Beta1-blockers yog siv los tshem tawm cov ntshav siab thiab ntau yam kab mob plawv. Ib qho ntawm cov tshuaj no yog cov tshuaj "Betak". Cov lus qhia rau kev siv characterizes nws raws li ib tug tshuaj uas nthuav tawm cardioselective, antihypertensive thiab sympathomimetic teebmeem.
yam ntxwv dav dav
Cov tshuaj no yog suav tias yog cov khoom siv hluavtaws beta1-blocker. Ua los ntawm Cypriot cog "Medocemi LTD" hauv daim ntawv ntsiav tshuaj nrog lub plhaub dawb lossis yuav luag dawb txheej.
Tshuaj "Betak" cov lus qhia rau kev siv cov lus piav qhia ntawm cov tshuaj muaj cov yam ntxwv hauv qab no: lawv muaj cov duab sib npaug nrog cov npoo biconvex, muaj cov kab sib faib hauv daim ntawv txaus ntshai. Yog tias koj ua txhaum cov tshuaj, ces nws cov ntsiab lus sab hauv yuav dawb los yog yuav luag dawb.
Rau cov tshuaj Betak, cov lus qhia rau kev siv piav qhia cov neeg siv khoom ntim raws li hauv qab no: hauv ib qhoLub pob muaj peb lub hlwv. 10 ntsiav tshuaj tau ntim rau hauv txhua daim ntawv qhia ntawm tes.
Composition
Hauv cov tshuaj, lub luag haujlwm tseem ceeb yog muab rau cov khoom xyaw nquag ntawm betaxolol hauv daim ntawv ntawm hydrochloride ntsev. Qhov koob tshuaj ntawm txhua ntsiav tshuaj yog 0.020 g.
Rau tus neeg sawv cev Betak, cov lus qhia rau kev siv piav qhia txog cov khoom xyaw uas tsis muaj zog yam tsis qhia txog lawv qhov ntau. Cov ntsiav tshuaj yog tsim los ntawm sodium starchy glycolate, mis nyuj qab zib, magnesium stearate, microcrystalline cellulose, aerosil, titanium oxide, hydroxymethylpropylcellulose thiab polyethylene glycol qib 400.
Mechanism of action
Rau tshuaj "Betak" cov lus qhia rau kev siv paub meej tias cardioselective beta1-adrenergic thaiv kev ua haujlwm yam tsis muaj kev cuam tshuam sab hauv sympathomimetic. Cov ntsiav tshuaj pom cov membrane tsis zoo stabilizing ua tau zoo.
Kev tiv thaiv kev mob ntshav siab yog vim kev ua haujlwm uas txo cov ntshav siab thiab txo cov kev xav ntawm kev xav hauv cov hlab ntsha peripheral.
Kev xaiv ntawm cov tshuaj muaj txiaj ntsig ntawm β1-adrenoreceptor formations tsis tuaj yeem hu ua yam tsis muaj xwm txheej, vim tias cov koob tshuaj ntau ntawm betaxolol tuaj yeem cuam tshuam β 2 -adrenergic receptor formations uas nyob rau hauv lub bronchi thiab cov hlab ntsha.
Cov nyhuv thaiv ntawm cov tshuaj, suav nrog cov yam ntxwv ntawm cov tshuaj pharmacodynamic, cuam tshuam nrog kev txo qis hauv lub plawv dhia thaum so thiab thaum lub sijhawm ua haujlwm. Nws tshwm sim vim inhibition.β-adrenergic formations nyob rau hauv lub sinus nodes, uas slows down lawv automatism.
Nws kuj txo cov zis myocardial hauv lub cev ua haujlwm thiab tsis muaj zog ntawm lub cev, uas yog tshwm sim los ntawm kev sib tw antagonism ntawm catecholamines hauv paj hlwb xaus ntawm peripheral thiab adrenergic hom.
Cov tshuaj txo cov systolic thiab diastolic siab hauv cov hlab ntsha thaum so thiab thaum lub sijhawm ua haujlwm, tshem tawm cov orthostatic reflex nce ntau zaus ntawm lub plawv contractions. Cov nyhuv ntawm cov tshuaj no txo cov load ntawm myocardium.
Beta-blocker muaj cov haujlwm tiv thaiv ntshav siab los ntawm cov txheej txheem hauv qab no:
- txo qis lub plawv tso zis;
- tshem tawm spasm nyob rau hauv cov hlab ntsha raws lub periphery vim lub hauv paus ua haujlwm, uas txwv tsis pub lub siab xav rau cov phab ntsa vascular thaum inhibition ntawm renin kev ua.
Kev siv tshuaj ntev ntev tsis txo nws cov nyhuv hypotensive. Yog tias koj noj ib koob tshuaj betaxolol 0.005 lossis 0.04 g, tom qab ntawd qhov txo qis yuav tshwm sim tom qab 3 lossis 4 teev.
Rau Betak, cov lus qhia rau kev siv qhia tau hais tias qhov kev taw qhia ntawm qhov ntau npaum li cas ntawm 0.005 g yuav ua rau cov nyhuv antihypertensive, qhov kev siv ntawm uas yuav qis dua ob zaug thaum siv tag nrho cov ntsiav tshuaj.
Kev ua haujlwm siab tshaj plaws ntawm txhua qhov kev sib xyaw ntawm betaxolol tshwm sim tom qab 7-14 hnub.
Kev kho tshuaj ntau npaum li cas ntawm cov tshuaj tsis ua rau muaj kev cuam tshuam txog kev mob plawv, tsis cuam tshuam rau cov metabolism hauv qabzib, tsis txhob nce cov tshuaj sodium cations thiabdej hauv cov ntaub so ntswg.
Yuav siv li cas
Betak cov lus qhia rau kev siv cov lus qhia suav nrog cov hauv qab no:
- ntshav siab;
- kab mob ischemic ntawm cov leeg nqaij myocardial, txheej txheem infarct hauv myocardium;
- hypertrophic cardiomyopathy.
Cov tshuaj tau sau tseg thaum muaj kev hloov pauv hauv kev ua haujlwm ntawm lub plawv, uas tau qhia los ntawm kev ua kom nrawm ntawm lub sinus atherosclerosis, supraventricular thiab ventricular tachyarrhythmia, untimely depolarization ntawm myocardium, arrhythmia txuam nrog mitral valve prolapse, ntau dhau. kev tsim cov thyroid hormones.
Yuav siv li cas
Rau cov tshuaj "Betak" cov lus qhia rau kev siv koob tshuaj yog sau nyob ntawm tus neeg mob tus mob. Tag nrho cov koob tshuaj txhua hnub yog qaug cawv hauv ib qho kev siv. Cov zaub mov tsis cuam tshuam rau kev nqus ntawm cov tshuaj. Cov ntsiav tshuaj yuav tsum tau noj nrog dej huv.
Kev nce ntshav siab yog kho nrog thawj koob tshuaj txhua hnub ntawm 0.005 txog 0.010 g. Tom qab 7 lossis 14 hnub, yog tias tsim nyog, cov tshuaj tau nce mus rau 0.020 g.
leej twg yuav tsum tsis thov
Tsis yog txhua tus raug tso cai siv Betak cov lus qhia rau kev siv. Contraindications yog txuam nrog ntau rhiab heev rau cov khoom xyaw, nrog rau betaxolol hydrochloride.
Nws tsis yog tshuaj rau cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev, sinoatrial thiab atrioventricular block nyob rau qib thib ob thiab thib peb, bradycardia, arterialhypotension, asthmatic bronchial tawm tsam, spontaneous angina pectoris.
Tshuaj "Betak" ntsiav tshuaj cov lus qhia rau kev siv kuj tsis pom zoo haus nrog cardiogenic poob siab, angiotrophoneurosis ntawm lub davhlau ya nyob twg, o ntawm myocardial nqaij, asthenic ophthalmoplegia, endarteritis obliterans, emphysema lesions ntawm lub ntsws cov ntaub so ntswg, mob bronchitis., mob ntshav qab zib mellitus.
Pom tseeb qhov kev hloov pauv ntawm lub raum thiab psoriasis pob khaus yog ib qho contraindication rau kev kho.
kev tawm tsam tsis zoo
Cov txiaj ntsig tsis zoo ntawm kev kho Betak suav nrog lub plawv dhia qeeb, atrioventricular blockage, lub plawv tsis ua haujlwm, orthostatic hypotension, tsis zoo peripheral ncig, feem ntau txias tes thiab ko taw, paresthesia. Qhov no cuam tshuam kev ua haujlwm ntawm cov hlab ntsha thiab lub plawv.
Bronchial spasm, pob khaus, urticaria, psoriasis, dryness ntawm mucous daim nyias nyias ntawm lub qhov muag yuav ua rau muaj kev phiv ntawm lub pa thiab lub cev qhov muag, daim tawv nqaij.
Cov tshuaj tuaj yeem ua rau qaug zog, mob asthenic, kev nyuaj siab, qaug zog ntau dhau, tsis meej pem, pom kev hnov qab, tawm tsam kiv taub hau thiab mob taub hau.
Cov txheej txheem tsis zoo hauv lub plab zom mov yog cuam tshuam nrog xeev siab, ntuav, raws plab, quav quav, cholestasis.
Lwm yam tshwm sim ntawm qhov kev ua ntawm cov tshuaj yuav txo qis hauv leukocyte thiab platelet hlwbntshav, nrog rau txo qis zog.
Txoj kev kho mob
Kev lees txais cov tshuaj yuav muaj nrog qee yam nuances uas nyob ntawm pawg kws kho mob, muaj pes tsawg leeg thiab ntau npaum li cas ntawm cov tshuaj siv.
Betak cov lus qhia rau kev siv muab cov lus qhia tshwj xeeb rau txhua rooj plaub uas tsis yog tus qauv yuav tsum tau saib xyuas.
Yog li ntawm thawj theem ntawm kev kho mob, kev ua haujlwm tsis txaus ntawm cov leeg nqaij yuav tshwm sim hauv cov neeg uas muaj qhov sib txawv no.
Noj cov ntsiav tshuaj Betak npog cov tsos mob ntawm lub xeev hypoglycemic, qhov tseem ceeb ntawm kev ua haujlwm ntawm lub plawv dhia. Qhov kev paub no yuav tsum raug coj mus rau hauv tus account los ntawm cov neeg mob uas muaj suab thaj ntau ntxiv. Lawv yuav tsum tau saib xyuas cov ntshav qabzib tsis tu ncua.
Thaum siv tshuaj Betak (cov ntsiav tshuaj), cov lus qhia rau kev siv pom zoo kom them nyiaj rau kev tswj lub plawv dhia. Nyob rau hauv cov kev tshwm sim ntawm ib tug bradycardiac sinus atherosclerosis, nws yog tsim nyog los txo cov koob tshuaj los yog tso tseg kev kho mob nrog cov tshuaj no.
Yuav tsum tau ceev faj siv cov tshuaj hauv cov neeg mob uas muaj pheochromocytoma tsim.
Kev sib xyaw ntawm cov tshuaj nrog kev nqus tshuaj loog ua rau inhibition ntawm myocardial cov leeg thiab txo cov ntshav siab. Non-depolarizing nqaij relaxants qhia cov nyhuv ntev dua thaum raug rau Betak ntsiav tshuaj.
Yog tias tsim nyog los ua qhov kev npaj cuam tshuam ntawm kev phaisxwm, ces cov tshuaj muab tso tseg ob hnub ua ntej qhov kev tshwm sim, kom cov tshuaj tsis muaj feem xyuam rau cov tshuaj loog.
Tom qab kev kho mob nrog tshuaj Betak, cov lus qhia rau kev siv tsis yog tam sim ntawd, tab sis maj mam, nrog kev txo qis hauv cov tshuaj ntau dua 7 lossis 14 hnub, txhawm rau zam lub cev cov tshuaj tiv thaiv rau kev tshem tawm tshuaj. Txhua peb hnub, tus nqi ntawm cov tshuaj raug txo los ntawm 0.005 g.
Tshuaj yuav tsum tsis txhob noj nrog cov tshuaj uas yog monoamine oxidase inhibitors.
Cov tshuaj tiv thaiv ntshav siab ntawm cov tshuaj txo qis los ntawm cov tshuaj uas tsis yog tshuaj steroidal los tiv thaiv kev mob thiab cov tshuaj estrogen, uas khaws cov sodium ions thiab dej, thiab tseem inhibit synthesis ntawm prostaglandin tebchaw nyob rau hauv lub raum.
Kev siv tib lub sijhawm ntawm diltiazem, amiodarone thiab verapamil nrog Betak ntsiav tshuaj ua rau muaj kev nce ntxiv hauv cov nyhuv inhibitory ntawm betaxolol hydrochloride ntawm kev contractility ntawm cov leeg myocardial thiab nws cov conductivity.
Kev sib xyaw ntawm cov tshuaj nrog cov tshuaj plawv glycoside pab txhawb kev txhim kho ntawm atrioventricular type block.
Kev sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob ua rau muaj kev ua haujlwm siab ntawm Betak ntsiav tshuaj.
Cocaine txo cov kev kho mob ntawm betaxolol thaum noj ib txhij.
Kev sib xyaw ntawm cov ntsiav tshuaj Betak nrog adrenomimetics lossis xanthines ua rau muaj kev cuam tshuam ntawm lawv cov haujlwm.
Phenotiazines thiab betaxolol hydrochloride, thaum sib cuam tshuam, nce lawvntshav qib.
Betak tiv thaiv kev tshem tawm cov tshuaj uas muaj lidocaine lossis theophylline.
Sulfasalazine tsub kom cov ntshav concentration ntawm betaxolol hydrochloride.
Tsis muaj ntaub ntawv qhia txog kev siv tshuaj hauv cov neeg mob menyuam yaus.
Kev ceev faj yuav tsum tau siv cov ntsiav tshuaj los ntawm cov neeg tsav tsheb, nrog rau cov poj niam cev xeeb tub thiab lactating.
Cov khoom zoo sib xws
Beta1-adrenergic thaiv cov tshuaj suav nrog cov tshuaj "Betak" cov lus qhia rau kev siv. Analogues kuj muaj nyob rau hauv chav kawm pharmacotherapeutic. Lawv cov khoom xyaw nquag yog betaxolol hydrochloride.
Fabkis analogue yog cov tshuaj "Lokren", tsim los ntawm lub tuam txhab "Sanofi Winthrop Kev Lag Luam" hauv daim ntawv ntsiav tshuaj coated nrog cov yeeb yaj kiab dawb. Lawv cov duab yog puag ncig nrog lub ntsej muag biconvex, uas muaj cov kab sib faib thiab cov npe extruded "KE 20".
Muaj nyob hauv ib koob ntawm 0.02 g ntawm betaxolol hydrochloride. Cov khoom siv ntawm cov tshuaj muaj xws li mis nyuj qab zib, microcrystalline cellulose, hom A sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate.
Hypromellose, polyethylene glycol qib 400, titanium dioxide tuaj yeem pom nyob rau hauv cov txheej txheem ntawm zaj duab xis txheej.
Cov tshuaj yog muag hauv cov thawv ntawv nrog ob lub hlwv ntawm 14 ntsiav tshuaj.
Siv los kho cov ntshav siab, nws kuj tseem ua ke nrog lwm yam tshuaj rau ntshav siab.
Cov tshuaj tuaj yeem siv los tiv thaiv kev ua rau mob angina pectoris ntau dua hauv daim ntawv ntxhov siab.
Ib yam tshuaj zoo sib xws hauv tebchaws Russia yog Betaxolol, uas yog tsim los ntawm Moscow Endocrine cog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb zaj duab xis-coated. Lawv muaj ib puag ncig zoo nrog biconvex nto. Lub active ingredient yog betaxolol hydrochloride nyob rau hauv tus nqi ntawm 0.020 g. Cov koom haum pab muaj xws li mis nyuj qab zib, sodium starch glycolate, dehydrated aerosil, magnesium stearate, microcrystalline cellulose. Cov zaj duab xis txheej yog tsim los ntawm polyvinyl cawv, titanium dioxide, talc, macrogol hom 3350, opraem-2 dawb.
Cov tshuaj no yog siv rau hauv cov ntshav siab.
Tseem muaj cov tshuaj "Betaxolol" nyob rau hauv daim ntawv ntawm qhov muag tee, uas yog siv topically nyob rau hauv mob qhib-angle glaucoma, nrog siab intraocular siab, thaum kho qhov muag pom tom qab laser trabeculoplasty.
Tus neeg mob tawm tswv yim
Hais txog lub cuab yeej Betak, cov lus qhia rau kev siv suav nrog kev tshuaj xyuas cov txiaj ntsig tsis zoo hauv ntu "kev cuam tshuam tsis zoo". Cov tsos mob no yuav tsis tshwm sim thaum siv tshuaj.
Los ntawm ntau tus neeg mob koj tuaj yeem hnov cov lus pom zoo txog beta1-blocker Betak, uas zoo kawg nkaus kho cov hlab ntshav siab thiab angina pectoris. Yeej, cov ntsiav tshuaj tau noj ua ke nrog lwm cov tshuaj antihypertensive rauKev kho mob nyuaj uas txhim kho lawv cov txiaj ntsig.
Tom qab kawm ntawv tiav, ntshav siab rov qab los zoo li qub, uas ua rau tus neeg mob muaj kev noj qab haus huv zoo heev.
Tseem muaj kev tshuaj xyuas txog cov tshuaj, uas qhia txog qhov tsis muaj txiaj ntsig ntawm kev kho mob nrog cov tshuaj no.
