Cov kab mob tau paub tias yog cov kab mob feem ntau ua rau cov kab mob inflammatory thiab kab mob. Txhawm rau tshem tawm lub cev ntawm lawv, ntau yam tshuaj tua kab mob yog siv. Muaj ntau pawg ntawm cov tshuaj, qhov kev txiav txim ntawm uas yog qhia tawm tsam cov kab mob. Ib tus neeg sawv cev zoo li no yog nalidixic acid. Nws yog cov khoom muaj nyob hauv ntau cov tshuaj tua kab mob. Ib qho piv txwv yog Nevigramon ntsiav tshuaj. Cov tshuaj no belongs rau quinolones, pawg kws tshuaj - tshuaj tua kab mob. Ua ntej pib kev kho mob, nws yog ib qho tsim nyog yuav tsum tau kuaj xyuas tus kab mob thiab xyuas nws qhov rhiab heev rau cov tshuaj.
Nalidicic acid - yog dab tsi?
Muaj tseeb txhua leej txhua tus paub txog cov tshuaj uas muaj nalidixic acid. Cov tshuaj no tau siv rau hauv cov tshuaj tau ntau xyoo los ua cov tshuaj tua kab mob thiab tshuaj tua kab mob. Nalidixic acid, raws li tau sau tseg, belongs rau pawg quinolones. Cov chaw kho mob koom nrog cov tshuaj no nrog cov tshuaj tua kab mob. Nalidixic acid yog cais raws li cov tshuaj hluavtaws, uas yog, tsim hauv chav kuaj. Nws yogNws yog lub teeb daj hmoov uas tsis tuaj yeem yaj hauv dej. Lub ntsiab ntawm cov kua qaub yog tshuaj. Nws yog ib feem ntawm qee cov tshuaj tua kab mob.
Kev ua ntawm nalidixic acid
Yuav kom paub seb cov kab mob twg siv nalidixic acid, nws yog ib qho tsim nyog los kawm txog cov txheej txheem ntawm nws qhov kev ua. Cov txiaj ntsig tseem ceeb ntawm cov tshuaj no yog kev tawm tsam ntawm cov kab mob loj hlob thiab lawv kev puas tsuaj. Lub mechanism ntawm nws qhov kev txiav txim yog kom nres lub synthesis ntawm DNA ntawm microorganisms los ntawm polymerization. Cov tshuaj Nalidixic acid npaj tau xaiv tawm tsam Gram(-) kab mob. Lawv zoo tiv thaiv kab mob ntawm cov genus Proteus, Escherichia coli. Yog li ntawd, tshem tawm cov kab mob inflammatory uas tshwm sim los ntawm cov kab mob no.
Cov nyhuv ntawm cov tshuaj nyob ntawm nws cov concentration hauv lub cev. Hauv cov koob tshuaj me me, nws tsuas muaj cov nyhuv bacteriostatic, uas yog, nws inhibits DNA replication. Qhov loj ntawm cov tshuaj kuj cuam tshuam rau kev sib txuas ntawm cov protein thiab RNA. Yog li ntawd, kev siv ntev ntev lossis kev tswj hwm ntawm cov ntsiav tshuaj hauv cov koob tshuaj loj ua rau muaj cov kab mob bactericidal. Nws yuav tsum nco ntsoov tias Gram (+) kab mob thiab anaerobes yog insensitive rau nalidixic acid. Yog li ntawd, ua ntej yuav tshuaj, nws yog ib qhov tsim nyog yuav tau ua ib qho kev kuaj bacteriological ntawm cov khoom lom (cov zis, ntshav) thiab ua ib qho tshuaj tua kab mob.
Cov lus qhia rau kev siv nalidixic acid
Muaj ntau yam kab mob uas ua raunalidixic acid yog siv. Cov lus qhia nyob rau hauv lub pob nrog cov tshuaj qhia raws nraim cov kab mob uas active tshuaj yog qhia rau. Txawm li cas los xij, nws yuav tsum nco ntsoov tias cov kab mob no tsis yog tshwm sim los ntawm Gram (-) flora. Yog li, yog tias cov tshuaj tsis zoo, nws yuav tsum tau hloov nrog lwm cov tshuaj tom qab 3 hnub. Mob raum mob yog lub ntsiab spectrum ntawm cov kab mob nyob rau hauv uas nalidixic acid yog tshuaj. Kev siv cov tshuaj uas muaj cov tshuaj no feem ntau tsis yog hauv nephrology nkaus xwb, tab sis kuj nyob rau lwm qhov chaw ntawm cov tshuaj. Cov lus qhia tseem ceeb yog:
- Cystitis. Kev mob ntawm lub zais zis feem ntau tshwm sim los ntawm Escherichia coli thiab Proteus, yog li cov tshuaj los ntawm pawg quinolone tau muab tshuaj, uas muaj txiaj ntsig zoo rau cov kab mob no.
- YPyelonephritis. Kev mob ntawm lub raum tubules teb zoo heev rau kev kho mob nrog nalidixic acid, tshwj xeeb tshaj yog nyob rau theem mob.
- Kev kuaj mob ntawm cov kab mob tso zis. Nyob rau hauv cov ntaub ntawv no, cov tshuaj raug sau ua ntej urological manipulations thiab kev khiav hauj lwm.
- Acute otitis media.
- Cholecystitis.
- Cov kab mob ua paug ntawm cov hnyuv loj thiab cov hnyuv (enterocolitis).
- YUrethritis thiab prostatitis.
Tsis tas li, nalidixic acid tuaj yeem raug sau rau lwm yam kab mob tshwm sim los ntawm Gram (-) kab mob.
Cov tshuaj twg muaj nalidixic acid?
Muaj ntau cov tshuaj uas muaj nalidixic acid. Tag nrho cov ntawm lawv muaj ib yam nkaus thiabindications rau siv. Qee zaum, qhov koob tshuaj ntawm cov tshuaj tseem ceeb sib txawv. Cov npe sib txawv thiab tus nqi rau cov tshuaj no nyob ntawm lub teb chaws ntawm kev tsim khoom thiab lub tuam txhab uas tsim cov tshuaj. Cov neeg sawv cev nto moo tshaj plaws yog cov tshuaj Nevigramon. Cov tshuaj no muaj ntau yam analogues. Ntawm lawv yog cov tshuaj: "Negram", "Nalid", "Cistidine", "Vintomilon", "Urogram" thiab lwm yam. Tag nrho cov tshuaj no muaj txiaj ntsig zoo rau lub cev.
Nalidic acid: cov lus qhia rau kev siv tshuaj
Kev npaj muaj nalidixic acid yuav tsum tau noj ntawm qhov ntau npaum ntawm 500 mg 3-4 zaug ib hnub. Feem ntau, cov khoom xyaw nquag no muaj nyob hauv ib ntsiav tshuaj lossis tshuaj ntsiav. Rau qhov mob hnyav, koj tuaj yeem noj 1000 mg 4 zaug hauv ib hnub. Hauv cov menyuam yaus, qhov koob tshuaj yuav tsum raug xam (60 mg / kg lub cev hnyav).
Contraindications thiab phiv
Zoo li feem ntau cov tshuaj tua kab mob, nalidixic acid yog contraindicated rau cov poj niam nyob rau hauv thawj peb lub hlis twg ntawm cev xeeb tub thiab pub niam mis. Tsis tas li ntawd, cov tshuaj no yuav tsum tsis txhob siv los ntawm cov menyuam yaus hnub nyoog qis dua 2 xyoos. Lwm yam contraindications suav nrog rau lub raum thiab lub siab tsis ua haujlwm.
Cov kev mob tshwm sim suav nrog kev cuam tshuam ntawm lub plab zom mov (flatulence, xeev siab, ntuav), kiv taub hau, ua xua. Nalidixic acid yuav tsum tau siv nrog ceev faj rau cov neeg uas raug kev txom nyem los ntawm cov kab mob neurological (Parkinson tus kab mob, qaug dab peg, mob stroke).
