"Amoxiclav" yog cov tshuaj tua kab mob ua ke. Nws spectrum ntawm kev ua yog dav heev. Puas yog tshuaj tua kab mob "Amoxiclav"? Nws tsis muaj qhov cuam tshuam zoo li no, yog li cov lus teb rau lo lus nug yuav tsis zoo. Cov tshuaj siv tau rau cov kab mob ntawm tus kab mob etiology nkaus xwb nyob rau hauv cov xwm txheej uas kis tus kab mob thib ob ntawm cov kab mob keeb kwm tshwm sim tawm tsam lawv keeb kwm.
Kev sib sau thiab tso tawm daim ntawv
Dab tsi yog cov tshuaj "Amoxiclav" hauv cov ntsiav tshuaj? Cov tshuaj tua kab mob no yog tsim nyob rau hauv daim ntawv ntawm cov tshuaj, coated nrog ib tug tshwj xeeb txheej, uas muaj cov ntsiab lus tseem ceeb. Qhov no yog amoxicillin ntawm ib koob ntawm 875, 500 lossis 250 mg thiab clavulanic acid hauv ib lub ntim ntawm 125 mg. Tsis tas li ntawd, Amoxiclav npaj muaj qee yam ntxiv: crospovidone, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, talc, microcrystalline cellulose. Cov ntsiav tshuajntim rau hauv cov hlwv thiab cov iav tsaus nti.
Ntxiv rau cov ntsiav tshuaj, cov tshuaj muaj nyob rau hauv cov hmoov rau kev ncua. Cov tom kawg yog npaj rau kev tswj qhov ncauj. Hauv 5 ml ntawm cov tshuaj tiav, cov khoom xyaw nquag muaj nyob rau hauv qhov sib piv ntawm 125 mg / 31.25 mg, 250 mg / 62.5 mg, 400 mg / 57 mg. Cov tshuaj pabcuam hauv cov tshuaj "Amoxiclav" nyob rau hauv daim ntawv ntawm kev ncua yog: citric acid, sodium citrate, MCC thiab carmellose sodium, xanthan gum, colloidal silicon dioxide, qus cherry tsw, txiv qaub tsw, sodium saccharinate, mannitol. Cov hmoov yog ntim rau hauv cov iav tsaus nti.
Lwm daim ntawv ntawm cov tshuaj no yog cov hmoov rau kev txhaj tshuaj uas muaj cov khoom tseem ceeb hauv qhov sib piv ntawm 1000 mg / 200 mg, 500 mg / 100 mg.
tshuaj muaj txiaj ntsig
Dab tsi yog pab pawg ntawm cov tshuaj "Amoxiclav"? Cov tshuaj tua kab mob yog ib qho tshuaj tua kab mob penicillin uas cuam tshuam rau ntau cov kab mob gram-positive thiab gram-negative microorganisms. Cov tshuaj no inhibits biological synthesis ntawm peptidoglycan, ib yam khoom uas muaj nyob rau hauv cov qauv ntawm cov kab mob cell membrane. Kev txo qis hauv kev tsim cov peptidoglycan ua rau txo qis hauv lub zog ntawm cov phab ntsa ntawm tes, uas tom qab ntawd provokes lysis thiab kev puas tsuaj ntawm cov kab mob pathogenic.
Tib lub sijhawm, amoxicillin nkag siab rau cov teebmeem ntawm beta-lactamases, uas rhuav tshem nws. Raws li qhov tshwm simlub spectrum ntawm cov tshuaj tua kab mob ntawm cov tshuaj no tsis suav nrog cov kab mob uas tsim cov tshuaj no. Clavulanic acid yog ib yam khoom uas inhibits zus tau tej cov beta-lactamases. Nws cov qauv zoo ib yam li cov tshuaj penicillic acid.
Cov tshuaj "Amoxiclav" no muaj peev xwm ua kom tsis muaj zog ntau beta-lactamases, uas tiv taus penicillins thiab cephalosporins. Cov txiaj ntsig zoo ntawm cov tshuaj muaj feem xyuam rau plasmid beta-lactamases, uas feem ntau txiav txim siab qhov tsis kam ntawm cov kab mob pathogenic rau cov tshuaj tua kab mob, kuj tau raug pov thawj.
Txawm li cas los xij, cov tshuaj no tsis tuaj yeem ua rau chromosomal hom I beta-lactamases, uas txhais tau hais tias lawv tsis yog nruab nrab los ntawm clavulanic acid. Lub xub ntiag ntawm cov tshuaj no nyob rau hauv muaj pes tsawg leeg ntawm cov khoom kho mob "Amoxiclav" ua rau nws muaj peev xwm mus tiv thaiv kev puas tsuaj ntawm amoxicillin thiab ho nthuav lub spectrum ntawm functionality ntawm cov tshuaj tua kab mob no..
Tshuaj tua kab mob dab tsi?
Kev tshawb fawb hauv vitro tau ua pov thawj siab rau qhov kev txiav txim ntawm cov tshuaj "Amoxiclav" ntawm cov kab mob hauv qab no:
- Gram-negative anaerobic kab mob: Bacteroides fragilis, Fusobacterium nucleatum, Prevotella, Porphyromonas, Capnocytophaga, Fusobacterium, Eikenella corrodens.
- Gram-positive anaerobic kab mob: Peptostreptococcus magnus, Peptococcus niger, Peptostreptococcus, Peptostreptococcusmicros, Clostridium.
- Gram-negative aerobic bacteria: Moraxella catarrhalis, Vibrio cholerae, Haemophilus influenza, Pasteurella multocida, Neisseria, Helicobacter pylori.
- Gram-positive aerobic kab mob: coagulase-negative staphylococci (qhia rhiab heev rau methicillin), Streptococcus agalactiae, Bacillus anthracis, Streptococcus pyogenes thiab lwm yam streptococci ntawm beta-hemolytic qeb, Listeria.
- Lwm cov kab mob: Treponema pallidum, Borrelia, Leptospira icterohaemorrhagiae. Peb yuav tham txog cov lus qhia ntawm cov tshuaj "Amoxiclav" hauv qab no.
Cov kab mob twg tiv taus tshuaj?
Cov kab mob hauv qab no yog tus cwj pwm los ntawm kev nkag mus rau cov tshuaj nquag ntawm cov tshuaj "Amoxiclav":
- Gram-positive aerobic: Streptococcus pneumoniae, Streptococcus class Viridans, Enterococcus faecium, kab mob ntawm genus Corynebacterium.
- Aerobic gram-tsis zoo: Proteus mirabilis, Shigella, Klebsiella oxytoca, Klebsiella, Escherichia coli thiab vulgaris.
Naturally resistant rau kev sib xyaw ntawm clavulanic acid thiab amoxicillin yog: Yersinia enterocolitica, Acinetobacter, Stenotrophomonas m altophilia, Citrobacter freundii, Enterobacter, Pseudomonas, Serratia, Hafnia alvei, Providencia, Copticophila, pseudomonas, pseudomonas. burnetii.
Pharmacokinetic indicators
Ua raws li cov lus qhia rau kev siv tshuaj"Amoxiclav", lub ntsiab pharmacokinetic qhov tseem ceeb ntawm cov khoom xyaw nquag ntawm cov khoom kho mob no zoo ib yam. Ob leeg cov khoom xyaw nquag qhia tau hais tias muaj kev solubility siab hauv cov tshuaj aqueous uas muaj pH physiological, thiab tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj tau sai sai absorbed los ntawm cov kab noj hniav ntawm lub plab zom mov.
Qhov kev nqus ntawm kev sib xyaw ntawm cov tshuaj nquag yog suav tias yog qhov zoo tshaj plaws tom qab noj cov tshuaj ua ntej noj mov. Tom qab kev tswj hwm qhov ncauj ntawm Amoxiclav, qhov muaj cov tshuaj nquag hauv lub cev nce mus txog 70 feem pua.
Kev sib xyaw "clavulanic acid + amoxicillin" yog tus cwj pwm los ntawm cov theem siab ntawm kev faib khoom hauv ntau lub cev, cov ntaub so ntswg thiab cov kua dej hauv lub cev (xws li lub ntsws, cov leeg, pob txha thiab cov ntaub so ntswg adipose, kab mob hauv plab, interstitial, peritoneal, synovial thiab pleural kua, hnoos qeev, kua tsib, kua paug, zis thiab tawv nqaij). Cov khoom xyaw nquag khi rau cov ntshav plasma protein: amoxicillin nyob rau hauv tus nqi ntawm 18% thiab clavulanic acid nyob rau hauv tus nqi ntawm 25% ntawm cov tshuaj tau txais. Kev faib tawm yog kwv yees li 0.3-0.4 l / kg (amoxicillin) thiab 0.2 l / kg (clavulanic acid). Cov tshuaj no tsis muaj peev xwm hla tau cov ntshav-hlwb barrier, tsuas yog nyob rau hauv cov ntaub ntawv no o ntawm meninges.
Zoo li ntau cov tshuaj penicillins, amoxicillin nkag mus rau hauv cov kua mis thaum lactation. Nws muaj cov kab mob siab ntawm clavulanic acid. Cov khoom xyaw nquag ntawm cov tshuaj kuj hla cov placenta.
Peb xav tau dab tsi ntxivQhia cov lus qhia rau kev siv tshuaj "Amoxiclav"? Kwv yees li 10-25% ntawm thawj koob tshuaj amoxicillin raug tso tawm hauv cov zis li penicillic acid, uas tsis yog tshuaj siv tshuaj. Clavulanic acid tau dhau los ua cov txheej txheem metabolic hnyav nrog kev tsim cov tshuaj tawm hauv lub raum, plab hnyuv, thiab thaum ua pa tawm (hloov mus rau carbon dioxide).
Raws li cov lus qhia ntawm cov tshuaj "Amoxiclav", amoxicillin raug tso tawm los ntawm lub cev feem ntau los ntawm lub raum pom, clavulanic acid - los ntawm ob lub raum thiab lwm yam txheej txheem. Tom qab kev tswj hwm qhov ncauj, kwv yees li 60-75% ntawm amoxicillin thiab 40-70% ntawm clavulanic acid tuaj yeem tawm hauv cov zis rau 6 teev tsis hloov pauv. Qhov nruab nrab, ib nrab-lub neej ntawm cov tshuaj nquag ntawm cov tshuaj yog ib teev, thiab tag nrho qhov nruab nrab tshem tawm yog kwv yees li 25 l / h. Hauv cov neeg mob uas lub raum tsis ua haujlwm, kev tshem tawm tau txo qis hauv kev faib ua feem rau qhov txo qis hauv lub raum ua haujlwm.
Cov lus qhia rau cov tshuaj
Raws li cov ntaub ntawv tau muab hauv cov lus qhia rau kev siv, cov tshuaj "Amoxiclav" tau muab rau kev kho mob ntawm cov kab mob sib kis uas tshwm sim los ntawm cov kab mob nkag mus rau nws. Cov tshuaj qhia rau kev siv:
- rau gynecological kab mob;
- kab mob ntawm cov kab mob ENT thiab cov kav dej ua pa: sinusitis (mob, mob ntev), pharyngitis, otitis media, tonsillitis, retropharyngeal abscess;
- kab mob ntawm cov pob txha thiab cov ntaub so ntswg;
- kis kab mob ntawm cov kab mob ua pa qis, suav nrog mob ntevbronchitis, mob bronchial mob nrog cov kab mob superinfection, mob ntsws;
- kab mob urinary tract;
- pathologies ntawm cov nqaij mos thiab tawv nqaij, nrog rau kab thiab tsiaj tom; kab mob biliary tract;
- kis kab mob ntawm cov qauv ntawm lub peritoneum;
- kis tau tus kab mob sib deev - chancre, gonorrhea.
Nws kuj yog siv los tiv thaiv kev txhim kho ntawm kev kis kab mob tom qab kev phais.
npe ntawm contraindications
Nrog rau cov lus qhia rau kev siv tshuaj "Amoxiclav" xam tawm. Tus neeg saib xyuas tshuaj tsis raug tshuaj rau kab mob siab thiab cholestatic jaundice tshwm sim los ntawm kev noj tshuaj tua kab mob los ntawm chav kawm penicillin. Tsis tas li ntawd, cov tshuaj no yog contraindicated:
- yog tias koj muaj kev nkag siab rau clavulanic acid, tshuaj penicillin, amoxicillin, lwm yam tshuaj muaj nyob hauv nws cov muaj pes tsawg leeg;
- lymphatic leukemia;
- kis kab mob mononucleosis.
Siv nrog saib xyuas
Cia li piav qhia ntxiv. Cov tshuaj "Amoxiclav" yog pom zoo kom siv nrog ceev faj nyob rau hauv xws pathological phenomena:
- pseudomembranous colitis keeb kwm;
- siab tsis ua hauj lwm;
- raum tsis ua haujlwm hnyav.
Qhov muaj peev xwm muab tshuaj tua kab mob no thaum cev xeeb tub thiab cov txheej txheem lactation yuav tsum tau txiav txim siab nrog tus kws kho mob ntawm tus kheej.
Cov lus qhia rau kev siv
txoj cai nkagCov tshuaj thiab lub sijhawm ntawm kev kho mob yog txiav txim siab nyob ntawm qhov hnyav ntawm cov kab mob uas twb muaj lawm, lub hnub nyoog ntawm tus neeg mob, lub raum ua haujlwm thiab lub cev hnyav. Nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab ncua kev kawm ntawv, cov tshuaj "Amoxiclav" yuav tsum tau qaug dej qaug cawv. Qhov no tso cai rau koj kom txo qis qhov tshwm sim ntawm kev tsim cov tshuaj tiv thaiv tsis zoo txog lub plab zom mov. Qhov nruab nrab ntawm kev kho mob yog 5-14 hnub. Kev kho mob ntev dua yog ua tau tom qab kev kuaj mob thib ob. Qhov no lees paub cov lus qhia rau kev siv tshuaj "Amoxiclav".
Kev noj tshuaj
Thaum muaj hnub nyoog qis dua 12 xyoos, cov tshuaj tau muab tshuaj ntawm qhov ntau npaum li 40 mg / kg ib hnub (qhov koob tshuaj yuav tsum muab faib ua peb koob). Cov tshuaj nyob rau hauv cov ntaub ntawv no yog sau nyob rau hauv daim ntawv ntawm kev ncua. Rau cov menyuam yaus uas hnyav dua 40 kg, cov koob tshuaj siv rau cov neeg laus yog qhia.
Cov tshuaj noj hauv qab no tuaj yeem ua tau rau cov neeg laus uas muaj kab mob me me thiab mob me:
- 1 ntsiav tshuaj (250 + 125 mg) txhua 8 teev.
- 1 ntsiav tshuaj txhua 12 teev (500 + 125 mg).
Yog tias muaj qhov hnyav ntawm cov txheej txheem pathological thiab nyob rau hauv cov kab mob ntawm cov kab mob ua pa, nws yuav tsum noj 1 ntsiav tshuaj txhua 8 teev hauv koob tshuaj 500 + 125 mg lossis 875 + 125 mg txhua 12 teev. Nrog rau cov kab mob odontogenic rau 5 hnub, kev siv 1 ntsiav tshuaj hauv koob tshuaj 250 + 125 mg (ib ntus - 8 teev) lossis 500 + 125 mg (ib ntus - 12 teev) tau qhia. Yog li nws hais hauv cov lus qhia rau cov tshuaj "Amoxiclav"
Cov menyuam yaus txog li 3 lub hlis, cov tshuaj tau muab rau hauv daim ntawv ncua ntawm 30mg / kg ntawm amoxicillin ib hnub twg (kwv yees txhua 12 teev). Yuav kom ua tau raws li qhov ntau npaum li cas ntawm cov tshuaj uas tau muab rau tus menyuam, nws yog ib qho tsim nyog yuav tsum siv lub pipette tshwj xeeb uas txuas rau lub pob.
koob tshuaj txhua hnub rau menyuam yaus tom qab 3 lub hlis:
- rau tus kab mob me mus rau nruab nrab - los ntawm 20 mg / kg ib hnub;
- Tus kab mob hnyav thiab kev kho mob ntawm cov kab mob, cov kab mob ua pa qis, sinusitis thiab otitis media - txog li 40 mg / kg ib hnub.
Nws yuav tsum tau nco ntsoov tias thaum xaiv cov koob tshuaj ntawm cov tshuaj hauv nqe lus nug rau tus menyuam, ib tus yuav tsum tsis txhob cia siab rau lub hnub nyoog, tab sis nyob ntawm qhov hnyav ntawm cov kab mob thiab lub cev hnyav. Ua tib zoo siv cov tshuaj "Amoxiclav".
Ib tshuaj tua kab mob nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj yog muab tso rau hauv cov hlab ntsha. Rau cov menyuam yaus tom qab 3 lub hlis, cov koob tshuaj suav nrog hauv qab no:
- nrog lub cev hnyav dua 4 kg, cov tshuaj tau muab tshuaj ntawm ib koob ntawm 30 mg / kg (tom qab 12 teev);
- yog tias qhov hnyav dua 4 kg - 30 mg / kg (tom qab 8 teev).
Rau cov menyuam mos txog li 3 lub hlis, cov tshuaj txhaj tshuaj tau maj mam, tsawg kawg 40 feeb. Rau cov menyuam yaus uas qhov hnyav tsis tshaj 40 kg, qhov koob tshuaj raug xaiv raws li qhov hnyav ntawm lub cev. Rau cov menyuam yaus hnub nyoog 3 hlis txog rau 12 xyoos, cov tshuaj yuav tsum tau noj ntawm ib koob ntawm 30 mg / kg txhua 8 teev, thiab yog tias muaj mob hnyav, txhua 6 teev. Kev hloov koob tshuaj yuav tsum tau rau cov neeg mob menyuam yaus uas kuaj pom lub raum tsis zoo.
Cov menyuam yaus hnub nyoog qis dua 12 xyoos (qhov hnyav - ntau dua 40 kg) thiab cov neeg laus, cov tshuaj "Amoxiclav" hauv daim ntawv ntawm kev txhaj tshuaj yog muab rau hauv ib koob.1200 mg txhua 8 teev lossis txhua 6 teev rau kev kis kab mob hnyav.
Cov tshuaj kuj tuaj yeem raug sau rau kev phais mob hauv cov koob tshuaj tiv thaiv kab mob (1200 mg nyob rau hauv cov tshuaj loog nyob rau hauv rooj plaub uas qhov kev ua haujlwm ntev dua 2 teev). Rau kev cuam tshuam ntev dua, tus neeg mob yuav tsum tau txais tib koob tshuaj txog li 4 zaug hauv ib hnub.
Cov teebmeem ntawm cov tshuaj "Amoxiclav"
Kev siv tshuaj los kho cov kab mob sib kis tuaj yeem ua rau muaj kev cuam tshuam tsis zoo hauv qab no:
- Hematopoietic system: eosinophilia, thrombocytopenia, txo hemoglobin, leukopenia, agranulocytosis.
- digestive system: flatulence, raws plab, gastritis, xeev siab, dyspeptic mob, stomatitis, glossitis, enterocolitis, anorexia, ntuav.
- CNS: kev ntxhov siab, kev coj tus cwj pwm tsis tsim nyog, ntau dhau arousal, qaug dab peg, tsis meej pem, hyperactivity, insomnia, kiv taub hau, mob taub hau.
- Daim tawv nqaij: puffiness, urticaria, pob khaus, nyob rau hauv tsawg zaus - erythema multiforme, exfoliative dermatitis, epidermal necrolysis ntawm cov tshuaj lom hom.
- YUrinary system: hematuria, interstitial nephritis.
Ntxiv rau cov kev mob tshwm sim saum toj no, superinfection (xws li candidiasis) tuaj yeem tshwm sim. Feem ntau, cov kev tshwm sim ntawm lub cev yog ib ntus thiab mob me.
Ntau tshaj
Qhia tias tshuaj"Amoxiclav" provokes lub neej hem thaum noj cov koob tshuaj ntau, tsis tuaj. Feem ntau, tus mob no tshwm sim los ntawm cov tsos mob xws li kev cuam tshuam ntawm electrolyte tshuav nyiaj li cas thiab kev ua haujlwm ntawm lub plab zom mov (zaub mov, ntuav, mob plab). Qee zaum noj cov tshuaj tuaj yeem ua rau crystalluria, thiab tom qab ntawd ua rau lub raum tsis ua haujlwm.
Cov neeg mob lub raum ua haujlwm tsis zoo lossis muaj ntau yam tuaj yeem ua rau qaug dab peg. Nyob rau hauv cov ntaub ntawv ntawm overdose, tus neeg mob yuav tsum nyob rau hauv kev saib xyuas ntawm ib tug kws tshwj xeeb, yog tias tsim nyog, yuav pom zoo kom kho cov tsos mob.
Yog tias cov tshuaj tau noj tsis pub dhau 4 teev dhau los, nws yog qhov tsim nyog los ua plab hnyuv thiab noj cov hnyuv sorbents kom txo nws txoj kev nqus mus rau hauv cov ntshav. Cov ntsiab lus nquag ntawm cov tshuaj no tau zoo tawm los ntawm hemodialysis.
Special Recommendations
Noj cov tshuaj thawj "Amoxiclav" nrog cov pluas noj yuav txo tau qhov tshwm sim tsis zoo los ntawm lub plab zom mov. Thaum lub sijhawm kho, nws yog ib qho tsim nyog los tswj kev ua haujlwm ntawm lub siab, lub raum thiab lub hematopoietic system. Tawm tsam keeb kwm yav dhau los ntawm lub raum ua haujlwm tsis zoo, kev kho qhov kev siv tshuaj kho mob lossis ncua sijhawm ncua sijhawm ntawm cov tshuaj tau pom zoo.
Yog tias thaum lub sijhawm kho tus neeg mob tau kuaj pom tias muaj kev cuam tshuam tsis zoo los ntawm lub hauv paus paj hlwb, nws raug nquahu kom tsis txhob tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev kub ntxhov ntawm kev puas siab puas ntsws thiab lub cev muaj zog.
Siv hauvLub sijhawm cev xeeb tub thiab lactation
Thaum ua kev sim rau tsiaj, qhov tsis zoo ntawm cov tshuaj no ntawm kev loj hlob ntawm embryonic ntawm tus menyuam hauv plab tsis tau lees paub. Txawm li cas los xij, nws paub tias kev siv tshuaj prophylactic ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob necrotizing enterocolitis nyob rau hauv lub sij hawm neonatal. Thaum cev xeeb tub, nrog rau thaum cev xeeb tub, kev siv Amoxiclav tsuas yog tso cai yog tias cov txiaj ntsig / kev pheej hmoo raug ntsuas los ntawm cov kws tshaj lij.
Cov ntsiab lus tseem ceeb ntawm cov tshuaj hauv koob tshuaj me me muaj nyob hauv cov kua mis. Hauv cov menyuam mos, qhov no tuaj yeem ua rau muaj kev hnov mob, raws plab, candidiasis ntawm cov mucous ntawm lub qhov ncauj kab noj hniav, yog li yog tias koj xav noj cov tshuaj, nws raug nquahu kom tsis txhob pub niam mis.
Kev sib raug zoo nrog lwm yam tshuaj
Raws li tau hais los ntawm cov lus qhia rau kev siv tshuaj "Amoxiclav", kev siv tshuaj sib xyaw nrog ascorbic acid txhim kho kev nqus ntawm nws cov khoom xyaw nquag. Kev siv ib txhij nrog aminoglycosides, antacids, laxatives, glucosamine txo qis qib ntawm lawv qhov nqus.
Kev siv NSAIDs, phenylbutazone, diuretics, allopurinol thiab lwm yam tubular secretion blockers ua rau kom cov concentration ntawm amoxicillin hauv cov ntshav.
Kev sib cuam tshuam ntawm "Amoxiclav" nrog rau lwm yam tshuaj, xws li "Probenecid", tuaj yeem ua rau muaj kev nce ntxiv thiab ua kom tsis muaj zog ntawm cov tshuaj nquag, yog li kev siv ib zaug ntawm cov nyiaj no raug txwv. Kev sib xyaw ua keclavulanic acid, amoxicillin thiab methotrexate nce cov tshuaj lom ntawm methotrexate.
Kev siv tshuaj "Amoxiclav" nrog "Allopurinol" tuaj yeem ua rau muaj kev fab tshuaj rau ntawm daim tawv nqaij. Nws tsis pom zoo kom siv cov tshuaj ua ke nrog "Disulfiram". Kev sib xyaw ua ke ntawm cov khoom tseem ceeb ntawm cov tshuaj txo cov kev ua tau zoo ntawm cov tshuaj, cov metabolism hauv uas txhawb kev tsim ntawm para-aminobenzoic acid. Kev tswj hwm nrog ethinylestradiol ua rau muaj kev pheej hmoo ntawm kev los ntshav.
Dab tsi ntxiv tuaj yeem hais txog kev sib raug zoo ntawm "Amoxiclav" nrog rau lwm yam tshuaj? Yog tias tsim nyog, kev tswj hwm ua ke nrog cov tshuaj tiv thaiv coagulants yuav tsum tau saib xyuas lub sijhawm prothrombin lossis INR. Hauv qhov no, nws yuav tsum tau kho cov koob tshuaj anticoagulants. Kev sib koom ua ke nrog "Rifampicin" tuaj yeem ua rau kev sib nrig sib tsis muaj zog ntawm cov tshuaj tua kab mob. Nws tsis pom zoo kom siv cov tshuaj ua ke nrog tetracyclines, macrolides thiab sulfonamides vim qhov yuav txo qis hauv nws cov txiaj ntsig. Amoxiclav cuam tshuam nrog lwm cov tshuaj li cas, koj tuaj yeem tshawb xyuas nrog koj tus kws kho mob.
Kev noj tshuaj ua rau txo qis ntawm kev noj cov tshuaj tiv thaiv qhov ncauj.
nqi tshuaj
Tus nqi ntawm cov tshuaj "Amoxiclav" hauv daim ntawv ntsiav tshuaj (875 mg / 125 mg) yog kwv yees li 400-440 rubles. Cov ntsiav tshuaj nrog ib koob tshuaj 500 mg / 125 mg nqi 330-400 rubles, ntawm ib koob ntawm 250 mg / 125 mg - 160-240 rubles. Hmoov rau kev tsim khoom ntawm kev ncua (koob tshuaj - 400 mg / 57 mg) yog muag ntawm tus nqi ntawm 160-270 rubles, koob tshuaj 250 mg / 62,5 mg - 210-300 rubles, koob 125 mg / 31, 25 mg - 100-120 rubles. Hmoov rau kev tsim cov tshuaj txhaj tshuaj ntawm ib koob tshuaj ntawm 1000 mg / 200 mg nqi ntawm 670-860 rubles, 500 mg / 100 mg - 460-490 rubles.
Analogues rau cov khoom tseem ceeb
Analogues ntawm cov tshuaj "Amoxiclav" yog:
- "Bactoclav";
- Klamosar;
- "Panklav";
- Arlette;
- "Medoclav";
- augmentin;
- "Liklav";
- Rapiclav;
- Ecoclave;
- Fibell;
- Amoxivan;
- Amovicomb.
Cov lus piv txwv saum toj no muaj cov yam ntxwv zoo ib yam thiab cov yam ntxwv, yog li lawv tuaj yeem siv rau tib yam kab mob raws li kev kho mob peb piav qhia.
Ib qho ntawm cov analogues nrov tshaj plaws yog "Augmentin". Nws yog ib qho tshuaj tua kab mob uas muaj ntau yam kev ua, nws kuj muaj amoxicillin thiab clavulanic acid. Nws inhibits ib tug loj tus naj npawb ntawm gram-positive thiab gram-negative microorganisms thiab muaj ib tug bactericidal nyhuv. Clavulanic acid, uas muaj nyob rau hauv cov tshuaj ntawm cov ntsiav tshuaj, tiv thaiv amoxicillin los ntawm kev puas tsuaj ntawm beta-lactamases uas tsim los ntawm cov kab mob, yog li pab txhawb rau kev nthuav dav ntawm cov tshuaj tua kab mob ntawm cov tshuaj..
Nws yog ua tsaug rau cov tshuaj no uas "Augmentin" tuaj yeem ua rau muaj kev phom sij rau cov kab mob uas tiv taus cov tshuaj penicillin thiab cephalosporins. Cov koob tshuaj yuav tsum tsuas yog txiav txim los ntawm tus kws kho mob, tshwj xeeb tshaj yog thaum nws los txog rau cov menyuam yaus.
Yam tsawg kawg nkauschav kawm ntawm kev kho tshuaj tua kab mob nrog cov tshuaj no yog tsib hnub. Kev kho mob yuav tsum tsis txhob txuas ntxiv rau ntau tshaj ob lub lis piam yam tsis muaj kev tshuaj xyuas ntawm qhov chaw kho mob. Txhawm rau kom nqus tau zoo thiab txo qis qhov tshwm sim ntawm kev phiv los ntawm txoj hnyuv, Augmentin tau pom zoo kom noj thaum pib noj mov.
Analogues los ntawm kev ua
Analogues ntawm cov tshuaj no raws li cov txheej txheem ntawm kev kho mob yog cov tshuaj hauv qab no:
- "Libakcil" yog tshuaj tua kab mob, uas suav nrog kev sib xyaw ua ke ntawm polysynthetic aminopenicillin - ampicillin thiab cov tshuaj uas inhibits beta-lactamase - sulbactam. Cov kab mob bactericidal ntawm lub ntsiab tseem ceeb yog vim kev khi rau cov kab mob transpeptidases koom nrog hauv kev sib txuas ntawm glycopeptides, cov txheej txheem ntawm cov kab mob ntawm cov phab ntsa. Ampicillin rhuav tshem beta-lactamases - cov enzymes tsim los ntawm cov kab mob, uas cuam tshuam qhov spectrum ntawm kev ua ntawm cov tshuaj no. Sulbactam los ntawm cov tshuaj muaj pes tsawg leeg yog derivative ntawm cov tub ntxhais penicillin. Nws tsis muaj cov haujlwm tseem ceeb hauv kev kho mob, tab sis inhibits beta-lactamases, yog li nws qhov muaj nyob hauv cov tshuaj muaj txiaj ntsig ua rau nws cov txiaj ntsig zoo.
- "Timentin" - lwm analogue ntawm cov tshuaj "Amoxiclav". Qhov no yog ib qho tshuaj sib xyaw ua ke raws li carboxypenicillin - sodium ticarcillin thiab potassium clavulanate nrog ntau qhov kev ua ub no rau kev kho mob parenteral ntawm ntau tus kab mob sib kis. Nws tuaj yeem siv rau hauv kev kho mob sepsis, septicemia, bacteremia, kab mob hauv plab, nrog rau peritonitis, postoperative.kab mob, gynecological pathologies, suav nrog endometritis, kis kab mob ntawm cov pob txha thiab pob qij txha, kab mob ua pa, raum, thiab lwm yam.
- Santaz yog tshuaj tua kab mob raws li piperacillin thiab tazobactam. Piperacillin yog ib tug semi-synthetic broad-spectrum bactericidal tshuaj uas yog active tiv thaiv ntau yam kab mob ntawm kis kab mob. Piperacillin inhibits lub synthesis ntawm cell membranes ntawm phab ntsa ntawm cov kab mob. Tazobactam yog ib qho derivative ntawm triazolmethylpenicillanic acid ntawm sulfonic series, muaj zog inhibitor ntawm beta-lactamase, provoking tsis kam rau cephalosporins thiab penicillins. Lub xub ntiag ntawm tazobactam nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj no txhim kho cov tshuaj tiv thaiv kab mob thiab nthuav ntau yam kev txiav txim ntawm piperacillin vim muaj cov kab mob uas ua rau beta-lactamase.
Tshuaj xyuas txog cov tshuaj "Amoxiclav"
Feem ntau, cov neeg mob thiab kws kho mob tawm tswv yim zoo txog cov tshuaj no. Cov kws kho mob nco ntsoov tias cov tshuaj no muaj txiaj ntsig zoo hauv kev kho mob ntawm pathologies ntawm lub ntsws, tso zis, lub cev xeeb tub, kab mob ntawm daim tawv nqaij, thiab lwm yam. Raws li kws kho mob, Amoxiclav yog ib qho tshuaj tua kab mob niaj hnub thiab zoo tshaj plaws uas tuaj yeem muab tshuaj rau yuav luag txhua yam kab mob.
Cov neeg mob uas tau siv cov tshuaj no qhia tias nws yog ib qho tshuaj pheej yig, pheej yig, siv tau zoo heev. Nws tuaj yeem siv tsis tau tsuas yog rau cov neeg laus, tab sis kuj rau cov menyuam yaus, thiab txij li thaum ntxov heev.
QeeKev tshuaj xyuas tsis zoo txog cov tshuaj yog vim muaj kev phiv los ntawm kev noj nws. Ntawm lawv, qhov tsis txaus ntawm cov hnyuv microflora feem ntau tau sau tseg, uas ua rau cov tsos mob tsis zoo nyob rau hauv daim ntawv ntawm xeev siab, kub hnyiab, thiab muaj roj ntau ntxiv. Qee tus neeg mob tsawg tau ntsib kev xeev siab luv. Kev ua txhaum ntawm kev ua haujlwm ntawm lub paj hlwb tsis tau piav qhia hauv kev tshuaj xyuas, yog li peb tuaj yeem txiav txim siab tias lawv tshwm sim tsis tshua muaj. Raws li txoj cai, cov kev phiv tshwm sim yog me me thiab tsis tas yuav tsum tau txiav cov tshuaj.
Cov menyuam yaus zam cov tshuaj "Amoxiclav" zoo, uas tseem tau lees paub los ntawm qhov loj ntawm kev tshuaj xyuas zoo. Nws feem ntau tau sau los ntawm kws kho menyuam yaus txawm tias muaj kab mob sib kis loj heev hauv cov menyuam mos.
