Probenecid yog dab tsi? Cov lus qhia rau kev siv, cov ntsiab lus, analogues thiab cov lus qhia rau kev siv cov tshuaj no yuav qhia hauv qab no.
Form, composition
Probenecid yog dab tsi? Cov lus qhia rau kev siv hais tias qhov no yog ib qho active tshuaj uas yog ib feem ntawm ntau yam tshuaj. Koj tuaj yeem yuav cov tshuaj no hauv txhua lub tsev muag tshuaj ntawm tus nqi tsim nyog. Lawv muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tshuaj ntsiav thiab txawm hmoov rau kev ncua.
tshuaj tua kab mob ntawm cov tshuaj tshuaj
Probenecid ua haujlwm li cas? Cov lus qhia rau kev siv, tshuaj xyuas hais tias qhov no yog ib qho tshuaj tiv thaiv kab mob gout uas tuaj yeem cuam tshuam cov reabsorption ntawm uric acid nyob rau hauv lub raum tubules thiab ua rau kom nws cov excretion.
Raws li cov kws tshaj lij, kev nce ntxiv hauv kev tso tawm ntawm uric acid nyob rau hauv kev cuam tshuam ntawm cov khoom hauv nqe lus nug tuaj yeem ua rau muaj kev nce ntxiv hauv cov txheej txheem ntawm nws tso tawm los ntawm tophi mus rau hauv cov ntshav, uas thaum kawg ua rau kev loj hlob ntawm tus kab mob. mob mob gout.
Tsis tas li, cov tshuaj "Probenecid", cov lus qhia rau kev siv uas tau piav qhia hauv qab no, feem ntau yuav pab ncua kev tso tawm ntawm lwm cov tshuaj los ntawm lub raum, ua rau lawv cov concentration hauv cov ntshav. Qhov no tso cai rau koj siv tus neeg sawv cev rau lo lus nug ua tshuaj ntxiv thaum kho tshuaj tua kab mob.
Kinetic yam ntxwv
Puas Probenecid absorbed? Tom qab kev tswj hwm qhov ncauj, nws yog absorbed tag nrho los ntawm txoj hnyuv. Nyob rau tib lub sijhawm, qhov siab tshaj plaws ntawm probenecid hauv cov ntshav tau mus txog tom qab peb teev, thiab nws cov protein khi yog li 85-96%.
Cov tshuaj hauv nqe lus nug puas tawg? Raws li cov lus qhia, nws yog metabolized nyob rau hauv daim siab. Qhov no ua rau lub ntsiab acylglucuronide thiab lwm yam metabolites.
Probenecid yog tawm los ntawm ob lub raum los ntawm kev tso tawm ntawm cov tubules ze ze thiab glomerular pom. Kwv yees li 75-86% ntawm cov metabolites pom nyob rau hauv tus neeg mob cov zis, thiab tus so yog excreted unchanged (nyob ntawm seb tus nqi ntawm cov zis ntws thiab nws acidity).
Kev qhia
Cov kab mob dab tsi Probenecid kho? Cov lus qhia rau kev siv hais tias cov tshuaj zoo li no tshwm sim nws tus kheej hauv kev kho mob hyperuricemia hauv cov kab mob gout, nrog rau hyperuricemia thaum siv cov tshuaj diuretics.
Nws tsis tuaj yeem hais tsis tau tias yog kev kho ntxiv cov tshuaj no tau muab rau kev kho tshuaj tua kab mob nrog penicillins thiab cephalosporins.
YContraindications
Nyob qhov twg yog txwv tsis pubsiv "Probenecid"? Cov lus qhia rau kev siv qhia xws li contraindications ntawm cov tshuaj xws li:
- porphyria;
- Acute gout attack;
- lub sijhawm cev xeeb tub;
- urolithiasis (xws li muaj cov pob zeb urate);
- menyuam yaus hnub nyoog qis dua ob xyoos;
- kev txawv txav hauv kev kuaj ntshav peripheral;
- hypersensitivity rau probenecid;
- thib ob hyperuricemia, uas yog vim yog siv cov tshuaj tua kab mob lossis cov txheej txheem qog.
Tshuaj "Probenecid": cov lus qhia rau kev siv
Analogues ntawm cov cuab yeej no yuav muaj nyob hauv qab no.
Rau tus mob gout, cov tshuaj hauv nqe lus nug yuav tsum tau noj ntawm koob tshuaj 250 mg ob zaug ib hnub rau ib hlis. Ib lub lis piam tom qab pib kho mob, tus nqi no tuaj yeem ua tiav ob npaug.
Yog tias cov txiaj ntsig kho tsis txaus, qhov koob tshuaj tuaj yeem nce ntxiv txhua hli los ntawm 500 mg. Nws yuav tsum nco ntsoov tias qhov siab tshaj plaws ntawm cov tshuaj no yog 2 g ib hnub twg.
Yog tias nyob rau hauv rau lub hlis tus neeg mob tsis tau ntsib kev mob hnyav ntawm gout, thiab qib ntawm urate hauv cov ntshav tsis siab tshaj qhov tso cai, ces cov tshuaj qhia tau maj mam txo kom tsawg kawg nkaus (Piv txwv li, los ntawm 500 mg txhua rau lub hlis).
Cov koob tshuaj probenecid hauv cov neeg tau txais cov tshuaj diuretics lossis pyrazinamide tuaj yeem nce ntxiv.
Thaum muaj tshuaj tua kab mobKev kho mob nrog cephalosporins thiab tshuaj penicillin hauv cov neeg mob laus, cov tshuaj hauv nqe lus nug yog muab 500 mg plaub zaug ib hnub.
Hauv cov menyuam yaus hnub nyoog ob xyoos, thawj koob tshuaj yuav tsum yog 25 mg rau ib kg ntawm lub cev hnyav, tom qab ntawd nce mus rau 40 mg ib kg. Lub sijhawm nruab nrab ntawm koob tshuaj no yog 6 teev.
Nyob rau hauv kev kho mob gonorrhea, Probenecid raug tso cai siv ntawm ib koob ntawm 1 g ib nrab teev ua ntej parenteral tswj cov tshuaj tua kab mob.
Side effects
Cov tshuaj tiv thaiv tsis zoo Probenecid ua li cas? Cov lus qhia uas tuaj nrog cov tshuaj qhia cov kev mob tshwm sim hauv qab no:
- pruritus, anorexia, nephrotic syndrome, mob pos hniav;
- mob taub hau, ua npaws, kiv taub hau;
- urticaria, xeev siab, tso zis ntau zaus, ntuav;
- leukopenia, Stevens-Johnson syndrome, daim siab necrosis, alopecia;
- anaphylactic shock, dermatitis, anemia, kub flashes;
- hemolytic anemia, exacerbation ntawm gout, aplastic anemia.
Drug interaction
Raws li cov lus qhia, xws li cov tshuaj nquag xws li probenecid tuaj yeem cuam tshuam kev tso tawm thiab ua kom cov ntshav ntawm cov tshuaj xws li Captopril, Acyclovir, sulfonamide conjugates, Paracetamol, sulfonylurea derivatives, Naproxen, aminosalicylates, Methotrexate, Lorazepam., Meclofenamate, Rifampicin, Indomethacin, Zidovudine thiab Ketoprofen.
Nws tseem yuav tsum tau muab sau tseg tias cov tshuaj hauv nqe lus nug txo qis cov ntsiab lus ntawm penicillamine thiab nitrofurantoin hauv cov zis, uas yuav pab txo tau lawv cov kev kho mob hauv cystinuria thiab kab mob urinary, feem.
Cov tshuaj Probenecid ua rau muaj kev nce ntxiv hauv kev tawm ntawm aminohyppuric acid, phenylsulfonthalein, 5-hydroxy-indoleacetic acid thiab sulfobromphthalein, nrog rau kev txo qis hauv kev tso tawm ntawm steroid hormone metabolites nrog zis.
Cov Ntaub Ntawv Tshwj Xeeb
Kuv yuav tsum paub dab tsi ua ntej siv tshuaj nrog probenecid? Raws li cov lus qhia, cov tshuaj no tsis raug pom zoo rau kev siv nyob rau hauv theem nrab hyperuricemia, uas yog tshwm sim los ntawm cov txheej txheem qog los yog siv cov tshuaj chemotherapeutic, vim hais tias cov tshuaj no tsis txo cov synthesis ntawm uric acid, tab sis tsuas yog nce nws excretion los ntawm cov tshuaj. lub raum system. Qhov tshwm sim hyperuricosuria tuaj yeem ua rau muaj kev pheej hmoo ntawm nephropathy.
Nrog ceev faj heev, cov tshuaj hauv nqe lus nug yuav tsum tau muab rau cov neeg muaj kab mob peptic ulcer thiab lub raum tsis ua haujlwm ntev. Nyob rau hauv rooj plaub tom kawg, probenecid tej zaum yuav tsis muaj txiaj ntsig.
Kev siv cov tshuaj no los kho tus mob gout yuav ua rau mob gout mob hnyav thiab ua rau kom pob zeb loj hlob ntxiv.
Hemolytic anemia tuaj yeem tshwm sim rau cov neeg muaj G6PD deficiency.
Kev noj ntau dhau ntawm probenecid ua rau CNS excitation, pab txhawb kev txhim kho ntawm qaug dab peg, thiab tuaj yeem ua rautuag vim ua tsis taus pa.
Nws yog qhov tsim nyog kom tsis txhob siv tib lub sijhawm ntawm probenecid nrog Ketorolac thiab salicylates.
Cov neeg siv cov tshuaj no xav tau cov tshuaj Thiopental tsawg, tshuaj loog.
Thaum siv methotrexate thiab probenecid nyob rau tib lub sijhawm, koob tshuaj ntawm yav dhau los yuav tsum raug txo kom txo qis nws cov kev mob tshwm sim.
Kev tso zis tsis zoo rau cov piam thaj yuav tshwm sim thaum noj cov tshuaj no.
Analogs, synonyms
Dab tsi tuaj yeem hloov cov tshuaj "Probenecid"? Analogues ntawm cov cuab yeej no tuaj yeem yuav ntawm txhua lub tsev muag tshuaj. Cov no suav nrog cov hauv qab no: Fitolizin, Citrokas, Uronefron, Uroholum, Baitach, Cyston, Cital, Fitolit, Urochol thiab lwm yam.
Raws li cov ntsiab lus, lawv suav nrog cov tshuaj xws li Santuril.
Kev tshuaj xyuas txog kev tshuaj tiv thaiv kab mob
Hmoov tsis zoo, tsis muaj ntau cov neeg siv tshuaj xyuas txog Probenecid. Txawm li cas los xij, muaj ntau cov lus ceeb toom txog kev ua ntawm Santuril. Cov neeg mob hais tias cov tshuaj no ua haujlwm zoo hauv kev kho mob hyperuricemia hauv cov mob gout, nrog rau hyperuricemia thaum siv cov tshuaj diuretics. Nws kuj yog ib qho kev kho zoo rau cov kab mob cystitis, nonspecific urethritis, postoperative urinary tract infections thiab lwm yam teeb meem urological.
Nws tsis tuaj yeem hais tias cov tshuaj hauv nqe lus nug kuj muaj qhov tsis zoo. Cov neeg siv khoomLawv muaj ntau yam kev phiv thiab contraindications.
