Osteoporosis yog ib yam kab mob hnyav uas ua rau cov pob txha degradation. Txawm tias me me raug mob los ntawm cov txheej txheem pathological no ua rau muaj kev cuam tshuam ntawm kev ua neej ib txwm muaj thiab kev tsis taus. Rau kev kho mob thiab tiv thaiv kev mob pob txha, "Ostalon" thiab "Ostalon Calcium-D" yog siv. Cov tshuaj no yog tsim los kom qeeb thiab nres tsis zoo cov ntaub so ntswg hloov pauv hauv cov poj niam postmenopausal. Tab sis kev noj tshuaj yuav tsum tau ua raws li cov lus qhia thiab ua raws li cov lus qhia rau kev siv "Ostalon", vim tsis quav ntsej cov lus pom zoo ua rau muaj kev cuam tshuam ntawm kev kho.
Form and composition
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntsiav tshuaj. Cov ntsiav tshuaj yog dawb, txhua tus muaj M14 engraving. Cov khoom xyaw nquag yog alendronic acid (70 mg). Tsis tas li ntawd, cov tshuaj muaj pes tsawg leeg muaj cov tshuaj ntxiv uas ua rau muaj kev faib tawm ntawm cov tshuaj nquag.tshuaj, thiab kuj txhim khu nws cov nyhuv.
Main auxiliary Cheebtsam:
- colloidal silicon dioxide;
- magnesium stearate;
- Ymicrocrystalline cellulose;
- croscarmellose sodium.
Nyob rau hauv pob ntawm cov tshuaj "Ostalon Calcium-D" muaj 2 hom ntsiav tshuaj. Ib tug ntawm lawv yog kiag li zoo tib yam rau cov tshuaj "Ostalon" nyob rau hauv tsos thiab muaj pes tsawg leeg, thiab lub thib ob muaj calcium carbonate nrog colcalciferol. Hom thib ob ntawm cov ntsiav tshuaj muaj cov duab oblong thiab xim av-daj tint.
Pharmacological kev txiav txim ntawm cov tshuaj
"Ostalon" belongs rau pawg bisphosphonates. Lawv cov txheej txheem ntawm kev ua haujlwm muaj nyob rau hauv kev xaiv tsim ntawm kev ruaj khov nrog cov pob txha pob txha. Tsis tas li ntawd, nws qhov kev txiav txim yog tsom rau kev ntes cov osteoclast, uas provokes degradation hloov pauv hauv cov pob txha. Qhov no txhais tau hais tias lub alendronic acid molecule yog nyob rau hauv qhov chaw uas cov pob txha cov ntaub so ntswg tau undergone deformation los ntawm osteoporosis.
Vim li ntawd, cov tshuaj nquag ntawm cov tshuaj thaiv cov synthesis ntawm farnesyl pyrophosphate synthase enzyme, uas ua rau lub cev tsis ua haujlwm ntawm osteoplast. Yog li ntawd, cov txheej txheem kev puas tsuaj qeeb qeeb thiab tom qab ntawd nres. Tsis tas li ntawd, alendronic acid ua haujlwm ua "lub hauv paus" rau kev tsim cov hlwb tshiab ntawm cov pob txha puas.
Tsis tas li, "Ostalon" thiab "Ostalon Calcium-D" nce tus nqi ciaj sia ntawm osteocyte hauv cov poj niam thaum lub sijhawmpostmenopausal.
Nyob rau hauv ib txoj hauv kev hais txog cov tshuaj, peb tuaj yeem hais tias nws ua cov haujlwm hauv qab no hauv lub cev:
- normalizes phosphorus-calcium metabolism;
- pab txhim kho cov muaj pes tsawg leeg thiab cov qauv ntawm cov pob txha.
Pharmacodynamics thiab pharmacokinetics
Cov khoom xyaw nquag, thaum nws nkag mus rau hauv lub cev, pib faib rau hauv cov ntaub so ntswg, thiab tom qab ntawd nkag mus rau hauv cov pob txha. Thaum nqus tau rau hauv cov ntshav, nws cov protein khi yog li 78%.
Noj cov tshuaj thaum sawv ntxov, 2 teev ua ntej noj mov, tso cai rau nws nqus tau ntawm qib 0.64%. Thiab nrog kev txo qis hauv lub sijhawm tos, qhov ntsuas no poob mus rau qib 0.39-0.46%, thiab qhov ua tau zoo ntawm cov khoom siv tsis poob.
Kev sib xyaw tshuaj nrog kas fes haus thiab kua txiv citrus txiv hmab txiv ntoo txo cov bioavailability ntawm cov tshuaj los ntawm 60%.
Kev tshawb fawb tsis tau lees paub cov tshuaj metabolism hauv lub cev. Lub absorbed active ingredient, uas tsis tau muab tso rau hauv cov pob txha cov ntaub so ntswg, yog excreted nyob rau hauv cov zis.
Rau 6 teev tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj, nws cov concentration hauv cov ntshav txo mus rau 95%. Lub neej ib nrab yog txog kaum xyoo, thiab qhov no ib zaug ua pov thawj tias alendronic acid tuaj yeem nyob hauv cov pob txha mus ntev.
Nyob rau hauv lub xub ntiag ntawm hypocalcemia, nws yuav tsum tau kho nws ua ntej pib kho nrog "Ostalon". Txoj kev kho yuav tsum tau ua ke nrog kev noj zaub mov nplua nuj hauv Ca2+ ntsev.
"Ostalon Calcium-D" muajQee qhov sib txawv ntawm cov txheej txheem ntawm kev nqus thiab tom qab tshem tawm ntawm lub cev vim muaj colcalciferol (ib qho khoom siv bioavailable) thiab calcium carbonate. Thaum noj qhov ncauj, cov khoom xyaw nquag yog absorbed los ntawm ib feem peb ntawm cov hnyuv. Qhov no yog vim muaj cov vitamin D thiab nyob ntawm qib acidity.
Colecalciferol yog ib feem tawm ntawm lub raum (20%) thiab cov nyiaj seem ntawm cov hnyuv.
Main indications
Kev txais tos ntawm "Ostalon" thiab cov tshuaj "Ostalon Calcium-D" raug sau rau hauv cov xwm txheej hauv qab no:
- Kev kho cov pob txha pob txha degradation mob tshwm sim los ntawm kev siv cov glucocorticosteroids mus ntev.
- Kom txo cov tsos mob thiab kho pob txha pob txha hauv cov poj niam postmenopausal. Tom qab tag nrho, nws yog nyob rau lub sijhawm no uas muaj kev pheej hmoo ntawm pob txha pob txha thiab lub taub hau ntawm pob txha pob txha nce.
- Rau cov txiv neej hauv txoj kev kho mob pob txha. Kev txais tos hauv qhov no tuaj yeem txo qhov tsis muaj zog ntawm cov pob txha ntawm tus txha nraub qaum thiab pelvis.
YContraindications
Cov tshuaj muaj ntau yam contraindications uas yuav tsum tau coj mus rau hauv tus account. Txwv tsis pub, cov tshuaj tuaj yeem ua rau muaj kev phiv tshwm sim.
Lub ntsiab contraindications:
- Kab mob ntawm txoj hlab pas, nrog rau lwm cov txheej txheem pathological uas cuam tshuam kev nkag mus ntawm cov zaub mov.
- Tsis muaj lossis ntau dhau ntawm cov vitamin D hauv lub cev.
- Y Hypocalcemia, hypercalciuria,hyperparathyroidism.
- Lub raum tsis ua haujlwm hnyav (creatinine tshem tawm tsawg dua 35 ml / min.).
- Ib tus neeg intolerance rau cov khoom uas tsim cov tshuaj.
- Kwv Txhiaj, lactation.
- Cov me nyuam, hluas.
- Osteoporosis provoked by immobilization.
- Tuberculosis thiab tsis txaus cov zaub mov metabolism, yuav tsum tau kho tus mob.
- Tus neeg tsis muaj peev xwm sawv ntsug tsawg dua li ib nrab teev.
Ua tib zoo sau tshuaj rau cov neeg mob uas muaj kab mob ntawm sab sauv ntawm lub plab zom mov. Qhov no yog vim muaj kev cuam tshuam ntawm alendronic acid rau ntawm daim tawv nqaij ntawm lub plab thiab txoj hlab pas. Yog li ntawd, nws yog ib qho tseem ceeb uas tus neeg mob yuav tsum nyob twj ywm nyob rau hauv ib tug upright txoj hauj lwm rau 30 feeb tom qab noj cov ntsiav tshuaj Ostalon, thiaj li yuav txo tau qhov tshwm sim ntawm ib tug irritating nyhuv.
Tshuaj yuav tsum tsis txhob noj thaum lub sij hawm hluav taws xob thiab tshuaj kho mob cancer.
Glucocorticosteroids yog contraindicated thaum kho nrog cov tshuaj no, vim qhov no ua rau muaj kev pheej hmoo ntawm osteonecrosis. Vim tib yam, kev phais yuav tsum zam thaum kho cov kab mob hniav.
Ib tus kheej cov tshuaj rau kev kho mob osteoporosis, yog tias qhov ua rau ntawm nws txoj kev loj hlob tsis cuam tshuam nrog kev mob ntshav qab zib thiab hnub nyoog hloov pauv. Nws yog txwv tsis pub noj "Ostalon" yam tsis muaj kev pom zoo los ntawm tus kws kho mob tuaj koom!
Cov lus qhia rau kev siv "Ostalon"
Cov tshuaj noj 1 ntsiav tshuaj ib lub lis piam. Kev txais tos yog pom zoo thaum sawv ntxov ntawm lub plab khoob kom zoo dua nqus cov khoom xyaw rau hauv cov ntshav. Cov ntsiav tshuaj yuav tsum tau nqos tag nrho yam tsis muaj kev ua txhaum ntawm lub plhaub. Haus dej kom ntau.
Nws raug nquahu kom noj tshais tom qab noj "Ostalon" tsis pub dhau 1 teev tom qab. Nws yog ib qho tseem ceeb uas yuav tsum tuav txoj hauj lwm ncaj nraim li ib nrab teev tom qab cov tshuaj tau qaug dej qaug cawv.
Colecalciferon thiab calcium carbonate ntsiav tshuaj, uas muaj nyob rau hauv kev npaj "Ostalon Calcium-D", yuav tsum tau noj 1 zaug hauv ib hnub. Ntxiv mus, lawv yuav tsum tau noj tsis pub dhau 3 teev tom qab alendronic acid.
Rau cov neeg laus, kev hloov kho "Ostalon" tsis tas yuav tsum tau, txij li hnub nyoog hloov pauv hauv lub cev tsis muaj peev xwm ua rau muaj kev cuam tshuam ntawm cov khoom siv hauv lub cev.
Raws li cov lus qhia rau kev siv "Ostalon", yog tias koj hla ib koob, koj yuav tsum haus cov tshuaj rau hnub tom qab thaum sawv ntxov. Nws tsis tsim nyog haus ob ntsiav tshuaj hauv ib hnub! Yav tom ntej, koj yuav tsum rov qab mus rau qhov kev kho mob yav dhau los - ib zaug ib lub lim tiam, xaiv ib hnub tshwj xeeb.
Lub sijhawm nkag mus rau txhua tus neeg mob yog teem rau tus kheej, nyob ntawm tus yam ntxwv ntawm tus neeg mob thiab qhov xwm txheej ntawm kev hloov pauv hauv cov pob txha.
Ntau dhau thiab phiv
Kev tsis ua raws li qhov zaus thiab cov qauv ntawm kev noj tshuaj ua rau muaj kev noj ntau dhau, uas qhia los ntawm hypophosphatemia thiabhypocalcemia. Tsis tas li ntawd, kev kho Ostalon rau lub sijhawm ntev tuaj yeem ua rau calcification ntawm cov ntaub so ntswg thiab cov hlab ntsha.
Kev noj ntau dhau yog tshwm sim los ntawm kev ua txhaum ntawm kev ua haujlwm ntawm lub plab zom mov: kub siab, xeev siab, gastritis, raws plab. Nyob rau tib lub sijhawm, kev dag ntxias ua rau lub gag reflex raug txwv, vim qhov no tuaj yeem ua rau khaus ntawm cov hlab pas.
Tsis muaj kev kho tshwj xeeb rau kev noj tshuaj ntau dhau. Yog tias ceeb toom cov tsos mob ntawm intoxication tshwm sim, koj yuav tsum sab laj nrog kws kho mob. Thiab raws li kev pab thawj zaug, nws raug pom zoo kom haus mis nyuj thiab noj tshuaj antacids.
Cov teebmeem tshwm sim thaum noj "Ostalon" yog raws li hauv qab no:
- mob heev - mob leeg thiab pob qij txha;
- nquag - mob taub hau, cem quav, mob hauv plab, dyspepsia, flatulence, qaub eructation, myalgia, dysphagia, ostalgia, o ntawm extremities, khaus, alopecia;
- tsis tshua muaj - xeev siab, kiv taub hau, ntuav, raws plab, tawv nqaij hyperemia, nqaim ntawm lumen ntawm txoj hlab pas, osteonecrosis ntawm lub puab tsaig,
- exceptional case - general tsis muaj zog, kub taub hau, gastric los ntshav, scleritis, angioedema, urticaria, uveitis, osteonecrosis ntawm sab nraud auditory kwj dej.
Yog tias cov tsos mob ntawm cov tshuaj tiv thaiv los ntawm lub cev tshwm sim, tus kws kho mob tuaj koom yuav tsum tau ceeb toom txog qhov no txhawm rau hloov "Ostalon" nrog cov tshuaj analogue.
Kev sib tham nrog lwm yam tshuaj
Kev tshawb fawb soj ntsuam ntawm kev cuam tshuam ntawm "Ostalon" nrog rau lwm yam tshuaj tsis tau ua. Tab sis nws yogCov xwm txheej ntawm cov neeg mob uas ua ke siv cov tshuaj no nrog rau lwm cov tshuaj tau txheeb xyuas. Yog li ntawd, cov qauv hauv qab no tau tsim:
- "Ranitidine" ua ke nrog "Ostalon" txhim kho qhov muaj alendronic acid.
- Diuretics txo qis kev tso tawm ntawm calcium, ua rau muaj qhov tshwm sim ntawm hypercalcemia. Hauv kev kho mob nyuaj nrog pab pawg tshuaj no, nws yog ib qho tsim nyog los tsim kev tswj hwm qib calcium hauv lub cev.
- Systemic corticosteroids, antacids, cov tshuaj calcium uas txo qhov nqus ntawm calcium. Tawm tsam keeb kwm yav dhau los no, kev nce qib ntawm calcium thiab vitamin D tau raug txiav txim siab.
- Non-steroidal anti-inflammatory tshuaj exacerbate dysfunction ntawm digestive system.
- "Tetracycline" txo nws cov txiaj ntsig. Yog li, nws raug pom zoo kom noj cov tshuaj no ob teev ua ntej noj "Ostalon" lossis 4 teev tom qab nws.
Thaum noj "Ostalon", nws cov txiaj ntsig ntawm cov tshuaj tiv thaiv tsis tau qhia tawm, yog li ntawd, thaum lub sijhawm kho, tus neeg tuaj yeem tsav tsheb thiab ua haujlwm uas yuav tsum tau ua kom muaj kev saib xyuas ntxiv. Txawm li cas los xij, tsawg zaus ntawm kev txo qis me ntsis hauv qhov pom kev pom tau raug kaw. Yog li ntawd, kom txog rau thaum cov tsos mob tsis kaj siab ploj mus, koj yuav tsum tsis txhob ua tej yam uas yuav tsum tau concentration.
Analogues ntawm "Ostalon"
Qhov tsis zoo ntawm cov tshuaj yog nws cov nqi nce ntxiv. Tus nqi ntawm "Ostalon" yog hais txog 500 rubles rau ib lub phaj nrog plaub ntsiav tshuaj. Thiab yog li ntawdRaws li cov txiaj ntsig kho tau tsuas yog ua tiav raws li kev siv mus ntev, qee zaum nws tau hloov los ntawm cov tshuaj uas muaj cov nyhuv zoo sib xws:
- "Alendronat" (Russia). Cov khoom xyaw nquag yog alendronate sodium trihydrate. Cov tshuaj muaj nyob rau hauv txawv ntim, uas tso cai rau tus neeg mob mus yuav cov tshuaj nyob rau hauv tus nqi qhia los ntawm tus kws kho mob. Ntxiv nrog rau kev mob pob txha, cov tshuaj siv los txo cov pob txha pob txha thiab Paget tus kab mob hauv cov txiv neej.
- "Foroza" (Slovenia). Cov tshuaj nquag yog alendronate trihydrate. Nws yog siv rau kev kho mob thiab tiv thaiv osteoporosis, nrog rau deforming osteitis. Ib qho kev txwv tsis pub noj yog ua txhaum ntawm cov ntxhia hauv cov metabolism hauv lub cev, nrog rau hnub nyoog txog 18 xyoo, cev xeeb tub thiab lactation.
- "Osterepar" (Poland). Cov khoom xyaw nquag yog alendronate sodium. Siv tau rau kev kho mob pob txha, kev txhim kho uas ua rau muaj kev siv ntev ntev ntawm glucocorticosteroids. Nws kuj tseem pab tiv thaiv kom tsis txhob muaj kev hloov pauv hauv cov pob txha vim yog hormonal tsis ua haujlwm thaum cev xeeb tub.
Nws yog txwv tsis pub hloov "Ostalon" nrog cov analogues ntawm koj tus kheej, vim qhov no tuaj yeem ua rau muaj kev noj qab nyob zoo. Tsuas yog tus kws kho mob tuaj yeem sib piv cov tshuaj uas tsim nyog thiab xaiv qhov kev hloov pauv uas tsim nyog.
Kev tshuaj xyuas
"Ostalon" tau siv rau kev kho mob rau 10 xyoo. Kev xyaum mus sij hawm ntev tau qhia txog kev ua haujlwm siab ntawm cov cuab yeej no. Raws li kev txheeb xyuas, "Ostalon" tsis tsuas yog kho cov kev hloov pauv hauv cov pob txha, tab sis kuj tiv thaiv lawv txoj kev loj hlob.
Cov kws kho mob hais kom ua tiav qhov txiaj ntsig ntawm kev kho mob, cov tshuaj yuav tsum tau noj 1 xyoos, ua raws li txoj cai kom raug.
Cov kev tshawb fawb soj ntsuam tau pom tias cov tshuaj muaj txiaj ntsig los tshem tawm cov tsos mob tsis zoo thiab kho pob txha pob txha ntawm cov poj niam thiab txiv neej hauv ntau dua 10 txhiab tus neeg mob.
Ntxiv rau, raws li kev txheeb cais, kev noj cov tshuaj alendronic tsis tu ncua txo qhov tshwm sim ntawm tus txha caj qaum los ntawm 55%, lub duav - los ntawm 51%, forearm - los ntawm 48%.
"Ostalon" thiab cov tshuaj analogues yog cov tshuaj siv tau zoo, kev noj zaub mov yuav tsum tau pom zoo nrog tus kws kho mob, vim tias, txawm tias lawv cov khoom siv kho mob, muaj qhov tshwm sim ntau ntawm kev tsim cov kev mob tshwm sim uas cuam tshuam rau tus neeg mob noj qab haus huv. Yog li ntawd, tsuas yog ib tus kws tshaj lij tuaj yeem ntsuas qhov kev pheej hmoo rau tus neeg, raws li nws tus yam ntxwv.
