Tsis muaj vitamin D3 hauv lub cev ua rau muaj teeb meem loj. Rau cov menyuam yaus, qhov tsis txaus no yog fraught nrog kev loj hlob ntawm rickets, thiab hauv cov neeg laus, nws qhov tsis muaj peev xwm ua rau muaj kev txhim kho pob txha thiab cov teeb meem zoo sib xws.
Kev lag luam niaj hnub ntawm cov tshuaj muaj nws cov neeg siv ntau cov tshuaj los tshem tawm qhov tsis txaus ntawm cov vitamin no. Ib qho ntawm cov tshuaj no yog Alfacalcidol. Cov lus qhia rau kev siv piav qhia tias nws yog ib qho cuab yeej zoo rau normalizing cov vitamin thiab ntxhia hauv lub cev.
Pharmacodynamics
Cov tshuaj no yog daim ntawv nquag ntawm vitamin D3. Kev tswj hwm ntawm cov metabolism hauv cov ntsiab lus tseem ceeb xws li phosphorus thiab calcium kuj yog cov cuab yeej tseem ceeb ntawm Alfacalcidol. Kev siv cov tshuaj zoo txhawb kev tsim cov pob txha. Nrog nws txoj kev koom tes ncaj qha, kev nqus ntawm calcium thiab phosphorus hauv cov hnyuv thiab ob lub raum nce. Ntxiv rau, cov tshuaj nonce cov mineralization ntawm cov pob txha cov ntaub so ntswg thiab nyob rau tib lub sij hawm txo cov theem ntawm parathyroid hormone nyob rau hauv cov ntshav. Yog li ntawd, Alfacalcidol muaj cov nyhuv antirachitic thiab pab txo cov pob txha pob txha.
Yog tias cov tshuaj tau noj hauv cov kev kawm, tom qab ntawd nyob rau hauv nws txoj kev sib koom tes ntawm kev txav mus los txhim kho, cov pob txha thiab cov leeg mob txo qis (uas yog qhov tshwm sim ntawm kev ua txhaum ntawm phosphorus-calcium metabolism).
Thaum twg cov tshuaj tsim nyog?
"Alfaklcidol" cov lus qhia rau kev siv thiab cov lus qhia ntawm cov kws kho mob tshwj xeeb tau pom zoo kom muab tshuaj rau hauv cov ntaub ntawv hauv anamnesis txog osteodystrophy, lub raum tsis ua haujlwm nyob rau hauv lub sijhawm ntev. Tsis tas li ntawd nws yog siv rau hypoparathyroidism. Lub hauv paus rau nws qhov kev teem caij yog rickets, osteomalacia (txo qis hauv cov pob txha cov ntaub so ntswg) thiab pob txha mos, qhov xwm txheej yuav txawv heev. Osteoporosis - steroid, senile, postmenopausal - kuj ua tiav nrog Alfacalcidol.
Cov tshuaj no yog siv rau cov neeg mob uas mob raum acidosis, los yog muaj keeb kwm ntawm Fanconi syndrome (ib tug kab mob complex uas muaj xws li raum acidosis, uas yog hereditary nyob rau hauv cov xwm, nephrocalcinosis, rickets, thiab tejzaum nws adiposogenital dystrophy).
Rau tag nrho cov teeb meem no, Alfacalcidol tuaj yeem pab tau zoo.
Thaum twg kuv yuav tsum tso tseg?
ListContraindications muaj rau cov tshuaj "Alfacalcidol" cov lus qhia rau kev siv. Kev tshuaj xyuas ntawm cov kws kho mob tshwj xeeb txwv tsis pub noj tshuaj yog tias muaj keeb kwm ntawm cov ntaub ntawv hais txog hypercalcemia, hyperphosphatemia (tshwj tsis yog kev txhim kho nrog hyperparathyroidism), hypermagnesemia. Tsis txhob siv cov tshuaj no nyob rau hauv cov ntaub ntawv ntawm intoxication ntawm lub cev txuam nrog ib tug ntau ntawm cov ntsiab lus ntawm vitamin D3. Nws tsis tuaj yeem muab tshuaj Alfacalcidol rau cov niam laus.
Zoo, nws mus yam tsis tau hais tias cov neeg uas muaj tus neeg mob siab rau cov tshuaj ntawm cov tshuaj yuav tsum tsis txhob noj.
Kev xaiv thiab siv ntau npaum li cas
Cov ntaub ntawv tiav tshaj plaws txog cov txheej txheem ntawm kev thov thiab kev noj tshuaj muaj rau cov tshuaj "Alfacalcidol" cov lus qhia rau kev siv. Daim ntawv tso tawm (capsules ntawm 0, 25 lossis 1 mcg), koob tshuaj thiab lub sijhawm ntawm chav kho mob raug xaiv los ntawm tus kws kho mob tus kheej, nyob ntawm qhov hnyav ntawm tus neeg mob tus mob thiab qhov xwm txheej ntawm tus kab mob.
Piv txwv li, cov neeg laus muaj mob rickets tshwm sim los ntawm vitamin D3 tsis txaus, teeb meem nrog rau txoj hnyuv, yuav tsum tau txais ib koob tshuaj txhua hnub ntawm 1 mus rau 3 micrograms. Qhov txiaj ntsig zoo hauv kev kho rau hypoparathyroidism yuav raug tau txais los ntawm 2 mus rau 4 mcg ntawm cov tshuaj ib hnub. Qhov ntim txhua hnub yog tias lub raum tsis txaus thiab osteodystrophy yuav tsum tsis pub tshaj qhov ntim ntawm cov tshuaj hauv 2 μg. Fanconi syndrome thiab lub raum acidosis tau kho tau zoo yog tias tus neeg mob tau txais ib koob tshuaj "Alfacalcidol" txhua hnub ntawm 2-6 mcg. Yog cov neeg mob muajosteomalacia thiab hypophosphatemic rickets, tus nqi ntawm kev noj tshuaj txhua hnub tuaj yeem muaj li ntawm 4 txog 20 mcg.
Cov kws kho mob pom zoo pib kho nrog qhov tsawg kawg nkaus koob tshuaj ntawm txhua tus kab mob tshwj xeeb. Thaum kho, nws yuav tsum tau saib xyuas cov ntsiab lus ntawm cov ntsiab lus xws li calcium thiab phosphorus hauv cov ntshav plasma (tsawg kawg 1 zaug hauv ib lub lis piam). Qhov ntau npaum ntawm Alfacalcidol tuaj yeem nce tsis pub ntau tshaj 0.5 mcg ib hnub. Thaum pom qhov tsawg kawg nkaus tau txais txiaj ntsig, cov ntsiab lus calcium hauv cov ntshav yuav tsum tau saib xyuas tsawg kawg txhua 3-5 lub lis piam.
Tsis xav pom
Zoo li txhua yam tshuaj, muaj cov npe ntawm cov kev mob tshwm sim thiab cov tshuaj "Alfacalcidol". Cov lus qhia rau kev siv (lub ntsiab lus, los ntawm txoj kev, kuj muaj cov nyhuv tib yam) qhia cov neeg mob tias lub plab zom mov yuav hnov mob rau cov tshuaj. Feem ntau, xeev siab, ntuav, mob hauv cheeb tsam epigastric, cem quav lossis raws plab, kub hnyiab, thiab qhuav ntawm cov mucous hauv qhov ncauj tshwm. Anorexia yuav tshwm sim.
Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb, tej zaum yuav muaj kev qaug zog thiab qaug zog, nce qaug zog, mob taub hau thiab kiv taub hau. Qee zaum cov neeg mob tham txog kev txhim kho ntawm tachycardia (lub plawv dhia ceev) thiab nce ntshav siab. Tej zaum cov tsos mob ntawm dermatological tshwm sim nyob rau hauv daim ntawv ntawm khaus thiab pob khaus ntawm daim tawv nqaij, kev loj hlob ntawm tsis heev khaus pob txha, cov leeg nqaij thiab mob pob qij txha. Tej zaum yuav txawv me ntsisLaboratory ntsuas nyob rau hauv cov kev taw qhia ntawm kev nce tus naj npawb ntawm high density lipoproteins. Nws muaj peev xwm tsim hypercalcemia, hyperphosphatemia (hauv cov neeg uas muaj lub raum tsis ua haujlwm).
Nyob zoo
Ntau qhov kev tshwm sim tsis zoo yuav raug pom yog tias ntau npaum li cas tso cai rau Alfacalcidol ntau dhau. Cov lus qhia rau kev siv ceeb toom cov neeg mob txog kev pheej hmoo ntawm kev tsim hypervitaminosis D. Cov tsos mob ntxov ntawm kev siv tshuaj ntau dhau yog vim hypercalcemia. Ntawm qhov kev tawm tsam tshaj plaws yog cov tshuaj tiv thaiv kab mob hauv plab, mob nqaij, xim hlau hauv qhov ncauj, qaug zog.
Nrog rau kev qaug dab peg ntev, cov neeg mob qhia tias tsaug zog thiab mob taub hau, tej zaum yuav muaj kev qaug zog, chim siab, insomnia, tsis nco qab thiab nce ntshav siab me ntsis. Cov seem ntawm nitrogen thiab creatinine qee zaum muaj nyob hauv cov ntshav. Muaj kev pheej hmoo ntawm kev txhim kho conjunctival hyperemia, calcification ntawm ob lub raum, ntsws, cov ntaub so ntswg thiab cov hlab ntsha, thiab tsim cov pob zeb hauv lub raum. Cov teeb meem ntawm lub suab (qhoarseness) yuav tshwm sim.
Txhawm rau tshem tawm qhov tshwm sim ntawm kev noj tshuaj ntau dhau, nws yuav tsum tau tshem tawm cov tshuaj, ntxuav lub plab, sau cov tshuaj diuretics, bisphofonates, thiab hemodialysis siv cov tshuaj calcium uas tsis muaj zog, nyob ntawm cov tsos mob.
txwv tsis pub siv tshuaj
Muaj ntau yam kab mob uas Alfacalcidol yuav tsum tau ceev faj. Cov lus qhia rau kev siv pom zoo kom ua tib zoo mloogLub xeev ntawm lawv cov kev noj qab haus huv rau cov neeg mob uas raug kev txom nyem los ntawm atherosclerosis, sarcoidosis (los yog lwm yam granulomatosis), pulmonary tuberculosis (active theem), lub plawv tsis ua hauj lwm thiab lub raum insufficiency (hloov daim ntawv). Alfacalcidol tau sau tseg nrog ceev faj yog tias tus neeg mob muaj cov tsos mob ntawm nephrourolithiasis. Cov menyuam yaus thiab cov neeg laus cov neeg mob kuj muaj kev pheej hmoo (thaum kawg, cov tshuaj tuaj yeem ua rau muaj kev loj hlob ntawm atherosclerosis).
Raws li rau cov poj niam cev xeeb tub thiab cov niam laus, cov lus qhia "Alfacalcidol" tso cai rau koj siv tsuas yog thaum qhov kev xav tau zoo rau leej niam tshaj qhov kev pheej hmoo rau kev loj hlob thiab kev noj qab haus huv ntawm tus menyuam.
Hypercalcemia nyob rau hauv ib tug expectant niam, provoked los ntawm kev siv mus sij hawm ntev ntawm Alfacalcidol, yuav muab impetus rau txoj kev loj hlob ntawm ib tug xov tooj ntawm cov teeb meem nyob rau hauv lub fetus. Ntawm cov kab mob loj tshaj plaws hauv tus menyuam hauv plab yog qhov tsis txaus ntseeg rau vitamin D, kev nyuaj siab ntawm kev ua haujlwm ntawm lub caj pas parathyroid, aortic stenosis, hlwb retardation, syndrome ntawm ib tug tshwj xeeb elf-zoo li tsos.
Ntxiv rau, "Alfacalcidol" hauv cov ntim me me tuaj yeem tso tawm hauv cov kua mis thaum lactation. Txhawm rau zam qhov kev pheej hmoo ntawm cov tsos mob ntawm hypercalcemia hauv menyuam yaus, cov tshuaj yuav tsum tau noj nrog kev saib xyuas zoo.
Kev sib tham nrog lwm yam tshuaj
"Alfacalcidol" cov lus qhia rau kev sivpom zoo kom tsis txhob noj nyob rau hauv parallel nrog anticonvulsants (barbiturates, phenitonite, thiab lwm yam) vim yog nce nyob rau hauv nws ("Alfacalcidol") metabolism. Inhibitors muaj qhov cuam tshuam. Kev siv cov tshuaj ua ke nrog cov khoom uas muaj foxglove tuaj yeem ua rau muaj kev loj hlob ntawm arrhythmias.
Kev nqus ntawm "Alfacalcidol" yuav txo qis thaum nws noj nyob rau tib lub sijhawm nrog albumin, antacids, ntxhia roj, colestipol, cholestyramine, sucralfate.
Kev sib xyaw nrog cov tshuaj laxative lossis magnesium-muaj tshuaj tiv thaiv kab mob ua rau muaj kev pheej hmoo ntawm kev tsim hypermagnesemia lossis hyperaluminemia. Thaum siv Alfacalcidol nrog cov tshuaj uas muaj vitamin D los yog ib qho ntawm nws cov derivatives, qhov kev pheej hmoo ntawm kev tsim hypercalcemia nce.
Cov nyhuv tshuaj lom ntawm "Alfacalcidol" txo qis nrog kev siv tib lub sijhawm ntawm tocopherol, ascorbic thiab pantothenic acids, thiamine, riboflavin, vitamin A. Cov nyhuv ntawm "Alfacalcidol" yog qhov tsis tshua muaj tshwm sim thaum muaj derivatives ntawm pamidronic thiab etindronic acids, glucocorticoids, calciton. Tsis tas li ntawd, cov tshuaj no txhawb nqa kev nqus ntawm phosphorus-muaj tshuaj, uas ua rau muaj kev pheej hmoo ntawm kev tsim hyperphosphatemia.
Zimilar drug
Alfacalcidol analogues yog dav sawv cev ntawm lub teb chaws cov khw muag tshuaj. Cov lus qhia rau kev siv muaj cov ntaub ntawv hais txog qhov zoo tshaj plaws ntawm lawv. Cov no suav nrog cov tshuaj "Etalfa", "Alpha D3-teva",Alfadol-Sa, Van-alpha, Oksidevit, Tevabon.
Chaw tsim tshuaj paus muab cov tshuaj no rau cov neeg siv khoom hauv ntau hom: ntsiav tshuaj thiab gelatin capsules, tee thiab hmoov, kev daws teeb meem rau cov hlab ntsha.
Reviews about the drug "Alfacalcidol"
Txhua yam tshuaj muaj adherents thiab tawm tsam, tib yam yog cov ntaub ntawv nrog Alfacalcidol. Cov lus qhia rau kev siv, cov duab ntawm cov neeg mob uas txaus siab rau cov nyhuv ntawm lub cev, qhia meej rau cov neeg siv khoom tias cov tshuaj no tuaj yeem txhim kho tib neeg lub neej zoo hauv ntau cov kab mob cuam tshuam nrog kev tsis txaus ntawm cov vitamins thiab minerals, kev ua txhaum ntawm calcium-phosphorus metabolism. Tsis tas li ntawd, Alfacalcidol tuaj yeem txhim kho cov xwm txheej ntawm cov rau tes thiab cov plaub hau, uas tseem ceeb heev.
Qee tus neeg mob tsis txaus siab rau qhov tseeb tias Alfacalcidol tsis tuaj yeem yuav khoom ntawm lub txee, vim nws yuav tsum tau muab tshuaj los ntawm kws kho mob. Txawm li cas los xij, cov kws paub txog kev noj qab haus huv tau xav tias cov tshuaj loj no yuav tsum tsis txhob muaj rau txhua tus.
