Diccycloverine hydrochloride belongs rau qeb ntawm antispasmodics uas tuaj yeem thaiv muscarinic receptors. Nws kuj muaj cov nyhuv anticholinergic, muaj cov nyhuv so ntawm cov leeg nqaij. Vim li no, cov tshuaj nrog nws nyob rau hauv muaj pes tsawg leeg zoo txo lub raum, plab hnyuv thiab biliary colic, txo qhov mob thaum lub sij hawm cev xeeb tub, yog siv nyob rau hauv kev loj hlob ntawm spastic cem quav, pylorospasm thiab chim siab plob tsis so tswj syndrome.
tshuaj muaj txiaj ntsig ntawm cov tshuaj no
Y Diccycloverine hydrochloride muaj anticholinergic, myotropic, antispasmodic teebmeem. Nws tshem tawm spasms ntawm cov nqaij ntshiv ntawm lub plab zom mov thiab txo qhov mob syndrome los ntawm lawv. Hauv kev tshawb fawb tshawb fawb txog tsiaj txhu (hauvkev tshawb fawb vitro siv cov kab mob guinea-npua cais) qhia tau hais tias qhov ua tau zoo ntawm cov tshuaj yog kho los ntawm ob lub tswv yim:
- tshwj xeeb anticholinergic nyhuv ntawm acetylcholine receptors, zoo ib yam li cov nyhuv ntawm atropine (lwm yam - kev ua haujlwm antimuscarinic);
- ncaj qha cuam tshuam rau cov leeg nqaij du, raws li pov thawj los ntawm lub peev xwm ntawm cov khoom tseem ceeb los thaiv histamine- thiab bradykinin-induced spasms (atropine tsis hloov cov lus teb rau cov agonists).
Hauv kev sim vivo hauv miv thiab dev, dicycloverine yog kwv yees li sib npaug ntawm cov tshuaj barium chloride thiab acetylcholine-induced plab hnyuv spasms. Qhov tsis muaj qhov cuam tshuam tseem ceeb ntawm dicycloverine rau cov menyuam kawm ntawv kuj tau tshwm sim (hauv kev ntsuam xyuas rau kev soj ntsuam cov nyhuv mydriatic hauv cov nas, qhov kev ua haujlwm yog kwv yees li 1/500 ntawm cov haujlwm ntawm atropine), ntawm kev ua haujlwm ntawm cov qog qaub ncaug (hauv kev ntsuam xyuas ntawm luav., 1/300 ntawm qhov kev ua ntawm atropine tau tshwm sim).
Cov ntaub ntawv ntawm qhov muaj peev xwm mutagenicity thiab carcinogenicity ntawm cov khoom tseem ceeb dicycloverine hydrochloride tsis muaj. Kev tshawb fawb tsiaj mus sij hawm ntev los ntsuas cov kab mob carcinogenic tsis tau ua. Hauv kev tshawb fawb ntawm nas, thaum noj tshuaj txog li 100 mg / kg, cov tshuaj tsis cuam tshuam rau kev xeeb tub thiab kev yug me nyuam.
YPharmacokinetics
Diccycloverine hydrochloride yog nqus tau zoo, yooj yim dua thiab sai dua tom qab txhaj tshuaj intramuscular (tom qab 10 feeb) dua tom qab noj qhov ncauj (tom qab 60 feeb). Kwv yees lub sijhawmKev tshem tawm ib nrab ntawm lub neej yog 1.8 teev. Tso tawm tom qab 10 teev nrog cov zis (kwv yees li 85%) thiab hauv me me nrog quav.
Kev sib xyaw thiab kev tso tawm ntawm cov tshuaj no
Raws li cov lus qhia qhia, dicycloverine hydrochloride yog tsim nyob rau hauv daim ntawv ntawm cov hmoov dawb crystalline hmoov, tsw thiab saj tsis qab. Cov khoom yog yooj yim soluble nyob rau hauv dej, chloroform, ethanol, me ntsis soluble nyob rau hauv ether. Qhov hnyav molecular ntawm cov tshuaj yog 345.97. Nws tsis yog tsim los ua cov tshuaj ywj pheej, tab sis suav nrog cov tshuaj xws li Trigan, Dolospa thiab lwm yam.
Tsis yog txhua tus paub tias qhov no yog dicycloverine hydrochloride.
Qhia tshuaj rau tshuaj raws li cov tshuaj no
Cov npe ntawm cov lus qhia tseem ceeb rau kev siv cov tshuaj no suav nrog:
- spasms ntawm cov leeg du ntawm cov kab mob hauv nruab nrog cev;
- mob siab, plab hnyuv thiab lub raum colic;
- hniav, mob taub hau, mob migraine;
- algodysmenorrhea;
- myalgia;
- neuralgia;
- kab mob sib kis nrog cov tsos mob ua npaws.
YContraindications
Txawm hais tias muaj kev siv ntau yam tshuaj uas muaj dicycloverine hydrochloride, ua ntej noj, koj yuav tsum tau nyeem cov lus qhia, uas sau cov npe ntawm cov contraindications. Cov no suav nrog cov kab mob hauv qab no:
- kev nyuaj siab;
- ulcerative colitis hauv cov ntaub ntawv hnyav(thaum siv ntau npaum li cas, theem ntawm txoj hnyuv motility yuav txo qis, mus txog rau qhov tsim ntawm paralytic ileus; kev siv cov tshuaj yuav ua rau muaj kev loj hlob los yog exacerbation ntawm xws li ib tug txaus ntshai teeb meem xws li tshuaj lom megacolon);
- obstructive pathologies ntawm lub plab zom mov, tso zis thiab kab mob siab;
- peptic ulcer;
- reflux esophagitis;
- tsis ruaj khov ntawm lub xeev ntawm cov hlab plawv;
- xiav;
- glaucoma thiab lwm yam qhov muag pathologies;
- myasthenia gravis;
- qis dua 6 lub hlis.
Nrog kev ceev faj thiab nyob rau hauv kev saib xyuas ntawm tus kws kho mob tshwj xeeb, cov tshuaj uas muaj dicycloverine hydrochloride yuav tsum tau siv rau cov neeg mob uas muaj lub siab tsis zoo lossis lub raum ua haujlwm, nrog kev kho nrog lwm cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob, nrog rau cov tshuaj tiv thaiv kab mob thiab cov tshuaj uas muaj cov tshuaj tiv thaiv kab mob. ncaj qha cuam tshuam rau hauv nruab nrab paj hlwb. Koj yuav tsum tau mus ntsib koj tus kws kho mob yog tias koj noj domperidone, metoclopramide, lossis cholestyramine.
Kev piav qhia ntxaws ntawm dicycloverine hydrochloride hauv cov lus qhia tau muab.
Txoj kev siv thiab ntau npaum li cas
Tshuaj raws li cov tshuaj no tau muab rau cov neeg laus thiab menyuam yaus hnub nyoog qis dua 15 xyoos, 1 ntsiav tshuaj tsis pub ntau tshaj 3 zaug hauv ib hnub. Qhov siab tshaj plaws ib koob tshuaj yog 2 ntsiav tshuaj, ib hnub twg - 4 ntsiav tshuaj. Duration ntawm kev txais neeg kawm yam tsis tau sab laj nrog ib tug kws kho mob tshwj xeeb - tsis pub ntau tshaj peb hnub thaum cov tshuaj nyob rau hauv daim ntawv ntawm ib tug tshuaj loogtshuaj thiab ob hnub - nyob rau hauv daim ntawv ntawm cov tshuaj antipyretic. Nrog rau kev siv lub sijhawm ntev ntawm cov tshuaj npaj tshuaj, nws yog ib qho tsim nyog los saib xyuas cov duab ntawm cov ntshav peripheral thiab lub siab ua haujlwm ntawm lub siab.
Nws tsis pom zoo kom tshaj qhov noj txhua hnub. Nws nce lossis siv ntev dua tsuas yog ua tau raws li kev saib xyuas ntawm tus kws kho mob, vim tias kev noj ntau dhau ntawm cov khoom tseem ceeb tuaj yeem ua rau daim siab tsis ua haujlwm.
Cov teebmeem ntawm cov tshuaj
Kev npaj muaj dicycloverine hydrochloride tuaj yeem ua rau qee qhov kev phiv tshuaj, uas, txawm li cas los xij, tsis tas yuav sau tseg thaum siv tshuaj. Qee tus ntawm lawv yuav tshwm sim tsawg heev, tab sis lawv muaj qhov tshwm sim loj heev. Nyob rau hauv cov ntaub ntawv ntawm nrhiav tau ntawm xws li tshwm sim, tshwj xeeb tshaj yog rau lub sij hawm ntev, yuav tsum tau ceev mus ntsib kws kho mob.
Dicycloverine hydrochloride tuaj yeem ua rau muaj qhov tsis zoo hauv qab no:
- dry mouth;
- qhov muag tsis pom kev;
- kiv taub hau;
- nausea;
- nce pw tsaug zog;
- kev qaug zog;
- quav quav (cem quav);
- tseem tsis meej;
- anorexia;
- nce intraocular siab;
- siab lub plawv dhia;
- kev tsis haum;
- txoov hws.
Ntau dhau ntawm dicycloverine hydrochloride
Yog siv tshuajLub hauv paus ntawm cov tshuaj nquag no rau lub sijhawm ntev lossis nrog kev nce ntxiv hauv cov tshuaj pom zoo, kev siv tshuaj ntau dhau tuaj yeem tshwm sim. Cov tsos mob no suav nrog:
- mob taub hau;
- ntuav, xeev siab;
- nrawm qhov muag tsis pom kev, nthuav dav cov menyuam kawm ntawv;
- fever, tawv nqaij qhuav;
- kiv taub hau;
- nyuaj nqos;
- dry mouth;
- txhawb nqa ntawm lub hauv paus paj hlwb.
Ntxiv rau, cov txiaj ntsig curariform tuaj yeem ua tau (ib qho thaiv kab mob neuromuscular uas ua rau muaj kev loj hlob ntawm cov leeg tsis muaj zog thiab ua rau qee kis mus rau tuag tes tuag taw).
Kev kho mob ntawm tus kab mob no muaj nyob rau hauv kev ua kom ntuav, plab hnyuv, noj activated charcoal lossis lwm yam enterosorbents. Txhawm rau tshem tawm kev ntxhov siab ntau dhau, cov tshuaj uas muaj cov nyhuv sedative (benzodiazepines, luv-acting barbiturates) yog siv. Cov tshuaj cholinergic tsim nyog yuav raug siv thaum qhia tias yog tshuaj tua kab mob.
Kev Sib Tham Tshuaj
Cov teebmeem tseem ceeb ntawm dicycloverine, suav nrog cov kev mob tshwm sim, tuaj yeem txhim kho cov txiaj ntsig ntawm cov tshuaj nrog cov tshuaj anticholinergic: antiarrhythmics ntawm pab pawg I (piv txwv li, quinidine), antihistamine pharmacological agents, tshuaj antipsychotic (piv txwv li, phenothiazine), tshuaj. uas inhibit monoamine oxidase, benzodiazepines, narcotic analgesics, nitrites thiab nitrates, tricyclic antidepressants, sympathomimetic tshuaj. Cov tshuaj Anticholinergic tuaj yeem tiv thaiv cov nyhuv antiglaucomacov tshuaj kho mob. Nrog rau kev nce siab hauv lub cev, cov tshuaj anticholinergic tuaj yeem ua rau muaj kev phom sij thaum siv nrog corticosteroids.
Cov tshuaj Anticholinergic tuaj yeem cuam tshuam nrog kev nqus ntawm digoxin hauv plab hnyuv thiab, vim li ntawd, nce qhov concentration ntawm cov tshuaj no hauv cov ntshav. Cov tshuaj Anticholinergic tuaj yeem cuam tshuam cov nyhuv ntawm cov tshuaj uas hloov cov motility ntawm lub plab zom mov (metoclopramide). Cov tshuaj antacids hauv qee kis tuaj yeem cuam tshuam rau kev nqus ntawm cov tshuaj anticholinergics, yog li lawv siv ua ke yuav tsum zam. Qhov inhibition ntawm hydrochloric acid ntau lawm los ntawm cov tshuaj anticholinergic counteracts cov nyhuv ntawm cov tshuaj siv nyob rau hauv kev ntsuam xyuas gastric secretion los yog kho achlorhydria.
Qhov no lees paub cov lus qhia siv rau dicycloverine hydrochloride.
Special Recommendations
Thaum siv cov tshuaj no, nws raug nquahu kom tsis txhob muaj kev phom sij ntawm cov kws tshaj lij thiab lwm yam haujlwm uas yuav tsum tau ua kom muaj zog ntxiv thiab nrawm ntawm kev puas siab puas ntsws thiab lub cev muaj zog.
Nrog rau kev kho mob ntev, nws yuav tsum tau saib xyuas cov khoom ntawm cov ntshav peripheral thiab kev ua haujlwm ntawm lub siab.
Cov ntsiav tshuaj twg muaj dicycloverine hydrochloride?
Tshuaj thiab lawv cov analogues
Cov tshuaj no muaj nyob rau hauv cov khoom tseem ceeb hauv qab noKev npaj tshuaj pharmacological:
- "Trigan";
- "Dolopa"
Cov tshuaj no muaj ib yam zoo sib xws. Kuj tseem muaj qee qhov analogues uas zoo sib xws tsuas yog hauv kev kho mob. Lawv cov npe suav nrog:
- "No-shpa";
- "Drotaverine";
- "Baralgin";
- Spazgan;
- "Ketanov";
- "Pentalgin";
- "Tempalgin";
- Caffetin;
- Avisan;
- "Bendazol";
- "Altaleks";
- "Dibazol";
- "Driptan";
- Galidor;
- "Duspatalin";
- Librax;
- "Dicetel";
- "Kellin";
- Niaspam;
- Novitropan;
- "Papaverine";
- "Platifillin";
- Spasmol;
- Spazmonet;
- "Spasmocystenal";
- "Cistenal";
- Enablex.
Analogues rau dicycloverine hydrochloride yuav tsum raug xaiv los ntawm kws kho mob.
Nws yog ib qho tsim nyog yuav tsum tau siv cov tshuaj yooj yim lossis hloov nrog cov tshuaj analogues, suav nrog cov xwm txheej ntawm tus kab mob thiab tau nyeem yav dhau los cov npe ntawm contraindications.
Peb saib nws yog dab tsi - dicycloverine hydrochloride.
