HIV hnub no tsis yog kab lus. Cov neeg mob tuaj yeem nyob kaj siab lug nrog tus kab mob no, ua haujlwm, pib tsev neeg. Txhua yam uas yuav tsum tau ua yog yuav tsum tau kho tsis tu ncua nrog tshuaj tua kab mob tshuaj tua kab mob. Tag nrho cov tshuaj no tau muab faib ua peb pawg: HIV protease inhibitors, nucleoside thiab non-nucleoside HIV reverse transcriptase inhibitors.
Nws tsim nyog nco ntsoov tias cov tshuaj tiv thaiv kab mob tsis tuaj yeem kho AIDS tag nrho. Kuj tsis muaj txoj hauv kev los tiv thaiv koj tus kheej los ntawm kev kis kab mob. Cov tshuaj tsuas yog tiv thaiv kev tsim tawm ntawm tus kab mob, pab txhim kho tus neeg mob tus mob. Cov tshuaj tiv thaiv kab mob uas thov tshaj plaws yuav raug piav qhia hauv qab no.
Lamivudine
Tus neeg sawv cev yog rau pawg ntawm nucleoside inhibitors ntawm HIV rov qab transcriptase. Cov tshuaj tua kab mob nkag mus rau hauv cov hlwb thiab metabolized nyob rau ntawd, yog li ua rau inhibition ntawm tus kab mob replication. Txoj kev kho rau tus kab mob HIV siv cov tshuaj "Lamivudine" qhia tau hais tias ua tau zoo. Tus neeg sawv cev kuj tseem ua haujlwm tawm tsam tus kab mob siab B, cov tshuaj no sai sai nqus los ntawm txoj hnyuv. Hauv ib teev tom qab noj cov tshuaj, plasma bioavailability nce mus txog 80%. Kev sib txuas lus nrog plasma proteins yog 30%. Tus nqicoj mus rau hauv tus account tias cov khoom xyaw nquag nkag tau yooj yim nkag mus rau hauv placental barrier.
Lamivudine yog siv los kho HIV rau cov neeg laus thiab menyuam yaus. Feem ntau, cov tshuaj yog siv los ua ib feem ntawm txoj kev kho mob nyuaj (lwm cov tshuaj tiv thaiv kab mob kuj tau siv los kho HIV). Tsis tas li ntawd, cov tshuaj tuaj yeem raug sau rau cov kab mob siab B ntev ntev. Cov tshuaj tsis yog contraindicated thaum cev xeeb tub thiab lactation. Cov cuab yeej siv tau los kho cov menyuam mos. Nws tsim nyog txwv tsis pub siv tshuaj tsuas yog tias muaj qhov tsis haum rau cov khoom tshwm sim.
Kev Sib Tham Tshuaj
Kev txais tos sib koom ntawm cov nyiaj "Lamivudine" thiab "Zimavudin" yog ua tau. Hauv qhov no, nws yuav tsum raug coj mus rau hauv tus account tias bioavailability ntawm cov tshuaj yuav txo qis. Nws tsis pom zoo kom siv ib txhij siv cov tshuaj uas muaj didanosine lossis sulfanilamine hauv lawv cov muaj pes tsawg leeg. Kev tsis saib xyuas cov lus pom zoo no tuaj yeem ua rau mob pancreatitis. Qhov tseem ceeb nce qhov concentration ntawm cov tshuaj nquag - lamivudine - hauv cov ntshav ntawm cov tshuaj "Trimethoprim"
Kev kho mob tsuas yog ua raws li kws kho mob qhia. Nws yuav tsis muaj peev xwm yuav Lamivudine ntawm lub tsev muag tshuaj yam tsis muaj tshuaj. Tus nqi ntawm cov tshuaj yog 3500 rubles. Cov koob tshuaj thiab kev kho mob yog teem los ntawm tus kws kho mob tshwj xeeb, raws li tus neeg mob tus yam ntxwv ntawm tus neeg mob lub cev, nrog rau daim ntawv ntawm tus kab mob.
Cov tshuaj yuav tsum tau siv ceev faj thaum ua txhaum lub raum ua haujlwm. Cov tshuaj yuav raug sau tsegtus kws kho mob tshwj xeeb hauv kev noj tshuaj tsawg kawg yog CC tsawg dua 50 ml / min. Thaum txhim kho txoj kev kho mob, tus kws kho mob yuav tsum coj mus rau hauv tus account tias cov khoom xyaw nquag yog tawm los ntawm ob lub raum. Cov neeg uas muaj lub siab tsis ua haujlwm tsis tas yuav tsum tau hloov cov tshuaj. Nrog rau qhov tshwm sim ntawm cov tsos mob txaus ntshai xws li mob plab, xeev siab, ntuav, cov tshuaj "Lamivudine" yuav tsum tau muab tso tseg. Tus kws kho mob tshwj xeeb tshuaj xyuas tus neeg mob. Kev kho mob tsuas tuaj yeem rov pib dua thaum kuaj pom tus mob pancreatitis tau raug txiav tawm.
Ib qho cuab yeej zoo hauv kev kho tus kab mob HIV yog Lamivudine. Tus nqi ntawm cov tshuaj yog qhov tsawg. Nws tsim nyog nco ntsoov tias tsis muaj tshuaj tiv thaiv kab mob los ntawm kev sib deev los yog kev sib deev. Cov tshuaj tsis tuaj yeem siv los ua kev tiv thaiv kab mob.
Didanosine
Ib tshuaj tiv thaiv kab mob muaj zog tiv thaiv HIV. Cov kws tshaj lij feem ntau siv cov cuab yeej "Didanosine". Cov lus qhia piav qhia txog cov txheej txheem ntawm kev thov, kev qhia thiab ntau npaum li cas. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, chewable ntsiav tshuaj, tsiav tshuaj. Lawv kuj tuaj yeem siv los npaj kev ncua. Cov khoom xyaw nquag yog didanosine. Tsis tas li ntawd, cov tshuaj xws li aspartame, magnesium hydroxide, titanium dioxide, sorbitol, calcium carbonate, magnesium stearate thiab tangerine tsw. Cov khoom muaj nyob rau hauv ntau npaum ntawm 100, 125, 200 thiab 400 mg.
Didanosine yog ib qho hluavtaws analog ntawm nucleoside dioxyadenosine uas inhibits HIV teb hauv cov hlwb ntawm lub cev. Lub bioavailability ntawm cov khoom xyaw nquag mus txog 60% dhau losteev tom qab noj cov tshuaj sab hauv. Cov tshuaj yuav zoo dua yog tias siv ib teev ua ntej noj mov lossis 2 teev tom qab noj mov. Kev siv ua ke nrog cov khoom noj khoom haus ua rau txo qis hauv bioavailability ntawm cov khoom xyaw nquag los ntawm 50%. Cov tshuaj yog tawm los ntawm lub siab thiab lub raum. Didanosine metabolism yog cuam tshuam ncaj qha rau qib ntawm lub raum tsis zoo.
Cov tshuaj tsuas yog siv tau ua ke nrog lwm cov tshuaj tiv thaiv kab mob rau kev kho tus kab mob HIV. Cov tshuaj raug tso cai muab rau cov poj niam thaum lub sij hawm cev xeeb tub thiab lactation. Cov tshuaj "Didanosine" tsis yog contraindicated rau cov me nyuam. Cov tshuaj tsis yog tshuaj rau cov menyuam yaus hnub nyoog qis dua peb xyoos xwb. Nws yog ib qho tsim nyog yuav tsum tshem tawm cov tshuaj yog tias muaj kev nkag siab ntau ntxiv rau cov khoom tseem ceeb. Cov neeg uas muaj lub siab ua haujlwm tsis zoo yuav tsum siv cov tshuaj kom ceev faj.
Yuav noj tshuaj li cas?
Cov koob tshuaj yog teem los ntawm tus kws kho mob nyob ntawm qhov mob hnyav ntawm tus kab mob, nrog rau tus yam ntxwv ntawm tus neeg mob lub cev. Kev kho mob antiretroviral tuaj yeem ua tau raws li cov lus pom zoo tau teev tseg hauv cov lus qhia. Tus nqi txhua hnub nyob ntawm lub cev hnyav. Cov neeg uas hnyav dua 60 kg yuav tsum noj tsis pub ntau tshaj 250 mg ib hnub twg. Rau cov neeg mob hnyav dua 60 kg, qhov koob tshuaj tuaj yeem ncav cuag 400 mg. Capsules yog noj ib zaug ib hnub. Lawv tsis tuaj yeem zom tau. Koj yuav tsum haus dej kom ntau. Nws raug nquahu kom ua kev kho thaum sawv ntxov, ntawm lub plab khoob.
Pills kuj siv tau rauKev npaj kev ncua. Txhua yam koj yuav tau ua yog dilute cov khoom nrog me ntsis boiled dej. Tag nrho cov nqi txhua hnub tuaj yeem muab faib ua ob zaug. Qhov kev ncua kev ncua tsis tuaj yeem khaws cia ntev dua ib teev. Thaum yav tsaus ntuj, cov tshuaj yuav tsum tau noj thaum sawv ntxov, 2 teev tom qab noj mov. Rau cov menyuam yaus hnub nyoog qis dua 5 xyoos, cov tshuaj tsuas yog muab rau hauv daim ntawv ntawm kev ncua.
Tus neeg mob tshaj 70 tau hloov kho koob tshuaj. Qhov no yog vim qhov tseeb tias thaum muaj hnub nyoog laus, lub raum ua haujlwm tsis zoo. Cov nyiaj pub dawb txhua hnub tuaj yeem ua rau muaj kev cuam tshuam loj xws li pancreatitis, peripheral neuropathy, lactic acidosis. Nyob rau ib feem ntawm txoj hnyuv, xws li tshwm sim tsis kaj siab xws li qhov ncauj qhuav, anorexia, xeev siab, thiab ntuav tuaj yeem tsim. Nyob rau hauv cov ntaub ntawv ntawm deterioration ntawm kev noj qab haus huv, tus neeg mob raug pom zoo mus ntsib ib tug kws kho mob tshwj xeeb. Tej zaum cov tshuaj yuav raug txiav tawm. Tus kws kho mob yuav muab tshuaj hloov zoo ("Thymidine" lossis analogues ntawm "Thymidine", "Abacavir", "Lamivudine").
Videx
Cov khoom xyaw nquag hauv cov tshuaj no kuj yog didanosine. Cov tshuaj antiretroviral los ntawm pab pawg no tau siv dav hauv kev kho mob HIV. Qhov zoo yog qhov tseeb tias cov tshuaj kuj tseem siv tau rau cov menyuam mos. Rau cov neeg mob hluas, Videx raug tshuaj nyob rau hauv daim ntawv ntawm cov hmoov rau kev npaj ntawm kev ncua. Qhov ntau npaum li cas yog xam ib tus zuj zus raws li qib ntawm kev kis kab mob, nrog rau cov yam ntxwv ntawm tus neeg mob lub cev. Cov tshuaj tsis yog siv xwb yog tias hypersensitivity raudidanosine.
Kev kho mob antiretroviral yog muab sai li sai tau thaum kuaj pom tus kab mob. Raws li prophylaxis, cov tshuaj tsis siv. Cov tshuaj muaj xyaum tsis muaj contraindications. Videx ntsiav tshuaj lossis hmoov tsis ua rau kev txhim kho ntawm cov kev mob tshwm sim yog tias cov tshuaj noj tau raug xaiv raug. Cov tshuaj yuav tsum raug txiav tawm yog tias xav tias mob pancreatitis.
Zidovudine
Ib tshuaj tiv thaiv kab mob muaj zog tiv thaiv HIV. Cov khoom xyaw nquag yog zidovudine. Cov lus qhia rau kev siv kuj piav txog excipients. Cov no suav nrog pregelatinized starch, magnesium stearate, microcrystalline cellulose. Lub plhaub zaj duab xis muaj titanium dioxide, polydextrose, glyceryl caprylocaprate. Cov tshuaj no yog siv los ua ib feem ntawm kev kho mob sib xyaw ua ke rau tus kab mob HIV-1. Thaum cev xeeb tub, cov tshuaj tuaj yeem siv los tiv thaiv kev kis tus kabmob perinatal ntawm niam mus rau fetus.
Cov tshuaj muaj ntau yam contraindications. Zidovudine ntsiav tshuaj tsis tau sau tseg rau cov menyuam yaus, nrog rau cov neeg laus cov neeg laus uas qhov hnyav tsis tshaj 30 kg. Nyob rau hauv tsawg zaus, hypersensitivity rau cov active ingredient yuav tsim. Cov tshuaj tau noj ntawm qhov ncauj, tsis hais noj mov. Cov neeg uas tau yuav Zidovudine 300 yuav tsum siv ob ntsiav tshuaj ib hnub. Yog tias tus neeg mob hnyav dua 60 kg, koj yuav tsum noj 20 mg ntawm cov tshuaj ob zaug ib hnub.
Nyob rau ib pab pawgkim tshuaj "Zidovudine". Tus nqi ntawm ib pob ntawm 60 ntsiav tshuaj yog tshaj 10,000 rubles.
Abacavir
Cov khoom xyaw nquag ntawm cov ntsiav tshuaj yog abacavir sulfate. Cov tshuaj no tau siv dav hauv kev kho tshuaj tiv thaiv kab mob HIV. Tsis tas li ntawd, cov tshuaj muaj pes tsawg leeg suav nrog cov khoom hauv qab no: microcrystalline cellulose, daj hlau oxide, polysorbate, titanium dioxide, magnesium stearate, daj opadry, triacetin. Cov tshuaj tsuas yog siv los ua ib feem ntawm kev kho ua ke. Cov ntsiav tshuaj "Abacavir" tsis tau sau tseg rau kev mob siab rau lub ntsiab lus tseem ceeb. Cov tshuaj yog contraindicated nyob rau hauv cov neeg mob me uas nws lub cev hnyav tsis tshaj 14 kg. Kev ceev faj yuav tsum tau siv rau cov neeg mob lub raum tsis txaus.
Cov koob tshuaj ntawm cov tshuaj yog xam ib tus zuj zus raws li daim ntawv kis tus neeg mob. Rau cov neeg laus, qhov nruab nrab qhov nyiaj pub dawb txhua hnub yog 600 mg ib hnub (sib faib ua peb koob). Kev siv cov ntsiav tshuaj hauv qhov ntau npaum li cas yuav ua rau muaj kev fab tshuaj.
Tseem hu ua cov cuab yeej kim "Abacavir". Tus nqi ntawm ib pob ntawm cov ntsiav tshuaj tuaj yeem tshaj 15,000 rubles.
Ziagen
Cov khoom xyaw nquag, zoo li hauv rooj plaub dhau los, yog abacavir sulfate. Cov tshuaj yog analogues thiab tej zaum yuav zoo hloov ib leeg. Txhais tau tias "Ziagen" yog siv tau zoo hauv kev kho mob ntawm tus kab mob HIV. Cov tshuaj tso cai rau koj los txhim kho tus neeg mob tus mob, rov qab mus rau lub neej tag nrho. Cov ntsiav tshuaj muaj suab tsis muaj contraindications. Cov tshuaj tsis yog tshuaj rau cov neeg mob hnyav xwbuas tsis tshaj 14 kg.
koob tshuaj txhua hnub yog tus kws kho mob txiav txim. Daim ntawv ntawm tus kab mob yog coj mus rau hauv tus account, nrog rau cov yam ntxwv ntawm tus neeg mob (qhov hnyav, hnub nyoog). Cov menyuam yaus uas qhov hnyav tsis tshaj 20 kg yog muab ib nrab ib ntsiav tshuaj ob zaug ib hnub twg. Qhov nyiaj pub dawb txhua hnub rau tus neeg mob laus tuaj yeem ncav cuag peb ntsiav tshuaj ib hnub.
siv cov tshuaj tsis raug tuaj yeem ua rau muaj kev phiv tshwm sim. Nws tsim nyog nrhiav kev pab los ntawm kws kho mob yog tias cov tsos mob xws li raws plab, mob plab, xeev siab, thiab ntuav. Cov xwm txheej no tuaj yeem ua rau mob pancreatitis. Tsis tas li, kev ua xua nyob rau hauv daim ntawv ntawm pob khaus thiab khaus feem ntau pom.
Ziagen ntsiav tshuaj tuaj yeem hloov Zidovudine zoo. Tus nqi tshuaj yuav luag tib yam.
Olithid
Ib tshuaj tiv thaiv kab mob muaj kev tiv thaiv kab mob HIV. Cov khoom xyaw nquag yog abacavir sulfate. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov hmoov rau kev npaj ntawm kev ncua, nrog rau cov ntsiav tshuaj. Txhais tau hais tias "Olitid" tsuas yog ib feem ntawm txoj kev kho mob. Cov tshuaj tsis yog siv los ntawm nws tus kheej. Qhov ntau npaum ntawm cov tshuaj yog txiav txim los ntawm tus kws kho mob. Hauv daim ntawv ntawm cov ntsiav tshuaj, cov tshuaj tsuas yog siv tau rau cov neeg mob uas hnyav tshaj 14 kg. Nrog kev ceev faj, cov ntsiav tshuaj "Olitid" raug sau tseg thaum muaj hnub nyoog laus. Qhov no yog vim muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm.
Cov tshuaj tiv thaiv kab mob, suav nrog cov tshuaj "Olitide", yog siv nruj me ntsis raws li cov kws kho mob tshwj xeeb. Yuav tshuaj ntawmlub tsev muag tshuaj uas tsis muaj tshuaj yuav ua tsis tau.
Retrovir
Cov tshuaj yog siv dav ua ib feem ntawm txoj kev kho mob HIV. Tom qab kev tswj hwm qhov ncauj, cov tshuaj tau nrawm nrawm los ntawm txoj hnyuv. Cov khoom xyaw nquag tau yooj yim nkag mus rau placental barrier. Qhov no yog coj mus rau hauv tus account thaum tsim ib qho kev kho mob rau cov poj niam cev xeeb tub. Cov tshuaj siv tau los ua ib qho kev tiv thaiv kab mob HIV ua haujlwm. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg ua haujlwm hauv chaw kuaj mob uas tshawb fawb txog cov khoom tsis huv.
Cov tshuaj noj yog teem rau tus kheej los ntawm tus kws kho mob. Qhov siab tshaj plaws txhua hnub pub rau cov neeg laus tsis tuaj yeem tshaj 600 mg. Cov kws tshaj lij pom zoo muab faib ua peb koob. Nws yuav ua tau zoo dua yog tias noj ntawm lub plab khoob. Yog tias koj ntsib kev mob tshwm sim, koj yuav tsum sab laj nrog koj tus kws kho mob.
