Ketonal Duo yog cov tshuaj uas tsis yog tshuaj steroidal los tiv thaiv kab mob uas yog siv rau kev kho mob ntawm cov leeg thiab pob qij txha. Xav txog cov lus qhia rau kev siv cov tshuaj no, nrhiav seb nws muaj pes tsawg leeg thiab analogues.
Cov tshuaj
Ib ntsiav tshuaj muaj 50 milligrams ntawm cov tshuaj nquag, uas yog ketoprofen. Cov excipients yog lactose nrog rau magnesium stearate thiab silicon dioxide. Cov tshuaj muaj pes tsawg leeg ntawm cov tshuaj capsule plhaub yog ua los ntawm gelatin, titanium dioxide thiab xiav proprietary dye.
Kev qhia rau Ketonal Duo qhia peb li cas?
Pharmacological teebmeem
Cov tshuaj no yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj muab los ntawm propionic acid. Nws tuaj yeem muaj qhov ua kom tsis haum, thiab tib lub sijhawm, muaj kev tiv thaiv kab mob thiab tshuaj tua kab mob. "Ketonal Duo" tuaj yeem thaiv qhov kev ua ntawm "COX-1" enzymes, thiab ntxiv rau, "COX-2", thiab qee qhov cuam tshuam rau lipoxygenase, uas ua rau muaj kev cuam tshuam ntawm cov txheej txheem ntawm prostaglandin synthesis.
Cov tshuaj no yuavstabilizes lysosomal daim nyias nyias, thiab nyob rau hauv lub siab tshaj plaws concentration, ketoprofen ua rau inhibition ntawm synthesis ntawm leukotrienes thiab bradykinin. Cov khoom xyaw nquag, ketoprofen, tsis muaj qhov tsis zoo rau lub xeev ntawm pob txha mos.
Tshuaj pharmacokinetics
"Ketonal Duo" yog daim ntawv ntau npaum uas txawv ntawm cov tshuaj ntsiav uas twb paub lawm hauv txoj kev uas cov khoom tseem ceeb raug tso tawm. Hloov kho cov tshuaj ntsiav muaj ob txoj kev xaiv pellet: dawb thiab daj. Cov tshuaj nquag (ketoprofen) tuaj yeem tso tawm sai heev los ntawm cov pellets dawb, thiab los ntawm cov xim daj, ntawm qhov tsis sib xws, maj mam. Qhov no ua rau muaj kev sib xyaw ua ke ntawm qhov kis tau sai thiab ntev.
Raws li lub zog ntawm nws cov nyhuv, "Ketonal Duo" tsis yog qis dua rau kev txhaj tshuaj.
Cov tshuaj uas tau nthuav tawm tau zoo nqus sai sai tom qab noj. Lub bioavailability ntawm ketoprofen nyob rau hauv daim ntawv ntawm tus qauv capsules thiab cov kev hloov kho tso tawm yog 90%.
Kev noj zaub mov tsis cuam tshuam rau bioavailability ntawm Ketoprofen, tab sis txo tus nqi ntawm kev nqus. Tom qab noj cov tshuaj nquag ntawm koob tshuaj 150 milligrams hauv daim ntawv hloov kho-tso tshuaj ntsiav, qhov siab tshaj plaws yog 9036 nanograms ib milligram hauv ib thiab ib nrab teev. Qhov no tau lees paub los ntawm cov lus qhia rau Ketonal Duo.
Tshuaj faib thiab metabolism
Kev khi ntawm ketoprofen rau cov ntshav plasma protein (xws li albumin) yog kwv yees li 99%. Ketoprofen yooj yim nkag mus rau hauv cov kua dej synovial, qhov twg nws nce mus txog 30% plasma concentration. Cov ntsiab lus tseem ceeb ntawm cov tshuaj nquag hauv cov kua dej synovial yog qhov ruaj khov thiab kav ntev txog 30 teev, vim tias qhov tshwm sim ntawm qhov mob thiab tawv nqaij hauv cov pob qij txha txo qis rau lub sijhawm ntev.
Ketoprofen tuaj yeem cuam tshuam ntau heev los ntawm daim siab microsomal enzyme uas tuaj yeem khi rau glucuronic acid thiab tom qab ntawd tawm mus ua glucuronide. Tsis muaj cov metabolites nquag ntawm ketoprofen.
Kwv yees li 80% ntawm cov khoom xyaw nquag tau tawm hauv cov zis, feem ntau hauv daim ntawv ntawm ketoprofen glucuronide. 10% tawm hauv lub cev los ntawm txoj hnyuv. Tawm tsam keeb kwm yav dhau los ntawm kev siv ketoprofen ntawm koob tshuaj 100 milligrams lossis ntau dua, kev tso tawm los ntawm ob lub raum yuav nyuaj.
Puas Ketonal Duo pab mob hniav? Peb yuav tham txog qhov no hauv qhov kawg ntawm tsab xov xwm.
Lwm yam khoom qhia
Nyob rau hauv cov neeg mob uas muaj mob raum tsis txaus, feem ntau ntawm cov tshuaj yuav raug tso tawm los ntawm txoj hnyuv. Tawm tsam keeb kwm yav dhau los ntawm kev noj ntau npaum li cas, lub siab tshem tawm kuj nce ntxiv. Los ntawm txoj hnyuv, txog li 40% ntawm cov tshuaj raug tso tawm.
Nyob rau hauv cov neeg mob uas raug kev txom nyem los ntawm daim siab tsis ua hauj lwm, lub plasma concentration ntawm lub ntsiab tivthaiv yog nce los ntawm ob lub sij hawm, uas yog feem ntau yog vim hypoalbuminemia, thiab kuj yog vim cov qib ntawm unbound ketoprofen. Cov neeg mob zoo li no raug pom zoosau cov tshuaj no nyob rau hauv qhov tsawg kawg nkaus koob tshuaj.
Hauv cov neeg mob uas mob raum tsis ua haujlwm, kev tshem tawm ntawm ketoprofen txo qis. Txawm li cas los xij, kev hloov koob tshuaj tsuas yog yuav tsum tau nyob rau hauv cov xwm txheej tsis txaus txaus. Hauv cov neeg laus, cov metabolism hauv kev tshem tawm ketoprofen qeeb qeeb, uas yog qhov tseem ceeb ntawm kev kho mob tsuas yog rau cov neeg mob uas muaj lub raum tsis txaus.
"Ketonal Duo": cov lus qhia rau kev siv
Cov kws kho mob qhia tshuaj feem ntau tau sau npe ua ib feem ntawm cov tsos mob ntawm kev kho mob, thiab ntxiv rau, cov txheej txheem inflammatory ntawm ntau lub hauv paus chiv keeb. Yog li, "Ketonal Duo" yog qhov tsim nyog siv rau hauv cov kab mob inflammatory thiab degenerative ntawm cov musculoskeletal thiab lub cev muaj zog:
- Yog koj muaj mob caj dab rheumatoid.
- Nrog cov tsos mob ntawm tus mob seronegative mob caj dab, uas yog, nrog ankylosing spondylitis, Bechterew tus kab mob, psoriatic lossis reactive mob caj dab thiab Reiter's syndrome.
- Rau gout thiab pseudogout.
- Nrog kev txhim kho ntawm osteoarthritis.
Tsis tas li ntawd, Ketonal Duo capsules kuj raug sau ua ib feem ntawm kev kho mob, nrog cov tsos mob xws li:
- Zoo taub hau.
- Kev muaj tendonitis, bursitis, myalgia, neuralgia, sciatica.
- Kev txhim kho ntawm kev mob ntshav qab zib thiab mob tom qab phais mob.
- Qhov tsos mob ntawm cov kab mob oncological.
- Presence of algomenorrhea.
Yuav siv sijhawm pes tsawg hnub"Ketonal Duo"? Kev kho mob yog txiav txim los ntawm tus kws kho mob.
Cov tshuaj no yog siv kom tau txais txiaj ntsig. Mob mob, thiab cov tshuaj nres. Yog tias qhov mob tsis tu ncua thiab cov tshuaj tau noj ntau tshaj li ib hlis, yuav tsum tau kuaj ntshav (general thiab biochemistry), urinalysis, thiab ntau qhov kev kuaj mob, xws li ultrasound ntawm lub plab thiab ob lub raum, yuav tsum tau noj.
Contraindications rau kev siv
Cov tshuaj tau nthuav tawm muaj ntau cov npe ntawm ntau yam contraindications:
- Kev muaj qhov tsis txaus siab rau lub ntsiab lus tseem ceeb - ketoprofen, lossis lwm yam tshuaj ntawm cov tshuaj. Tsis tas li ntawd, cov khoom siv tshuaj no yuav tsum tsis txhob siv yog tias muaj kev cuam tshuam rau cov tshuaj xws li salicylates thiab thiaprofenic acid.
- Qhov muaj qhov ua tiav lossis tsis tiav ua ke ntawm bronchial hawb pob nrog polyposis ntawm lub qhov ntswg thiab paranasal sinuses, nrog rau kev tsis haum rau acetylsalicylic acid thiab lwm yam tshuaj uas tsis yog tshuaj steroidal anti-inflammatory.
- Kev muaj erosive thiab ulcerative lesions ntawm lub plab zom mov, uas yog nyob rau theem ntawm lawv exacerbation.
- Cov tsos mob ntawm tus kab mob ulcerative thiab Crohn tus kab mob.
- Kev muaj hemophilia thiab lwm yam los ntshav.
- Kev mob siab rau lub siab tsis ua haujlwm.
- Kev txhim kho daim siab mob siab.
- Kev txhim kho lub raum tsis ua haujlwm hnyav.
- Kev mob raum mob raum.
- Kev txhim kho ntawm lub plawv tsis ua haujlwm.
- Cov tshuaj no yuav tsum tsis txhob noj thaum lub sijhawm ua haujlwm tom qabcoronary hlab ntsha bypass grafting.
- Qhov tsos ntawm plab hnyuv, cerebrovascular thiab lwm yam los ntshav. Thiab kuj rau qhov xav tias yuav los ntshav.
- Presence of diverticulitis.
- Kev tshwm sim ntawm kab mob plab hnyuv.
- Kev pom muaj tseeb ntawm hyperkalemia.
- Kev txhim kho ntawm kev mob ntev ntev.
- Cov menyuam yaus hnub nyoog qis dua 15 xyoos, thiab ntxiv rau, hauv peb lub hlis thib peb ntawm cev xeeb tub vim muaj kev phom sij rau tus menyuam hauv plab.
- Thaum pub niam mis.
- Tus neeg mob lactose intolerance nrog rau lactase deficiency thiab qabzib-galactose malabsorption syndrome.
Thaum twg yuav tsum tau siv tshuaj nrog ceev faj?
Nrog ceev faj, txhaj tshuaj Ketonal Duo thiab tshuaj ntsiav tau muab tshuaj rau hauv cov xwm txheej hauv qab no:
- peptic ulcer keeb kwm.
- Asthma.
- Clinically nthuav qhia cerebrovascular pathologies, nrog rau vascular thiab kab mob plawv.
- kab mob peripheral arterial nrog rau dyslipidemia thiab kab mob siab heev.
- daim siab tsis ua haujlwm, hyperbilirubinemia thiab cawv cirrhosis.
- Lub raum thiab lub plawv tsis ua haujlwm ntev nrog rau cov hlab ntshav siab.
- kab mob ntshav, lub cev qhuav dej thiab ntshav qab zib.
- Cov kab mob ntawm lub plab zom mov ua ke nrog kev muaj tus kab mob Helicobacter pylori.
- Cov kab mob hnyav heev nrog rau kev haus luam yeeb.
- Kev siv tshuaj tiv thaiv kab mob sib kis, piv txwv li,"Warfarin".
- Kho nrog cov tshuaj tiv thaiv kab mob, xws li acetylsalicylic acid.
- Siv qhov ncauj glucocorticosteroids, xws li Prednisolone.
- Kev siv sib xyaw ua ke ntawm kev xaiv inhibitors, piv txwv li, Sertraline, Citalopram.
Dab tsi pab Ketonal Duo, tam sim no peb paub.
tshuaj tshuaj
Cov tshuaj no yuav tsum tau noj los ntawm qhov ncauj. Tus qauv koob tshuaj rau cov neeg laus thiab menyuam yaus hnub nyoog qis dua 15 xyoos yog 150 milligrams. Cov tshuaj nquag no muaj ib lub tshuaj ntsiav.
Capsules tuaj yeem noj thaum lub sijhawm lossis tom qab noj mov. Ntxuav cov tshuaj nrog dej, koj tuaj yeem siv mis nyuj. Hauv qhov no, tag nrho cov kua yuav tsum yog tsawg kawg yog 100 milliliters. Qhov siab tshaj plaws txhua hnub koob tshuaj ntawm ketoprofen yog 200 milligrams.
Side effects
Cov tshuaj no yuav ua rau muaj kev phiv. Yog li, cov ntshav thiab lymphatic system nyob rau hauv tsawg zaus teb nrog hemorrhagic anemia, purpura, agranulocytosis, thrombocytopenia thiab mob pob txha hematopoiesis. Lub cev tiv thaiv kab mob yuav hnov mob nrog cov tshuaj tiv thaiv anaphylactic.
Kev ua haujlwm ntawm lub paj hlwb tawm tsam keeb kwm yav dhau los ntawm kev siv "Ketonal Duo" tuaj yeem nrog mob taub hau, kiv taub hau, tsaug zog, paresthesia, convulsions, tsis hnov tsw saj thiab lub siab lub ntsws lability. Cov kev hnov mob nrog qhov muag tsis pom kev thiab tinnitus.
Cov neeg mob kuj tseem muaj lub plawv tsis ua haujlwmnrog rau kev nce siab thiab vasodilation. Cov kab mob ua pa reacts nrog exacerbation ntawm bronchial hawb pob, qhov tsos ntawm bronchospasm thiab rhinitis. Nws yuav tsum tau hais tias bronchospasms feem ntau pom nyob rau hauv cov neeg mob uas muaj hypersensitivity rau non-steroidal anti-inflammatory tshuaj.
Lub plab zom mov yuav ua rau xeev siab, ntuav, dyspepsia, mob plab, cem quav, raws plab, tsam plab, gastritis, peptic ulcers, thiab stomatitis nrog cov tshuaj no. Tsis tshua muaj, exacerbation ntawm colitis nrog Crohn tus kab mob, plab hnyuv los ntshav thiab perforation yog pom. Lub siab thiab biliary kab mob tshwm sim nrog kab mob siab, nce qib ntawm transaminases, thiab ntxiv rau, bilirubin.
pob khaus thiab khaus tuaj yeem tshwm rau ntawm daim tawv nqaij. Photosensitivity kuj yuav tshwm sim nrog rau alopecia, urticaria, angioedema, erythema, bullous pob, thiab tshuaj lom epidermal necrolysis.
Cov kab mob tso zis tuaj yeem teb nrog lub raum tsis ua haujlwm, cuam tshuam rau nephritis, nephritic syndrome, thiab lub raum tsis ua haujlwm.
Lwm cov kev mob tshwm sim muaj xws li edema nrog nce qaug zog, hnyav nce hauv cov neeg mob, thiab lwm yam.
Ntau tshaj
Cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm cov tshuaj tua kab mob Ketonal Duo, zoo li lwm yam mob uas muaj ntau tshaj ntawm ketoprofen, tuaj yeem raug cim los ntawm qhov tsos ntawm xeev siab, ntuav, mob plab, melena, tsis nco qab, ua pa nyuaj siab, convulsions thiablub raum tsis ua haujlwm.
Thaum noj tshuaj ntau dhau, plab hnyuv thiab qhov xav tau ntawm cov hluav taws xob hluav taws xob yuav tsum tau noj. Nws raug nquahu kom ua cov tsos mob. Cov nyhuv ntawm ketoprofen ntawm lub plab zom mov tsis muaj zog los ntawm kev txo qis hauv cov qog ua kua, piv txwv li, proton twj tso kua mis inhibitors thiab prostaglandins. Hauv cov neeg mob lub raum tsis ua haujlwm, hemodialysis raug pom zoo.
Kev Sib Tham Tshuaj
Ketoprofen ntsiav tshuaj - "Ketonal Duo", tuaj yeem ua rau tsis muaj zog ntawm cov tshuaj diuretics thiab tshuaj tiv thaiv ntshav siab. Tsis tas li ntawd, nws txhim kho kev ua haujlwm ntawm qhov ncauj tshuaj ntawm hypoglycemic thiab anticonvulsant hom. Kev siv nrog lwm cov tshuaj uas tsis yog-steroidal anti-inflammatory, salicylates, thiab ntxiv nrog ethanol tuaj yeem ua rau muaj kev pheej hmoo ntawm kev tsis zoo ntawm lub plab zom mov.
Kev siv ib txhij nrog cov pab pawg tshuaj xws li tshuaj tiv thaiv coagulants, thrombolytics thiab cov tshuaj tiv thaiv kab mob ua rau muaj kev pheej hmoo los ntshav. Kev siv tib lub sijhawm nrog cov poov tshuaj, potassium-sparing diuretic, qis molecular hnyav heparin thiab cyclosporins tuaj yeem ua rau muaj kev pheej hmoo ntawm hyperkalemia.
Cov tshuaj tau nthuav tawm ua rau kom muaj zog ntawm lub plawv glycosides hauv plasma. Nws kuj tseem pab txhawb kom qeeb calcium channel blockers, cyclosporins thiab methotrexates. Tawm tsam nws keeb kwm yav dhau, toxicity ntawm methotrexates thiab nephrotoxicity ntawm cyclosporins nce. Kev siv tib lub sijhawm ntawm cov tshuaj "Ketonal Duo" nrog cov tshuaj probenecides txo qis kev tshem tawm. Ketoprofen hauv cov ntshav.
cov lus qhia tshwj xeeb rau kev siv tshuaj
Tawm tsam keeb kwm yav dhau los ntawm kev siv cov tshuaj uas tsis yog-steroidal anti-inflammatory mus ntev, nws yog ib qho tsim nyog los saib xyuas lub xeev ntawm cov ntshav, nrog rau kev ua haujlwm ntawm lub raum thiab lub siab, tshwj xeeb tshaj yog cov neeg laus (dhau) 65 xyoo).
Ntxiv rau, yuav tsum tau saib xyuas thiab tswj ntshav siab thaum siv ketoprofen hauv kev kho cov neeg mob ntshav siab thiab kab mob plawv thiab vascular. Cov kab mob no tuaj yeem ua rau cov kua dej khaws cia hauv lub cev. Zoo li lwm cov tshuaj uas tsis yog-steroidal anti-inflammatory, ketoprofen tuaj yeem npog cov tsos mob ntawm cov kab mob sib kis.
Ketonal Duo kav ntev npaum li cas? Cov tshuaj relieves mob li 5-6 teev. Kev siv cov tshuaj nyob rau hauv cov koob tshuaj pom zoo tsis cuam tshuam rau lub peev xwm tsav tsheb. Tab sis, txawm li cas los xij, cov neeg mob uas pom tias tsis yog tus qauv tshwm sim thaum noj Ketonal Duo tau qhia kom ceev faj thaum koom nrog kev ua phem. Qhov no siv tau rau cov uas xav tau kev saib xyuas thiab ceev ntawm cov tshuaj tiv thaiv psychomotor.
Ketonal Duo thiab cawv
Kev siv cawv thiab tshuaj no tuaj yeem ua rau muaj kev kho mob hnyav, ua rau muaj kev pheej hmoo los ntshav. Kuj tseem muaj feem pua ntawm kev lom thiab lub siab puas tsuaj.
Siv thaum cev xeeb tub
Cov txheej txheem ntawm inhibition ntawm prostaglandin synthesis tuaj yeem muajundesirable cuam tshuam rau lub sij hawm ntawm cev xeeb tub, nrog rau kev loj hlob ntawm embryonic. Cov ntaub ntawv los ntawm kev tshawb fawb txog kev sib kis nrog kev siv cov synthesis inhibitors nyob rau theem pib pom tseeb tias muaj kev pheej hmoo ntawm kev rho menyuam tawm thiab kev loj hlob ntawm cov kab mob plawv.
Kev muab cov tshuaj no rau cov poj niam cev xeeb tub thaum thawj ob peb lub hlis twg tsuas yog tso cai rau cov xwm txheej uas cov txiaj ntsig zoo rau tus poj niam txoj kev noj qab haus huv ua pov thawj tias yuav muaj kev pheej hmoo rau tus menyuam hauv plab.
Ketoprofen yog contraindicated kiag li rau cov poj niam cev xeeb tub nyob rau hauv lub thib peb lub hlis twg ntawm lub peb hlis ntuj, vim hais tias muaj peev xwm ntawm tsim tsis muaj zog nyob rau hauv lub tsev menyuam thaum yug me nyuam. Nws tseem tuaj yeem ua rau lub sijhawm kaw ntawm lub ductus arteriosus, lub sijhawm los ntshav ntau ntxiv, oligohydramnios, thiab lub raum tsis ua haujlwm.
Tam sim no, tsis muaj ntaub ntawv qhia txog kev faib cov ketoprofen nrog mis nyuj. Yog li, yog tias xav tau kev noj tshuaj ketoprofen los ntawm tus poj niam laus, nws yuav tsum tsis txhob pub niam mis.
Dab tsi yog qhov analogues ntawm cov tshuaj "Ketonal Duo"? Cia peb xav txog qhov nthuav dav yuav hloov pauv li cas.
Analogues ntawm cov tshuaj
Ntawm cov npe nrov tshaj plaws ntawm cov tshuaj "Ketonal Duo" tuaj yeem hu ua cov tshuaj xws li "Fastum Gel" nrog rau "Ketonal", "Bystrumgel", "Artrosilene", "Flexen", "Flamax forte. "," Arketal thiab Artrum.
Reviews about tshuaj
Cov kws kho mob hu rau qhov kev kho mob uas nthuav tawm uas tsis yog-steroidal anti-inflammatory tshuaj uas ua ke nrog kev kub ceev ntawm kev ua tiav cov nyhuv nrog lub sijhawm ntev ntawm kev ua. Nyob tom qabCov kab mob loj heev, cov nyhuv ntawm cov tshuaj no, raws li kev soj ntsuam ntawm cov kws kho mob tshwj xeeb, tuaj yeem kav ntev txog 20 teev.
Raws li qhov mob me me, tawm tsam lawv keeb kwm yav dhau, tag nrho lub sijhawm ntawm cov nyhuv yog sib npaug rau qhov tshaj tawm 24 teev. Zoo li lwm yam tshuaj nrog ketoprofen, cov nyhuv analgesic ntawm cov tshuaj predominates me ntsis dhau cov nyhuv anti-inflammatory.
Ncaj nraim, cov neeg mob sau rau hauv lawv cov kev tshuaj xyuas ntawm Ketonal Duo tias nws yog ib qho tshuaj zoo heev uas txo qhov mob nrog o. Nws feem ntau yog muab rau tib neeg rau cov tsos mob ntawm lub raum colic, mob cystitis, prostatitis thiab urethritis, uas yog ua raws li ib feem ntawm txoj kev kho.
Ntawm cov minuses, cov neeg mob hauv kev tshuaj xyuas ntawm "Ketonal Duo" nco ntsoov cov tshuaj muaj zog heev ntawm kev zom zaub mov. Tsis tas li ntawd, nws tsis haum rau cov neeg mob uas muaj kab mob peptic ulcer thiab feem ntau muaj ntau yam contraindications. Tsis tas li ntawd, cov neeg mob yws yws ntawm cov tsos mob dyspeptic. Cov neeg siv khoom kuj tsis txaus siab rau tus nqi siab ntawm cov tshuaj, uas pib ntawm 400 rubles ib pob.
Txawm li cas los xij, cov tshuaj nthuav tawm yog qhov nrov heev thiab nquag yuav tshuaj. Tib neeg nco ntsoov nws cov nyhuv analgesic muaj zog, thiab tseem hais tias nws ua haujlwm maj mam thiab sai, twb 10 feeb tom qab noj nws, relieves, piv txwv li, mob hniav. Cov neeg mob kuj txaus siab rau nws qhov yooj yim npaum li cas.
