"Trimectal", lub hauv paus tseem ceeb ntawm uas yog cov tshuaj nquag trimetazidine, belongs rau cov pab pawg ntawm cov tshuaj uas muaj cov tshuaj tiv thaiv hypoxic ntawm kev ua haujlwm thiab feem ntau yog siv hauv plawv plawv kom stabilize cov hlab plawv. Cov tshuaj, raws li txoj cai, yog muab raws li ib tug saib xyuas / kho tus neeg saib xyuas nyob rau hauv complex txoj kev kho thiab, los ntawm stimulating cov txheej txheem ntawm cellular metabolism, pab txhawb rau tag nrho cov kev txhim kho ntawm tus neeg mob tus mob.
Form and composition
Muaj ntau hom kev tsim cov tshuaj "Trimectal". Cov lus qhia rau kev siv qhia tau hais tias cov no tuaj yeem yog cov tawv gelatin capsules (hlawv ntawm 10/20 units lossis polymer cov kaus poom nrog lub peev xwm ntawm 60 units), thiab cov ntsiav tshuaj nrog lub plhaub zaj duab xis uas ua rau qeeb tso tawm cov tshuaj reagents (hlawv ntawm 10/20). / 30 pcs. lossis pob yas rau 60/100/120 pcs.). Cov khoom tseem ceeb hauv ob qho tib si yog trimetazidine dihydrochloride. Txawm li cas los xij, daim ntawv ntawm cov tshuaj, uas yog tus cwj pwm los ntawm kev txo qis ntawm kev nqus thiab cov metabolism, muaj lub npe sib txawv - "Trimectal. MV."
Pharmacological action
Ua ib qho tshuaj tiv thaiv hypoxic, "Trimectal" (cov lus qhia rau kev siv hauv qhov no muab cov kev faib tawm meej ntawm cov tshuaj thiab tib lub sijhawm hais txog qhov tseem ceeb ntawm nws cov khoom antioxidant) muaj qhov ncaj qha "invigorating" cuam tshuam rau cardiomyocytes thiab hlwb neurons. Yog li, cov tshuaj tsub kom cov coefficient ntawm lawv functionality. Kev ua tiav cov txiaj ntsig cytoprotective yog ib qho txiaj ntsig ntawm kev nce hauv lub zog muaj peev xwm ntawm cov hlwb tiv thaiv keeb kwm yav dhau los ntawm kev ua kom zoo dua qub ntawm kev noj cov pa oxygen.
Cov tshuaj nquag tsis tso cai rau asynchronous myocardial contraction los ntawm "preserving" qhov tsawg kawg nkaus ntawm phosphocreatine. Nyob rau hauv kev ua txhaum ntawm acid-base tshuav nyiaj li cas, "Trimectal" tswj cov concentration ntawm calcium thiab sodium, uas yog, nws tiv thaiv cov tsub zuj zuj ntawm derivatives ntawm cov ntsiab lus nyob rau hauv cardiomyocytes thiab nyob rau hauv txoj kev normalizes qhov nyiaj tshuav ntawm poov tshuaj ions nyob rau hauv lub hlwb. Hauv kev sib ntaus tawm tsam angina pectoris, cov tshuaj pom nws tus kheej ua qhov nruab nrab ntawm cov hauv paus hauv paus: qhov txo qis hauv nitrate kom tsawg ua rau lub fact tias tom qab 14 hnub ntawm kev kho mob, cov neeg mob muaj kev vam meej nyob rau hauv ib ce muaj zog (qhov loj ntawm cov ntshav siab poob qis heev.).
Y Absorption thiab metabolism
Cov lus qhia rau kev siv piav qhia txog cov tshuaj kinetics ntawm cov tshuaj "Trimectal", suav nrog hauv daim ntawv ntawm nws tso tawm. Yog li, tshwj xeeb, cov ntsiab lus ntawm cov tshuaj ntsiav, nkag mus rau hauv lub cev, tau nqus sai heev (thiab yuav luag tag nrho) nyob rau hauv ntu ntawm txoj hnyuv. Ob teev tom qab nojQhov siab tshaj plaws concentration ntawm reagents nyob rau hauv cov ntshav plasma yog sau tseg. Ib koob tshuaj ntawm 20mg teem qhov no ntawm 55ng / mL.
Raws li rau qib ntawm kev faib tawm ntawm cov khoom nquag, kev khi rau cov plasma proteins, raws li txoj cai, tsis pub tshaj 16%. Tib lub sijhawm, cov teeb meem histohematic tau kov yeej los ntawm trimetazidine yooj yim heev. Kwv yees li 60% ntawm cov koob tshuaj tau muab tso tawm tsis hloov pauv hauv cov zis, nrog thawj 50% hauv 4-5 teev.
Nyob rau hauv lem, "Trimectal MV" (cov ntsiav tshuaj daim ntawv ntawm ntau lawm), vim muaj ib tug tshwj xeeb plhaub, muab lub siab tshaj plaws concentration ntawm reagents nyob rau hauv cov ntshav plasma tom qab peb teev. Kev tshem tawm ib nrab-lub neej, nyob ntawm lub hnub nyoog ntawm cov neeg mob, tuaj yeem sib txawv ntawm 7 mus rau 12 teev.
Cov lus qhia rau cov tshuaj
Cov ntaub ntawv tshuaj "Trimectal" cov lus qhia rau kev siv txhais cov hauv qab no:
- tiv thaiv ntawm angina pectoris (raws li ib feem ntawm txoj kev kho mob nyuaj);
- kev cuam tshuam hauv kev ua haujlwm ntawm cov hlab ntsha chorioretinal;
- kiv taub hau tshwm sim los ntawm kev ua haujlwm tsis txaus ntawm cov hlab plawv;
- hnov tsis hnov lus (qhov tshwm sim ntawm cov txheej txheem ischemic hauv vestibular apparatus).
Ntxiv rau, tus kws kho mob tuaj yeem txiav txim siab txog kev tawm tswv yim ntawm kev siv tshuaj ntev ntev hauv kev tshem tawm cov focal erosions ntawm retina.
Siv thiab pom zoo ntau npaum li cas
Cov tshuaj yog noj hauv qhov ncauj, ncaj qha nrog zaub mov. Lub sijhawm ntawm chav kawm yog teem los ntawm tus kws kho mob (raws li cov txiaj ntsig ntawm kev kuaj mob kom ntxaws thiab kuaj mob).
Rau daim ntawv tshuaj ntsiav, qhov nruab nrab yog 40-60 mg / hnub (koj yuav tsum siv 2-3 zaug).
Nyob rau hauv cov ntaub ntawv ntawm cov tshuaj "Trimectal MB" (cov lus qhia rau kev siv nyob rau hauv no hwm yog me ntsis txawv ntawm cov lus pom zoo saum toj no), nws yog feem ntau yog muab ib ntsiav tshuaj nyob rau hauv thaum sawv ntxov thiab yav tsaus ntuj.
Side effects
Nrog rau cov txiaj ntsig zoo, cov kev mob tshwm sim ntawm cov khoom xyaw nquag muaj qee zaum tshwm sim. Hais txog qhov tshwm sim tsis haum rau kev siv Trimectal capsules, cov lus qhia rau kev siv, tus nqi uas yog kev noj qab haus huv ntawm tus neeg mob, nyeem:
- Qee tus neeg mob yuav muaj kev khaus khaus hauv zos;
- nrog rau kev siv tshuaj ntev, kev ua haujlwm tsis zoo ntawm cov khoom noj (xws li, ntuav) tsis tshua muaj;
- qee zaum qhov tsis zoo ntawm kev siv tsis tu ncua yog qhia txog mob taub hau thiab migraines;
- cov kab ntshav thiab cov leeg hauv lub plawv qee zaum raug kev ntxhov siab ntau dhau, qhia tias yuav tsum tau txo qis npaum li cas.
Hais txog cov tshuaj "Trimectal MV" cov lus qhia rau kev siv hais tias:
- txhim kho ntawm orthostatic hypotension thiab tsim "blush" ntawm lub ntsej muag tsis zoo li (tsawg dua ib tus neeg mob rau ib txhiab tus neeg);
- tsis sib npaug hauv kev ua haujlwmplab hnyuv (mob hauv plab, raws plab, ntuav, thiab lwm yam) - ntau zaus (ntau tshaj ib tus neeg ib puas koob tshuaj).
Tsis tas li ntawd, cov xwm txheej tsis raug txiav txim siab thaum siv cov ntsiav tshuaj nrog hloov kho cov tshuaj reagents tuaj yeem ua rau lub hauv paus ua rau rov qab asthenia, tshee, akinesia thiab urticaria.
Contraindications rau kev sau ntawv
Peb tab tom xav txog cov tshuaj tiv thaiv hypoxic "Trimectal". Cov lus qhia rau kev siv, tus nqi ntawm cov tshuaj, cov npe ntawm cov tshuaj hloov pauv, nrog rau ntau yam kev xav ntawm cov kws kho mob tshwj xeeb tau nthuav tawm hauv qhov kev tshuaj xyuas no txhawm rau paub txog cov neeg nyiam. Cov tshuaj no muaj ib tug xov tooj ntawm contraindications uas sib npaug zos rau txhua hom kev tso tawm (capsules / ntsiav tshuaj).
Tshuaj tsis yog tshuaj yog tias:
- kuaj mob raum tsis ua haujlwm (xws li CK<15 ml / min);
- tus neeg mob muaj cov tsos mob ntawm daim siab ua haujlwm tsis zoo;
- tus neeg mob tseem tsis tau txog hnub nyoog kaum yim;
- Cov tshuaj tiv thaiv hnyav rau cov tshuaj tiv thaiv tau taug qab.
Lwm yam contraindications suav nrog cev xeeb tub thiab lactation.
cov lus qhia tshwj xeeb thiab kev cuam tshuam tshuaj yeeb tshuaj
"Trimectal", tus nqi ntawm qhov sib txawv (nyob ntawm daim ntawv tso tawm thiab lub teb chaws tsim khoom - 300-1100 rubles), tsis tau raug rau cov kev tshawb fawb soj ntsuam loj rau kev cuam tshuam nrog lwm cov tshuaj. Los ntawm noYog li ntawd, nws muaj peev xwm tham txog cov txheej txheem ntawm kev sib xyaw ua ke ntawm cov teebmeem tsuas yog los ntawm cov lus xaus uas tau txais los ntawm kev ua haujlwm hauv chav kuaj nrog trimetazidine, qhov tseem ceeb ntawm cov tshuaj tau piav qhia. Nws tau raug sau tseg tias trimetazidine plays lub luag haujlwm ntawm kev ua kom muaj zog ntawm kev tiv thaiv ischemic, uas yog qhov tshwm sim ntawm kev noj lwm yam tshuaj antianginal. Kev sib cuag ntawm hom sib txawv nrog kev koom tes ntawm Trimectal reagents tsis tau pom.
cov lus qhia tshwj xeeb rau kev sau tshuaj:
- tsis tuaj yeem siv rau thawj hnub ntawm kev mus pw hauv tsev kho mob ntawm tus neeg mob uas tau kuaj pom tias tsis ruaj khov angina (los yog muaj mob ua ntej infarction);
- Kev sib raug zoo ntawm kev noj tshuaj Trimectal capsules (cov ntsiav tshuaj) thiab chav kawm ntawm tus kab mob Parkinson, uas tau nthuav tawm hauv kev nce / txo qis hauv kev tshee, yuav tsum tau saib xyuas tus neeg mob ntxiv (peb tab tom tham txog kev kuaj mob raws sij hawm los ntawm kws kho mob hlwb);
- rau cov neeg mob hnub nyoog 75 xyoo, cov kev kho mob yog fraught nrog teeb meem hauv kev ua haujlwm ntawm lub raum, yog li qhov kev txiav txim zaum kawg yog nyob ntawm tus kws kho mob;
- cuam tshuam ntawm cov kev xav psychomotor provoked los ntawm trimetazidine yog qhov laj thawj xav txog kev tawm tswv yim ntawm kev siv tshuaj thaum tus neeg mob nyob sab nraum tsev kho mob, thiab nws txoj haujlwm tshaj lij cuam tshuam nrog kev hem thawj ntawm kev raug mob.
Txheej txheem cej luam ntawm analogues
Qhov ntau tshaj ob npaug ntawm cov tshuaj "Trimectal" (analogues, cov tshuaj nquag uas tseem yog trimetazidine):
- Trimetazidin-Biocom MV, Russia;
- Trimetazid, Poland;
- Trimet, India;
- Antisten, Russia;
- Medarum 20, Russia;
- Preductal MV, Fabkis;
- Rimecore MV, Ukraine.
Txawm hais tias muaj cov tshuaj formula, cov nyhuv ntawm generics ntawm lub cev tej zaum yuav txawv me ntsis li qub. Yog li ntawd, qhov kev xaiv ntawm ib qho tshuaj tshwj xeeb yog qhov muaj cai ntawm tus kws kho mob.
Timectal tshuaj: kev xav thiab cov lus pom
Cov teeb meem kev noj qab haus huv ntsig txog qhov teeb meem ntawm arterial arrhythmia feem ntau yog tsom los ntawm kev sib tham thematic. Cov neeg uas xav hnov cov kev xav ntawm cov neeg mob thiab cov neeg uas muaj kev kawm kho mob hais txog cov tshuaj "Trimectal" (kev tshuaj xyuas, raws li txoj cai, muaj lub siab zoo connotation) tsis muaj teeb meem nrhiav cov ntaub ntawv. Txawm li cas los xij, txawm tias ib qho kev soj ntsuam ntawm cov kev xav pom pom tau hais tias qhov tshwj xeeb ntawm kev teem caij cuam tshuam rau lub hom phiaj ntawm cov ntsiab lus ntawm kev pom. Tom qab tag nrho, cov tshuaj hais nyob rau hauv feem ntau ntawm cov neeg mob yog muab "ua ke", uas yog, ua ke nrog rau lwm yam tshuaj.
Piv txwv li, ib pawg neeg mob loj heev, thiab cov neeg mob ib nrab hnub uas tau kawm txog kev kho mob raws li "Trimectal", pom zoo hauv lawv cov kev ntsuam xyuas cov lus xaus uas muaj kev hloov pauv tseem ceeb hauv kev kho cov mob xws li mob ntshav siab thiab mob plawv mob plawv, tshuaj tsis muab.
