Fibrin yog cov protein uas yog qhov kawg ntawm cov ntshav txhaws. Nws yog tsim los ntawm kev ua ntawm thrombin ntawm fibrogen.
Fibrin yog ib qho protein uas tsis txaus ntseeg uas tsim tawm hauv lub cev hauv kev teb rau los ntshav. Cov protein no yog cov khoom muaj zog uas muaj fiber ntau filaments. Lub progenitor ntawm fibrin yog fibrinogen. Nws yog ib qho protein uas tsim los ntawm lub siab. Nws nyob hauv cov ntshav. Thaum cov ntaub so ntswg puas lawm, los ntshav tshwm sim. Txhawm rau nres nws, thrombin pib ua haujlwm. Nws cuam tshuam rau fibrinogen, yog li provoking nws transformation mus rau hauv fibrin.
Ua ntej, cov protein molecules sib xyaw ua ke ntev ntev uas cuam tshuam cov platelet, tsim kom muaj qhov hnyav. Maj mam, nws hardens thiab shrinks, tsim cov ntshav txhaws. Cov txheej txheem sealing yog ruaj khov los ntawm cov khoom siv fibrin stabilizing.
Lub luag haujlwm ntawm fibrin hauv kev mob
Fibrin ntau lawm thiab mob yog ob txoj kev sib raug zoo. Protein plays lub luag haujlwm tseem ceeb hauv kev sib cuag nrog cov ntaub so ntswg puas. Thrombokinase tso tawm los ntawm cov ntaub so ntswg los rau hauv kev sib cuag nrog fibrinogen.
Thaum cov ntshav coagulates, tag nrho cov tshuaj lom raug thaiv hauv cov hlab ntshav. Qhov no featureCov nyhuv ntawm cov protein thaum lub sij hawm inflammatory txheej txheem tiv thaiv lub cev los ntawm ntxiv kis ntawm co toxins thiab lawv cov teebmeem. Cov tshuaj tiv thaiv no hu ua fixation. Yog li, fibrin kuj yog lub cev tiv thaiv los ntawm co toxins.
tiv thaiv lub cev
Kev tsim cov fibrin insoluble pab tiv thaiv lub cev los ntawm cov ntshav poob, nrog rau cov txheej txheem inflammatory. Txawm li cas los xij, xws li cov tshuaj tiv thaiv ua rau mob thiab o, cov ntaub so ntswg puas, thiab ua txhaum ntawm lawv txoj haujlwm. Tom qab ntawd, qhov no yog tshem tawm los ntawm cov txheej txheem kho dua tshiab. Nyob rau theem pib, cov tshuaj tshwj xeeb raug tsim tawm uas ua rau fibrin depolymerization. Xws li cov tshuaj tiv thaiv, txawm tias thaum pib ntawm cov txheej txheem inflammatory, tuaj yeem cuam tshuam cov nyhuv ntawm cov protein ntawm cov kab mob pathological.
Fibrin muaj nuj nqi
Thaum fibrinogen hloov mus rau hauv fibrin, tshwj xeeb enzymes nyob rau hauv lub hom phiaj ntawm o pib ua raws li inhibitors. Cov txheej txheem no yog tshwm sim los ntawm polymerization ntawm fibrinogen rau hauv fibrin. Raws li qhov no, kev ua haujlwm ntawm proteases yog txiav txim siab, uas muaj nyob rau hauv liquefying cov ntaub ntawv los ntawm splitting fibrin thiab lwm yam protein molecules rau peptides thiab amino acids. Tsis tas li ntawd, txoj haujlwm ntawm proteases yog inhibit qhov tsim ntawm cov molecules loj ntawm hom insoluble.
Kev sim ua tiav
Cov kws tshawb fawb tau ua qhov kev sim ntawm cov tsiaj, thaum lub sijhawm nws tau pom tias cov proteases qhia los ntawm sab nraud ua ntej cov txheej txheem inflammatory tuaj yeem tiv thaiv nws txoj kev loj hlob, thiab qee zaum cov kab mob tau ua rau mob me. Kev paub tau qhia tiasKev siv cov tshuaj tryptic feem ntau nres kev txhim kho ntawm cov txheej txheem inflammatory thaum pib ntawm tus kab mob.
Prophylactic koob tshuaj ntawm enzymes txo cov protein ntau lawm.
Fibrin tsis yog tsuas yog cov protein xwb, tab sis yog tus tsim ntawm kev tiv thaiv kev tiv thaiv ib puag ncig cov kab mob, uas tiv thaiv kab mob. Tom qab ntawd, qhov no insoluble tivthaiv pab tsim cov ntaub so ntswg. Nws kuj koom nrog cov txheej txheem ntawm kev rov tsim dua tshiab. Kev tsim cov caws pliav yog nyob ntawm lub sijhawm khaws cia thiab qhov ntau ntawm fibrin tsim los ntawm lub cev.
Yog li cas fibrin yog dab tsi thiab nws yog dab tsi? Cov tshuaj no yog tsim los ntawm cov hlwb ntawm lub cev nyob rau hauv xws li ib tug npaum li cas uas yog tsim nyog los sai sai tso tseg los ntshav thiab yuav pab kom sai li sai tau cov ntaub so ntswg puas. Qee zaum, fibrin yog kab tsuag. Yog tias nws tau tsim thiab tso rau hauv qhov ntau, ces cov protein tuaj yeem ua mob rau lub cev. Raws li peb paub, fibrinolysis yog txheej txheem ntev uas tsis tuaj yeem yaj tag nrho cov protein ntau. Tsis tas li ntawd, qee yam yuav tsum muaj rau cov txheej txheem no.
Txhawm rau tshem tawm cov fibrin ntau dhau, tshuaj kho enzyme tshwj xeeb.
Kev kho cov enzyme
Tsis ntev los no, kev saib xyuas tshwj xeeb tau them rau cov khoom ntawm enzymes. Qhov no yog tshwj xeeb tshaj yog muaj tseeb rau proteases. Rau kev kho mob ntawm fibrin, enzymes siv cov tshuaj ntawm hom tshwj xeeb no. Lawv pab yaj cov protein ntau, yog li tiv thaiv cov teeb meem loj hauv daim ntawv ntawm cov ntshav txhaws.
PropertiesProteolytic enzymes txawv. Lawv muaj peev xwm muaj fibrinolytic thiab immunomodulatory nyhuv ntawm lub cev, nrog rau txhim kho cov ntshav ncig, ua hauj lwm raws li decongestant, anti-inflammatory tshuaj.
Txij li thaum tsim cov thrombus raws li kev tsim cov fibrin, xav tau ib qho protease, uas ua rau cov tshuaj tiv thaiv cleavage ntawm cov khoom no. Yog tsis muaj cov enzyme no, nws tsis tuaj yeem tawg cov protein rau hauv cov molecules, yog li ntawd, yuav tsis muaj kev txhim kho hauv cov ntshav microcirculation.
Nrog lub zos raug rau protease, tshem tawm ntawm necrotic plaque, resorption ntawm fibrinous tsim, thinning ntawm viscous secretion yog ua tau.
