tswm ciab "Loksidol" - tshuaj tiv thaiv kab mob uas tsis yog tshuaj tiv thaiv kab mob. Meloxicam, tam sim no nyob rau hauv nws cov muaj pes tsawg leeg, yog ib tug derivative ntawm enolic acid thiab belongs rau qeb ntawm anti-inflammatory non-steroidal tshuaj, muaj ib tug pronounced analgesic, anti-inflammatory thiab antipyretic nyhuv. Cov txheej txheem ntawm nws txoj haujlwm yog vim muaj peev xwm los cuam tshuam cov kev sib txuas ntawm cov tshuaj lom neeg ntawm prostaglandins, uas yog cov neeg kho kom haum xeeb ntawm kev mob tshwm sim los ntawm kev xaiv inhibition ntawm COX-2.
Koj kawm tau dab tsi los ntawm cov lus qhia rau tswm ciab "Loksidol"?
Cov tshuaj
Tus neeg sawv cev tshuaj no yog tsim los ntawm cov tshuaj suppositories rau kev siv lub qhov quav. Cov muaj pes tsawg leeg ntawm ib suppository muaj xws li lub active caij - meloxicam 15 mg, thiab ntxiv tshuaj: khoom rog thiab macrogolglyceryl hydroxystearate.
YPharmacokinetics
Absorption tsis zoo ib yam liqhov ncauj daim ntawv ntawm cov tshuaj. Qhov siab tshaj plaws plasma concentration tau pom 6 teev tom qab kev tswj hwm ntawm suppository rectally.
Lub ntsiab tseem ceeb ntawm tswm ciab "Loksidol" khi zoo heev nrog cov ntshav plasma proteins, feem ntau nrog albumin (98%). Nws muaj peev xwm nkag mus rau hauv lub synovial kua, qhov concentration ntawm uas yog kwv yees li 50% ntawm cov ntshav plasma. Cov khoom tseem ceeb yog tag nrho metabolized nyob rau hauv daim siab nrog tsim ntawm plaub inactive derivatives. Lub ntsiab metabolite yog 5'-carboxymeloxicam, uas yog tsim los ntawm oxidation ntawm intermediate metabolites, 5'-hydroxymethylmeloxicam, uas yog kuj excreted, tsuas yog rau ib tug tsawg npaum li cas. Cov tshuaj yog tawm los ntawm lub cev nyob rau hauv sib npaug zos npaum li cas nrog zis thiab quav, feem ntau nyob rau hauv daim ntawv ntawm metabolites. Kwv yees li ntawm 5% ntawm cov koob tshuaj niaj hnub no tau tso tawm tsis hloov pauv hauv cov hnyuv, cov kab mob muaj nyob hauv cov zis hauv kev npaj kho mob.
Qhov nruab nrab ib nrab-lub neej ntawm cov khoom nquag yog 19 teev. Plasma clearance - 8 ml / min. Hauv cov neeg mob laus, daim duab no me ntsis qis dua. Pharmacokinetic tsis nyob rau hauv daim siab lossis lub raum tsis ua haujlwm tsis hloov.
Cov lus qhia rau kev siv
Cov lus qhia rau kev siv tswm ciab "Loksidol" tau piav qhia meej hauv cov lus qhia.
Cov tshuaj no yog siv los kho cov tsos mob ntawm qhov mob ntawm cov kab mob xws li osteoarthritis (arthrosis, degenerative joint puas), ankylosing spondylitis, rheumatoidmob caj dab.
Kev noj tshuaj thiab kev tswj hwm
tswm ciab "Loksidol" yog siv rau hauv lub qhov quav, ib hnub ib zaug (15 mg ntawm meloxicam). Qhov tshwm sim ntawm cov kev mob tshwm sim nyob ntawm qhov ntau npaum li cas thiab lub sijhawm siv. Cov tshuaj yuav tsum tau siv rau lub sijhawm luv tshaj plaws. Qhov siab tshaj plaws pub noj ib hnub yog 15 mg.
Side effects
tswm ciab "Loksidol" tuaj yeem ua rau muaj kev loj hlob ntawm cov kev cuam tshuam tsis zoo ntawm lub cev:
- digestive disorders, ntuav, xeev siab, mob plab, cem quav, flatulence, kev loj hlob ntawm raws plab;
- plab hnyuv los ntshav, perforation thiab mob hnyav, tshwj xeeb tshaj yog rau cov neeg laus;
- ntshav ntshav, thrombocytopenia, leukopenia, agranulocytosis, tshwj xeeb tshaj yog thaum siv methotrexate ib txhij;
- khaus, pob khaus;
- photosensitivity reactions, Stevens-Johnson syndrome thiab epidermal toxic necrolysis, urticaria, blistering dermatitis, angioedema;
- anaphylactoid lossis anaphylactic cov tshuaj tiv thaiv;
- mob hawb pob, tshwj xeeb tshaj yog rau cov neeg ua xua rau cov tshuaj aspirin lossis lwm yam tshuaj uas tsis yog-steroidal anti-inflammatory;
- xav qaug cawv, mob taub hau, kiv taub hau, tsaug zog, suab nrov hauv pob ntseg, tsis meej pem, tsis meej pem;
- puffiness;
- ntshav siab, palpitations, kub flashes;
- nce ib ntus ntawm bilirubin lossis transaminase qib;
- hloovraum kev ua haujlwm (ntau ntxiv ntawm creatinine lossis urea hauv cov ntshav), tsis tshua muaj - mob raum tsis ua haujlwm;
- kab mob siab;
- kev tsis pom kev.
YContraindications
Raws li cov lus qhia rau tswm ciab "Loksidol", cov xwm txheej uas siv cov tshuaj no yog contraindicated:
- hypersensitivity rau lub ntsiab ntawm cov tshuaj los yog rau ntxiv tshuaj;
- nrog rau kev nkag siab zoo rau cov tshuaj aspirin thiab lwm yam NSAIDs;
- Keeb kwm ntawm plab hnyuv los ntshav lossis perforations txuam nrog NSAIDs;
- peptic ulcer nyob rau theem mob;
- mob siab ua tsis taus pa;
- raum tsis ua haujlwm (tshwj tsis yog muaj hemodialysis);
- GI los ntshav, cerebrovascular lossis lwm yam los ntshav;
- mob ntev lossis nyuaj mob plawv tsis ua haujlwm;
- muaj keeb kwm ntawm proctitis lossis los ntshav ntawm qhov quav;
- under 15;
- lactation, cev xeeb tub.
Kev Sib Tham Tshuaj
Lwm NSAIDs, suav nrog salicylates: kev siv ib txhij ntawm ntau dua ib qho ntawm cov tshuaj no ua rau muaj kev pheej hmoo ntawm cov kab mob hauv plab hnyuv thiab plab hnyuv los ntshav vim muaj kev sib koom ua ke. Kev siv meloxicam thiab lwm yam NSAIDs tsis pom zoo.
Cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, kab mob heparin, tshuaj thrombolytic: nceqhov yuav los ntshav. Nyob rau hauv rooj plaub uas nws tsis tuaj yeem zam kev siv cov tshuaj no ua ke, nws yuav tsum tau saib xyuas cov nyhuv anticoagulant.
Lithium: Cov tshuaj ua kom cov concentration ntawm lithium hauv plasma vim qhov txo qis hauv nws lub raum tso tawm. Kev siv ua ke ntawm lithium thiab NSAIDs raug txwv. Yog tias qhov kev kho mob ua ke no tsim nyog, tswj cov qib lithium hauv ntshav thaum pib kho, thaum xaiv cov tshuaj thiab tshem tawm cov tshuaj "Loksidol"..
"Methotrexate": NSAIDs tuaj yeem txo cov tubular tso tawm ntawm cov tshuaj no thiab yog li nce qib ntawm methotrexate hauv ntshav. Yog tias qhov kev kho mob nyuaj, nws yog ib qho tsim nyog los tswj cov khoom ntawm cov ntshav thiab lub raum ua haujlwm. Qee qhov kev saib xyuas yuav tsum tau ua thaum NSAIDs thiab methotrexate tau siv ib txhij rau peb hnub, vim tias qhov concentration ntawm methotrexate hauv cov ntshav tuaj yeem nce ntxiv, ua rau muaj ntau yam tshuaj lom.
"Cyclosporin": NSAIDs, ua rau lub raum prostaglandins, tuaj yeem ua rau muaj tshuaj lom ntawm cyclosporine rau lub raum. Nyob rau hauv rooj plaub ntawm txoj kev kho nyuaj nrog kev siv cov tshuaj no, lub raum yuav tsum tau saib xyuas.
Cov tshuaj tiv thaiv hauv lub cev: "Loksidol" txo cov nyhuv ntawm cov tshuaj tiv thaiv hauv plab.
Diuretics: Kev siv cov tshuaj no nrog cov tshuaj diuretics tib lub sijhawm ua rau muaj kev pheej hmoo ntawm kev mob raum tsis ua haujlwm rau cov neeg mob lub cev qhuav dej. Cov neeg mob uas nojmeloxicam thiab diuretics tib lub sijhawm, yuav tsum tau txais cov kua dej ntau. Ua ntej pib kho, yuav tsum kuaj xyuas lub raum ua haujlwm.
Cov tshuaj tiv thaiv hypertensive (piv txwv li, angiotensin-hloov enzyme inhibitors, beta-blockers, vasodilators) Loxidol txo cov txiaj ntsig ntawm cov tshuaj tiv thaiv ntshav siab los ntawm inhibiting prostaglandins, uas muaj vasodilatory nyhuv..
"Cholestyramine": txhim kho qhov tso tawm ntawm meloxicam zoo heev vim nws txoj kev khi hauv plab hnyuv.
Cov lus qhia rau tswm ciab "Loksidol" hauv gynecology yuav nthuav tawm hauv qab no.
Special Recommendations
Kev siv tshuaj, zoo li lwm yam NSAIDs, yuav tsum tau saib xyuas nruj ntawm cov neeg mob uas muaj keeb kwm ntawm cov kab mob ntawm lub plab zom mov, nrog rau cov neeg mob noj cov tshuaj tiv thaiv kab mob. NSAIDs inhibit zus tau tej cov prostaglandins raum, uas yog tsim nyog los tswj cov ntshav txaus nyob rau hauv lub raum. Hauv cov neeg mob uas lub raum qis qis, kev siv cov tshuaj no tuaj yeem ua rau lub raum tsis ua haujlwm, uas ploj mus tom qab txiav cov tshuaj. Hauv cov neeg mob uas muaj kev hloov pauv hauv lub raum tsis ua haujlwm, qhov ntau npaum li cas ntawm cov tshuaj tsis tuaj yeem hloov pauv, tab sis kev soj ntsuam tas li ntawm lub raum ua haujlwm yog qhov tsim nyog. Muaj tsawg zaus, cov tshuaj "Loksidol" tuaj yeem ua rau muaj kev cuam tshuam ntawm nephritis, lub raum medullary necrosis thiab glomerulonephritis, lossis kev loj hlob ntawm cov tsos mob.nephrotic syndrome. Cov pawg hauv qab no ntawm cov neeg mob yog qhov ua rau muaj teeb meem xws li:
- nrog raum tsis ua haujlwm;
- cov neeg uas tau txais kev phais loj (uas ua rau muaj kev tsis haum xeeb);
- neeg mob cirrhosis.
Raws li tau hais los ntawm cov lus qhia rau kev siv "Loxidol", tus kws tshuaj tshuaj, thaum siv ua ke nrog cov tshuaj diuretics, tuaj yeem ua rau kom khaws cov poov tshuaj, sodium thiab dej hauv lub cev thiab cuam tshuam rau kev ua haujlwm ntawm natriuretic ntawm cov tshuaj diuretic, xws li qhov tshwm sim ntawm cov neeg mob uas tau pom muaj peev xwm ua tau lossis ua rau lub plawv tsis ua haujlwm lossis kub siab.
Tshuaj yog muab nrog qee qhov ceev faj rau cov neeg mob hnyav, cov neeg laus, thiab cov neeg mob plawv.
Dab tsi ntxiv yog cov lus qhia siv rau tswm ciab "Loksidol" qhia rau peb? Cov tshuaj, zoo li lwm yam NSAID, tuaj yeem ua rau cov tsos mob ntawm cov kab mob sib kis. Zoo li lwm yam tshuaj uas inhibit zus tau tej cov COX / prostaglandins, Loksidol tuaj yeem cuam tshuam cov txheej txheem fertilization, yog li nws tsis pom zoo rau cov poj niam npaj cev xeeb tub.
Txoj kev cuam tshuam ntawm cov tshuaj no ntawm lub peev xwm tsav tsheb lossis cov txheej txheem txaus ntshai yog tias thaum siv cov tshuaj, ntau yam tsis zoo tshwm sim los ntawm lub hauv paus paj hlwb yuav tshwm sim, uas yog vim li cas nws thiaj li tsim nyog los tswj cov saum toj no. technical devices onLub sijhawm kho mob tsis kam lees.
Cov lus qhia rau kev siv "Loksidol" yuav tsum tau ua nruj me ntsis saib.
Siv hauv gynecology
Cov tshuaj tiv thaiv kab mob no, vim nws cov khoom, tam sim no tau siv dav hauv kev kho mob gynecology thaum muaj cov kab mob sib kis hauv qab no thiab cov mob uas muaj nrog:
- adnexitis;
- endometritis;
- cervicitis;
- colpitis;
- salpingoophoritis;
- lwm cov txheej txheem inflammatory hauv cov poj niam cev xeeb tub uas ua rau mob hnyav.
Raws li kev tshuaj xyuas, tswm ciab "Loksidol" hauv gynecology yog suav tias yog siv tau, vim tias lawv sai sai pab tshem tawm cov kab mob.
Analogues
Daim ntawv teev cov analogues ntawm qhov kev npaj tshuaj no yog qhov loj heev. Qee cov tshuaj no yog:
- "Amelotex" - ib yam tshuaj uas muaj nyob rau hauv pawg kws tshuaj ntawm cov tshuaj tiv thaiv kab mob uas tsis yog-steroidal, catalyzes zus tau tej cov prostaglandins. Vim yog kev xaiv, cov khoom tseem ceeb thaiv COX-2, vim tias cov tshuaj tiv thaiv kev ua haujlwm ntawm tus neeg sawv cev no thiab muaj kev puas tsuaj tsawg kawg nkaus ntawm cov mucous daim nyias nyias ntawm lub plab zom mov.
- "Zeloxim" - NSAIDs, qhov tseeb analogue ntawm "Loksidol", xaiv inhibitor ntawm COX-2. Nws tuaj yeem raug categorized li oxicam vim nws yog ib qho derivative ntawm enolic acid. Rendersanalgesic, anti-inflammatory thiab antipyretic teebmeem. Cov txheej txheem ntawm kev cuam tshuam yog cuam tshuam nrog kev txo qis hauv biosynthesis ntawm prostaglandins vim inhibition ntawm enzyme kev ua ntawm COX.
- "Melox" - nyob rau hauv muaj pes tsawg leeg thiab cov tshuaj pharmacological zoo ib yam li cov tshuaj hauv nqe lus nug. Blocks prostaglandins, muaj cov tshuaj tua kab mob, tshuaj tua kab mob.
Reviews about tshuaj
Cov tshuaj "Loksidol" yog suav tias yog ib qho ntawm cov tshuaj kws tshaj lij ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory, uas yog tsim nyob rau hauv daim ntawv ntau npaum - suppositories. Muaj ntau qhov kev tshuaj xyuas txog cov tshuaj no, uas yog vim qhov dav ntawm cov khoom kho mob no. Nws yog siv los tshem tawm cov mob uas tshwm sim los ntawm ntau yam kab mob ntawm cov kab mob sib kis - thaj tsam ntawm neurology, traumatology, urology, gynecology, thiab lwm yam. Cov neeg mob hais hauv kev tshuaj xyuas tswm ciab "Loksidol" uas cov cuab yeej pab kom tshem tau sai. ntawm qhov mob hnyav thaum siv lwm yam tshuaj tsis pab.
Cov tshuaj yog siv los txo qhov mob hauv kev txhim kho cov kab mob ntawm cov pob txha thiab pob qij txha, txawm li cas los xij, cov neeg mob uas siv nws rau lwm yam kab mob kuj tau sau tseg tias nws cov txiaj ntsig zoo.
tswm ciab "Loksidol" nyob rau hauv gynecology feem ntau yog muab rau cov poj niam nrog kev loj hlob ntawm inflammatory dab nyob rau hauv lub me me pelvis, piv txwv li, nrog adnexitis. Cov neeg mob tau pom tias tom qab kev qhia txog cov tshuaj suppository, qhov mob tau dhau mus sai, txawm li cas los xij, muaj qee qhov. Cov kev phiv tsis zoo.
mob xeev siab, kiv taub hau, quav quav nyob rau hauv daim ntawv ntawm raws plab feem ntau pom ntawm cov kev mob tshwm sim. Ntau tus neeg mob uas tawm tswv yim tawm tswv yim txog cov tshuaj no tau hais tawm qhov tsis zoo, uas lawv yuav tsum tsis txhob siv cov tshuaj "Loksidol" thiab hloov nrog cov tshuaj analogues.
Peb tau tshuaj xyuas cov lus qhia thiab tshuaj xyuas rau tswm ciab "Loksidol". Hauv gynecology, lawv siv kuj tau piav qhia.
