Txhawm rau txo cov ntshav siab, cov kws kho mob feem ntau siv tshuaj raws li amlodipine. Ib qho ntawm cov tshuaj no yog tshuaj "Stamlo"
Kev piav qhia
Cov tshuaj no yog tsim los ntawm Indian tuam txhab Dr. Reddy's Laboratories Ltd.
Tshuaj "Stamlo" qhia tau hais tias lub sijhawm ntev thiab kev siv tshuaj kho tau zoo.
Ua ib qho dihydropyridine derivative, cov khoom xyaw nquag amlodipine belongs rau tiam thib ob ntawm Ca2+ antagonists uas kaw cov channel uas tso cai rau calcium ions dhau mus.
Dose form
Cov khoom muaj nyob rau hauv ob qhov ntau npaum li cas: 0.005 thiab 0.010 g ntawm cov tshuaj tiv thaiv.
Cov lus qhia piav qhia txog qhov me me ntawm cov tshuaj Stamlo li cov ntsiav tshuaj puag ncig nrog lub ntsej muag dawb lossis yuav luag dawb, uas yog tiaj tus, muaj cov duab beveled raws ntug. Rau lub hom phiaj ntawm kev sau cov tshuaj, ib lub dav hlau muaj qhov extrusion ntawm "R 177", lwm qhov muaj kab sib cais.
Ib koob tshuaj loj "Stamlo" yog tus cwj pwm los ntawm kev paub daws teeb meem raws li cov ntsiav tshuaj oval nrog lub ntsej muag dawb lossis yuav luag dawb biconvex. Rau lub hom phiaj ntawm kev sau tshuajib lub dav hlau muaj ib tug extrusion "R", nyob rau lwm yam - lub digital designation "178" yog siv. Dosed solids muaj nyob rau hauv blister packs ntawm 14, packs muaj ob blister packs.
Cov khoom xyaw tshuaj
Cov khoom xyaw nquag ntawm cov tshuaj yog ntsev ntawm amlodipine ntawm hom besilate, nyob rau hauv tus nqi ntawm 6.42 thiab 12.838 mg, sib npaug rau 0.005 thiab 0.010 g ntawm ntshiab amlodipine.
Hauv cov qauv ntawm Stamlo ntsiav tshuaj, cov khoom tsis ua haujlwm tuaj yeem pom, uas yog microcrystalline cellulose hais, sodium starch glycolate, lub cev qhuav dej aerosil, magnesium stearate.
Mechanism of action
Amlodipine molecules khi rau receptor outgrowths ntawm hom dihydropyridine, thaiv cov channel ntawm qeeb nkag ntawm calcium ions cuam tshuam rau qib thib ob, uas muab kev ua haujlwm antianginal thiab antihypertensive.
Cov lus qhia rau kev siv "Stamlo" characterizes nws raws li ib tug tshuaj uas txo cov kev hloov ntawm transmembrane ntawm Ca2+ ions rau hauv cov leeg nqaij leeg ntawm phab ntsa vascular.
Nrog rau kev ua haujlwm antianginal, cov hlab ntsha loj thiab me me ntawm coronary thiab peripheral hom nthuav dav. Nyob rau hauv lub xub ntiag ntawm qhov mob tom qab lub sternum, muaj ib tug txo nyob rau hauv lub manifestation ntawm lub ischemic xeev ntawm lub plawv cov leeg.
Cov tshuaj muaj cov nyhuv tsis muaj zog natriuretic, inhibition ntawm platelet cell aggregation, nce pom tus nqi hauv glomeruli.
Kev nthuav dav ntawm cov hlab ntsha nyob deb ua rauKev txo qis hauv kev ua haujlwm ntawm lub txaj dav dav peripheral vascular, txo qis hauv preload ntawm cov ntaub so ntswg myocardial, txo qis ntawm cov pa oxygen molecular xav tau rau lub plawv.
Kev noj los ntawm cov neeg mob ntshav qab zib nephropathy tsis nce microalbuminuria.
Kev ua ntawm cov tshuaj tsis hloov cov txheej txheem metabolic thiab qib lipid hauv cov hlab ntsha.
Kev kho mob tshwm sim tom qab ob peb teev thiab kav ntev li ib hnub.
Yuav siv li cas
Pills pab kho tus kheej thiab kev tawm dag zog vim mob hauv siab.
Cov lus qhia rau kev siv "Stamlo" pom zoo kom noj nrog nce ntshav siab. Nws tuaj yeem siv ib leeg lossis ua ke nrog lwm cov tshuaj tiv thaiv ntshav siab.
Yuav ua li cas
ntsiav tshuaj "Stamlo M" cov lus qhia rau kev siv qhia kev kho mob ntshav siab thiab mob tom qab lub sternum nrog thawj koob tshuaj ntawm 0.005 g, uas yog qaug dej qaug cawv 1 zaug hauv ib hnub. Kev saib xyuas tus nqi ntawm amlodipine ntawm siab siab yog 0.005 g ib hnub twg. Qhov siab tshaj plaws pub noj txhua hnub ntawm tus neeg sawv cev yuav tsum tsis pub tshaj 0.010 g.
Ntawm thiab tawm dag zog angina yog kho nrog koob tshuaj 0.005 txog 0.010 g ib hnub.
Kho qhov nyiaj ntawm cov tshuaj "Stamlo M" tsis yog ua tiav yog tias nws tau ua ke nrog thiazide diuretics, angiotensin-hloov pauv enzyme inhibitors, beta-blocker thiab nitrate cov tshuaj ntawm lub sijhawm ntev thiab cov lus hais.nitroglycerins.
Nrog rau kev ua haujlwm hypotensive rau tus neeg mob hnub nyoog, nrog lub cev me me, nrog cov leeg nqaij qis, nrog rau lub siab ua haujlwm tsis zoo, koob tshuaj 0.0025 g yog siv ua ntej. kev kho mob.
Yog tias lub raum tsis ua haujlwm, ces tsis tas yuav kho cov tshuaj amlodipine.
Txoj kev kho mob
Rau cov tshuaj "Stamlo" cov lus qhia rau kev siv qhia txog qhov ua tau ntawm nws siv hauv ntau tus neeg mob rau kev kho mob monotherapy. Yog tias pom tias muaj kev ua haujlwm tsis txaus, ces angiotensin-hloov enzyme inhibitors, diuretic thiazide cov ntsiab lus, alpha- thiab beta-adrenergic thaiv cov tshuaj ntxiv rau cov tshuaj.
Thaum lub sijhawm noj tshuaj, nws yog ib qho tsim nyog los tswj tib neeg lub cev qhov hnyav thiab noj sodium, cov lus pom zoo yuav tsum ua raws.
Cov tshuaj tuaj yeem suav nrog hauv kev kho mob monotherapy, lawv tau ua ke nrog cov tshuaj antianginal rau cov neeg mob uas tiv taus cov teebmeem ntawm kev kho cov tshuaj nitrate thiab beta-blockers.
Txhawm rau tiv thaiv los ntshav, mob thiab loj hlob ntawm cov ntaub so ntswg hauv cov pos hniav, kev kho hniav tas li thiab mus ntsib kws kho hniav txhua lub sijhawm.
Cov tshuaj uas thaiv qhov kev nkag mus qeeb ntawm calcium ions los ntawm cov channel tsis ua rau lub cev tiv thaiv kev tshem tawm cov tshuaj, txawm li cas los xij, tsis kam kho, cov tshuaj yuav tsum tau maj mam txo.
Cov ntsiab lus ntawm cov poov tshuaj cations, qabzib,Cov roj cholesterol, triglyceride molecules, uric acid thiab creatinine hauv cov ntshav tsis hloov pauv raws li cov tshuaj Stamlo.
Thaum pib ntawm kev kho mob, cov neeg mob yuav tsaug zog thiab kiv taub hau, uas yuav tsum tau ceev faj thaum tsav tsheb.
Leej twg yuav tsum tsis tau
Cov lus qhia rau kev siv "Stamlo" yam tsis tau ua tsis tiav muaj cov npe contraindications uas cov neeg mob tsis tau sau tshuaj. Cov no suav nrog:
- mob ntshav siab ntshav siab, thaum lub siab systolic qis dua 90 millimeters mercury;
- kev poob siab thiab poob siab lub xeev cardiogenic;
- mob hauv siab tsis ruaj tsis yog qhov tshwm sim;
- mob xeeb thiab pub mis niam;
- ua rau muaj kev cuam tshuam ntau dhau rau cov khoom xyaw tshuaj thiab cov tshuaj dihydropyridine.
- Tsis txhob siv cov khoom uas muaj hnub nyoog qis dua 18 xyoo, vim nws qhov kev nyab xeeb tsis tau muaj pov thawj.
Yuav tsum tau ceev faj txog kev siv cov neeg mob uas tau decompensated insufficiency ntawm cov mob ntev ntawm cov leeg mob, me me los yog nruab nrab nce siab hauv cov hlab ntsha, aortic thiab mitral daim ntawv ntawm vasoconstriction, mob myocardial infarction, ntau qab zib, lub siab ua haujlwm tsis zoo thiab fat metabolism.
kev tawm tsam tsis zoo
Cov lus qhia rau kev siv "Stamlo" hais txog txhua yam tsis zoo uas yuav tshwm sim tom qab noj tshuaj.
Ntawm plawv thiab vascularamlodipine system muaj kev cuam tshuam nrog cov tsos mob ntawm lub plawv dhia tsis tu ncua, ua tsis taus pa, txo qis hauv siab, fainting, vasculitic cov tshuaj tiv thaiv, cov txheej txheem edematous nyob rau hauv qis qis ntawm ob txhais ceg thiab caj npab.
Cov tshuaj ua rau lub paj hlwb thiab ua pa nrog rau qhov pib ntawm qhov mob hauv lub taub hau, qaug zog, lub siab hloov pauv, qaug zog, ua tsis taus pa, kev nyuaj siab, hnoos lossis mob rhinitis.
Los ntawm kev noj tshuaj, koj tuaj yeem hnov mob, ntuav, mob plab, mob pancreatitis, gastritis thiab jaundice, qhuav tawm ntawm qhov ncauj, cuam tshuam peristalsis, thiab nce siab ntawm daim siab enzymes.
Kev hloov pauv hauv cov kab mob genitourinary yog tshwm sim los ntawm kev nquag los yog mob tsub kom tso zis, excretion disorders, nocturia, txo potency.
Cov tshuaj tiv thaiv tawv nqaij cuam tshuam nrog xeroderma, plaub hau poob, purpura, o ntawm epithelium, khaus, pob khaus, angioedema nrog kev ua xua.
Amlodipine muaj kev cuam tshuam tsis zoo rau cov kab mob musculoskeletal nrog cov tsos mob ntawm arthralgia, arthrosis, mob nraub qaum thiab cov leeg tsis muaj zog.
Kev xav hauv nruab nrog cev yuav raug kev txom nyem los ntawm kev loj hlob ntawm ob lub zeem muag, o ntawm lub qhov muag, qhov muag tsis pom kev thiab kev nkag siab ntawm kev hnov qab, ringing hauv taub hau, ocular kev pab, dryness nyob rau hauv lub cornea thiab mucous membranes.
Nws cuam tshuam nrog tshuaj li cas
Cov lus qhia rau kev siv cov ntsiav tshuaj txuas nrog Stamlo tshuaj tsis pom zoo kom muab nws nrog cov tshuaj uas inhibit microsomal oxidation. Raws li lawv cov kev cuam tshuam, qib plasma ntawm amlodipine nce,tus naj npawb ntawm cov txheej txheem tsis xav tau. Kev sib xyaw nrog inducers uas ua kom lub siab microsomal enzymes muaj qhov cuam tshuam.
Hypotensive kev ua haujlwm tsis muaj zog nyob rau hauv kev cuam tshuam ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory. Indomethacin khaws cov sodium thiab blocks prostaglandin synthesis nyob rau hauv lub raum, alpha-agonists thiab estrogens kuj ua rau qeeb lub excretion ntawm Na+ ions, thiab muaj sympathomimetic nyhuv.
Warfarin, cimetidine thiab digoxin tsis hloov qhov txiaj ntsig ntawm cov tshuaj pharmacokinetic ntawm cov ntsiav tshuaj.
Antianginal thiab hypotensive teebmeem tuaj yeem txhim kho los ntawm thiazide, voj diuretics, beta-blockers, verapamil, angiotensin-hloov enzyme inhibitors thiab nitrates.
Tshuaj muaj Ca2+ ions txo cov nyhuv thaiv ntawm calcium channels.
Qhov kev tshwm sim ntawm cov nyhuv neurotoxic ntawm lithium tshuaj yog txhim kho los ntawm amlodipine, uas yog tus yam ntxwv ntawm xeev siab, raws plab, ntuav, tshee, ataxia, tinnitus.
Amiodarone, alpha-blockers, quinidine, tshuaj tiv thaiv kev puas siab puas ntsws ntawm hom neuroleptic nce kev ua haujlwm siab.
Nyob zoo
Thaum siv tshuaj ntau dhau ntawm Stamlo, cov lus qhia piav qhia txog kev hloov pauv uas pom los ntawm kev txo qis hauv siab, mob plawv tsis tu ncua, thiab ntau dhau peripheral vasodilation.
Kev ntsuas txhawm rau tshem tawm cov tshuaj ntau dhau kuj raug txiav txim siab,txuam nrog gastric lavage, teem caij ntawm sorbents. Nws yog ib qho tseem ceeb kom rov ua haujlwm ntawm lub ntsws, lub plawv thiab cov hlab ntsha, kom tswj tau lawv cov kev ua tau zoo. Yuav tsum ua kom cov ceg tawv kom siab, tswj qhov ntim ntawm cov zis.
Kom normalize vascular tone, vasoconstrictors siv. Txhawm rau tshem tawm cov teebmeem ntawm tubular blockage, siv cov calcium hauv cov hlab ntsha hauv daim ntawv ntawm gluconate.
Zimilar drug
Rau cov tshuaj "Stamlo" analogues kuj muaj nyob rau hauv ob koob tshuaj: 0.005 thiab 0.010 g ntawm amlodipine. Qhov zoo ntawm cov khoom xyaw uas tsis muaj zog ntawm cov ntsiav tshuaj los ntawm cov tuam txhab sib txawv yuav txawv me ntsis, uas tsis cuam tshuam rau bioavailability.
Cov tshuaj "Amlodipine" yog tsim los ntawm cov nroj tsuag "ALSI Pharma" CJSC. Nws yog suav hais tias yog ib qho ntawm cov pheej yig analogues ntawm Indian tshuaj. Nws muaj antihypertensive thiab antianginal kev ua.
Lavxias teb sab analogues yog cov tshuaj "Vero-Amlodipine", tsim los ntawm lub tuam txhab "Veropharm" JSC, thiab cov tshuaj "Amlodipine-Biocom" ntawm cov nroj tsuag "Biocom" CJSC.
Tshuaj "Amlodipine-Teva" muaj nyob rau hauv ob koob tshuaj: 0.005 thiab 0.010 g txhua. Tsim los ntawm Hungarian kws tshuaj tuam txhab TEVA Private Co. Ltd."
Amlodipine Sandoz yog tsim los ntawm Slovenian lub tuam txhab Sandoz nyob rau hauv daim ntawv ntawm tiaj tus, round ntsiav tshuaj units nrog tus qhab nia thiab bevel.
Reviews
Ntau tus neeg mob nyiam cov tshuaj no vim nws cov txiaj ntsig thiabtus nqi pheej yig. Txog cov tshuaj "Stamlo" tshuaj xyuas tuaj yeem hnov qhov zoo thiab qhov tsis zoo. Rau qee tus neeg mob, cov tshuaj pab txo cov ntshav siab, thaum lwm tus tsis tshem tawm cov ntshav siab.
Ntxiv rau, cov tshuaj tuaj yeem ua rau qaug zog, kiv taub hau, qaug zog, mus ob peb vas, tsaug zog, xeev siab. Hauv qhov no, koj yuav tsum tsis txhob noj tshuaj.
