Non-steroidal anti-inflammatory tshuaj (NSAIDs) yog cov tshuaj uas tau sau tseg. Lawv yog siv nyob rau hauv kev kho mob ntawm ntau yam kab mob nrog mob los yog o. Cov tshuaj pleev raws li diclofenac yog ib qho ntawm cov neeg sawv cev ntawm NSAIDs. Lawv kho qhov mob thiab mob hauv zos, nrog me me kom tsis muaj lub cev nqus, txo cov kev mob tshwm sim.
YDiclofenac yog dab tsi?
Diclofenac yog sodium ntsev, ib qho derivative ntawm phenylacetic acid, tshuaj tsis-steroidal anti-inflammatory (NSAID lossis NSAID). Nws qhov txawv tshwj xeeb yog tias nws inhibits COX-2 - inducible cyclooxygenases (ua haujlwm hauv cov txheej txheem inflammatory) nrog kev ua haujlwm zoo dua li COX-1 (ua haujlwm tas li).
Txij li thaum muaj cov tshuaj - 1973 - ntau yam tshuaj uas muaj diclofenac tau tsim nyob rau hauv thiaj li yuav ncepharmacological kev ua tau zoo, tolerability thiab yooj yim ntawm kev siv. Thaum pib, thaum txhim kho, kev nyab xeeb thiab yooj yim ntawm kev siv tshuaj tau muab coj los rau hauv tus account kom ntau dua. Hauv cov tshuaj tshiab, qhov tseem ceeb ntawm kev nqus sai. Cov tsos mob ntawm cov gels, tshuaj pleev raws li diclofenac ua rau nws muaj peev xwm kho qhov mob thiab mob hauv zos, nrog tsawg kawg nkaus kev nqus ntawm cov tshuaj nquag.
Lub khw muag tshuaj muaj ntau yam kev npaj ntawm cov yas mos mos, uas suav nrog sodium ntsev, ib qho derivative ntawm phenylacetic acid. Lub npe ntawm cov tshuaj pleev raws li diclofenac tsis yog ib txwm muaj lub npe ntawm cov khoom xyaw tseem ceeb. Cov ntsiab lus siv yuav tsum yog cov ntawv sau npe hauv qab lub npe lag luam, nws qhia txog cov tshuaj nquag ntawm cov tshuaj.
tshuaj muaj txiaj ntsig
Raws li cov lus qhia, cov tshuaj pleev diclofenac muaj cov tshuaj tua kab mob (mob-relieving), los tiv thaiv kab mob. Lawv inhibit cyclooxygenase, raws li qhov tshwm sim ntawm cov synthesis ntawm prostaglandins, tus neeg kho mob, thromboxanes, thiab cov khoom uas ua rau cov ntshav siab, cuam tshuam. Qee cov tshuaj pleev nrog rau kev siv ntev ntev muaj cov nyhuv anti-allergic. Ua kom cov ntsiab lus ntawm cov ntaub so ntswg sib txuas, uas yog cov roj nplua nyeem hauv cov pob qij txha.
Diclofenac-raws li tshuaj pleev txo qhov mob thaum lub sijhawm ua haujlwm thiab so. Lawv txo cov tawv nqaij ntawm kev txav uas tshwm sim thaum sawv ntxov, txo qhov o ntawm cov pob qij txha, ua kom lub cev muaj zog. Nyob rau hauv o tshwm sim los ntawm kev raug mob los yog kev phais, txo qhov mob spontaneous, txo o ntawm qhov chaw.qhov txhab.
Cov tshuaj pleev nrog diclofenac ua cov tshuaj nquag muaj txiaj ntsig zoo tshaj hauv kev tiv thaiv kab mob rau cov tshuaj raws li butadione, ibuprofen, acetylsalicylic acid. Tom qab thov rau ntawm daim tawv nqaij, cov nyhuv analgesic ntawm ntau yam tshuaj pleev yog ua tiav tom qab 30-60 feeb thiab kav rau 3-5 teev.
Diclofenac-raws li tshuaj pleev: cov lus qhia rau kev siv
Yuav luag txhua NSAIDs yog cov tsos mob. Txawm hais tias kev kho mob sai sai thiab kav ntev, nws yuav rov qab mus txog thaum qhov ua rau raug txheeb xyuas thiab tshem tawm.
Kev siv cov tshuaj pleev diclofenac yog qhia rau cov kab mob hauv qab no:
- Mob nraub qaum nrog sciatica, lumbago, osteoarthritis, sciatica.
- mob ntawm qhov sib txawv hauv cov pob qij txha ntawm cov ntiv tes, hauv caug, lub duav, lub luj tshib thiab lwm yam.
- mob hauv cov leeg vim kev raug mob, kev tawm dag zog ntau dhau, bruises.
- mob tom qab phais thiab mob o vim kev phais hniav thiab orthopedic.
- Kab mob hauv cov ntaub so ntswg thiab pob qij txha nrog tendovaginitis, dab teg syndrome, bursitis, qhov txhab ntawm cov ntaub so ntswg nyob ib puag ncig kev sib koom tes.
- o thiab mob hauv pob qij txha thiab cov nqaij mos uas ua rau raug mob.
YContraindications
Hauv qee lub npe ntawm cov tshuaj pleev raws li diclofenac, cov chaw tsim khoom qhia tias lwm yam tshuaj muaj nyob rau hauv cov muaj pes tsawg leeg hauv siab concentration. Cov kws kho mob thiab cov kws muag tshuaj tam sim ntawd txiav txim siab leej twgKev kho mob yog contraindicated. Tab sis lub npe lag luam tuaj yeem yuav los ntawm lwm lub chaw tsim khoom, uas muaj txoj cai los kho qhov concentration ntawm cov khoom xyaw, yog li koj yuav tsum nyeem cov lus qhia ua ntej siv.
Diclofenac-based tshuaj pleev yog contraindicated rau cov neeg uas muaj cov kab mob hauv qab no:
- Kev tsis haum rau cov tshuaj uas tsim cov tshuaj.
- YPeptic ulcer ntawm lub plab thiab duodenum.
- Asthma of allergic origin.
- mob ntawm qhov ntswg mucosa (rhinitis).
- Lub peb hlis ntuj kawg ntawm cev xeeb tub.
- Abrasions, khawb, qhov txhab ntawm qhov chaw thov.
txwv hnub nyoog rau cov tshuaj pleev sib txawv. Kev siv thaum yau yog ua tau zoo tshaj plaws raws li kws kho mob qhia.
Tsis muaj ntaub ntawv hais txog kev nkag mus ntawm cov tshuaj rau hauv cov kua mis, yog li nws yog qhov zoo dua kom tsis txhob siv cov tshuaj pleev thaum lactation. Txawm li cas los xij, yog tias muaj qhov yuav tsum tau siv tshuaj sai sai, ces nws yuav tsum tau ua tib zoo thov, sim tsis txhob nkag mus rau hauv cov qog mammary.
npe tshuaj pleev diclofenac
Hauv khw muag tshuaj koj tuaj yeem yuav tshuaj tsis yog los ntawm cov tuam txhab Lavxias nkaus xwb. NSAIDs los ntawm pawg phenylacetic acid yog cov kws tshaj lij tshaj plaws. Feem ntau ntawm lawv yog muag yam tsis muaj tshuaj. Cov ntaub ntawv mos ntawm cov tshuaj raws li diclofenac yog tsim nyob rau hauv daim ntawv ntawm cov tshuaj pleev thiab gels. Qhov txawv ntawm qhov tom kawg yog tias lawv muaj qhov sib xws ntau dua thiab muaj elasticity thiab plasticity. Nyob ntawmkev ua tau zoo ntawm tshuaj tsis cuam tshuam tshwj xeeb los ntawm cov yam ntxwv zoo li no.
Txheej txheem cej luam ntawm diclofenac tshuaj pleev:
- "Ortofen" - tshuaj pleev 5% Lavxias teb sab ntau lawm.
- Y "Diclofenac-Akrikhin". Cov tshuaj muaj pes tsawg leeg (1%) suav nrog diclofenac sodium, dimexide, macrogol, propylene glycol.
- Y "Diclofenac-MFF". Rau cov menyuam yaus hnub nyoog 6 txog 12 xyoos, cov tshuaj pleev yog siv tsis pub ntau tshaj ob zaug hauv ib hnub.
- "Diklak Lipogel". Gel muaj pes tsawg leeg: diclofenac, tocopherol, lecithin, carbomer. Cov khoom raug pom zoo siv txij li hnub nyoog 12.
- "Dicloran plus" - 1% gel ua nyob rau hauv Russia thiab Is Nrias teb. Ntxiv rau diclofenac, muaj pes tsawg leeg ntawm cov khoom muaj xws li flax noob roj, levomycetin, methyl salicylate.
- "Diclogen" - gel nrog cov ntxhiab tsw ntawm lavender. Cov khoom xyaw muaj xws li diclofenac diethylamine, sodium sulfite, propylene glycol, benzine cawv, trolamine, lavender roj. Tawm los ntawm ob lub raum, cov neeg mob uas muaj porphyria yuav tsum siv cov gel raws li kev saib xyuas kev kho mob.
- "Voltaren Emulgel" - gel 2%. Pom zoo siv los ntawm 12 xyoo. Ntxiv rau diclofenac, muaj pes tsawg leeg ntawm cov khoom muaj xws li carbomers, cetostearomacrogol, cocoylcaprylocaprate, diethylamine.
- "Diklak - gel 5% nrog cov ntxhiab tsw tshwj xeeb.
- "Ortofer - tshuaj pleev (2%). Cov dej-cawv hauv paus ntawm cov khoom muaj cov tshuaj loog me ntsis hauv zos.
Cov lus qhia dav dav rau kev siv
Txhua cov tshuaj pleev diclofenac (cov duab tau nthuav tawm hauv tsab xov xwm) tau nqus tau zoo los ntawm qhov hws ntawm daim tawv nqaij hauv 3-5 feeb. Nkag mus rau hauv cov kua dej uas ua rau cov kab noj hniav ntawm cov pob qij txha (synovium), uas lawv khaws cia rau hauvtas li concentration rau 4-6 teev. Yog li ntawd, nws yog tsim nyog los thov cov tshuaj pleev ib ce nyob rau hauv ib tug nyias txheej ntawm qhov chaw mob tsis muaj ntau tshaj li 3-4 zaug ib hnub twg. Lub sijhawm ntawm kev kho tus kheej yuav tsum tsis pub tshaj 10 hnub. Qhov ua tau thiab kev nyab xeeb ntawm kev siv mus ntev yuav tsum tau tham nrog tus kws kho mob.
Diclofenac los ntawm nws cov tshuaj muaj pes tsawg leeg yog cov kua qaub uas ua rau cov mucous membranes thiab muag heev ntawm daim tawv nqaij. Yog hais tias lub hom phiaj ntawm qhov mob yog, piv txwv li, ntawm lub ntsej muag, cov tshuaj pleev yuav tsum tau ua tib zoo thov kom tsis txhob nkag mus rau hauv lub qhov muag. Ntxuav koj ob txhais tes tom qab tus txheej txheem.
Thaum lub sijhawm kho, koj yuav tsum tau saib xyuas cov tshuaj pleev uas siv, nws cov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 8 g. Kev siv tsis tswj yuav ua rau muaj qhov tshwm sim tsis zoo ntawm daim tawv nqaij pob.
Side effects
Kev siv cov tshuaj pleev diclofenac yog txuam nrog kev pheej hmoo ntawm kev tsis zoo. Cov tshuaj muaj bioavailability siab (txog 98%), tsis ua raws li cov lus pom zoo hauv cov lus qhia ua rau muaj kev nce hauv cov ntsiab lus ntawm cov tshuaj nquag hauv cov ntshav. Thaum muaj kev nce ntxiv, diclofenac pib muaj tshuaj lom, uas tau qhia hauv cov tsos mob hauv qab no:
- Daim tawv nqaij. Ib qho erythematous (ci liab) thiab urticarial (me me papules) ua pob liab vog tshwm rau ntawm daim tawv nqaij, kev xav ntawm khaus, tingling. Tsawg feem ntau muaj qhov o hauv zos ntawm cov mucous daim nyias nyias, cov ntaub so ntswg subcutaneous, mob hnyav, khaus khaus, eczema, nce rhiab heev rau ultraviolet hluav taws xob.
- Digestive system. Paroxysmalmob hauv plab thiab pelvis, ntuav, raws plab, tsam plab. Muaj tsawg zaus, cov kab mob ntawm lub plab, kev puas tsuaj ntawm hepatocytes nyob rau hauv kev cuam tshuam ntawm diclofenac (kev mob siab mob siab).
- Nervous system. Mob hauv lub taub hau, nrawm thiab nce qaug zog, pw tsaug zog cuam tshuam txog nws qhov poob, psychasthenia, saj cuam tshuam.
- Sense organs. Pom pom ob lub qhov muag, txo qhov pom kev pom, tsis pom kev peripheral, tinnitus.
- Kev tso zis. Kev puas tsuaj rau lub glomerular apparatus ntawm ob lub raum, nce protein ntau hauv cov zis.
- Circulatory system. Txo cov qib ntawm platelets, hemoglobin, leukocytes hauv cov ntshav.
- Cov kab mob plawv. Mob hauv siab, nce ntshav siab, palpitations.
Kev sib cuam tshuam ntawm diclofenac nrog lwm cov tshuaj
Diclofenac yog concentrated tsis tsuas yog nyob rau hauv cov ntshav, tab sis kuj nyob rau hauv cov ntaub so ntswg o, qhov uas tsis muaj acidity txo protein synthesis. Qhov no ua rau muaj kev nce hauv cov tshuaj pharmacological ntawm cov tshuaj thiab pab txhawb kev nkag mus rau hauv qhov chaw extracellular. Cov lus qhia rau kev siv cov tshuaj pleev diclofenac qhia tau hais tias kev siv tib lub sijhawm ntawm lwm cov NSAIDs txhim kho nws cov txiaj ntsig kho.
Kev siv cov tshuaj potassium-sparing diuretics (Triamterin, Amiloride) thiab NSAIDs ua rau muaj kev pheej hmoo ntawm kev nce qib ntawm cov poov tshuaj hauv cov ntshav.
Diclofenac tshuaj pleev txo cov nyhuv diuretic ntawm lub voj diuretics (Furosemide, Britomar, Ethacrynic acid).
Siv cov tshuaj pleev ib txhij thiab lwm cov ntawv siv tshuajKev npaj muaj diclofenac, nce qib ntawm lithium thiab digoxin hauv cov ntshav plasma. Kev siv cov diclofenac thiab cov tshuaj tiv thaiv coagulants (Coumarin, Indandion, Heparin) tuaj yeem ua rau los ntshav.
lwm yam
NSAIDs suav nrog ntau tus txhais tau tias sib txawv. Tag nrho cov ntawm lawv muaj ib tug pharmacological kev txiav txim - anti-inflammatory, analgesic, antipyretic. Dhau li diclofenac, feem ntau yog acetylsalicylic acid thiab ibuprofen. Cov tom kawg muaj kev phiv tsawg dua piv rau lwm cov NSAIDs, nws tseem tso cai rau cov menyuam yaus hnub nyoog qis dua ib xyoos thiab cov poj niam cev xeeb tub.
Ibuprofen belongs rau pawg ntawm propionic acid derivatives. Nws, zoo li diclofenac, tau teev nyob rau hauv daim ntawv teev cov tshuaj tseem ceeb. Cov tshuaj pleev raws li ibuprofen tau dav siv. Lawv raug sau rau kev kho mob ntawm degenerative thiab inflammatory kab mob ntawm musculoskeletal system, mob syndrome tshwm sim los ntawm pathologies, sprains ntawm ligamentous apparatus, raug mob, thiab kev phais.
Review of ibuprofen gels
Hmoov tsis zoo, vim muaj ntau cov contraindications, nws tsis yog ib txwm ua tau los kho mob thiab mob nrog diclofenac-raws li tshuaj pleev. Analogues hauv cov xwm txheej zoo li no tuaj yeem txhais tau tias nrog ibuprofen. Lawv kuj tau zoo thiab sai sai txo qhov mob thiab tshem tawm qhov mob thiab yog tus nqi tib yam.
Daim npe ntawm cov tshuaj pleev ibuprofen feem ntau:
- "Ibuprofen gel" - gel rau n / a 5%,muaj nyob rau hauv cov raj ntawm 20, 30, 50 thiab 100 g. Cov khoom xyaw muaj xws li ibuprofen, propylene glycol, dimexide, triethanolamine, neroli thiab lavender roj. Siv cov tshuaj pleev rau qhov mob tsis pub ntau tshaj 4 zaug hauv ib hnub. Lub sijhawm kho yuav tsum tsis pub tshaj peb lub lis piam.
- "Nurofen Express" - gel rau n / a 5%. Thaum ua ntawv thov, cov khoom muaj qhov ua kom txias, uas ua rau kom mob sai sai. Cov nyhuv no yog tsim los ntawm benzyl cawv muaj nyob rau hauv gel. Cov tshuaj yog contraindicated rau cov poj niam cev xeeb tub thiab cov menyuam yaus hnub nyoog qis dua 14 xyoos. Lub sij hawm ntawm cov tsos mob yuav tsum tsis pub tshaj 2 lub lis piam.
- "Long". Cov cuab yeej muaj nyob rau hauv daim ntawv ntawm gel thiab cream. Cov tom kawg, ntxiv rau cov tshuaj loog thiab tshuaj loog, kuj muaj cov nyhuv decongestant. Cov gel tuaj yeem siv los ntawm hnub nyoog 12 xyoos, thiab cov tshuaj pleev los ntawm hnub nyoog 14.
Reviews
NSAIDs pab txo qhov mob. Cov tshuaj no yog cov nyiam tshaj plaws. Qhov teeb meem nkaus xwb yog kev xaiv ntau dhau, vim tias nws nyuaj rau kev txiav txim siab. Peb tshuaj xyuas cov tshuaj pleev raws li diclofenac thiab analogues yuav pab kom nkag siab txog kev xaiv me ntsis.
Cov neeg muaj kab mob ntev ntawm cov kab mob musculoskeletal, nrog rau cov neeg ncaws pob, hais tias cov tshuaj no ib txwm nyob hauv lawv cov khoom pab thawj zaug. Cov tshuaj pleev niaj hnub no tau nqus sai sai, xyaum tsis txhob tso cov cim ntawm cov khaub ncaws thiab yeej ib txwm siv tau.
Cov niam txiv ntawm cov menyuam kawm ntawv thov tias cov khoom siv diclofenac yog qhov pom tiag. Ntxiv mus, tsis zoo li lwm tus, lawv ua tau zoo sib npaug nrog cov nqaij ntshiv tshiab thiab pob txha, thiab nrog cov laus.
