Epidermal loj hlob yam yog ib qho polypeptide uas rov tsim cov hlwb epidermal. Nws qhov kev txiav txim yog manifested tsis tau tsuas yog nyob rau hauv lub cellular, tab sis kuj nyob rau hauv lub molecular theem. Nws yog qhia nyob rau hauv slows down lub aging ntawm daim tawv nqaij. EGF qhov tseem ceeb tau kawm thiab pom rov qab rau xyoo 60s. Xyoo 20th los ntawm American xibfwb Stanley Cohen. Nws qhov kev tshawb pom tau txais txiaj ntsig zoo heev, thiab xyoo 1986 nws tau txais txiaj ntsig Nobel nqi zog hauv Physiology lossis Tshuaj raws li lub cim ntawm qhov no. Niaj hnub no, qhov tseem ceeb no tau txais daim ntawv thov dav tshaj plaws hauv ntau thaj chaw tshuaj thiab tshuaj pleev ib ce.
Nws cov qauv thiab nws ua haujlwm li cas?
Epidermal growth factor (EGF - urogastron) yog ib qho complex compound, ntau precisely ib polypeptide nrog ib tug molecular hnyav ntawm 6054 d altons, muaj 53 amino acids. Nws yog thawj zaug cais tawm ntawm cov qog qaub ncaug ntawm nas. Tom qab ntawd nws tau pom nyob rau hauv lwm cov ntaub so ntswg noj qab haus huv thiab muaj kab mob thiab.
EpidermalKev loj hlob ntawm EGF tau pom nyob rau hauv tag nrho cov tib neeg cov kua roj ntsha - ntshav, zis, CSF, qaub ncaug, digestive kua txiv, mis nyuj.
Tab sis rau nws ua haujlwm, nws xav tau receptors - EGFR. Lub epidermal loj hlob yam receptor yog ib tug molecule nyob rau hauv lub cell membrane uas pib signaling rau hauv lub cell.
EGF ua los ntawm daim nyias nyias receptor EGFR, uas belongs rau tsev neeg ErbB receptor.
Raws li qhov tshwm sim ntawm cov tshuaj tiv thaiv nyuaj, tom qab cuam tshuam nrog nws cov receptors, EGF ua rau phosphorylation ntawm cov protein uas ua rau mRNA synthesis. Qhov no ua rau kev hloov pauv ntawm cov noob muaj lub luag haujlwm rau kev loj hlob ntawm tes.
Vim li cas EGF tsuas muaj tam sim no?
Nws tau tsim tsis yog tsuas yog cov ntsiab lus ntawm qhov tseem ceeb hauv cov ntaub so ntswg thiab kua dej ntawm lub cev, tab sis nws kuj tau qhia tias tus neeg muaj nws txij thaum yug los. Tab sis nyob rau hauv tus txheej txheem ntawm lub neej, nws maj mam tawm ntawm lub cev los ntawm cov zis, uas piav txog nws lub npe thib ob.
EGF yog thawj zaug cais tawm ntawm cov zis nkaus xwb. Koj puas paub tias kom tau txais 1 g ntawm EGF, koj yuav tsum ua kom txog li 200 txhiab litres ntawm cov zis? Xws li ib gram raug nqi txog $2 lab.
Rau kev siv noob neej nyob txhua qhov chaw, nws tsis muaj tseeb. Qhov xwm txheej hloov tsuas yog thaum pib ntawm lub xyoo pua 21st, thaum bioengineering nrog nanotechnologies pib siv.
Tus nqi ntawm qhov kev kho txuj ci tseem ceeb no tau raug txo los ntawm ib txhiab zaug thiab tau dhau los ua rau txhua tus. Tsis tas li ntawd, vim lub tshuab nqus tsev ntim, kev khaws cia ntev ntawm EGF tau dhau los ua qhov tseeb.
Tshuaj formula
Cov ntaub ntawv ntawm cov qauv ntawm cov kab mob epidermal loj hlob tseem tsis tau muaj. Nws hais txog regenerants thiab reparants. Pharmacological kev txiav txim - kho qhov txhab, thiab tseem txhawb nqa epithelialization thiab rov tsim dua tshiab.
EGF feature today
Recombinant human epidermal growth factor (EGFR) yog ib qho tshuaj peptide uas ua tau zoo heev uas tsim los ntawm kev ua ntawm tus neeg ua mov ci poov xab 96, 102 (Saccharomyces cerevisiae strain), nyob rau hauv uas nws genome EGFR noob tau qhia.
Genome yog ib txheej ntawm cov noob hauv ib pawg chromosomes, thiab kev tsim kho caj ces tuaj yeem cuam tshuam rau nws. Lub EGFR noob, nyob rau hauv lem, yog tau los ntawm lub hauv paus ntawm recombinant proteins. Cov no yog cov protein uas nws DNA yog tsim tawm.
Raws li cov txheej txheem ntawm kev ua, xws li qhov tshwm sim loj hlob zoo ib yam rau cov endogenous, uas yog tsim nyob rau hauv lub cev nws tus kheej.
EGFR hauv daim tawv nqaij thiab cov ntaub so ntswg txhawb kev loj hlob ntawm cov hlwb uas xav tau los kho kev raug mob; Txhim kho epithelialization, caws pliav thiab kho cov tawv nqaij elasticity.
YPharmacokinetics
EGFR tsis muaj nyob rau hauv plasma tab sis pom muaj nyob rau hauv platelets (kwv yees li 500 mmol / 1012 platelets). Yog li ntawd, nws muaj peev xwm tau txais autologous epidermal loj hlob yam.
Qhov no yog dab tsi? Autologous epidermal kev loj hlob zoo tshaj plaws - qhov tseeb, siv los xa mus rau kev hloov pauv, thaum cov ntaub so ntswg hloov pauv tau coj los ntawm tus neeg tau txais nws tus kheej. Hauv qhov no, lub luag haujlwm no yog ua los ntawm cov ntshav.
Autologous plasma yogplatelet plasma npaj los ntawm cov ntshav autologous los ntawm cov hlab ntsha, uas yog tom qab ntawd centrifuged.
Nws hloov tawm cov tshuaj txhaj rau hauv thaj chaw uas xav tau kev kho mob lossis kho dua tshiab. Kev txhaj tshuaj yog ua subcutaneously, lossis ib daim ntaub qhwv ntub nrog nws thiab siv rau qhov txhab.
Tshuaj siv tshuaj ntawm tib neeg cov txheej txheem kev loj hlob ntawm cov epidermal mus rau qhov kub hnyiab qhov txhab tsis ua rau nws nqus mus rau hauv cov ntshav.
Kev qhia
Indications:
- Kho mob ko taw mob ntshav qab zib, thaum cov qhov txhab tob tshaj li 1 cm tau tsim uas tsis kho tau ntau tshaj ib hlis2, uas twb mus txog ligaments, leeg thiab pob txha.
- trophic ulcers vim endarteriosis, venous disorders.
- Hlawv ntawm qhov tob thiab qib; bedsores.
- Kev puas tsuaj rau daim tawv nqaij, tom qab kev kho kom zoo nkauj lossis kev phais; nkauj kho siab.
- Kab mob tom qab kev qhia txog cytostatics, frostbite.
Ib daim ntawv loj loj tuaj yeem ntxiv nrog kev kho mob dermatitis tom qab hluav taws xob.
koob tshuaj thiab txoj kev tswj hwm ntawm EGF
Epidermal tib neeg recombinant kev loj hlob zoo tshaj plaws yog tswj hwm hauv kev sib xyaw ua ke hauv daim ntawv txhaj tshuaj, thiab nrog nyiaj sulfadiazine nws yog siv tshuaj pleev ib ce, sab nraud.
Kev txhaj tshuaj - tsuas yog hauv tsev kho mob, nrog cov hnab looj tes tsis muaj menyuam.
Lub qhov txhab yog pre-ntxuav nrog sterile saline. tov thiab sterile qhuavgauze pads, ces chipped nrog yam.
Thaum qhov loj ntawm qhov txhab ntau dua 10 cm 2, 10 txhaj tshuaj ntawm 0.5 ml yog nqa tawm. Kev taw qhia yog ua kom sib npaug, raws cov npoo ntawm qhov txhab, thiab tom qab ntawd hauv nws lub txaj. Qhov tob ntawm rab koob yog tsis ntau tshaj 5 mm. Yog tias qhov txhab tsawg dua 10 cm2 - suav nrog 0.5 ml ib 1 cm2.
Yog li no, rau kev kho mob ntawm qhov txhab 4 cm2 - yuav muaj 4 koob txhaj tshuaj. Txhua tus yog tsim los nrog ib rab koob tshiab kom tsis txhob muaj kab mob.
Thaum kawg ntawm kev tswj hwm, qhov chaw ntawm lub qhov txhab yog npog nrog cov ntaub qhwv ntsej muag lossis nws tau moistened los tsim cov dej noo hauv lub cev. solution.
Kev txhaj tshuaj tsawg kawg yog 3 zaug hauv ib lub lis piam kom txog thaum cov ntaub so ntswg granulation tsim los npog tag nrho lub qhov txhab.
Kev kho mob tuaj yeem kav ntev txog 2 lub hlis. Kev suav ua tiav - 1 lub raj mis rau 1 tus neeg.
Yog tias cov granulations tsis tshwm sim, nws yuav tsum tau kuaj xyuas seb puas muaj osteomyelitis lossis cov txheej txheem kis hauv zos. Daim ntawv thov kev loj hlob hauv cheeb tsam yog ua los ntawm kev sib xyaw nrog cov nyiaj, ntawm txhua theem ntawm qhov txhab.
Lub qhov txhab kuj tau kho ua ntej nrog cov tshuaj tua kab mob thiab qhuav. Tom qab ntawd 1-2 hli ointment pea yog siv rau lub qhov txhab. Cov nyiaj tshuav tsis tau siv thiab qhov khoom tas sij hawm yuav tsis raug khaws cia, lawv muab pov tseg.
Side effects
Cov kev cuam tshuam tsis zoo hauv feem pua tau txheeb xyuas raws li hauv qab no:
- 10-30% kev tshee thiab txias;
- 24, 0% - mob thiab kub hnyiab ntawm qhov chaw txhaj tshuaj;
- y 4,4% - kab mob hauv zos;
- 3% kub taub hau.
Mob thiab kub hnyiab tuaj yeem cuam tshuam nrog cov txheej txheem ntxig nws tus kheej. Tag nrho cov kev mob tshwm sim yog ib ntus, tsis hnyav, thiab tsis tas yuav tsum tau txiav cov tshuaj.
Contraindications rau kev siv
Muaj peev xwm contraindications:
- mob ntshav qab zib - ketoacidosis, coma;
- decompensated cardiac activity: CHF 3-4 theem;
- arrhythmias thiab atrial fibrillation;
- 3rd degree AV thaiv;
- OSSN - ua ib feem ntawm MI, mob stroke, tob vein thrombosis, PE;
- oncology;
- mob necrosis;
- OPN;
- osteomyelitis.
Cov txheeb ze contraindications yog cev xeeb tub, pub niam mis thiab hnub nyoog qis dua 18.
Epidermal Factor yuav raug muag raws li cov npe lag luam sib txawv:
- "Eberprot-P"®;
- "Ebermin" - tshuaj ua ke nrog nyiaj sulfadiazine.
EGF ua haujlwm li cas hauv tshuaj pleev ib ce?
Cov kws tshawb fawb tau pom tias muaj hnub nyoog ntawm cov tawv nqaij hloov pauv pib tom qab 25 xyoo. Txij no mus, koj yuav tsum saib xyuas nws tshwj xeeb. Tus nqi ntawm EGF cov ntsiab lus yog ncaj qha proportional rau qhov zoo ntawm daim tawv nqaij.
Natural EGF ntau lawm hauv daim tawv nqaij yog txo. Qhov tshwm sim yog thinning ntawm daim tawv nqaij thiab poob ntawm nws lub suab. Yog li ntawd, qhov kev loj hlob ntawm epidermal, tus neeg sawv cev ntawm 4 tiam ntawm tshuaj pleev ib ce, tuaj yeem hu ua elixir ntawm cov hluas nrog kev ua tiav tiav. Nws saib xyuas ntawm daim tawv nqaij ntawm qib molecular. Lub rejuvenating complex hu ua: Sijhawm Hla - Tig Rov Qab Lub Sijhawm.
EGF ua li cas nrogdaim tawv nqaij?
Epidermal loj hlob yam tseem ceeb hauv cosmetology pib tag nrho cov txheej txheem ntawm daim tawv nqaij tshiab:
- synthesis ntawm tus kheej elastin thiab collagen nce ntau;
- ntom thiab elasticity ntawm daim tawv nqaij rov qab los rau nws qhov qub;
- pigmentation disappears;
- wrinkles txo ntau;
- txhua daim tawv nqaij kho sai sai.
Vim li ntawd, qhov ua kom rov zoo li qub tau tshwm sim.
Cov tshuaj twg muaj qhov xwm txheej?
Epidermal kev loj hlob feem ntau yog siv hauv Japanese thiab Kauslim cov tshuaj pleev ib ce los tiv thaiv kev laus. Nws tuaj yeem pom muaj nyob rau hauv cov tshuaj tiv thaiv kab mob, tshuaj pleev, tshuaj pleev ib ce hydrogel (cov kab xev ntawm cov ntaub so ntswg tshwj xeeb uas tau muab tso rau hauv cov as-ham), daim npog ntsej muag, BB cream, thiab txawm tias moisturizing mists (dej-raws li tshuaj tsuag).
Txawm tias tsawg li 0.1% EGF cov ntsiab lus yuav ua haujlwm tau zoo, thiab cov neeg tsim cov nyiaj tau txais txiaj ntsig ntawm qhov no. Yog li ntawd, nyob rau hauv daim ntawv teev cov Cheebtsam, nws feem ntau nyob rau theem kawg. Zoo, dhau li qhov tseem ceeb no, cov muaj pes tsawg leeg kuj suav nrog lwm cov khoom xyaw moisturizing: qwj mucin, collagen, adenosine, matrixyl thiab lwm yam peptides.
Nws yog qhov nthuav tias cov khoom lag luam nrog cov kab mob epidermal hauv cov teb chaws Esxias tsis yog tshwj xeeb, lawv tau tsim los rau cov neeg siv khoom nruab nrab, cov no yog cov tshuaj pleev ib ce nruab nrab thiab txawm tias khw muag khoom loj.
Qee yam ntawm cov hom no yog Secret Key, Mizon, Purebess, Nws Daim tawv nqaij, Japanese DHC, Shiseido, Kanebo, Dr. Ci:Labo, thiab lwm yam. Lawv txhua tus ua haujlwm.
Cov tshuaj pleev ib ce nyob sab Europe kuj muaj EGF, tab sis cov khoom no yog cov khoom lag luam thiab cov khoom xaiv(xws li Medik8) thiab kim.
Epidermal kev loj hlob tuaj yeem hu ua: Human Epidermal Growth Factor (hEGF), HGF, Human EGF, rh-Oligo- lossis Polypeptide-1 (tsis yog 1 yuav muaj lwm tus lej), sh-Oligo- lossis Polypeptide -1, transforming growth factor TGF.
Reviews
Cov neeg siv khoom hauv kev tshuaj xyuas ntawm qhov tshwm sim ntawm kev loj hlob ntawm cov tshuaj nplaum hu cov khoom no "pob zeb", thiab hauv txoj kev zoo.
Korean cream "Mizon" - muab cov nyhuv tam sim tom qab thawj daim ntawv thov. Ntau tus neeg hais tias lawv pib zoo li yog tias lawv tau pw tsawg kawg 9 teev hauv ib hnub, thiab muaj kev zoo siab. Cov neeg siv tsuas yog npau suav tias cov nyiaj tsis raug txiav thiab hloov pauv.
Cov neeg siv khoom hais tias cov khoom siv tshuaj tua kab mob ua haujlwm zoo tshaj plaws. Peb tab tom tham txog It'sskin, Purebess. Qhov kev txiav txim yog sau tseg tsis tsuas yog ntawm lub ntsej muag, tab sis kuj ntawm ob txhais ceg, bikini, thiab lwm yam. Serums nrog epidermal loj hlob yam, piv txwv li, Bodyton, muaj txawm ntau zoo xyuas. Kev tshuaj xyuas qhia tias lawv zoo kawg nkaus rejuvenate, brighten thiab tshem tawm wrinkles. Cov poj niam saib tsawg kawg yog 10-15 xyoos. Nov yog qhov tseeb tshwj xeeb rau cov tshuaj pleev ib ce Japanese.
ib me ntsis tar
Tab sis puas yog txhua yam zoo heev hauv lub nceeg vaj ntawm kev loj hlob? Kev ua tau zoo tau raug pov thawj thiab pom, tab sis muaj ib qho kev rho tawm txaus ntshai heev. Kev cuam tshuam rau kev loj hlob kuj tseem txhawb kev loj hlob ntawm cov hlwb tsis zoo, tsis yog cov neeg noj qab haus huv xwb. Nws yog qhov txaus ntshai rau kev loj hlob ntawm daim tawv nqaij. Yog li qhov kev xaiv yog koj li. Raws li lawv hais, tsis muaj lus pom. Tsis tas li ntawd, TGF txhim kho cov khoom ntawm nws tus kheej collagen ntau npaum li ntawdqhov caws pliav tuaj yeem tshwm sim.
