Dopamine zoo li cov hmoov dawb crystalline nrog cov ntxhiab tsw ntawm hydrochloric acid. Nws zoo li qhov no hauv daim ntawv ntawm hydrochloride. "Dopamine" yog ib yam khoom uas yog soluble hauv dej thiab cawv. Nws cuam tshuam los ntawm alkalis, ntau yam oxidizing cov neeg ua haujlwm thiab cov ntsev hlau. Indications thiab contraindications rau kev siv cov tshuaj "Dopamine", cov lus qhia rau nws siv yog muaj nyob rau hauv peb tshaj tawm.
Cov khoom muaj nyob rau hauv cov tshuaj concentrate rau infusion tov.
tshuaj yam ntxwv
"Dopamine" yog cov tshuaj neurotransmitter. Raws li cov khoom metabolic, dopamine yog qhov ua ntej ntawm adrenaline thiab norepinephrine. Cov tshuaj cuam tshuam rau cov neeg txais kev sib raug zoo, thiab nyob rau hauv siab concentration txhim kho kev ua haujlwm ntawm α- thiab β-adrenergic receptors. Txoj haujlwm ntawm "Dopamine" yog tsom rau:
- nce peripheral vascular resistance;
- nce ntshav siab systolic;
- txhawb lub plawv dhia;
- nce siab tso zis;
- hloov me ntsis hauv lub plawv dhia;
- khoom noj muaj pa oxygen.
"Dopamine" kuj ua rau cov ntshav ntws hauv cov hlab ntsha ntawm lub hlwb, lub plawv, ob lub raum thiab cov hnyuv. Nce glomerular pom thiab sodium excretion nyob rau hauv lub raum.
"Dopamine" yog cov tshuaj ua kom sai. 5-10 feeb tom qab IV infusion, qhov kev txiav txim xaus. Lub neej ib nrab yog kwv yees li ob feeb. Ib nrab ntawm cov tshuaj cuam tshuam nrog cov protein hauv cov ntshav plasma. Cov tshuaj tau dhau los ua cov txheej txheem ntawm cov metabolism sai hauv lub raum, lub siab thiab cov ntshav ntshav vim yog kev cuam tshuam ntawm MAO thiab catechol-O-methyltransferase rau lub xeev ntawm cov metabolites tsis ua haujlwm thiab ua haujlwm tsim tawm los ntawm lub raum. Ib feem peb ntawm cov koob tshuaj noj tau hloov mus rau norepinephrine hauv cov txheej txheem ntawm cov hlab ntsha adrenergic. Vim yog kev tshem tawm kom nquag plias, tsis muaj cov tshuaj tsub zuj zuj hauv tib neeg lub cev txawm tias tom qab siv sijhawm ntev.
"Dopamine": daim ntawv thov
Indications rau nkag:
- Ntau hom kev poob siab, suav nrog kev raug mob, cardiogenic, postoperative, hypovolemic, endotoxic.
- Mob vascular thiab lub plawv tsis ua haujlwm.
- tso zis siab.
"Dopamine" yog qhov tsim nyog tshwj xeeb rau kev poob siab cardiogenic, nws ua rau kom muaj kev ua haujlwm ntawm lub paj hlwb ntawm myocardium.
Cov tshuaj yog muab tso rau hauv txoj hlab ntshav. 125 lossis 400 ml ntawm tsib feem pua qabzib lossis sodium chloride tov yog xav tau rau 25 lossis 200 mg, feem. Yog li, hauv 1 ml ntawm kev daws, 200 lossis 500 mg ntawm cov tshuaj yuav tau txais. Yog tias tus neeg mob tsis tuaj yeem muab cov kua dej ntau, ntau duaconcentrated tov kom 1 ml muaj 800 μg ntawm Dopamine. Txhawm rau ua qhov no, koj yuav tsum noj 200 mg rau 250 ml ntawm kev daws. Tus nqi ntawm kev tswj hwm nce mus txog 1-4 mcg / kg ib feeb rau qhov nruab nrab lub cev hnyav ntawm 70 kg (los ntawm 2 mus rau 11 tee ntawm cov tshuaj 0.05% lossis los ntawm 1.5 mus rau 6 tee ntawm cov tshuaj 0.08%). Kev siv tshuaj kho mob - los ntawm 5 mus rau 9 mcg / kg ib 1 feeb. Qhov ntau npaum ntawm "Dopamine" 10-15 mg / kg ib feeb yog siv rau vasodilation, nrog rau cov hlab ntsha hypotension. Tus nqi ntawm kev tswj hwm tuaj yeem nce mus txog 18 mcg / kg ib feeb. Txoj kev lis ntshav yuav siv qhov chaw tsis muaj kev cuam tshuam thiab tsim rau lub sijhawm 2-3 teev mus rau 1-4 hnub thiab ntev dua. Qhov koob tshuaj ib hnub tsis pub tshaj 800 mg. Nrog kev taw qhia ntawm "Dopamine", ib qho ECG raug saib xyuas. Kev txiav txim siab ntawm koob tshuaj thiab tus nqi ntawm kev tswj hwm tshwm sim raws li qib ntawm cov ntshav siab, lub plawv dhia, lub plawv dhia, lub plawv dhia thiab diuresis. Yog tias arterial hypotension tsis tau tshwm sim, thiab diuresis tau txo qis, koob tshuaj yuav tsum raug txo.
YContraindications
Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv ntawm teeb meem xws li:
- arrhythmia;
- pheochromocytoma;
- prostate hypertrophy;
- Angle-kaw glaucoma.
Side effects
Kev tswj hwm cov tshuaj hauv koob tshuaj loj, qib siab ntawm "Dopamine" tuaj yeem ua rau muaj kev phiv, suav nrog:
- tremor;
- tachycardia;
- vasospasm;
- arrhythmia;
- kev ua pa tsis zoo;
- anginal thiab mob taub hau;
- psychomotor agitation;
- lwm yam tshwm simadrenomimetic action.
Vim tias kev tshem tawm dopamine ua haujlwm, cov tsos mob saum toj no ploj mus yog tias koob tshuaj txo qis lossis tsis siv tshuaj. Yog hais tias lub atherosclerosis cuam tshuam, nws yog ib qhov tsim nyog yuav tau siv cov tshuaj antiarrhythmic, xws li Verapamil, Lidocaine thiab lwm yam. Extravasation ntawm cov tshuaj Dopamine tuaj yeem ua rau necrosis ntawm subcutaneous rog thiab daim tawv nqaij nws tus kheej.
Cov lus qhia tshwj xeeb
"Dopamine" thaum cev xeeb tub tuaj yeem raug tshuaj tsuas yog thaum kev kho mob nruj me ntsis rau leej niam, thiab cov txiaj ntsig kho mob ntau dua qhov kev pheej hmoo rau tus menyuam hauv plab.
Cov tshuaj tsw qab tshiab yuav tsum muaj qhov sib xws thiab tsis muaj qhov txawv txav.
siv nrog lwm yam tshuaj
Cov tshuaj tuaj yeem noj ua ke nrog lub plawv glycosides thiab diuretics (piv txwv li, furosemide thiab lwm yam). Hypovolemic poob siab xav tau kev tswj hwm ntawm "Dopamine" nrog rau tag nrho cov ntshav, ntshav lossis ntshav hloov pauv.
Tsis txhob noj "Dopamine" tib lub sijhawm li "Cyclopropane", MAO inhibitors thiab tshuaj loog nrog halogen ("Ftorotan" thiab lwm yam).
Tshuaj daws yuav tsum tsis txhob muab tov nrog cov tshuaj alkaline ntawm lwm cov tshuaj.
"Dopamine" yog ib yam tshuaj uas tsuas yog siv rau hauv daim ntawv tshuaj. Nws tus nqi nyob ntawm qhov ntau npaum li cas thiab tus naj npawb ntawm ampoules nyob rau hauv pob thiab txawv ntawm 80 mus rau 300 rubles ib pob (5-10 ampoules).
