Hauv kab lus, peb yuav txiav txim siab cov lus qhia thiab tshuaj xyuas rau Memantine Canon. Qhov no yog ib qho tshuaj npaj rau kev kho mob ntawm qhov hnyav thiab nruab nrab Alzheimer's dementia. Cov chaw tsim khoom ntawm cov khoom kho mob no yog lub tuam txhab kws tshuaj Lavxias Canonpharma Production CJSC.
Kev sib sau thiab tso tawm daim ntawv
Daim ntawv ntau npaum ntawm cov tshuaj no yog cov ntsiav tshuaj uas muaj zaj duab xis: puag ncig, biconvex, dawb, ntawm ib koob ntawm 5, 15 thiab 20 mg. Los yog xiav, ntawm ib koob ntawm 10 mg. Cov tshuaj tau ntim rau hauv cov pob hlwv ua los ntawm PVC zaj duab xis thiab luam tawm aluminium lacquered ntawv.
Cov ntsiav tshuaj muaj cov khoom nquag ntawm cov tshuaj - memantine hydrochloride, nrog rau cov tshuaj ntxiv: colloidal silicon dioxide, lactose monohydrate, povidone, calcium hydrogen phosphate dihydrate, croscarmellose sodium, magnesium stearate. Cov txheej txheem ntawm lub plhaub zaj duab xis muaj xws li: hyprolose, titanium dioxide, hydroxypropyl methylcellulose, talc, dub hlau oxide.
tshuaj muaj txiaj ntsig
Cov tshuaj nquag ntawm cov tshuaj los ntawm CJSC "Canonpharma Production" - memantine - yog qhov tsis sib tw muaj peev xwm-nyob ntawm blocker ntawm NMDA receptors nrog kev sib raug zoo nruab nrab. Cov tshuaj no cuam tshuam tag nrho cov teebmeem ntawm glutamate, uas muaj peev xwm ua rau muaj kev loj hlob ntawm neuronal dysfunction nyob rau hauv pathologically siab concentrations.
Tus yam ntxwv tseem ceeb ntawm cov tshuaj nquag ntawm Memantine Canon yog tias qhov no adamantane derivative zoo ib yam hauv cov tshuaj pharmacological thiab cov qauv tshuaj rau amantadine. Nws thaiv NMDA-glutamate receptors (xws li hauv substantia nigra), yog li txo cov nyhuv stimulatory ntau dhau ntawm glutamate cortical neurons ntawm neostratum, uas tsim tawm tsam keeb kwm yav dhau los ntawm dopamine tsis txaus. Txog niaj hnub no, tsis muaj ntaub ntawv pov thawj ntseeg tau tias muaj peev xwm ntawm cov tshuaj no los tiv thaiv lossis ua kom qeeb ntawm cov tsos mob ntawm tus kab mob Alzheimer's.
NMDA-glutamate receptor antagonists muaj cov tsos mob nootropic, thiab, raws li kev sim cov ntaub ntawv, lawv ua raws li neuroprotectors hauv vascular thiab sib xyaw dementia. Lawv cov txheej txheem yog ua raws li kev txo qis ntawm glutamate neurotoxicity. Kev ua haujlwm ntau dhau ntawm glutamatergic system tau pom ob qho tib si hauv cov txheej txheem neurodegenerative thiab hauv cerebral ischemia. Cov tshuaj yuav siv tau rau cov kab mob Alzheimer's siab heev.
Cov lus qhia rau kev siv tshuaj
Raws li cov lus qhia siv rau Memantine Canon,cov khoom lag luam tshuaj no yog siv rau hauv kev kho dementia ntawm Alzheimer's hom nrog hnyav thiab nruab nrab siv. Qee zaum, cov tshuaj tsis raug sau tseg. Xav paub ntau ntxiv tom qab.
Contraindications rau kev sau ntawv
Tsis muaj contraindications rau kev siv Memantin Canon yog:
- mob siab tsis ua haujlwm (Child-Pugh qib C);
- lactose deficiency lossis malabsorption ntawm qabzib lossis galactose, congenital galactose intolerance;
- qis dua 18;
- siab rhiab heev rau cov nquag lossis ntxiv cov tshuaj.
Tseem muaj qee qhov txheeb ze contraindications rau noj cov tshuaj, nyob rau hauv lub xub ntiag ntawm cov tshuaj yuav tsum tau ceev faj:
- convulsive syndrome, qaug dab peg (keeb kwm);
- mob plawv tsis ua hauj lwm;
- hlab ntshav siab (tsis tswj tau);
- myocardial infarction (yav dhau los);
- daim siab lossis lub raum ua haujlwm tsis zoo;
- yam uas ua rau cov zis pH nce ntxiv, xws li kev noj zaub mov kom siab alkaline buffers, kev noj zaub mov hloov, tubular raum acidosis, lossis kab mob urinary;
- co-administration nrog NMDA receptor antagonists (amantadine, ketamine, dextromethorphan).
Cov lus qhia rau kev siv
Kev kho mob nrog tshuaj "Memantine Canon" los ntawm cov chaw tsim khoom "Canonpharma Production" yuav tsum tau ua raws li kev tswj hwmtus kws kho mob tshwj xeeb nrog kev paub txog kev kho mob thiab kev kuaj mob dementia hauv cov neeg mob Alzheimer's. Nws raug nquahu kom pib noj cov tshuaj no tsuas yog thaum tus neeg mob (lossis tus neeg saib xyuas nws) npaj txhij los saib xyuas nws qhov kev noj haus. Tsis tas li ntawd, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam tas li ntawm qhov kev zam ntawm cov tshuaj thiab qhov ua tau zoo ntawm cov tshuaj noj, zoo dua li ntawm 3 lub hlis tom qab pib kho.
Dab tsi ntxiv yog cov lus qhia siv rau "Memantine Canon" qhia peb? Nws yuav tsum tau ua raws li kev soj ntsuam kev ua tau zoo ntawm cov khoom kho mob thiab kev kam rau siab ntawm kev kho raws li tag nrho cov txheej txheem kho mob uas twb muaj lawm. Lub sijhawm ntawm kev saib xyuas kev kho mob tsis txwv rau lub sijhawm, raws li kev ua siab ntev ntawm cov tshuaj thiab coj mus rau hauv tus account qhov txiaj ntsig zoo tau txais thaum noj nws. Thaum tsis muaj tom kawg, lossis yog tias tus neeg mob ua tsis taus rau qhov kev kho no, kev noj cov tshuaj Memantine Canon yuav tsum raug cuam tshuam.
Cov tshuaj noj hauv qhov ncauj, tib lub sijhawm, 1 ntsiav tshuaj ib hnub. Lawv tsis chewed, ntxuav nrog kua. Kev noj haus tsis cuam tshuam rau cov nyhuv ntawm cov tshuaj. Qhov siab tshaj plaws hauv ib hnub, koj tuaj yeem noj tsis pub ntau tshaj 20 mg ntawm cov ntsiab lus tseem ceeb ntawm cov tshuaj. Tus kws kho mob tshwj xeeb teev cov tshuaj noj ib tus zuj zus. Thaum pib ntawm kev kho mob, nws raug nquahu kom sau cov koob tshuaj tsawg kawg nkaus. Txhawm rau txo qhov tshwm sim ntawm qhov tsis xav tau qhov tshwm sim tsis zoo, qhov ntau npaum li cas raug xaiv los ntawm titration nrog nce ntawm 5 mg ib zaug ib lub lim tiam (rau 3 lub lis piam).
Side effects
Raws li Memantine Canon tshuaj xyuas, cov tshuaj tag nrho cov tshuaj tiv thaiv tsis zoo muaj xws li:
- Mental disorders: hallucinations, tsis meej pem, psychotic tshua.
- Lub plawv thiab cov hlab ntsha: nce ntshav siab, thromboembolism lossis venous thrombosis, plawv tsis ua haujlwm, lub plawv tsis ua haujlwm.
- CNS: sib npaug cuam tshuam, kiv taub hau, tsaug zog, mob taub hau, hloov pauv hauv kev mus, convulsions, qaug dab peg.
- Ua pa, mediastinal thiab hauv siab hauv siab: ua tsis taus pa.
- cov ntaub so ntswg subcutaneous thiab tawv nqaij: Stevens-Johnson syndrome.
- Immune system: nce rhiab heev rau cov ntsiab lus ntawm cov tshuaj.
- Digestive system: cem quav, dyspeptic mob, pancreatitis.
- kab mob biliary thiab siab: kev kuaj lub siab ua haujlwm tsis zoo, kab mob siab.
- tso zis thiab lub raum: mob tsis ua haujlwm.
- Kab mob thiab kab mob parasitic: kab mob fungal ntawm daim tawv nqaij thiab mucous daim nyias nyias.
- cov kab mob hematopoietic: leukopenia (xws li neutropenia), agranulocytosis, thrombocytopenic purpura, thrombocytopenia, pancytopenia.
- Kev tsis sib haum xeeb: qaug zog, tsis muaj zog.
Nyob rau hauv cov neeg mob uas muaj tus kab mob Alzheimer, thaum noj cov tshuaj no, lub xeev kev nyuaj siab, kev xav tua tus kheej, thiab kev sim ua nws kuj tau sau tseg.
Special Recommendations
Siab,cov neeg uas muaj kev ntxhov siab rau qaug dab peg lossis kev txom nyem los ntawm cov kab mob no, nrog rau cov neeg mob uas muaj keeb kwm ntawm qaug dab peg, raug qhia kom ceev faj thaum kho nrog Memantine Canon. Txij li thaum tib lub sijhawm siv cov tshuaj nrog rau lwm cov NMDA receptor antagonists (amantadine, ketamine, dextromethorphan) tuaj yeem ua rau muaj kev phiv ntau dua, thiab lawv yuav muaj kev siv zog (tsuas yog nyob rau theem ntawm lub hauv nruab nrab lub paj hlwb), nws raug nquahu kom tsis txhob muaj kev phiv tshuaj. lawv siv ua ke.
Kev saib xyuas tus neeg mob yuav tsum ua tib zoo saib xyuas yog tias nws muaj qhov cuam tshuam rau qhov nce hauv cov zis pH: kev hloov pauv ntawm cov khoom noj khoom haus tam sim ntawd (hloov mus rau cov neeg tsis noj nqaij noj, siv cov plab alkaline buffers); cov kab mob loj heev ntawm cov kab mob urinary; tubular raum acidosis.
Memantine Canon txoj kev kho rau cov neeg mob uas muaj teeb meem ntawm cov hlab plawv system yuav tsum tau ua raws li kev saib xyuas ntawm kws kho plawv. Hauv Alzheimer's tus kab mob nyob rau theem ntawm qhov mob hnyav lossis nruab nrab dementia, kev ua haujlwm tsis zoo ntawm lub peev xwm los tswj cov txheej txheem nyuaj thiab kev thauj mus los feem ntau pom. Tsis tas li ntawd, kev siv cov khoom kho mob "Memantine Canon" tuaj yeem cuam tshuam ncaj qha rau kev ceev ntawm cov tshuaj tiv thaiv. Hauv qhov no, pawg neeg mob no yuav tsum tsis txhob ua haujlwm li no.
Siv thaum cev xeeb tub thiab lactation
Txij li tsis muaj cov ntaub ntawv kho mob ntawm cov tshuaj no thaum cev xeeb tub, nws yog contraindicated siv Memantine Canon thaum lub sij hawm xav txog. Nyob rau hauv cov chav kawm ntawm kev tshawb fawb, nws tau pom tiasCov tshuaj nquag ntawm cov tshuaj tuaj yeem ua rau muaj kev loj hlob ntawm cov menyuam hauv plab thaum raug qhov zoo sib xws lossis zoo dua (kev sim tau ua rau tsiaj txhu).
Tsis muaj ntaub ntawv qhia txog kev tso tawm ntawm cov tshuaj nquag hauv cov kua mis. Txawm li cas los xij, cov kws tshaj lij hais tias vim nws cov qauv lipophilic, memantine tuaj yeem nkag mus rau hauv cov kua mis, yog li kev noj tshuaj thaum lub sijhawm lactation yog contraindicated.
Kev Sib Tham Tshuaj
Thaum noj Memantine Canon ua ke nrog lwm cov tshuaj, cov tshuaj hauv qab no tuaj yeem tshwm sim:
- M-anticholinergics, levodopa, dopamine receptor agonists: cov nyhuv ntawm cov tshuaj no tuaj yeem txhim kho, nrog rau thaum noj nrog lwm cov NMDA receptor antagonists.
- Neuroleptics thiab barbiturates: muaj qhov txo qis hauv lawv cov nyhuv.
- Anticonvulsant tshuaj tshuaj (baclofen, dantrolene): cuam tshuam rau lawv txoj kev ua tau zoo - ntxiv dag zog lossis ua kom tsis muaj zog ntawm cov tshuaj kho mob.
- Amantadine, ketamine, dextromethorphan: nce kev pheej hmoo ntawm kev mob hlwb thiab kev nyuaj siab.
- Phenytoin: kev siv sib xyaw tsis pom zoo.
- Cimetidine, ranitidine, quinidine, procainamide, quinine, nicotine: lawv cov ntshav plasma concentration yuav nce, cov ntsiab lus no siv tib lub raum cation thauj system raws li memantine.
- Indirect anticoagulants (warfarin): tuaj yeem nce hauv MHO.
- Hydrochlorothiazide (lossis ib qho kev sib xyaw nrog hydrochlorothiazide): tuaj yeem txo qis hauv cov ntshav ntawm hydrochlorothiazide. Txawm hais tias tsis tau tsim muaj kev sib raug zoo, kev saib xyuas ntawm INR thiab prothrombin lub sij hawm raug pom zoo rau cov neeg mob noj cov tshuaj no ua ke nrog warfarin.
- Monoamine oxidase inhibitors, tshuaj tiv thaiv kev nyuaj siab thiab serotonin reuptake inhibitors: yuav tsum tau saib xyuas tus neeg mob kom zoo.
Qhov txawv ntawm "Memantine" thiab "Memantine Canon" yog dab tsi?
Ob cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob Alzheimer's disease, nrog rau qhov tshwm sim ntawm qhov sib txawv ntawm qhov hnyav. Cov tshuaj no yog siv raws li ib feem ntawm txoj kev kho mob thiab muaj ib tug kiag li zoo tib yam muaj pes tsawg leeg thiab daim ntawv tso tawm. Lawv qhov sib txawv tseem ceeb yog tias cov tshuaj yog tsim los ntawm cov tuam txhab tshuaj sib txawv thiab muag ntawm tus nqi sib txawv. Cov tshuaj "Memantine" yog pheej yig dua "Mementine Canon", yog li cov kws kho mob feem ntau sau cov kev xaiv no. Cov tshuaj raug nqi txog 400 rubles.
Analogues
Cov npe ntawm cov ntsiab lus tseem ceeb ntawm "Memantine Canon" suav nrog cov tshuaj hauv qab no:
- "Alzeim" yog ib qho analogue ntawm cov tshuaj nyob rau hauv nqe lus nug nrog ib tug zoo tib yam muaj pes tsawg leeg. Cov cuab yeej no yog tsim nyob rau hauv Argentina.
- Maruksa yog Lavxias teb sab analogue ntawm Memantine Canon raws li memantine, tab sis yuav luag ob zaug li kim.
- "Noodzheron" - ib yam tshuaj uas tsim nyob rau hauv Croatia, nrog memantine nyob rau hauv lub ntsiab muaj pes tsawg leeg. Yog ibQhov tseeb analogue ntawm cov tshuaj "Memantine Canon". Txawm li cas los xij, nws yog cov tshuaj kim heev - nws tus nqi hloov pauv ntawm 2500 rubles.
Tus kws kho mob yuav tsum xaiv qhov hloov pauv.
Reviews
Muaj ntau qhov kev tshuaj xyuas zoo txog Memantine Canon ntawm cov chaw kho mob thiab cov rooj sab laj rau kev sib tham txog tshuaj. Nws yog qhov zoo dua kom paub koj tus kheej nrog lawv ua ntej. Cov kws tshaj lij hu "Memantine Canon" rau Alzheimer's tus kab mob yog cov tshuaj zoo tshaj plaws. Lawv kuj qhia tau hais tias kev ywj pheej ntawm kev siv cov tshuaj no tawm ntawm cov lus nug, vim nws yog cov khoom lag luam tshuaj loj heev uas tuaj yeem ua rau muaj kev phiv ntau heev, feem ntau cuam tshuam rau cov qauv ntawm lub paj hlwb. Nyob rau tib lub sijhawm, ntau yam kev puas siab puas ntsws, mus txog rau kev hnov lus thiab lub xeev kev nyuaj siab loj, dhau los ua cov tsos mob feem ntau ntawm kev kho tshuaj. Hais txog qhov no, cov kws kho mob tsis pom zoo kom noj tshuaj rau tus kheej thiab yuav cov tshuaj no yam tsis muaj tshuaj los ntawm tus kws kho mob tshwj xeeb.
Cov neeg mob uas tau kho nrog Memantine Canon lossis nws cov analogues nco ntsoov tias qhov txiaj ntsig zoo ntawm kev kho tsis tau pom tam sim ntawd. Yog tias kev kho mob tsis ua rau cov tsos mob tsis zoo, ces qhov tshwm sim los ntawm kev noj tshuaj tuaj yeem pom tsuas yog tom qab li ib hlis ntawm kev kho.
Raws li cov kev mob tshwm sim ntawm cov tshuaj no, cov neeg mob hauv kev tshuaj xyuas sau tias qhov tsis zoo ntawm lub cev tsim los ntawm nws yuav luag txhua kis. Qhov tsis zoo tshaj plaws ntawm lawv yog dyspepticcov kab mob uas tau daws nyob rau hauv feem ntau yam tsis tau siv cov tsos mob. Qhov tshwm sim loj dua ntawm cov kev mob tshwm sim yog kev ua txhaum ntawm lub plawv, qib siab, kev hloov hauv kev nco qab, kiv taub hau loj. Kev tshuaj xyuas ntawm Memantine Canon lees paub qhov no.
