Lipid peroxidation (LPO) yog qhov txuas tseem ceeb hauv cov metabolism hauv metabolic. Nws lub luag haujlwm tseem ceeb yog rov ua dua cov lipids ntawm cov cell membranes.
Nyob rau hauv tus neeg noj qab haus huv, cov txheej txheem lipid peroxidation yog tswj los ntawm lub npe hu ua antioxidant system, uas tswj tus nqi thiab kev ua haujlwm ntawm phosphorylation los ntawm kev sib txuas ua rau muaj kev cuam tshuam los yog nruab nrab peroxides txaus los tiv thaiv cov khoom kawg ntawm cov khoom metabolism. Kev ua kom muaj zog ntawm cov txheej txheem oxidation tuaj yeem yog qhov pib ntawm cov txheej txheem pathophysiological ntawm cov kab mob tseem ceeb. Cov txheej txheem no suav nrog cov kauj ruam ntawm enzymatic thiab non-enzymatic autoxidation.
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Rau qhov kev hloov kho ntawm phospholipid bilayer ntawm cell membranes, enzymatic oxidation tshwm sim. Tsis tas li ntawd, nws muaj kev koom tes hauv kev tsim cov tshuaj lom neeg lom neeg, detoxification ntawm lub cev, cov tshuaj tiv thaiv metabolic. Tsis yog-enzymatic oxidation, ntawm qhov tod tes, manifests nws tus kheej ua ib qho kev puas tsuaj hauv lub neej ntawm tes. Vim kev kawmIb tug loj tus naj npawb ntawm cov dawb radicals thiab tsub zuj zuj ntawm peroxides, cov kev ua ntawm antioxidant zog txo thiab, raws li, kev tuag ntawm lub cev hlwb raug soj ntsuam.
Sex cycle
Txhawm rau pib lipid peroxidation, muaj cov pa oxygen dawb radicals, uas muaj ib qho hluav taws xob tsis sib xws ntawm qib siab zog, yog qhov tsim nyog. Tom qab txo cov molecule, oxygen superoxide yog tsim, uas reacts nrog hydrogen atoms, tig mus rau hydrogen peroxide. Txhawm rau tswj tus nqi ntawm superoxides hauv lub cell, muaj superoxide dismutase, uas tsim hydrogen peroxide, thiab catalase, peroxidase neutralize nws rau dej. Yog tias cov kab mob muaj sia nyob tau raug ionizing hluav taws xob, tus nqi ntawm cov dawb hydroxyl radicals yuav nce ntau. Ntxiv nrog rau cov pa oxygen hydroxide, nws lwm cov ntaub ntawv nquag tuaj yeem ua tus pib ntawm lipid peroxidation.
Cov khoom ntawm lipid peroxidation yog siv los ntawm lub cev lossis siv rau kev sib txuas ntawm prostaglandins (cov tshuaj koom nrog hauv cov tshuaj tiv thaiv kab mob), thromboxanes (suav nrog cov cascade ntawm cov tshuaj tiv thaiv thrombogenic), adrenal hormones.
Control system
Nyob ntawm cov qauv ntawm cov cell membrane, tus nqi, kev ua thiab tus nqi ntawm cov khoom oxidation tshwm sim yuav txawv. Yog li, piv txwv li, qhov kev ua ntawm lipid peroxidation yog siab dua qhov twg unsaturated fatty acids predominate nyob rau hauv lub cell phab ntsa, thiab qeeb yog tias cov roj cholesterol yog lub hauv paus ntawm CS. Tsuas yogTsis tas li ntawd, cov enzymes metabolic yog ib qho tseem ceeb tswj tus nqi thiab tus nqi ntawm kev tsim cov pa dawb radicals, nrog rau kev siv peroxides. Cov tshuaj uas cuam tshuam rau lipid muaj pes tsawg leeg ntawm cov cell membrane thiab nws txoj kev hloov pauv raws li qhov xav tau ntawm lub cev kuj koom nrog cov tshuaj tiv thaiv lipid peroxidation. Cov no suav nrog cov vitamin E thiab K, thyroxine (cov thyroid hormone), hydrocortisone, cortisone, thiab aldosterone (feem). Hlau ions, vitamins C thiab D destabilize lub cell phab ntsa.
Kev ua txhaum cai
Metabolic cov khoom ntawm lipid peroxidation tuaj yeem sib sau hauv cov ntaub so ntswg thiab cov kua dej hauv lub cev yog tias cov kab mob antioxidant tsis muaj sijhawm los siv lawv ntawm tus nqi xav tau. Raws li qhov tshwm sim, kev thauj cov ions hla cov cell membrane cuam tshuam, uas tuaj yeem cuam tshuam ncaj qha rau cov ionic muaj pes tsawg leeg ntawm cov kua hauv cov ntshav, tus nqi ntawm polarization thiab depolarization ntawm cov leeg cell membranes (ua rau muaj kev cuam tshuam ntawm cov hlab ntsha impulses, lawv contractility., nce lub sij hawm refractory), txhawb kev tso tawm ntawm cov kua rau hauv qhov chaw extracellular (edema, ntshav txhaws, electrolyte imbalance). Tsis tas li ntawd, cov khoom tseem ceeb ntawm lipid peroxidation, tom qab ib tug series ntawm biochemical tshuaj, tau hloov mus rau hauv aldehydes, ketone lub cev, acids, thiab lwm yam. Cov tshuaj no muaj ib tug toxic nyhuv ntawm lub cev, manifested nyob rau hauv ib tug txo nyob rau hauv tus nqi ntawm DNA synthesis, nce hauv capillary permeability, nce oncotic siab thiab, raws li qhov tshwm sim, sludge syndrome.
Kev kho mob tshwm sim
Vim tias qhov nce ntxiv ntawm cov pa oxygen dawb radicals muaj kev puas tsuaj rau ntawm phab ntsa ntawm tes, thiab cov khoom lag luam metabolic cuam tshuam cov txheej txheem ntawm cov metabolism thiab synthesis ntawm nucleic acids, thiab kuj lom lub cev, lawv yog cov kab mob pathophysiological hauv txoj kev loj hlob ntawm ib tug xov tooj ntawm kev kho mob tej yam kev mob. Lub luag haujlwm ntawm lipid peroxidation yog qhov tseem ceeb hauv cov kab mob ntawm daim siab, pob qij txha, kab mob sib kis, kab mob hemodynamic, mob qog noj ntshav, raug mob thiab kub hnyiab. LPO yog ib qho tseem ceeb hauv kev txhim kho atherosclerosis. Dawb radicals, oxidizing cov roj cholesterol thiab nws qhov tsis tshua muaj qhov hnyav molecular, tsim cov khoom uas ua rau cov phab ntsa vascular puas. Qhov no ua rau muaj kev cuam tshuam ntawm cov tshuaj tiv thaiv kab mob uas cuam tshuam rau kev tshem tawm kev puas tsuaj. Qhov no provokes thrombosis, tsub zuj zuj ntawm cov ntshav txhaws nyob rau hauv lub lumen ntawm cov hlab ntsha me me los yog txuas rau lawv cov phab ntsa. Raws li qhov tshwm sim, kev txav ntawm cov ntshav hauv cheeb tsam no qeeb, txij li lub lumen ntawm lub nkoj tau dhau los ua qhov nqaim. Qhov no ua rau cov ntshav txhaws ntxiv. Qhov cuam tshuam tshaj plaws rau cov kev hloov pauv no yog cov hlab ntsha coronary, aorta, uas tshwm sim lawv tus kheej hauv tsev kho mob raws li cov tsos mob ntawm tus kab mob plawv.
ntsuas kev tiv thaiv
Cov kws kho mob yuav tsum paub tias cov txheej txheem kuaj mob thiab kho cov txheej txheem tuaj yeem qhib lub lipid peroxidation mechanism. Tus neeg mob yuav tsum tau ceeb toom txog qhov no. Cov teeb meem tshwm sim muaj xws li kev kho hluav taws xob (rau oncology), ultravioletirradiation (rau rickets, inflammatory kab mob ntawm lub sinuses, antibacterial kev kho mob ntawm thaj chaw), magnetic teb (MRI, CT, physiotherapy), zaug nyob rau hauv lub siab chamber (rau poliomyelitis, mob roob).
Cov neeg ua haujlwm hauv chav x-ray, cov kws saib xyuas neeg mob, kws kho lub cev, cov neeg nce toj, cov neeg rog rog yuav tsum tau noj zaub mov uas muaj cov tshuaj antioxidants: ntses, paj noob hlis lossis roj txiv roj, tshuaj ntsuab, qe, tshuaj yej ntsuab.
Ntxiv rau kev hloov pauv kev noj zaub mov, koj tuaj yeem siv cov tshuaj uas khi qee pawg ntawm cov dawb radicals lossis ua ke nrog cov hlau ntawm cov valence sib txawv. Yog li, lawv hloov cov molecules dawb ntawm cov pa oxygen, tiv thaiv lawv los ntawm kev khi rau LPO enhancers.
Diagnosis
Tam sim no ntawm kev txhim kho kev tshawb fawb hauv chav kuaj, peb muaj sijhawm los kuaj xyuas cov peroxides hauv cov kua dej lom neeg ntawm tib neeg lub cev. Qhov no yuav tsum tau fluorescence microscopy. Cias muab, txheeb xyuas lipid peroxidation. Qhov tseem ceeb ntawm qhov kev kuaj mob no yuav tsum tsis muaj lus piav qhia. Tom qab tag nrho, lub hauv paus ntawm tus lej tseem ceeb ntawm cov kab mob yog kev ua haujlwm ntau dhau ntawm lipid peroxidation. Kev txheeb xyuas tus mob no txiav txim siab txog kev kho mob.
Los ntawm qhov pom ntawm lub cev ib txwm muaj, lipid peroxidation yog qhov tsim nyogRau kev tsim cov tshuaj hormones steroid, inflammatory mediators, cytokines thiab thromboxanes. Tab sis thaum tus nqi ntawm cov khoom ntawm kev sib pauv ntawm cov tshuaj tiv thaiv no ntau tshaj qhov tso cai tus nqi thiab peroxides puas cell organelles, cuam tshuam cov synthesis ntawm DNA thiab cov proteins, lub antioxidant system los rau hauv kev txiav txim, txo tus nqi ntawm cov dawb oxygen radicals, hlau ions nrog variable. valence. Tsis tas li ntawd, nws ua rau kom cov synthesis ntawm catalase thiab peroxidase kom siv ntau tshaj peroxides thiab cov khoom ntawm lawv cov metabolism ntxiv.
