntawm cov ntsiav tshuaj no nrog rau lwm yam tshuaj.
Ntev "Mirapex": cov lus qhia dav dav txog cov tshuaj thiab cov lus qhia rau kev siv
Cov khoom xyaw nquag ntawm Mirapex yog pramipexole. Cov khoom pab ntawm cov ntsiav tshuaj: povidone, mannitol, starch, aerosil, magnesium stearate.
Cov tshuaj no yog siv los kho idiopathic (tsis yog nyob ntawm lwm yam mob) nyob tsis tswm ob txhais ceg syndrome thiab Parkinson tus kab mob, nrog rau lwm yam lub cev muaj zog thiabCov kab mob extrapyramidal.
Daim ntawv tso tawm: Mirapex PD ntsiav tshuaj 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0.375 mg. Lawv tau ntim rau hauv cov hlwv ntawm 10 daim, thiab tom qab ntawd hauv cov thawv ntawv.
Pills of white color. Lawv muaj ib tug bevelled ntug thiab ib tug ca puab ntawm ob sab, ib tug ntawm cov uas muaj ib tug tob tob.
Cov ntsiav tshuaj yuav tsum noj hauv qhov ncauj, tsis hais noj mov. Nws tso cai siv cov tshuaj txhua lub sijhawm. Nyob rau tib lub sijhawm, nws yuav tsum tau haus dej. Nws raug pom zoo kom faib cov koob tshuaj txhua hnub rau hauv peb koob.
Mechanism of action (pharmacodynamics) of Mirapex tablets
Cov tshuaj nquag pramipexole, uas muaj Mirapex, tshwj xeeb thiab nrog kev xaiv siab txhim kho cov lus teb ntawm dopamine receptors los ntawm D2 pawg. Ua tsaug rau nws, qhov tsis muaj lub cev muaj zog hauv cov ntaub ntawv ntawm tus kab mob Parkinson tau them nyiaj. Qhov no tshwm sim vim kev ua kom cov dopamine receptors nyob rau hauv lub striatum. Nyob rau tib lub sijhawm, pramipexole tiv thaiv cov degeneration ntawm lawv cov neurons, uas tshwm sim vim neurotoxicity lossis ischemia. Nws inhibits lossis txo tus nqi ntawm dopamine synthesis, metabolism, thiab tso tawm. Ua tsaug rau pramipexole, neurons raug tiv thaiv los ntawm cov tshuaj lom neeg los ntawm cov tshuaj tiv thaiv Parkinsonian Levodopa. Tsis tas li, vim nws cov teebmeem, kev tsim cov prolactin txo qis (dose-dependent).
Thaum siv cov ntsiav tshuaj Mirapex mus sij hawm ntev rau kev kho mob Parkinson tus kab mob (ntau tshaj peb xyoos) thiab tsis xis nyob ob txhais ceg (ntau tshaj ib xyoos), tsis muaj qhov txo qis hauv kev ua haujlwm ntawm pramipexole.
Cov txheej txheem biochemical tshwm sim nrog cov tshuajMirapex hauv tus neeg mob lub cev (pharmacokinetics)
Cov tshuaj nquag ntawm Mirapex yog tag nrho thiab sai sai absorbed tom qab noj qhov ncauj. Nws muaj peev xwm assimilate (bioavailability) yuav luag tag nrho - ntau dua 90%. Qhov siab tshaj plaws ntawm cov tshuaj hauv plasma yog pom tom qab 1-3 teev tom qab siv. Nrog kev noj zaub mov, tus nqi ntawm kev nqus ntawm pramipexole txo qis. Tib lub sijhawm, cov zaub mov digestible tsis hloov.
Pramipexole khi me ntsis rau cov proteins (tsawg dua 20%). Nws muaj qhov ntim loj ntawm kev faib tawm - 400 litres, uas txhais tau hais tias nws cov concentration hauv cov ntshav qis. Ntawm qhov me me, cov tshuaj tau dhau los ua cov txheej txheem metabolic. Kwv yees li 90% ntawm cov koob tshuaj Mirapex tau tawm los ntawm lub raum, thaum 80% tsis hloov pauv. Hauv cov quav, pramipexole pom muaj tsawg dua 2% ntawm cov tshuaj noj. Cov ntaub so ntswg thiab cov kua dej hauv lub cev raug tshem tawm ntawm Mirapex ntsiav tshuaj ntawm qhov nruab nrab ntawm 500 ml / min.
Siv Mirapex thaum cev xeeb tub
Cov tshuaj Mirapex puas siv tau thaum cev xeeb tub? Cov lus qhia rau kev siv cov tshuaj piav qhia tias cov nyhuv ntawm cov tshuaj rau kev loj hlob ntawm tus me nyuam hauv plab thiab nyob rau hauv lub lactation txheej txheem tsis tau kawm.
Qhov ua tau ntawm pramipexole ntawm cov kab ke thiab cov kabmob uas lub luag haujlwm rau cov txheej txheem fertilization tau kawm nyob rau hauv chav kawm ntawm kev sim ntawm cov tsiaj. Tib lub sijhawm, tsis muaj kev ua txhaum ntawm kev loj hlob ntawm fetus thaum cev xeeb tub hauv luav thiab nas.
Tsis muaj kev tso tawm ntawm pramipexole hauv cov kua mistau kawm. Nws tsuas tuaj yeem xav tias cov tshuaj tuaj yeem cuam tshuam lactation, vim nws inhibits qhov tsim ntawm luteotropic hormone. Yog li, nws tsis pom zoo kom noj Mirapex ntsiav tshuaj thaum pub niam mis.
Thaum cev xeeb tub, cov tshuaj yuav tsum tau noj tsuas yog thaum cov txiaj ntsig zoo rau tus niam uas xav tau ntau dua qhov kev pheej hmoo rau tus menyuam hauv plab.
Contraindications rau kev siv Mirapex ntsiav tshuaj
Mirapex yuav tsum tsis txhob noj yog tias muaj qhov tsis haum rau pramipexole, nrog rau cov neeg muaj hnub nyoog qis dua 18 xyoo.
Nrog kev ceev faj heev, nws raug nquahu kom siv cov ntsiav tshuaj uas muaj ntshav siab thiab lub raum tsis ua haujlwm.
Cov teebmeem ntawm Mirapex ntawm lub paj hlwb
Mirapex yog ib ntsiav tshuaj uas tuaj yeem ua rau cov kev tshwm sim hauv qab no los ntawm lub paj hlwb:
- tsis meej;
- tsaug zog ntau dhau los yog tsis muaj;
- kev xav;
- amnesia;
- asthenia;
- kiv taub hau;
- extrapyramidal syndrome;
- hypesthesia;
- tremor;
- myoclonus;
- dystonia;
- kev nyuaj siab;
- tsis muaj;
- kev xav tua tus kheej;
- hypokinesia;
- ataxia;
- xov xwm;
- Neuroleptic malignant syndrome.
Cov tom kawg tshwm sim nws tus kheej hauv daim ntawv ntawm hyperthermia, tsis nco qab thiab kev xav, cov leeg nruj, autonomic lability, akathisia.
Cov kev mob tshwm sim ntawm Mirapex ntsiav tshuaj ntawm lwm tustib neeg lub cev systems
Lub cev musculoskeletal yuav hnov mob rau kev siv Mirapex nrog cov tsos mob hauv qab no:
- muscle hypertonicity, lawv cramps, twitches;
- pom kev mob caj dab, myasthenia gravis lossis bursitis;
- mob hauv siab, caj dab, lossis txha nraub qaum (lumbosacral).
Cov kab mob digestive abnormal kuj tshwm sim. Qhov no ua rau:
- poob qab los;
- cem quav;
- nausea;
- dyspepsia;
- flatulence;
- mob plab;
- ntua;
- dry mouth;
- txoj kev xav hauv plab.
Rau cov kab mob ua pa, noj Mirapex tuaj yeem ua rau muaj kev loj hlob ntawm sinusitis, pharyngitis, rhinitis, thiab mob khaub thuas zoo li. Ua tsis taus pa luv, hnoos ntxiv, thiab lub suab hloov tau.
Cov ntsiav tshuaj Mirapex cuam tshuam li cas rau cov hlab plawv? Cov lus qhia rau kev siv tshuaj qhia txog kev txhim kho ntawm tachycardia, arrhythmia, angina pectoris, orthostatic hypotension.
Lwm yam kev mob tshwm sim
Thaum noj cov tshuaj Mirapex nyob rau hauv lub genitourinary system, muaj teeb meem xws li mob plab hnyuv thiab kab mob yuav tshwm sim. Qhov no txawm hais tias txo qis libido thiab potency.
Ntxiv rau, diplopia, cataracts, conjunctivitis, kev pab tuag tes tuag taw, ua xua, nrog rau tsis hnov lus, intraocular siab yog ua tau.
Lwm yam tsis zookab mob:
- Yretroperitoneal fibrosis;
- pleural effusion;
- ntsws infiltration;
- poob phaus;
- peripheral edema.
Txoj kev thov thiab ntau npaum li cas ntawm Mirapex ntsiav tshuaj
Koj yuav tsum siv cov tshuaj sab hauv, 3 zaug ib hnub. Thawj koob tshuaj Mirapex PD yog 0.375 mg ib hnub twg. Maj mam, qhov ntim ntawm cov tshuaj yuav tsum tau nce ntxiv (txhua 7 hnub) kom txog thaum tau txais cov txiaj ntsig kho mob. Hauv lub lim tiam thib ob ntawm kev kho mob, 0.75 mg yuav tsum tau noj txhua hnub, thib peb - 1.5 mg, thaum lub sijhawm thib plaub - 2.25 mg, hauv thib tsib koj yuav tsum haus Mirapex 3 mg txhua hnub, hauv thib rau - 3.75 mg, xya - 4.5 mg.
Nyob rau hauv lub raum tsis ua haujlwm, qhov ntau npaum li cas raug kho raws li qib ntawm creatinine tshem tawm. Tus kws kho mob yuav tsum sau tus nqi ntawm cov tshuaj.
Qhov tshwm sim ntawm kev noj tshuaj ntau dhau thaum noj Mirapex ntsiav tshuaj
Yog tias qhov tshuaj tau ua txhaum cai thaum siv Mirapex, cov tsos mob hauv qab no tej zaum yuav tshwm sim: hnov lus, hyperkinesia, ntuav, xeev siab, txo qis ntshav siab thiab ntxhov siab.
Tsis tau tsim tshuaj tua kab mob rau qhov xwm txheej no. Cov xwm txheej ntawm overdose nrog Mirapeks tsis tau sau tseg. Cov tsos mob kho, gastric lavage thiab dynamic soj ntsuam yog pom zoo. Yog tias cov tsos mob ntawm excitation ntawm lub hauv nruab nrab lub paj hlwb tshwm sim thaum lub sij hawm ib tug overdose, ces yuav tsum tau siv tshuaj antipsychotic.
Kev sib cuam tshuam ntawm Mirapex ntsiav tshuaj nroglwm yam tshuaj
Pramipexole khi rau plasma proteins rau me me thiab ua rau biotransformation. Yog li ntawd, nws txoj kev cuam tshuam nrog lwm cov tshuaj uas cuam tshuam rau cov txheej txheem no tsis zoo li.
Cov tshuaj uas txwv lossis txwv tsis pub tsim cov tshuaj cationic lossis nws tus kheej tawm los ntawm lub raum tubules tuaj yeem cuam tshuam nrog Mirapex ntsiav tshuaj. Cov lus qhia rau kev siv piav qhia tias nyob rau hauv rooj plaub no, yuav muaj qhov txo qis ntawm kev ua kom huv ntawm cov ntaub so ntswg thiab cov kua dej lom, los ntawm ob qho tib si tshuaj, lossis los ntawm ib qho ntawm lawv.
Yog tias cov tshuaj no siv ib txhij nrog Mirapex ntsiav tshuaj, ces koj yuav tsum xyuam xim rau qhov ua rau pom kev xav, dyskinesia, arousal. Yog tias muaj cov tsos mob tshwm sim, ces cov tshuaj yuav tsum raug txo kom tsawg.
Compatibility ntawm Mirapex ntsiav tshuaj nrog Amantadine thiab Levodopa
Yuav ua li cas thaum Levodopa thiab Selegiline noj ua ke nrog Mirapex PD ntsiav tshuaj? Cov lus qhia hais tias tsis yog thawj lossis thib ob cuam tshuam rau cov tshuaj pharmacokinetics ntawm cov khoom siv. Nyob rau tib lub sijhawm, Mirapex ntsiav tshuaj tsis cuam tshuam rau kev ua tiav ntawm lub cev thiab tshem tawm Levodopa hauv txoj kev ntuj.
Kev sib cuam tshuam ntawm pramipexole nrog cov tshuaj "Amantadine" tsis tau kawm. Tab sis lawv txoj kev sib raug zoo tuaj yeem ua tau hauv kev kho mob, vim tias lawv muaj cov txheej txheem tshem tawm zoo sib xws.
Thaum koob tshuaj Mirapex nce ntxiv, qhov kev siv Levodopa tau pom zootxo. Nyob rau tib lub sijhawm, tus lej ntawm lwm cov tshuaj tiv thaiv Parkinsonian yuav tsum tau khaws cia nyob rau tib theem.
Cov yam ntxwv ntawm kev sib raug zoo ntawm Mirapex nrog rau lwm yam tshuaj
Vim qhov muaj peev xwm ntawm cov teebmeem tshwm sim, nws raug nquahu kom siv Mirapex ntsiav tshuaj nrog kev ceev faj heev hauv kev sib xyaw nrog cov tshuaj sedatives, cawv thiab tshuaj uas ua rau kom cov concentration ntawm pramipexole hauv cov ntshav (piv txwv li, nrog cov tshuaj Cimetidine).
cov lus qhia tshwj xeeb rau kev siv Mirapex ntsiav tshuaj
Cov tshuaj piav qhia los ntawm peb tsis pom zoo kom noj ib txhij nrog tshuaj tiv thaiv kab mob.
Nrog kev kho dopamine agonist, paub cov kev mob tshwm sim yog kev tsis meej pem thiab kev hnov lus. Nyob rau hauv cov ntaub ntawv ntawm kev siv cov ntsiav tshuaj Mirapex ua ke nrog Levodopa, xws li deviations tau pom ntau zaus nyob rau hauv cov theem tom qab ntawm tus kab mob tshaj li nyob rau hauv thaum ntxov theem nrog monotherapy.
Tus kws kho mob yuav tsum qhia cov neeg mob txog qhov tshwm sim ntawm qhov pom kev pom. Cov kev mob tshwm sim no cuam tshuam rau lub peev xwm tsav tsheb thiab txiav txim siab lub luag haujlwm.
Tom qab kev txiav tawm sai sai ntawm cov tshuaj nyob rau hauv cov ntaub ntawv ntawm Parkinson tus kab mob, qhov pib ntawm cov tsos mob complex uas zoo li neuroleptic malignant syndrome tau tshwm sim.
Tus cwj pwm txawv txav thaum siv Mirapex
Cov neeg mob thiab lawv cov neeg saib xyuas yuav tsum paub tias noj tshuaj dopaminergic, tshwj xeeb yog cov tshuaj"Mirapex" (kev tshuaj xyuas paub meej qhov no), feem ntau ua rau tus neeg mob tus cwj pwm txawv txav. Hyperphagia (ib qho kev nyiam rau overeat), kab mob kev yuav khoom (ib lub siab xav ua ntau qhov kev yuav khoom), qhov kev nyiam tsis txaus ntseeg rau kev twv txiaj thiab kev sib deev yuav tshwm sim. Hauv cov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tsum tau txo qhov ntau npaum ntawm cov tshuaj los yog maj mam tso tseg.
Ceev faj thaum siv cov tshuaj Mirapex
tshuaj Mirapex yuav tsum tau siv nrog ceev faj los ntawm cov neeg mob uas muaj kab mob loj ntawm cov hlab plawv. Thaum ua kev kho mob nrog tshuaj dopaminergic, muaj kev pheej hmoo ntawm kev txhim kho orthostatic hypotension. Yog li ntawd, yuav tsum tswj ntshav siab, tshwj xeeb tshaj yog nyob rau theem pib ntawm kev kho mob.
Yog tias qhov tsis pom kev tsis pom kev, nws yuav tsum tau kuaj xyuas tsis tu ncua tam sim tom qab teem sijhawm ntawm Mirapex ntsiav tshuaj thiab tom qab ntawd ntawm qee lub sijhawm.
Cov neeg mob yuav tsum paub tias cov tshuaj yuav muaj cov nyhuv sedative. Cov xwm txheej ntawm kev pw tsaug zog tam sim ntawd thiab tsaug zog ntau dhau ntawm kev ua ub ua no txhua hnub tau paub. Xws li qhov no tuaj yeem tshwm sim txhua lub sijhawm thaum ua haujlwm cov txheej txheem nyuaj lossis tsav tsheb.
Muaj peev xwm tsim melanoma
Raws li kev tshawb fawb txog kev kis mob, nws tau pom tias cov neeg mob Parkinson's disease muaj kev pheej hmoo ntawm kev tsim melanoma. Puas yog nws tshwm sim los ntawm tus kab mob no lossis lwm yam, xws li kev siv tshuajMirapex, tsis tsim.
Nyob rau hauv qhov tsis xis nyob ceg syndrome
Mirapex cuam tshuam li cas rau Cov Kab Mob Tsis Txaus Siab? Cov neeg mob tawm tswv yim qhia tias cov tshuaj dopaminergic tuaj yeem txhim kho nws. Qhov no manifests nws tus kheej nyob rau hauv daim ntawv ntawm ib tug ua ntej pib ntawm cov tsos mob ntawm tus mob nyob rau hauv yav tsaus ntuj, thiab tej zaum nyob rau hauv yav tav su. Cov tsos mob kuj kis mus rau lwm cov ceg. Hauv 26 lub lis piam soj ntsuam kev sim tshuaj uas tau tsim los tshawb xyuas cov txiaj ntsig no, tsis muaj qhov sib txawv tseem ceeb ntawm cov pab pawg pramipexole thiab cov placebo ua rau cov tsos mob hnyav zuj zus.
khaws cia thiab hnub tas sijhawm
Mirapex ntsiav tshuaj yog tshuaj los ntawm daim ntawv teev npe B. Lawv yuav tsum muab khaws cia rau hauv qhov chaw tsaus. Hauv qhov no, qhov ntsuas kub hauv chav yuav tsum tsis pub tshaj 30 ° C.
Lub txee lub neej ntawm cov tshuaj yog 36 lub hlis (3 xyoos) txij li hnub tsim khoom.
Kev siv cov tshuaj Mirapex thaum yau thiab cov xwm txheej rau lawv yuav
Cov tshuaj yog contraindicated rau kev siv thaum yau. Nws raug tso cai noj tshuaj rau cov neeg uas muaj hnub nyoog 18 xyoo. Mirapex muaj nyob rau hauv cov khw muag tshuaj raws li kev nthuav qhia ntawm cov tshuaj.
Analogues ntawm Mirapex
Tsis tuaj yeem yuav Mirapex ntsiav tshuaj yog vim li cas? Yuav hloov cov tshuaj li cas, koj yuav tsum tau hais kom tus kws muag tshuaj lossis kws kho mob. Thiab peb muab cov analogues hauv qab no.
- Motopram ntsiav tshuaj. Cov lus qhia rau kev siv: Parkinson's disease. Nws tuaj yeem siv ua monotherapy lossis ua ke nrog tshuaj"Levodopa". Kuj tseem siv tau rau qhov mob hnyav idiopathic lossis nruab nrab nyob tsis tswm ceg.
- Oprimea ntsiav tshuaj. Lub hom phiaj: antiparkinsonian tshuaj-stimulant ntawm dopaminergic kis mus rau hauv nruab nrab paj hlwb.
- Pramipexole ntsiav tshuaj. Tus neeg sawv cev kho mob yog siv rau hauv tus kab mob Parkinson. Nws feem ntau lees paub tias lub tshuab ntawm nws qhov kev ua tau ncaj qha ntsig txog lub peev xwm ntawm cov tshuaj pramipexole los txhawb cov dopamine receptors hauv striatum.
ntsiav tshuaj "Mirapex" - analogues lossis thawj? Tsis kho tus kheej
Daim ntawv teev npe saum toj no teev cov tshuaj uas yog analogues ntawm Mirapex ntsiav tshuaj. Lawv muaj tib lub npe tshwj xeeb, tsis muaj npe thoob ntiaj teb (lossis ATC code) raws li pom zoo los ntawm WHO (World He alth Organization).
Yog tias koj xav tau kev kho mob nrog Mirapex ntsiav tshuaj, analogues kuj tseem yog lwm txoj hauv kev zoo. Tab sis ua ntej hloov txoj kev kho mob, nco ntsoov sab laj nrog tus kws kho mob tshwj xeeb. Nyob rau hauv tsis muaj xwm txheej nws tus kheej tshuaj! Qhov no tuaj yeem ua rau muaj kev cuam tshuam tsis zoo rau koj txoj kev noj qab haus huv.
Nco ntsoov! Kab lus no piav qhia txog kev npaj Mirapeks yog ib qho kev nthuav dav thiab yooj yim ntawm cov lus qhia rau kev siv. Cov ntaub ntawv hais txog cov tshuaj yog nthuav tawm rau lub hom phiaj ntawm kev paub. Tsis txhob nyob rau hauv ib qho xwm txheej siv nws los ua ib qho kev qhia rau tus kheej noj tshuaj.
