Nyob rau hauv kev kho mob bronchial hawb pob, nrog rau beta-adrenergic agonists, nqus tau glucocorticosteroids tau dav siv los txo qhov zaus thiab qhov hnyav ntawm bronchospasm tawm tsam. Ntawm cov tshuaj no, nws tsim nyog hais txog "Budenit" rau kev nqus pa. Cov lus qhia rau kev siv "Budenit" muaj cov lus qhia dav dav ntawm kev siv tshuaj, yog li peb yuav ua tib zoo saib xyuas nws cov yam ntxwv tseem ceeb thiab kev siv tsis zoo ntawm kev siv thaum lub sij hawm kho nebulizer.
Composition of "Budenit Steri-Neb" (raug ncua)
Cov lus qhia hais tias cov tshuaj yog ncua kev nqus pa, tsis muaj xim thiab tsw, ntim rau hauv 2 ml polyethylene ampoules uas muaj 1 mg (0.5 mg / ml) lossis 0.5 mg (0. 25 mg / ml) ntawm active tshuaj budesonide. Cov khoom nobelongs rau pawg kws tshuaj ntawm glucocorticoid cov tshuaj hormones rau kev siv tshuaj pleev ib ce.
Pharmacodynamics
Raws li tau pom los ntawm cov tshuaj "Budenit" rau kev nqus cov lus qhia, budesonide (cov khoom xyaw tseem ceeb) muaj kev tiv thaiv kev ua xua, tiv thaiv kab mob thiab tiv thaiv edematous. Los ntawm stimulating zus tau tej cov lipocortin protein, budesonide muaj ib tug inhibitory nyhuv ntawm synthesis ntawm phospholipase, uas, nyob rau hauv lem, ua rau ib tug txo nyob rau hauv lub synthesis ntawm arachidonic acid, ib tug txo nyob rau hauv zus tau tej cov prostaglandins thiab leukotrienes. Cov txheej txheem no ntawm qib cellular ua rau txo qis hauv kev tsim cov cytokines, txo cov migration ntawm macrophages thiab ua rau txo qis hauv cellular infiltration. Thaum kawg, qhov no ua rau txo qis ntawm cov neeg kho mob inflammatory, uas muaj txiaj ntsig zoo rau kev kho mob hawb pob thiab ua kom ruaj khov ntawm nws cov kev kho mob.
Raws li muaj pov thawj los ntawm cov tshuaj "Budenit Steri-Neb" cov lus qhia rau kev siv, nws cov kev siv tsis tu ncua ua rau kev kho kom rov zoo li qub ntawm tsob ntoo bronchial rau cov tshuaj uas ua rau lub bronchi. Qhov no, nyob rau hauv lem, txo qhov zaus ntawm kev siv tom kawg, txo tus nqi ntawm bronchial sputum secretion tsim, txo rhiab heev rau allergens, uas kuj muaj ib tug zoo ntxim rau cov kev kho mob ntawm tus kab mob.
Cov tshuaj tsis muaj cov haujlwm mineralocorticoid, thiab tseem tsis muaj kev cuam tshuam rau lub cevvim qhov kev ua hauv zos, uas txo qhov zaus thiab qhov hnyav ntawm cov kev mob tshwm sim, tau txais txiaj ntsig zoo nrog kev siv mus ntev.
Raws li pov thawj los ntawm cov tshuaj "Budenit Steri-Neb" cov lus qhia rau kev siv, analogues ntawm cov tshuaj no kuj tau txais txiaj ntsig zoo thiab tsis ua rau muaj kev phiv cuam tshuam nrog kev siv cov kab mob glucocorticosteroids.
Tom qab ib daim ntawv thov, cov tshuaj kho tau tsim tom qab ob peb teev, ncav cuag qhov siab tshaj plaws hauv 1-2 lub lis piam tom qab pib siv. Cov tshuaj tuaj yeem siv tau zoo los tiv thaiv qhov tshwm sim ntawm bronchial hawb pob ntawm kev tawm dag zog lub cev, txawm li cas los xij, vim lub sijhawm ntev latent ntawm qhov pib ntawm kev kho mob, nws tsis tsim nyog rau kev kho mob ntawm cov mob hnyav nrog bronchospasm.
YPharmacokinetics
Cov tshuaj no yog siv los ntawm ib tug nebulizer. Tom qab nqus tau cov aerosol zoo, budesonide nyob rau saum npoo ntawm tsob ntoo bronchial. Kwv yees li 15% ntawm cov tshuaj, vim yog nqus tau nyob rau hauv lumen ntawm tsob ntoo bronchial, nkag mus rau hauv lub cev thiab yog ntxiv metabolized siv lub cytochrome system mus xyaum tsis ua hauj lwm metabolites (lawv kev ua ub no yog 100 lub sij hawm tsawg tshaj li cov kev ua ntawm cov niam txiv tshuaj). Kwv yees li 70% ntawm cov tshuaj yog tawm los ntawm ob lub raum, lwm 10% yog tawm los ntawm txoj hnyuv.
Cov lus qhia rau kev siv
Raws li cov tshuaj yooj yim, budesonide thiab nws cov analoguesyog qhia rau kev kho mob thiab tiv thaiv kev mob hawb pob, nrog rau qhov tsis muaj txiaj ntsig ntawm kev siv cov beta-agonists xaiv los tiv thaiv qhov pib ntawm tus kab mob thiab ua kom lub cev ruaj khov ntawm daim duab kho mob, nrog rau txo cov koob tshuaj ntawm qhov ncauj glucocorticoid cov neeg ua haujlwm. Cov tshuaj siv tau zoo rau kev kho mob stenosing laryngotracheitis thiab mob ntsws obstructive pulmonary.
YContraindications
"Budenit Steri-Neb" (raug ncua kev nqus pa) yog contraindicated nyob rau hauv lub xub ntiag ntawm kev tsis haum tshuaj rau ib los yog ntau yam khoom uas ua rau cov tshuaj, nrog rau cov me nyuam nyob rau hauv 6 xyoo. Nrog kev saib xyuas zoo, cov tshuaj tau sau tseg rau cov kab mob ntsws ntsws, kev puas tsuaj rau lub ntsws ua pa los ntawm cov kab mob, kab mob, fungal microflora, lub siab ua haujlwm tsis zoo. Kev txwv tsis pub siv cov tshuaj thaum muaj kab mob sib kis yog vim muaj kev tiv thaiv kab mob hauv zos ntawm cov mucous membrane, uas tuaj yeem ua rau txo qis hauv kev tiv thaiv kab mob thiab kev loj hlob ntawm tus kab mob.
Side effects
Vim qhov tseeb tias cov tshuaj tau muab tshuaj los ntawm kev nqus pa siv lub tshuab nqus tsev, muaj qhov tshwm sim ntau ntawm qhov qhuav ntawm cov mucous ntawm qhov ncauj kab noj hniav thiab cov kab mob ua pa sab saud, hnov mob caj pas thiab khaus, txawv txav thiab tsis kaj siab saj, hoarseness los yog hoarseness, hnoos. Qhov no yog vim lub deposition ntawm microparticles ntawm cov tshuaj nyob rau saum npoo ntawm lub mucosa.
Tseem tsis tshua muaj kev ua txhaum caipaj hlwb, uas manifest lawv tus kheej nyob rau hauv daim ntawv ntawm nervousness thiab nce neuropsychic excitability, cwj pwm tsis zoo, mob taub hau. Tsis tas li ntawd, cov neeg mob siv Budenit qee zaum nco ntsoov qhov tshwm sim ntawm kev tsis haum tshuaj nyob rau hauv daim ntawv ntawm urticaria, khaus lossis liab ntawm daim tawv nqaij, spasm ntawm cov leeg nqaij ntawm tsob ntoo bronchial, nrog rau kev txhim kho candidiasis ntawm qhov ncauj kab noj hniav thiab txoj hlab pas.
Qhov tshwm sim ntawm paradoxical bronchospasm thiab kev ua tsis taus pa tom qab pib nqus pa ntawm thawj koob yog vim qhov ua rau cov tshuaj tsis haum rau ntawm cov pa mucosa. Nrog rau kev txhim kho ntawm cov kev mob tshwm sim no, nws raug nquahu kom tsis txhob nqus pa thiab muab tshuaj kho lwm yam.
Txawm hais tias qhov tsis muaj bioavailability ntawm cov tshuaj thiab nws cov txiaj ntsig hauv zos feem ntau, nrog rau kev siv ntev, cov teebmeem ntawm glucocorticosteroids tuaj yeem txhim kho. Qhov no yog tshwm sim los ntawm inhibition ntawm cov kev ua ntawm lub adrenal cortex, ib tug slowdown ntawm kev loj hlob ntawm cov me nyuam, ib tug txo nyob rau hauv cov pob txha ntxhia pob zeb ceev, thiab kev loj hlob ntawm kev pom kev tsis pom kev.
Qee qhov xwm txheej (tsis tshua muaj), tawv nqaij tawv nqaij tuaj yeem tshwm sim thaum siv lub npog ntsej muag. Txhawm rau tiv thaiv qhov teeb meem no, nws yog qhov yuav tsum tau siv cov tshuaj tua kab mob rau lub ntsej muag, thiab tom qab nqus pa, yaug cov tawv nqaij ntawm lub ntsej muag nrog dej sov. Koj tseem tuaj yeem xoob cov hlua elastic uas tuav lub ntsej muag ntawm koj lub ntsej muag. Ib txoj hauv kev zoo yog siv lub qhov ncauj lossis lub qhov ncauj rau kev nqus pa.
Siv thaum cev xeeb tub thiab lactation
Kev qhia rau "Budenit" pom zoo kom sau cov tshuaj nrog ceev faj rau cov poj niam cev xeeb tub, nrog rau thaum pub niam mis (txawm tias tsis muaj ntaub ntawv hais txog cov tshuaj nkag mus rau hauv niam mis). Cov tshuaj tau pom zoo kom siv tsuas yog thaum nws cov txiaj ntsig zoo rau leej niam tshaj qhov ua tau tsis zoo thiab muaj teeb meem rau tus menyuam hauv plab. Nyob rau hauv cov ntaub ntawv no, budesonide yuav tsum tau siv nyob rau hauv qhov tsawg kawg nkaus npaum npaum li cas uas tso cai rau koj los tswj tag nrho cov chav kawm ntawm tus kab mob.
Kev Sib Tham Tshuaj
Nyob rau theem ntawm kev sib cuam tshuam tshuaj, cov tshuaj tau ua tiav nrog isotonic sodium chloride tov, nrog rau lwm cov tshuaj inhaled beta-agonists, mucolytics thiab expectorants. Txhawm rau ua kom muaj txiaj ntsig zoo ntawm kev kho mob thiab kho cov nyhuv hauv kev kho mob ntawm bronchial spasm, cov tshuaj ntawm cov pab pawg no tuaj yeem muab tso ua ke rau hauv lub chamber nebulizer. Kev siv cov bronchodilators ua ke tsis yog tsuas yog txhim kho qhov ntws ntawm "Budesonide" rau hauv tsob ntoo bronchoalveolar, tab sis tseem ua rau nws nkag mus tob dua los ntawm lumen.
Vim kev koom tes ntawm enzymes ntawm pawg cytochrome P450 hauv cov metabolism ntawm budesonide, koob tshuaj yuav tsum tau tshuaj xyuas thaum siv cov tshuaj uas inhibit lossis txhawb kev ua haujlwm ntawm cov enzyme no. Kev siv cov tshuaj ua ke nrog cov tshuaj tiv thaiv kab mob xws li Ketoconazole thiab Intraconazole tsis pom zoo, vim qhov no yuav ua rau muaj kev nce ntxiv hauv cov concentration."Budesonide" hauv plasma.
Tshuaj uas ua rau kom muaj kev ua haujlwm ntawm microsomal enzymes (Phenobarbital, Phenytoin, Rifampicin) txo cov haujlwm ntawm Budesonide.
Yuav siv li cas
Nws yooj yim zoo nkauj siv "Budenit" rau kev nqus pa. Cov lus qhia rau kev siv qhia tias yuav tsum tau siv lub nebulizer rau kev kho mob. Cov tshuaj yog muab tso rau hauv lub nebulizer chamber ntawm lub ntaus ntawv, thiab inhalation yog ua. Lub sijhawm ntawm kev nqus tau thiab ntau npaum li cas yuav tsum raug xaiv nyob rau hauv txhua rooj plaub, suav nrog kev kho mob thiab qhov hnyav ntawm tus neeg mob tus kab mob thaum siv Budenit rau inhalation. Cov lus qhia rau cov me nyuam los ntawm 6 lub hlis mus rau 12 xyoo qhia txog kev teem caij ntawm budesonide ntawm ib nrab ntawm cov tshuaj. Rau cov neeg mob uas muaj hnub nyoog tshaj 12 xyoos, cov tshuaj kho yuav tsum tau kho ib tus zuj zus.
Yog tias nws tsim nyog los muab "Budenit" nrog rau qhov ncauj glucocorticoid tshuaj, nws raug nquahu kom nce koob tshuaj "Budenit" txhawm rau tiv thaiv qhov tshwm sim thiab txo qhov mob hnyav.
Reviews
Kev cob qhia kws kho mob thiab cov neeg mob txaus siab rau qhov ua tau zoo ntawm cov tshuaj. Qhov no yog pov thawj los ntawm txhua qhov kev tshuaj xyuas ntawm (Teva "Budenit" ncua kev nqus pa yog cov tshuaj nrov nrov) tshuaj. Ib tus cwj pwm zoo rau nws yog tsim los ntawm qhov tshwm sim tsawg ntawm cov kev mob tshwm sim thiab kev ua haujlwm siab ntawm kev kho mob. Kev xav txog cov tshuaj "Budenit" rau kev nqus pa rau cov menyuam yaus (kev qhia, ntau npaum li cas tau muab rau hauv tsab xov xwm) hauv cov niam yog qhov zoo, uas tseem yog vim qhov tshwm sim tsawg.kev mob tshwm sim. Painless inhalation nrog nebulizers (uas tuaj yeem ua rau ntau yam khoom ua si) hauv cov menyuam yaus kuj txhawb kev siv cov tshuaj no lossis nws cov analogues.
Ntau tshaj
Thaum mob hnyav dhau ntawm cov tshuaj, tsis pom cov tsos mob tshwm sim. Kev kho mob yog cov tsos mob, nrog rau kev tshem tawm cov tshuaj thiab cov tshuaj bronchodilators luv luv.
Nws yuav tsum tau nco ntsoov tias nrog kev siv sijhawm ntev ntawm "Budenit" hauv cov koob tshuaj ntau tshaj qhov kev kho mob nruab nrab, cov kev mob tshwm sim tuaj yeem tshwm sim ntawm cov kab ke (hypercorticism, kev ua haujlwm ntawm adrenal). Qhov no yog pov thawj los ntawm cov tshuaj "Budenit" rau inhalation cov lus qhia. Nws tus nqi yog pheej yig rau kev siv ntev ntawm cov tshuaj no raws li kev kho mob tseem ceeb rau kev mob ntsws asthma.
cov lus qhia tshwj xeeb thiab cov lus pom zoo
Cov lus qhia rau kev siv tshuaj "Budenit" hais tias nws tsis yog los daws qhov mob hnyav ntawm bronchospasm. Lub sij hawm nruab nrab ntawm kev txhim kho cov nyhuv kho mob yog li 10 hnub, tab sis nws tuaj yeem nce ntxiv yog tias muaj cov hnoos qeev ntau los yog cov kua nplaum tso rau hauv lub lumen ntawm tsob ntoo bronchial. Hauv qhov no, nws tuaj yeem ua tiav kev kho mob ua ke nrog qhov ncauj glucocorticoids, ua raws li kev hloov pauv tsuas yog "Budenit Steri-Neb" rau kev nqus pa.
Cov lus qhia rau cov tshuaj hais tias txawm tiasQhov tshwm sim ntawm cov kev mob tshwm sim ntawm cov kab mob hauv lub cev yog qis dua, nws yog ib qho tsim nyog yuav tsum tau titrate qhov tsawg kawg nkaus cov tshuaj kho mob kom tau txais cov txiaj ntsig siab tshaj plaws. Thaum siv cov tshuaj nyob hauv cov menyuam yaus, txhawm rau txhawm rau txheeb xyuas cov kev cuam tshuam nrog kev phiv, kev loj hlob ntawm tus menyuam yuav tsum tau saib xyuas tas li lub sijhawm ntev. Nrog rau kev txhim kho ntawm cov kev mob tshwm sim, koob tshuaj yuav tsum raug txo kom tsawg kawg nkaus, uas tso cai rau koj los tswj kev mob hawb pob.
Txhawm rau tiv thaiv qhov tshwm sim ntawm cov kab mob fungal nyob rau hauv lub qhov ncauj kab noj hniav, tus neeg mob yuav tsum tau ceeb toom txog qhov yuav tsum tau yaug lub qhov ncauj thiab tshem tawm cov seem ntawm cov tshuaj tom qab txhua qhov nqus tau. Qhov no yuav pab txhawb kev tiv thaiv hauv zos ntawm qhov ncauj kab noj hniav thiab mucous daim nyias nyias.
Tsev yam ntxwv ntawm kev siv
Kev nqus pa "Budenit" siv ultrasonic nebulizers yog contraindicated. Cov koob tshuaj zoo ntawm cov tshuaj yuav tsum tau suav nrog suav nrog cov yam ntxwv ntawm tus neeg mob tshwj xeeb (siv rau hauv tus account huab cua ntws tus nqi, qhov ntim ntawm nebulizer chamber, thiab lwm yam) thiab tus mob ntawm tus neeg mob.
Ua ntej siv cov tshuaj "Budenit" rau kev nqus pa hauv lub tshuab nqus tsev, cov lus qhia ntawm nebulizer yuav tsum tau kawm yam tsis poob. Qhov no yuav zam kev sib txuas tsis raug ntawm cov cuab yeej thiab siv cov tshuaj tsis zoo. Yog hais tias lub nebulizer siv thawj zaug, nws raug nquahu kom sim nws nrog saline sodium chloride tov kom paub tseeb tias nws.noj qab haus huv ces siv tshuaj.
Ua ntej nqus pa, lub hnab yas tau muab tshem tawm ntawm lub thawv, qhib los ntawm kev rhuav tshem lub hau, cov tshuaj tau muab tso rau hauv lub tshuab nqus tsev nqus tsev, lub npog ntsej muag yog muab tso rau ntawm lub ntsej muag (los yog lub qhov ncauj clamped) thiab huab cua ntws yog muab. Thaum nqa tawm kev nqus pa siv lub qhov ncauj, nws yog ib qho tsim nyog yuav tsum ua pa ntawm lub qhov ncauj nkaus xwb (ib qho tshwj xeeb clip yog muab tso rau ntawm lub qhov ntswg). Thaum siv daim npog qhov ncauj, siv lub qhov ntswg clip yog xaiv tau.
Kev nqus pa, nws raug nquahu kom siv lub tshuab nqus tsev nrog lub tshuab valve uas txhaj tshuaj aerosol ncaj qha rau lub sijhawm nqus pa thiab kaw lub qhov hluav taws xob thaum lub sijhawm exhalation. Qhov no yuav pab txhawb kev xa tshuaj mus rau tsob ntoo bronchoalveolar thiab txo cov tshuaj poob thaum exhalation.
"Budenitis Steri-Neb": analogues, nqe
Analogues ntawm cov tshuaj "Budenit Steri-Neb" yog cov tshuaj xws li "Pulmicort" thiab "Pulmicort Turbuhaler", "Cortimen", "Tafen", "Budoster", "Budenofalk" thiab ntau lwm tus. Rau cov tshuaj no, nrog rau cov tshuaj "Budenit" rau inhalation, cov lus qhia yog zoo tib yam vim muaj cov tib yam active tshuaj. Tus nqi ntawm cov tshuaj no nyob ntawm cov khw muag tshuaj thiab cheeb tsam, nrog rau qhov ntau npaum li cas. Qhov nruab nrab, tus nqi ntawm 650 txog 2550 rubles.
Zoo kawg
Cov tshuaj muaj txiaj ntsig zoo rau kev kho mob thiab tiv thaiv kev tawm tsam bronchialMob hawb pob yog "Budenitis" rau inhalation. Cov lus qhia rau cov tshuaj muab cov lus qhia ntxaws txog qhov ntau npaum li cas thiab cov xwm txheej rau kev siv cov tshuaj no. Muab hais tias budesonide tau siv raws li cov lus qhia thiab cov koob tshuaj pom zoo, cov tshuaj muab kev kho mob zoo. Yog tias vim li cas koj tsis tuaj yeem yuav cov khoom qub, muaj cov analogues. "Budenit Steri-Neb" (nqi, cov lus qhia uas koj tam sim no paub) yuav cawm koj ntawm ntau yam kab mob ntawm txoj hlab pa.
