Hauv khw muag tshuaj, cov tshuaj pheej yig rau cystitis feem ntau nug. "Negram" yog ib qho ntawm cov tshuaj no uas muaj cov nyhuv antibacterial thiab yog ib feem ntawm pawg quinolone. Cov tshuaj muaj cov nyhuv bacteriostatic los yog bactericidal, uas yog vim lub concentration ntawm cov kab mob thiab nws rhiab heev. Nws qhov kev ua nyob rau hauv qhov tseeb tias los ntawm inhibiting cov chav kawm ntawm polymerization, cov synthesis ntawm cov kab mob DNA yog suppressed.
Ib ntsiav tshuaj muaj tsib puas milligrams ntawm nalidixic acid, nrog rau cov khoom pabcuam xws li potassium sorbate, dye E172, calcium hydrogen phosphate dihydrate, starch, gelatin, pob kws starch, magnesium stearate, microcrystalline cellulose. tsib puas milligrams thiab nyob rau hauv tus nqi ntawm tsib caug-rau daim. Cov tsos mob: puag ncig, biconvex, tsaus liab dawb, nrog ib tug ntswj ntawm ib sab. Cov ntsiav tshuaj Pyelonephritis yuav tsum tau muab cia rau hauv qhov chaw txias uas cov menyuam yaus nkag tsis tau. Cov tshuaj siv tau peb xyoos.
Pharmacological action
1. Pharmacodynamic ntsuas. Nalidixic acid (cov tshuaj nquag ntawm Negram ntsiav tshuaj) yog ib qho derivative ntawm carboxylic acid, tus kws khomob kws kho mob cuam tshuam nrog gyrase inhibitors. Nws muaj cov kab mob bactericidal rau feem ntau cov kab mob gram-tsis zoo, thiab tshwj xeeb tshaj yog ntawm E. coli thiab hom xws li Enterobacter, Klebsiella thiab Proteus. Cov tshuaj muaj txiaj ntsig zoo tiv thaiv salmonella thiab shigella.
2. Pharmacokinetic yam ntxwv. Tom qab lub qhov ncauj txoj kev ntawm kev noj cov tshuaj, nalidixic acid yog absorbed yuav luag tag, nrog ib tug bioavailability ntawm cuaj caum-rau feem pua. Qhov siab tshaj plaws plasma concentration tshwm sim ib mus rau ob teev tom qab noj. Metabolism ntawm nalidixic acid yog nqa tawm nyob rau hauv daim siab nrog rau zus tau tej cov plaub metabolites. Tsuas yog hydroxynalidixic acid txawv ntawm cov tshuaj tua kab mob. Nalidixic acid yog qhov nyuaj rau nkag mus rau hauv lub cev thiab cov ntaub so ntswg. Feem ntau ntawm nws (txog yim caum cuaj caum feem pua) yog tawm los ntawm ob lub raum, thiab tus so - los ntawm cov hnyuv. Qhov no tau lees paub los ntawm cov lus qhia rau kev siv txuas nrog cov tshuaj "Negram".
Qhov concentration ntawm cov kab mob thiab cov cim qhia raws li kev nkag siab zoo rau cov khoom ntawm cov tshuaj txiav txim qhov xwm txheej: bactericidal lossis bacteriostatic. Cov tshuaj no tsis zoo rau cov kab mob Gram-positive thiab anaerobic. Nrog rau kev siv ntev, kev tiv thaiv rau cov tshuaj yuav txhim kho.
Dab tsi yog qhov qhia tau rau cov tshuaj "Negram"? Cia peb kawm.
Thaum thov?
"Negro" raug muab rau hauv cov xwm txheej hauv qab no:
- rau cov kab mob sib kis thiab mob ntawm cov kab mob genitourinary: urethral syndrome thiab urethritis, pyelonephritis, cystitis, kab mob prostate;
- rau cov kab mob cuam tshuam rau lub plab thiab txoj hnyuv, cholecystitis;
- raws li kev tiv thaiv kev kis kab mob thaum tus kws phais neeg ua haujlwm ntawm ob lub raum, zais zis thiab ureters.
Siv
Pills "Negro" yog siv sab hauv. Rau cov neeg laus, thawj koob tshuaj yog ib gram txhua 6 teev. Lub sijhawm kho yog ib lub lis piam. Rau kev saib xyuas, tsib puas milligrams yuav tsum tau noj plaub zaug hauv ib hnub. Qhov siab tshaj plaws koob tshuaj nyob rau hauv nees nkaum plaub teev yog plaub grams, yog hais tias qhov teeb meem yog tshwj xeeb tshaj yog hnyav - mus txog rau rau grams. Cov menyuam yaus hnub nyoog qis dua ob xyoos raug pom zoo noj thawj zaug ntawm rau caum milligrams ib kilogram ntawm lub cev qhov hnyav, ib koob tshuaj ntawm peb caug milligrams, noj txhua rau 6 teev.
Side effects
Cov kev cuam tshuam tsis zoo hauv qab no tuaj yeem ua tau:
1. Los ntawm ib sab ntawm lub hauv paus paj hlwb: mob taub hau, tsaug zog, tsis muaj zog, nce intracranial siab, pom qhov tsis xws luag, nrog rau cov xim xaum, diplopia, dysphoria, yog siv rau ib lub sij hawm ntev los yog nyob rau hauv loj koob tshuaj, psychotic tshua thiab convulsions yuav tshwm sim.
2. Los ntawm gastrointestinal ib ntsuj av:xeev siab thiab ntuav, raws plab, gastralgia, cholestasis, los ntshav, kev hloov hauv kev ua haujlwm ntawm daim siab enzymes.
3. Los ntawm cov kab mob musculoskeletal: myalgia, arthralgia, hauv cov menyuam yaus - kev puas tsuaj rau pob txha mos ntawm pob qij txha.
4. Los ntawm excretory system: raum tsis ua haujlwm.
5. Kev ua xua tshwm sim: urticaria, khaus, angioedema, tawm pob.
6. Hematopoietic defects: leukopenia, thrombocytopenia, hemolytic anemia.
7. Cov tshuaj tiv thaiv tawv nqaij: photosensitivity.
Vim tias cov tshuaj no tuaj yeem ua rau muaj kev phiv ntau, cov tshuaj cystitis pheej yig no muaj ntau yam contraindications.
rau leej twg thiab nyob rau hauv dab tsi yog "Negro" contraindicated?
Tsis txhob siv "Negram" nyob rau hauv cov ntaub ntawv ntawm intolerance rau ib yam ntawm cov tshuaj, cov menyuam yaus hnub nyoog qis dua ob xyoos, cov poj niam cev xeeb tub, cov neeg mob uas muaj mob qaug dab peg, atherosclerosis ntawm lub paj hlwb ntawm lub taub hau, tsis muaj peev xwm. Glucose-6-phosphate dehydrogenase, daim siab thiab lub raum tsis ua haujlwm
Thaum lactation, haus cov ntsiav tshuaj Negram tsuas yog ua tau thaum muaj xwm txheej hnyav thiab nyob rau hauv kev saib xyuas ze ntawm tus kws kho mob tshwj xeeb, yog tias leej niam xav tau nws siab dua qhov kev pheej hmoo ntawm kev tsis xav tau ntawm tus menyuam. Thaum kho nrog cov tshuaj no, cov niam tsev laus tau sau tseg cov kev hloov ntawm cov xim thiab qhov sib xws ntawm tus menyuam cov quav. Hauv cov xwm txheej no, nws raug nquahu kom muab tus menyuam "Bifidumbacterin", txij li ib feem ntawm cov tshuaj nkag mus rau hauv lub cev nrog niam cov kua mis, uas txhais tau hais tias dysbacteriosis tuaj yeem tsim.
Ua cov no pabCov tshuaj rau pyelonephritis, thiab lawv puas tuaj yeem muab rau cov menyuam yaus?
Kev siv "Negram" rau kev kho menyuam yaus
Cov tshuaj no muab rau cov menyuam yaus tom qab lawv muaj hnub nyoog ob xyoos. Thaum pib ntawm kev kho mob, cov koob tshuaj yog rau caum milligrams ib kilogram ntawm tus me nyuam qhov hnyav, cov tshuaj noj yog txo mus rau peb caug milligrams. Cov kev suav no siv rau cov menyuam yaus hnub nyoog ntawm ob thiab kaum ob. Cov koob tshuaj txhua hnub yuav tsum muab faib ua peb lossis plaub zaug.
Kev sib tham nrog lwm yam tshuaj
ntsiav tshuaj "Negram" tuaj yeem ua ke nrog nitrofurans. Tab sis nyob rau hauv kev kho mob nrog nitrofurazides, kev siv cov tshuaj yog categorically contraindicated. Tsis tas li ntawd, "Negram" tsis tau sau ib txhij nrog cov tshuaj tiv thaiv coagulants, vim qhov no tuaj yeem ua rau los ntshav ntawm cov hnyuv thiab plab.
Ntau tshaj
Cov tsos mob tshwm sim ntawm kev noj tshuaj ntau dhau: muaj kev phiv ntau ntxiv, metabolic acidosis, dyspepsia, tsis meej pem thiab tsis nco qab, convulsions, psychotic tshua.
Nyob rau hauv cov xwm txheej zoo li no, kev kho yog ua los ntawm plab hnyuv nrog 3% sodium bicarbonate tov, kho cov tsos mob thiab tshem tawm lub cev qhuav dej.
"Negro" tshuaj xyuas
"Negro" muaj kev tshuaj xyuas zoo. Raws li cov ntaub ntawv tau txais thaum lub sij hawm kev soj ntsuam, peb tuaj yeem tham txog nws cov kev ua haujlwm siab, kev tshem tawm sai sai ntawm kev mob tshwm sim ntawm inflammatory thiab kis kab mob. Tsis tas li ntawd, raws li qhov zoo ntawm cov tshuaj, cov neeg mob npeNws muaj thiab tus nqi qis, uas yog los ntawm 150 rubles ib pob. Raws li qhov tsis zoo ntawm cov tshuaj, cov neeg mob hais tsuas yog ib qho kev mob tshwm sim - tsaug zog tom qab siv tshuaj.
sau ntawv ntxiv
Yog tias txoj kev kho mob kav ntev tshaj li ob lub lis piam, nws yuav tsum tau saib xyuas cov haujlwm ntawm lub siab thiab lub raum. Yog tias tus neeg mob muaj lub raum tsis ua haujlwm hnyav, nws tsis pom zoo kom siv cov ntsiav tshuaj Negram, vim nws tsuas yog tawm hauv cov zis, thiab yog tias creatinine tshem tawm tsawg, ces nws nkag mus rau hauv lub cev. Thaum kho, koj yuav tsum tsis txhob nyob hauv tshav ntuj ncaj qha. Yog tias tus neeg mob muaj porphyria, ces nalidixic acid tuaj yeem ua rau rov muaj tus kab mob no. Hauv cov menyuam yaus thiab cov tub ntxhais hluas, cov tshuaj yuav cuam tshuam rau pob txha mos ib ntus, thiab kev kho mob yuav tsum tau txiav yog tias muaj cov tsos mob tshwm sim.
