Nrog rau lwm yam pathologies, purine metabolism tsis zoo kuj tseem suav tias yog kab mob hnyav, kev kho mob uas yuav tsum tau saib xyuas. Ua ntej ntawm tag nrho cov, cov no yog malfunctions nyob rau hauv lub metabolism ntawm pab tau cov khoom uas provoke tshwm sim ntawm lwm yam kab mob, xws li gout, nephropathy los yog raum tsis ua hauj lwm.
Raws li txoj cai, muaj kev ua txhaum ntawm purine metabolism hauv cov menyuam yaus, tab sis cov neeg laus kuj raug rau cov kab mob no. Tsuas yog feem ntau cov neeg mob hauv cov neeg laus ntsib ntau yam mob thiab muaj teeb meem.
cov ntaub ntawv dav dav
Kev ua txhaum ntawm purine metabolism raws li ICD-10 muaj tus lej E79. Feem ntau tus kab mob no yog mob ntev thiab ncaj qha cuam tshuam rau kev tso cov kua qaub ntsev hauv cov ntaub so ntswg ntawm lub raum thiab cov pob qij txha. Cov tsos mob ntawm cov teeb meem ntawm cov metabolism hauv purine yog qhov tshwj xeeb thiab tshwm sim raws li kev rov ua dua ntawm kev mob caj dab, nrog rau qhov mob.
Ib qho teeb meem uas tsis tau kuaj pom thiab kho tsis tau tuaj yeem ua rau mob hnyav duaqhov tshwm sim: piv txwv li, qhov pib ntawm urolithiasis thiab lub raum tsis ua haujlwm. Txhua yam kev kho mob hauv qhov xwm txheej no feem ntau yog tsom rau kev txwv tsis pub cov tsos mob tsis zoo, txo qhov hnyav ntawm daim duab kho mob, tiv thaiv kev txhim kho ntawm cov teeb meem thiab normalizing cov metabolism ntawm cov khoom siv tau zoo.
ua rau ntawm pathology
Qhov yuav tsum tau ua ua ntej rau kev loj hlob ntawm tus kab mob yog kev tsim cov purine ntau dhau los yog lawv cov uric acid qeeb dhau lawm.
Lub hom phiaj tseem ceeb ntawm pathology tau piav qhia los ntawm kev hloov pauv hloov pauv. Tab sis hom kab mob thib ob tuaj yeem cuam tshuam nrog kev noj cov tshuaj diuretics, tshuaj tiv thaiv kab mob thiab lwm yam tshuaj.
Purine metabolism tsis txaus ua rau:
- xab;
- mob hnyav hypothermia;
- qee kws tshuaj;
- khoom muaj kev kawm cuam tshuam;
- pathologies ntawm qhov kis kab mob;
- psycho-emotional and physical overstrain.
Symptoms
Cov tsos mob ntawm cov teeb meem ntawm purine metabolism zoo ib yam li cov tsos mob ntawm metabolic tsis ua haujlwm. Pathology yog tus cwj pwm los ntawm kev nce qib ntawm creatinine kinase, uas tshwm sim hauv yuav luag txhua tus neeg mob. Lwm cov cim qhia tsis meej ntawm tus kab mob tuaj yeem kuaj pom los ntawm kev kuaj electromyographic.
Nyob rau hauv cov neeg mob uas muaj teeb meem ntawm purine metabolism, muaj ib tug tsis tshua muaj ntau lawm ntawm ammonia, vim hais tias nws yog ho.efficiency txo thiab qab los noj mov yuav luag tag. Cov neeg mob xav tias tag nrho malaise, lethargy, kev nyuaj siab. Qee qhov xwm txheej, kev hais lus tsis muaj zog tshwm sim.
Cov menyuam yaus uas muaj kev cuam tshuam ntawm cov metabolism hauv purine rau lub sijhawm ntev feem ntau nyob rau hauv lub hlwb tsis muaj kev tsim kho thiab muaj kev xav ntau ntxiv rau kev puas hlwb. Muaj tsawg zaus, cov neeg mob me thiab cov neeg laus muaj kev qaug dab peg zoo li qaug dab peg, nrog rau convulsions. Ntawm lwm yam, kev txhim kho psychomotor ntawm tus neeg mob qeeb lossis nres tag nrho.
Ntse
Qhov kev cuam tshuam loj tshaj plaws ntawm cov metabolism hauv purine suav nrog kev tsim ntau dhau thiab ntxiv cov uric acid ntxiv, uas tau pom hauv gout thiab Lesch-Nyhan syndrome. Cov tom kawg yog nyob rau hauv keeb kwm tsis muaj qee yam enzyme, uas ua rau tsis siv cov purines rov tso tawm. Yog li ntawd, lawv tau oxidized, hloov mus rau hauv uric acid.
Diagnosis
Kev txheeb xyuas tus kab mob yog qhov nyuaj heev thiab tsis tas yuav muab qhov tseeb, txij li cov kab mob no muaj ntau yam zoo ib yam li lwm yam kab mob hauv homeostasis. Txawm li cas los xij, nrog rau kev soj ntsuam mus sij hawm ntev ntawm tus neeg mob tus mob thiab nws cov kev soj ntsuam hauv cov ntsiab lus dav dav, nws muaj peev xwm txheeb xyuas qhov ua tsis tiav hauv purine metabolism thiab cov laj thawj rau nws tshwm sim.
Kev kuaj mob tuaj yeem ua tau raws li qhov ua tiav ntawm lub raum tsis ua haujlwm.enzymes, active tshuaj ntawm daim siab thiab skeletal leeg. Nrog kev pab los ntawm kev kuaj sim, ib feem tsis txaus tuaj yeem kuaj pom hauv lymphocytes thiab fibroblasts.
Kev kho tshwj xeeb uas yuav tsom rau kev tshem tawm cov enzyme tsis ua haujlwm tseem tsis tau tsim, yog li koj tuaj yeem cia siab rau txoj kev kho mob nkaus xwb.
Kev kho mob
Purine metabolism tsis txaus yuav tsum tau kev kho mob nyuaj, uas yog raws li kev noj zaub mov nruj, suav nrog cov khoom noj uas tsis muaj uric acid, thiab kev kho tshuaj.
Txoj kev tshuaj tshuaj muaj xws li ob peb kauj ruam:
- sib npaug thiab normalization ntawm cov txheej txheem metabolic nrog kev pab ntawm kev tiv thaiv;
- tsim kom muaj metabolic acidosis thiab tswj cov acidic ib puag ncig hauv cov zis;
- txhim kho thiab txuas ntxiv kev saib xyuas ntawm qib ib txwm muaj ntawm cov ntshavlipidemia;
- tswj thiab normalization ntawm tus neeg mob ntshav siab thaum nruab hnub;
- kho mob ntawm qhov tshwm sim ntawm pathology.
Kev kho mob ntawm qhov tshwm sim
Gout yog ib qho teeb meem ntawm purine metabolism uas tsis tau kuaj pom thiab kho raws sijhawm. Cov kab mob no muaj kev sib raug zoo heev. Yog li ntawd, cov tsos mob thiab kev kho mob ntawm gout tsis txawv ntau ntawm cov neeg uas muaj metabolic tsis ua haujlwm. Feem ntau, kev kho mob ntawm cov kab mob no los ntawm kev kho cov purine metabolism. Rau qhov no, tus neeg mob tau pom zoo:
- txwv kev ua si lub cev thaum lub ntsej muag;
- ua raws li kev noj haus;
- kev haus dej haus cawv, suav nrog2 litres dej txhua hnub;
- siv cov compresses hauv zos siv "Dimexide";
- siv cov koob tshuaj NSAIDs.
Kev kho mob ntawm cov kab mob purine metabolism tuaj yeem ua tau ob qho tib si nyob rau hauv qhov chaw nyob thiab hauv tsev. Txawm li cas los xij, qhov kev xaiv tom kawg tsuas yog siv tau tom qab kev sab laj nrog tus kws tshaj lij thiab lees paub qhov kev kuaj mob.
Drug therapy
Kev kho mob yooj yim yog ua raws li kev siv cov tshuaj mus sij hawm ntev uas normalize cov uric acid hauv cov ntshav. Koj tuaj yeem siv tshuaj tsuas yog thaum lub sijhawm tshem tawm. Raws li qhov tshwm sim, muaj ntau ntau yam tshuaj pom zoo:
- tshuaj uas txo qis kev tsim cov uric acid, xws li Allopurinol;
- tshuaj muaj etebenecid - nce tus nqi ntawm kev tso tawm ntawm uric acid los ntawm lub cev;
- mixed tshuaj.
Kev kho tshuaj ntev ntev yog qhov tsim nyog rau kev tawm tsam ntau zaus, pom cov duab pom ntawm tus kab mob, tsim cov tophi thiab raug mob rau lub raum.
Thaum lub sijhawm tshem tawm, cov neeg mob kuj tau qhia ntau yam kev kho lub cev: zaws, da dej paraffin, ultrasound.
Kev noj zaub mov ua txhaum ntawm purine metabolism
Nyob rau hauv yuav luag txhua txoj kev kho mob pathology, kws kho mob haisua raws li kev noj haus. Kev noj zaub mov tshwj xeeb pab tus neeg mob kom tshem tawm qhov tsis zoo ntawm cov kab mob metabolic. Feem ntau, thawj qhov teeb meem uas kev noj zaub mov muaj txiaj ntsig zoo tiv nrog yog qhov teeb meem hauv cov roj metabolism. Tawm tsam keeb kwm ntawm cov kab mob no, tus neeg mob tau hnyav zuj zus, thiab qee zaum ntsib nrog atherosclerosis, kab mob plawv, nrog rau kev nce ntshav siab tsis tu ncua.
Hauv txhua qhov xwm txheej tau piav qhia, cov kws tshaj lij tau sau cov zaub mov rau cov neeg mob uas cov zaub mov muaj purine muaj tsawg lossis tsis tuaj yeem ua tiav. Cov no muaj xws li: nceb, nqaij, legumes, ntses. Tsis tas li ntawd, cov neeg mob tau qhia hnub yoo mov nrog zaub, khoom noj los yog txiv hmab txiv ntoo.
Nws tsim nyog hais tias kev noj zaub mov rau kev ua txhaum ntawm purine metabolism yuav tsum tau siv ntev heev. Tus neeg mob txoj kev noj zaub mov muaj feem ntau 4-5 zaug hauv ib hnub.
Cov ntawv qhia zaub mov tsis suav nrog cov khoom muaj oxalic acid thiab purines, muaj qee yam kev txwv txog ntsev, proteins, rog thiab carbohydrates. Lub zog tus nqi ntawm cov khoom noj txhua hnub yuav tsum nyob ntawm 2700-2800 calories. Cov zaub mov txhua hnub muab rau kev noj 80 g ntawm cov protein, 90 g rog, 400 g ntawm carbohydrates.
khoom pom zoo:
- nqaij thiab ntses;
- khoom xyaw;
- bread los ntawm qib thawj ntawm hmoov;
- txhua yam cereals;
- zaub thiab txiv hmab txiv ntoo hauv txhua daim ntawv.
Yuav tsum tsis suav nrog:
- ntses ntses thiab nqaij;
- raspberries;
- tshuaj yej thiab kas fes;
- chocolate;
- cocoa hmoov;
- legumes;
- cranberries;
- sorrel.
Ntau hom roj ua noj kuj raug txwv.
Nrog rau kev xaiv noj zaub mov kom raug thiab lwm yam ntawm kev kho mob nyuaj, tus neeg mob tau hnov zoo heev hauv ob peb lub lis piam.
