Muaj ntau cov tshuaj bisoprolol uas tau siv los kho cov ntshav siab thiab lub plawv tsis ua haujlwm. Ntawm lawv, cov tshuaj hauv tsev "Bisoprolol-Prana" yog qhov txawv.
yam ntxwv
Qhov no xaiv beta-adrenergic thaiv tus neeg sawv cev yog tsim los ntawm Lavxias lub tuam txhab PRANAPHARM LLC.
Muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj round, biconvex uas muab faib thiab zaj duab xis-coated.
Thaum siv Bisoprolol-Prana, cov lus qhia rau kev siv yog thawj yam uas koj yuav tsum tau xyuam xim rau. Cov tshuaj muaj nyob rau hauv cov koob tshuaj hauv qab no: 5 thiab 10 mg. Cov xim ntawm lub plhaub ntawm cov ntsiav tshuaj me yog lub teeb daj, thiab cov loj yog lub teeb txiv kab ntxwv. Cov ntsiab lus ntawm cov tshuaj yuav luag dawb.
Composition
Ib ntsiav tshuaj ntawm cov tshuaj "Bisoprolol-Prana" muaj 5 thiab 10 mg ntawm bisoprolol hemifumarate ua cov tshuaj nquag. Muajmagnesium stearate, pob kws starch, microcrystalline cellulose, crospovidone, colloidal silicon oxide, calcium anhydrous hydrogen phosphate tso cai rau koj los tsim cov tshuaj thiab muab cov tsim nyog solubility thiab bioavailability.
Cov 5mg zaj duab xis txheej muaj cov hlau oxide daj, polyethylene glycol (qib 400), titanium dioxide, silicone. Cov txheej uas qhwv ib ncig ntawm cov ntsiav tshuaj loj muaj lwm cov xim uas yog xim liab oxide.
Mechanism of action
Bisoprolol-Prana raug xa mus rau xaiv cov beta-adrenergic thaiv cov neeg ua haujlwm uas tsis muaj lawv tus kheej cov kev ua sympathomimetic. Cov lus qhia rau kev siv piav qhia txog nws cov yam ntxwv pharmacodynamic. Cov ntsiav tshuaj muaj cov txiaj ntsig ntawm kev txo qis, normalizing lub atherosclerosis thiab tshem tawm myocardial leeg ischemia. Thaum thaiv beta 1-adrenergic receptors ntawm lub plawv nrog me me ntawm cov tshuaj, muaj qhov txo qis hauv kev tsim cov cyclic adenosine monophosphate thiab ntws ntawm calcium ions hauv cov hlwb. Kuj tseem muaj qhov txo qis hauv kev cog lus ntawm lub plawv dhia thiab nws qhov zaus, cov txheej txheem cuam tshuam nrog kev ua thiab excitability yog inhibited.
Hypotensive nyhuv yog tshwm sim los ntawm underestimation ntawm tus nqi uas txiav txim lub feeb ntim ntawm cov ntshav ncig, txo cov kev cuam tshuam ntawm peripheral vascular txaj. Kev txo qis hauv kev kub siab tshwm sim tom qab ob peb hnub, thiab kev kho ob lub hlis yog qhov tsim nyog los ua kom qhov kev ua haujlwm ruaj khov.
Antiarrhythmiccov nyhuv yog tshwm sim thaum cov ua txhaum cai lub plawv dhia raug tshem tawm. Cov no suav nrog lub xeev ntawm tachycardia, nce kev ua haujlwm ntawm lub paj hlwb hauv lub luag haujlwm sympathetic, nce cov ntsiab lus ntawm cyclic adenosine monophosphate, arterial hypertension.
Cov lus qhia rau kev siv
Ua ntej siv, nws yog ib qho tsim nyog los kawm txog cov pab pawg twg ntawm cov neeg mob "Bisoprolol-Prana" npaj. Cov lus qhia rau kev siv yog txuam nrog cov teebmeem antianginal. Nws yog vim qhov kev xav tau qis dua ntawm lub plawv myocardium rau cov pa oxygen molecules vim qhov txo qis ntawm cov zaus ntawm kev cog lus, nce ntshav thiab lub sijhawm thaum lub sijhawm diastole.
Yuav ua li cas yog cov tshuaj xws li Bisoprolol-Prana ntsiav tshuaj, lawv muab los ntawm dab tsi? Muab lawv cov tshuaj pharmacotherapeutic yam ntxwv, lawv siv rau:
- kev kho mob siab;
- mob plawv ischemic;
- strain angina;
- rau kev tiv thaiv ntawm kev mob ntshav qab zib theem nrab:
- kev tsis txaus siab.
Ntawm no yog cov pab pawg tseem ceeb uas siv cov tshuaj "Bisoprolol-Prana" yog qhov xav tau. Cov lus qhia rau kev siv yog txuam nrog kev ua haujlwm tsis zoo ntawm lub plawv. Cov no muaj xws li sinus nce hauv atherosclerosis, supraventricular thiab ventricular extrasystole, kev hloov hauv lub plawv dhia nrog protrusion ntawm lub mitral valve thiab hyperthyroidism.
Kev siv tshuaj tshwj xeeb
Cov lus qhia rau kev siv "Bisoprolol-Prana" pom zoo kom noj cov tshuaj thaum sawv ntxov ua ntej noj tshais, tag nrho tsis zom.
Rau kev kho mob ntshav siab, plawv ischemia thiab kev tiv thaiv ntawm angina pectoris, ib koob tshuaj me me ntawm cov ntsiav tshuaj, suav nrog 5 mg ntawm bisoprolol, yog siv. Yog tias tsim nyog, qhov ntau npaum li cas yog ob npaug, tab sis nws kuj yog siv ib zaug. Qhov siab tshaj plaws ntawm bisoprolol yuav tsum tsis pub tshaj 20 mg ib hnub twg.
Tsuas yog tus kws kho mob tuaj koom tuaj yeem sau cov tshuaj thiab lub sijhawm ntawm kev noj "Bisoprolol-Prana" tshuaj. Cov lus qhia yuav tsum ua raws li cov lus qhia ntawm cov tshuaj. Ua ntej lub sij hawm teem, xyuas qhov zaus ntawm contractions ntawm lub plawv cov leeg. Nws tuaj yeem hloov kho cov ntsiav tshuaj tom qab kawm cov lus teb kho mob.
Ntau tus neeg mob xav tias Bisoprolol-Prana tuaj yeem muab faib ua ib nrab. Lub xub ntiag ntawm lub tshuab cais ua rau nws tuaj yeem txo cov ntsiav tshuaj yog xav tau ntau npaum li cas.
Txhawm rau tshem tawm lub plawv tsis ua haujlwm, siv 1.25 mg ntawm bisoprolol thawj lub lim tiam. Cov koob tshuaj no tuaj yeem tau los ntawm kev faib cov ntsiav tshuaj uas muaj cov tshuaj nquag 2.5 mg. Txawm li cas los xij, koj yuav tsum pib kho nrog tshuaj los ntawm lwm lub chaw tsim khoom, txij li Bisoprolol-Prana tsuas yog muaj nyob rau hauv 5 thiab 10 mg. Thaum lub lim tiam thib ob xaiv 2.5 mg. Txij hnub 14 ntawm kev kho mob, noj 3.75 mg ntawm cov tshuaj. Nyob rau lub lim tiam thib plaub, cov koob tshuaj tau nce mus rau 5 mg, thiab tom qab ob lub hlis ntawm kev kho mob, 7.5 mg ntawm bisoprolol yog siv. Lub lis piam thib kaum ob pib nrog koob tshuaj 10 mg.
Yog tias tus neeg mob muaj ntau yam teeb meem hauv kev ua haujlwm ntawm lub raum lossis daim siab, thiab qhov txiaj ntsig ntawm creatinine tshem tawm tsawg dua 20 ml ib 1 feeb, ces qhov siab tshaj plaws tausau ntawv tsis pub tshaj 10 mg ntawm cov tshuaj.
Thaum ua tiav qhov kev npaj ua haujlwm, bisoprolol raug tso tseg ob hnub ua ntej kom nws tsis cuam tshuam rau kev siv tshuaj loog. Yog hais tias ib ntsiav tshuaj tau qaug dej qaug cawv, ces xaiv cov tshuaj tua kab mob uas muaj cov nyhuv inotropic, qhov tsis zoo ntawm qhov tsawg kawg nkaus.
Thaum tus neeg mob laus muaj qhov mob bradycardia nrog lub plawv dhia qis dua 52 zaug ib feeb, cov hlab ntsha hypotension nrog lub siab systolic tsawg dua 100 millimeters mercury, bronchospasm, ventricular arrhythmia, lub siab thiab lub raum ua haujlwm. cuam tshuam, ces qhov ntau npaum li cas yog txo, mus txog rau kom tiav tshem tawm ntawm txoj kev kho. Kev cais tawm ntawm bisoprolol tuaj yeem ua rau kev txhim kho ntawm lub xeev kev nyuaj siab, uas yog tshwm sim los ntawm qhov no beta-blocker.
kev hloov pauv tsis yog ua rau cov neeg laus.
Kev cuam tshuam ntawm kev kho mob tsis raug tso cai, uas tuaj yeem ua rau muaj kev loj hlob ntawm arrhythmia lossis myocardial infarction. Kev tshem tawm cov tshuaj yog ua los ntawm maj mam txo cov koob tshuaj ntau dua 14 hnub. Rau peb hnub, kev txo qis ntawm 25% tau tso cai.
Txoj kev kho mob
Rau kev siv "Bisoprolol-Prana" cov lus qhia rau kev siv suav nrog cov npe ntawm kev ntsuas uas tswj tus neeg mob. Cov no suav nrog txhua hnub, nyob rau theem pib, kev txiav txim siab ntawm lub plawv dhia thiab ntsuas qhov siab, uas tom qab ntawd kuaj xyuas tom qab peb lub hlis. Lwm qhov kev ntsuas tseem ceeb yog qhov ntsuas electrocardiogram thiab cov piam thaj hauv cov ntshav qab zib, uas ntsuas tsis ntau dua tom qab 5 lub hlis.
Cov neeg mob laus xav tau kev saib xyuas lub raum ua haujlwm tsis tu ncua, uas yog ua tiav tom qab 4 lub hlis.
Kev kho mob plawv tsis ua hauj lwm nyob rau theem pib ntawm kev noj tshuaj tsawg yuav tsum tau kuaj plaub teev ntawm tus neeg mob, thaum lub sijhawm kuaj lub plawv dhia, ntshav siab thiab kuaj electrocardiogram.
Ua ntej sau tshuaj kho nrog bisoprolol, tus neeg mob tau qhia yuav ua li cas xam lub plawv dhia. Nyob rau hauv rooj plaub uas tus nqi qis ntawm qhov ntsuas no (txog 50 tus neeg ntaus ib feeb), kev sab laj kho mob yuav tsum tau.
Tseem piav qhia txog cov txiaj ntsig ntawm cov tshuaj "Bisoprolol-Prana", cov lus qhia suav nrog cov ntaub ntawv hais txog qhov xav tau kev tshawb fawb uas txiav txim siab ua pa sab nraud rau cov neeg mob uas muaj kab mob bronchopulmonary.
Beta-blockers tsis pab kho angina pectoris rau txhua tus neeg mob. Lawv inefficiency yog vim muaj cov kab mob loj heev atherosclerosis, uas muaj qhov qis ischemic pib. Hauv lub xeev no, lub plawv dhia yuav tsawg dua 100 tus neeg ntaus ib feeb, thiab tseem muaj qhov nce ntawm qhov kawg-diastolic ntim hauv sab laug ventricle nrog kev ua txhaum ntawm cov ntshav subendocardial. Bisoprolol kuj tseem pab cov neeg haus luam yeeb hnyav dua.
Cov neeg muaj kab mob bronchospastic tau muab tshuaj rau tus neeg saib xyuas cardioselective yog tias muaj kev tsis txaus siab thiab tsis muaj txiaj ntsig ntawm cov tshuaj uas txo cov ntshav siab. Kev noj tshuaj ntau dhau yuav ua rau mob bronchial spasm.
Yog tias cov neeg mob uas muaj thyrotoxicosis tau kho nrog beta-blocker, kev npog ntsej muag yog ua tauCov tsos mob ntawm tus kheej ntawm cov thyroid ua haujlwm ntau dhau, feem ntau tachycardia. Cov neeg mob zoo li no yuav tsum tsis txhob ncua tam sim ntawd kom tsis txhob muaj cov tsos mob hnyav dua.
Yog tias cov neeg mob hnav cov lo ntsiab muag, ces noj bisoprolol tuaj yeem ua rau txo qis ntawm cov kua muag kua muag, uas yuav tsum tau ntxiv cov tshuaj pleev qhov muag tshwj xeeb.
Thaum cov tshuaj siv los ntawm cov neeg mob pheochromocytoma, paradoxical arterial hypertension yog ua tau. Hauv qhov no, qhov kev txiav txim ua ntej alpha-blockade yog qhov tsim nyog.
Kev muaj ntshav qab zib qhov ncauj qhov ntswg tawm tsam ntawm tachycardia tshwm sim los ntawm kev txo qis hauv cov ntshav qabzib. Ua ib qho kev xaiv beta-blocker, cov tshuaj tsis tuaj yeem txhim kho cov tshuaj insulin hauv lub xeev hypoglycemic thiab ua rau qeeb ntawm cov piam thaj hauv cov ntshav mus rau qhov xav tau.
Catecholamines, normetanephrine, antinuclear antibodies thiab vanillylmandelic acid hauv cov ntshav thiab zis tsuas yog txiav txim siab thaum Bisoprolol-Prana raug cais tawm.
Rau cov poj niam cev xeeb tub thiab lactating cov tshuaj, cov tshuaj tau sau rau hauv tus account cov txiaj ntsig rau leej niam lub cev, tab sis muaj peev xwm ua rau muaj qhov tshwm sim tsis zoo hauv lub embryo.
Leej twg yog kev kho mob contraindicated rau?
Cov ntsiav tshuaj "Bisoprolol-Prana" cov lus qhia rau kev siv tsis pom zoo kom siv nrog kev nce siab, mob lossis mob ntev ntawm decompensated insufficiency ntawm lub plawv cov leeg, cardiogenic poob siab, blockade ntawm sinoauricular thiab atrioventricular ntawm hom thib ob thiab thib peb, nrog tus mob syndrome,cuam tshuam nrog kev qaug zog hauv lub qhov txhab, lub plawv dhia qeeb nrog kev siv tsawg dua 60 tus neeg ntaus.
Contraindication yog lub xub ntiag ntawm:
- cardiomegaly nrog nce qhov loj thiab loj ntawm cov leeg plawv;
- qis siab hauv cov hlab ntsha nrog tus nqi systolic tsawg dua 90 millimeters mercury;
- kab mob obstructive pulmonary;
- bronchial hawb pob;
- mob ntshav qab zib hauv cov hlab ntsha peripheral nyob rau theem tom ntej.
Tsis xav tau qhov tshwm sim
Cov tshuaj "Bisoprolol-Prana" tuaj yeem ua rau muaj kev phiv ntau yam uas cuam tshuam rau thaj chaw nruab nrab thiab sab hauv ntawm lub paj hlwb. Lawv tshwm sim los ntawm mob taub hau, qaug zog, pw tsaug zog cuam tshuam, kev nyuaj siab thiab hnov qab.
Cov txheej txheem tsis zoo hauv lub plawv thiab cov hlab ntsha yog tshwm sim los ntawm orthostatic hypotension, kub flashes, tawm hws, lub plawv dhia qeeb thiab myocardial insufficiency.
Lwm yam tshwm sim ntawm cov kev mob tshwm sim yog txo qis ntawm cov qog lacrimal, kev txhim kho ntawm conjunctivitis, raws plab, khaus tawv nqaij, cem quav, xeev siab, leeg tsis muaj zog thiab cramps. Obstructive tsos mob yuav tshwm sim nyob rau hauv lub bronchi.
Kev npaj zoo sib xws
Cov tshuaj qub raws li bisoprolol yog cov ntsiav tshuaj "Concor". Lawv yog tsim los ntawm German tuam txhab Merck.
Raws li cov tshuaj no, cov kev npaj zoo sib xws tau tsim muaj cov tshuaj bisoprolol ua cov khoom xyaw nquagfumarate.
Lavxias teb cov tshuaj manufacturers tsim beta-blockers nrog ntau lub npe lag luam. Ib qho piv txwv yog cov tshuaj "Bisoprolol-Prana": nws cov analogues muaj ntau npaum li cas ntawm 2.5 mg, 5 mg thiab 10 mg. Cov tshuaj no suav nrog tshuaj:
- "Bisogamma";
- Niperten;
- "Kordinorm";
- Biprol.
Cov khoom zoo sib xws kuj tsim los ntawm cov tuam txhab txawv teb chaws. Muaj cov tshuaj nyob rau hauv lub khw muag tshuaj, lub npe uas muaj lub npe ntawm lub enterprise, piv txwv li, Bisoprolol-Teva, Bisoprolol-Ratiopharm, Bisoprolol-Sandoz, Bisoprolol-Lugal.
Muaj cov analogues uas tsuas yog hu ua "Bisoprolol". Cov tshuaj no yog tsim los ntawm Lavxias teb sab factories: CJSC Vertex, CJSC Severnaya Zvezda, LLC Ozon Pharmaceuticals, CJSC Biokom.
Yog tias peb piv cov ntsiav tshuaj "Bisoprolol" thiab "Bisoprolol-Prana", qhov sib txawv yuav yog nyob rau hauv qhov zoo thiab muaj pes tsawg leeg ntawm cov khoom pabcuam. Xws li qhov tsis sib xws tsis cuam tshuam rau bioavailability thiab permeability ntawm cov tshuaj nquag hauv lub cev, uas txhais tau hais tias cov tshuaj kho tau zoo ib yam.
Reviews
Ntau tus neeg mob nco ntsoov qhov yooj yim ntawm kev siv tshuaj uas muaj bisoprolol, vim tias lawv tau noj ib hnub nkaus xwb. Ib ntsiav tshuaj txaus rau tag nrho ib hnub kom normalize ntshav siab.
Txog cov cuab yeej "Bisoprolol-Prana" tshuaj xyuas tsis yog qhov phem. Lawv qhia nws qhov kev xaiv siab, uas yog vim li cas noj cov tshuaj yog nrog los ntawm ib qho me meCov kev mob tshwm sim piv rau lwm cov beta-blockers.
Cov neeg mob qhia yooj yim ntawm kev siv thiab tsis tshua muaj tshwm sim uas txhawb qee tus neeg mob hloov mus rau cov tshuaj no.
Txiv neej hais tias noj tshuaj tsis ua rau muaj zog. Tsis tas li ntawd, qhov tseeb no tau raug pov thawj los ntawm ntau qhov kev tshawb fawb.
Cov tshuaj "Bisoprolol-Prana" qhia cov metabolism hauv nruab nrab ntawm kev cuam tshuam rau cov roj cholesterol, triglyceride thiab qabzib metabolism. Cov cuab yeej no tso cai rau nws muab tshuaj rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus lossis muaj kev pheej hmoo rau cov ntshav qabzib ntau ntxiv. Raws li, cov neeg mob no kuj tawm tswv yim zoo txog cov tshuaj.
Vim tias muaj qhov tsis zoo tshwm sim tsawg, cov ntsiav tshuaj tau muab rau cov neeg mob laus. Cov neeg mob hais tias cov tshuaj no zoo dua thiab muaj kev nyab xeeb dua li lwm cov tshuaj beta-blocker antihypertensive.
Qhov kom zoo dua ntawm cov tshuaj "Bisoprolol-Prana" yog nws tus nqi qis, uas yog tus nqi pheej yig heev rau cov neeg tau nyiaj tsawg, uas kuj tau cuam tshuam nrog kev tshuaj xyuas ua tsaug.
Tab sis txawm tias tag nrho cov txiaj ntsig ntawm cov tshuaj, tsuas yog tus kws kho mob tuaj yeem sau tshuaj raws li cov txiaj ntsig ntawm kev tshuaj xyuas.
