Metoclopramide yog tshuaj tiv thaiv. Lub npe Latin rau cov tshuaj no yog Metoclopramide. Nws yog tsim los ntawm ob peb lub tuam txhab tshuaj - LLC "Ellara", Tsoom Fwv Teb Chaws State Unitary Enterprise "Moscow Endocrine Plant", CJSC "PharmFirma SOTEKS", OJSC "Novosibkhimfarm", LLC "Promomed Rus", Indian tuam txhab PROMED EXPORTS, CJSC "PFC Renewal", Belarusian Borisov Nroj Tsuag ntawm Cov Khoom Siv Tshuaj, Polish JSC "Pharmaceutical Plant POLFARMA". Hauv qab no yog cov lus piav qhia ntxaws ntxaws ntawm cov tshuaj Metoclopramide.
Kev sib xyaw thiab kev tsim cov tshuaj
Cov tshuaj muaj nyob rau hauv ob hom tshuaj - hauv daim ntawv ntawm cov ntsiav tshuaj thiab cov kua dej rau kev siv cov hlab ntsha thiab intramuscular. Qhov feem pua ntawm cov tshuaj "Metoclopramide" yog 0.5%, nws yog poured rau hauv ampoules, nyob rau hauv ib tug ntim ntawm 2 ml. Ntim hauv iav ampoulescardboard packs ntawm 5 los yog 10 daim los yog 5 los yog 10 ampoules - nyob rau hauv yas los yog cell contour pallets, 1 los yog 2 pallets nyob rau hauv ib lub thawv ntawv.
Nyob rau hauv cov tshuaj muaj pes tsawg leeg ntawm kev txhaj tshuaj ntawm cov tshuaj muaj ib tug active caij - metoclopramide hydrochloride.
Pharmacological action
Tshuaj "Metoclopramide" belongs rau qeb ntawm cov blockers tshwj xeeb ntawm serotonin (5-HT3) thiab dopamine (D2) receptors. Nws ua rau muaj kev cuam tshuam ntawm kev ua haujlwm ntawm chemoreceptors, uas yog nyob rau hauv thaj tsam ntawm lub paj hlwb qia, thiab txo qhov rhiab heev ntawm cov hlab ntsha visceral lub luag haujlwm rau kev xa tawm ntawm impulses los ntawm pylorus thiab duodenum mus rau ntuav receptors. Cov tshuaj "Metoclopramide" cuam tshuam rau cov kab mob parasympathetic thiab hypothalamus, uas ua rau lub plab zom mov ntawm lub plab zom mov thiab tswj hwm lub suab ntawm lub plab hnyuv siab raum (xws li lub plab hnyuv sphincter) thiab nws lub cev muaj zog. Tsis tas li ntawd, cov tshuaj tsub kom lub suab ntawm cov hnyuv thiab lub plab, activates plab hnyuv peristalsis, accelerates tus txheej txheem ntawm tshem tawm cov zaub mov ntawm lub plab, tiv thaiv qhov tshwm sim ntawm esophageal thiab pyloric reflux, thiab txo cov kev siv ntawm hyperacid stasis..
Cov tshuaj normalizes cov kua tsib thiab tshem tawm spasms ntawm sphincter ntawm Oddi thiab dyskinesia ntawm lub gallbladder, tsis muaj kev cuam tshuam lub suab ntawm lub tom kawg. Rau lub active caij, nws yog uncharacteristic, m-anticholinergic, ganglioblocking, antihistamine thiab antiserotonin nkaus. Tsis tas li ntawd, cov tshuaj no tsis hloov pauv kev ua haujlwmdaim siab thiab ob lub raum, ua pa ua haujlwm, tsis muaj kev cuam tshuam rau vascular tone ntawm lub hlwb, vascular siab, hematopoiesis, tso tawm ntawm pancreas thiab plab. Cov tshuaj nkoos lub synthesis ntawm prolactin thiab tsub kom lub rhiab heev ntawm lub cev cov ntaub so ntswg rau acetylcholine (cov nyhuv no tsis yog txiav txim los ntawm vagal innervation, tab sis yog nres nrog kev pab los ntawm anticholinergics). Tsis tas li ntawd, nws activates zus tau tej cov aldosterone, thaum slowing down lub excretion ntawm poov tshuaj thiab sodium ions los ntawm lub cev.
Metoclopramide cov tshuaj pib cuam tshuam rau lub plab zom mov kwv yees li 10-15 feeb tom qab txhaj tshuaj intramuscular thiab 1-3 feeb tom qab kev tswj hwm cov hlab ntsha, uas tau tshwm sim hauv kev khiav tawm sai ntawm plab hnyuv thiab cov nyhuv antiemetic. Lub ntsiab tseem ceeb yog metabolized nyob rau hauv daim siab thiab tawm los ntawm lub cev, feem ntau nyob rau hauv cov zis rau 24-72 teev. Kwv yees li 30% ntawm cov khoom uas nkag mus rau hauv lub cev yog excreted unchanged. Metoclopramide yooj yim hla cov placental thiab ntshav-hlwb teeb meem, nyob rau hauv ib tug npaum li cas yog txiav txim nyob rau hauv cov kua mis. Cov ntshav siab tshaj plaws ntawm metoclopramide yog ncaj qha proportional rau cov tshuaj noj thiab feem ntau mus txog hauv 1-2 teev.
Nyob rau hauv cov neeg mob uas muaj cirrhosis, metoclopramide yuav tsub zuj zuj vim 50% txo cov ntshav plasma clearance.
Cov lus qhia rau cov tshuaj
Metoclopramide cov tshuaj nyob rau hauv daim ntawv ntawm kev txhaj tshuaj yog sau nyob rau hauv lub xub ntiag ntawm cov nram qab no pathological mob:
- xeev siab, hiccups, ntuav ntawm ntau yam keeb kwm (hauv qee qhovrooj plaub, cov tshuaj yuav muaj txiaj ntsig zoo hauv kev kho mob ntuav los ntawm kev siv cytostatics lossis kev kho hluav taws xob);
- pyloric stenosis ntawm lub hauv paus chiv keeb;
- atony lossis hypotension ntawm lub plab zom mov, suav nrog kev ua haujlwm tom qab;
- flatulence;
- reflux esophagitis;
- hloov pauv hauv duodenum thiab plab (thaum lub sijhawm exacerbation, ib txhij nrog lwm cov tshuaj);
- dyskinesia ntawm bile ducts los ntawm hom hypomotor.
Ntxiv rau cov lus qhia saum toj no, cov tshuaj Metoclopramide feem ntau tau muab tshuaj rau kev kuaj mob radiopaque ntawm lub plab zom mov (kom txhim kho peristalsis) thiab ua cov tshuaj uas pab txhawb lub suab duodenal (kom ua kom cov txheej txheem tshem tawm ntawm lub plab zom mov). plab thiab txav cov khoom noj los ntawm txoj hnyuv).
npe ntawm contraindications
Metoclopramide cov tshuaj muaj qee qhov tseeb thiab cov txheeb ze contraindications. Thawj qeb suav nrog:
- glaucoma;
- los ntshav los ntawm lub plab zom mov;
- Ypyloric stenosis;
- prolactin-dependent qog;
- perforation ntawm phab ntsa ntawm txoj hnyuv lossis plab;
- Parkinson's disease;
- mechanical yam plab hnyuv obstruction;
- pheochromocytoma;
- mob vwm;
- extrapyramidal ntshawv siab;
- ntuav vim noj ntau dhau lossis kho nrog neuroleptics, nrog rau cov neeg mob qog noj ntshav mis;
- bronchial hawb pob nrogsiab rhiab heev ntawm tus neeg mob lub cev rau sulfites;
- Kuv lub hlis twg ntawm cev xeeb tub, lactation;
- hnub nyoog qis dua 6 xyoos;
- siab rhiab heev rau cov khoom xyaw.
Raws li cov lus qhia, cov tshuaj "Metoclopramide" yuav tsum tsis txhob siv tom qab kev phais mob ntawm cov plab hnyuv siab raum (pyloroplasty, plab hnyuv anastomosis), vim cov leeg mob hnyav tuaj yeem cuam tshuam kev kho.
txheeb ze contraindications rau Metoclopramide yuav tsum tau siv nrog ceev faj thaum muaj cov kab mob pathological:
- hlab ntshav siab;
- raum lossis siab tsis ua haujlwm;
- bronchial hawb pob;
- II-III trimesters ntawm cev xeeb tub;
- laus (tom qab 65 xyoos) thiab menyuam yaus hnub nyoog.
Rules of application
Raws li cov lus qhia, cov tshuaj Metoclopramide yog siv rau hauv cov hlab ntsha lossis intramuscularly. Qhov ntau npaum ntawm cov tshuaj yog muab raws li nyob rau hauv qeb hnub nyoog:
- cov neeg mob laus: 10-20 mg 1-3 zaug hauv ib hnub (qhov ntim siab tshaj - 60 mg);
- menyuam yaus tom qab 6 xyoo: 1-3 zaug hauv ib hnub, 5 mg.
Ib nrab teev ua ntej noj cov tshuaj tua hluav taws xob lossis cytostatics rau kev kho mob thiab tiv thaiv ntuav thiab xeev siab, cov khoom siv kho mob no tau muab tso rau hauv cov hlab ntshav ntawm qhov ntau npaum li 2 mg / kg ntawm tus neeg mob qhov hnyav. Yog tias tsim nyog, tom qab 2-3 teev, cov lus qhia txog kev daws tuaj yeem rov ua dua. 5-15 feeb ua ntej kuaj X-ray10-20 mg ntawm cov tshuaj yog muab intravenously. Nyob rau hauv cov ntaub ntawv kho mob hais tias daim siab los yog lub raum tsis ua hauj lwm, qhov ntau npaum ntawm cov tshuaj yuav tsum tau txo los ntawm 2 lub sij hawm, cov tshuaj tom ntej yog nyob ntawm tus neeg cov lus teb rau kev kho mob. Daim ntawv qhia hauv Latin rau cov tshuaj Metoclopramide yuav muab hauv qab no.
Siv rau lub raum thiab lub siab tsis ua haujlwm
Yog tias tus neeg mob muaj tus mob no, nws yuav tsum tau kho cov tshuaj Metoclopramide raws li hauv qab no:
- theem kawg (creatinine tshem tawm tsawg dua 15 ml / min): 25% ntawm txhua hnub ntim.
- theem hnyav thiab nruab nrab (creatinine tshem tawm 15-60 ml / min): 50% ntawm qhov noj txhua hnub.
Rau qhov tshwm sim hnyav ntawm daim siab tsis ua haujlwm, qhov koob tshuaj yog halved.
Cov teebmeem ntawm Metoclopramide kua
Tshuaj yuav ua rau cov tshuaj tsis zoo no:
- Lub plawv thiab cov hlab ntsha: atrioventricular block.
- CNS: extrapyramidal ntshawv siab - spasm ntawm lub ntsej muag nqaij, torticollis (spastic type), rheev protrusion ntawm tus nplaig, bulbar hom kev hais lus, extraocular nqaij spasms (oculogiric ntsoog), hypertonicity, nqaij opisthotonus, parkinsonism, dyskinesia (nrog rau lub siab tsis ua hauj lwm thiab cov neeg laus), mob taub hau, kev nyuaj siab, ntxhov siab vim, tsaug zog, tinnitus, tsis meej pem.
- Cov kab mob endocrine: nrog kev kho mob ntev ntawm kev noj ntau, gynecomastia, galactorrhea, mobkev coj khaub ncaws.
- digestion system: cem quav, raws plab, qhov ncauj qhuav.
- Metabolism: kev loj hlob ntawm porphyria.
- Hematopoietic system: neutropenia, sulfhemoglobinemia hauv cov neeg laus, leukopenia.
- Cov tshuaj tsis haum: bronchospasm, angioedema, urticaria.
- Lwm yam: thaum pib ntawm kev kho mob - agranulocytosis, thaum muab tshuaj ntau - hyperemia ntawm qhov ntswg mucosa.
Yog tias cov tsos mob saum toj no tshwm sim, hnyav zuj zus los yog tsim lwm yam kev phiv, nws raug nquahu kom hu rau tus kws kho mob tshwj xeeb uas tau sau tshuaj rau cov tshuaj Metoclopramide.
Cov tsos mob ntawm cov tshuaj overdose
Cov tsos mob tshwm sim feem ntau ntawm kev siv tshuaj ntau dhau yog cov kab mob extrapyramidal, mob plawv thiab ua pa tsis ua pa, tsaug zog ntau dhau, tsis nco qab, hnov lus, kiv taub hau thiab ua tsis taus pa. Yog tias tus neeg mob tau kuaj pom tias muaj cov tsos mob ntawm extrapyramidal, provoked los ntawm kev noj tshuaj ntau dhau los yog lwm qhov ua rau, kev kho mob pom zoo (benzodiazepines hauv cov menyuam yaus lossis cov tshuaj anticholinergic antiparkinsonian hauv cov neeg laus). Raws li kev kho mob tshwm sim ntawm cov kab mob pathology, cov tsos mob ntawm kev kho mob thiab kev saib xyuas tsis tu ncua ntawm kev ua pa thiab lub plawv yuav tsum tau ua.
Cov lus qhia tshwj xeeb rau kev siv
Nrog ntuav ntawm qhov chaw vestibular ntawm keeb kwm, cov tshuaj "Metoclopramide" hauv ampoules tsis zoo. Thaum nws siv, kuaj tsis ua haujlwm ntawm daim siab ua haujlwm thiab kev txiav txim siab ntawm qib aldosterone thiabplasma prolactin. Cov kev mob tshwm sim feem ntau tshwm sim hauv 36 teev tom qab txhaj tshuaj thiab ploj mus yam tsis muaj kev kho ntxiv hauv ib hnub tom qab tshem tawm. Kev kho mob nrog cov tshuaj no, yog tias ua tau, yuav tsum yog luv luv. Thaum siv cov tshuaj, nws tsis pom zoo kom haus dej cawv. Thaum kho, nws raug nquahu kom ceev faj thaum ua haujlwm nrog kev siv cov txheej txheem txaus ntshai uas xav tau kev saib xyuas tshwj xeeb thiab kev xav sai, nrog rau thaum tsav tsheb.
Metoclopramide cov tshuaj tau muab tso rau hauv cov khw muag tshuaj los ntawm cov tshuaj. Koj tuaj yeem tau txais los ntawm tus kws kho mob lossis tus kws kho mob hauv cheeb tsam.
Siv thaum cev xeeb tub thiab lactation
Tshuaj tshuaj raws li metoclopramide hauv peb lub hlis twg ntawm cev xeeb tub yog contraindicated, vim qhov no tuaj yeem ua rau muaj kev cuam tshuam ntawm extrapyramidal hauv cov menyuam mos. Thaum muab tshuaj rau cov poj niam cev xeeb tub, kev saib xyuas tas li ntawm cov menyuam yug tshiab yuav tsum tau ua. Cov tshuaj tseem ceeb yog txiav txim siab hauv cov kua mis, thiab yog li lub sij hawm lactation yog contraindication rau kev teem caij ntawm cov tshuaj no. Ua ntej pib kho, nws raug nquahu kom tsis txhob pub mis niam. Qhov no tau lees paub los ntawm cov lus qhia siv rau cov tshuaj Metoclopramide.
Kev siv tshuaj thaum yau
Txoj kev kho rau cov menyuam yaus yog sau nrog ceev faj heev. Qhov no muaj tseeb tshwj xeeb rau cov menyuam mosThaum muaj hnub nyoog ntxov, txij li qhov tshwm sim ntawm qhov tshwm sim ntawm dyskinetic syndrome nce ntau.
Drug interaction
Thaum siv cov tshuaj sib xyaw rau kev txhaj tshuaj "Metoclopramide" nrog qee cov khoom siv kho mob tuaj yeem tsim cov teebmeem hauv qab no:
- Cholinesterase inhibitors: inhibition ntawm kev ua ntawm metoclopramide.
- Ethanol: nce cov teebmeem ntawm lub hauv nruab nrab paj hlwb.
- tshuaj tsaug zog: nce sedative teebmeem.
- H2-histamine receptor blockers: nce cov txiaj ntsig ntawm kev kho.
- Digoxin, cimetidine: inhibition ntawm cov txheej txheem nqus.
- Tetracycline, diazepam, ampicillin, acetylsalicylic acid, paracetamol, levodopa: nce absorption.
- Neuroleptics: nce kev pheej hmoo ntawm cov tsos mob extrapyramidal.
Tsis tas li ntawd, kev siv cov tshuaj sib xyaw nrog zopiclone ua rau lub cev nqus tau tom qab, nrog cabergoline - txo qis hauv nws cov txiaj ntsig tau, nrog ketoprofen - nws bioavailability txo.
Raws li qhov tshwm sim ntawm dopamine receptor antagonism, metoclopramide tuaj yeem txo cov nyhuv anti-Parkinsonian ntawm levodopa, thaum nws muaj peev xwm ua kom cov bioavailability ntawm levodopa ua rau kom ceev nws khiav tawm ntawm lub plab kab noj hniav nyob rau hauv tus ntawm metoclopramide.. Cov txiaj ntsig ntawm qhov kev sib cuam tshuam no yog sib xyaw.
Thaum siv ua ke nrog mexiletine, qhov nqus ntawm mexiletine yog nrawm, nrog mefloquine, nqus ntawm mefloquine thiab nws cov ntshav plasma tau txhim kho, thaum nws cov kev mob tshwm sim yuav raug txo.
ThaumKev siv ib txhij ntawm cov tshuaj rau kev txhaj tshuaj "Metoclopramide" nrog morphine accelerates qhov nqus ntawm morphine thaum noj qhov ncauj thiab txhim kho nws cov nyhuv sedative.
Thaum siv ib txhij nrog nitrofurantoin, qhov nqus ntawm nitrofurantoin txo qis. Nrog metoclopramide, lawv cov koob tshuaj induction yuav tsum tau txo ua ntej kev tswj hwm ncaj qha lossis thiopental.
Hauv cov neeg mob tau txais metoclopramide, cov teebmeem ntawm suxamethonium chloride tau ntev thiab txhim kho. Qhov no tseem ceeb heev uas yuav tau xav txog.
Cov lus qhia rau cov tshuaj Metoclopramide yuav tsum tau ua nruj me ntsis. Thaum ua ke nrog tolterodine, qhov ua tau zoo ntawm cov tshuaj tau kawm txo qis, nrog fluvoxamine - cov ntaub ntawv ntawm cov kab mob extrapyramidal paub, nrog fluoxetine - muaj peev xwm ntawm cov kab mob extrapyramidal hauv tus neeg mob, nrog cyclosporine - kev nqus ntawm cyclosporine nce thiab nws cov ntshav concentration. nce.
Ua ntej koj pib noj lwm yam tshuaj tib lub sijhawm, koj yuav tsum tau txais lus qhia los ntawm tus kws kho mob tshwj xeeb.
Daim ntawv qhia rau "Metoclopramide" hauv Latin hauv tshuaj thiab ntsiav tshuaj
Tus kws kho mob yuav tsum sau daim ntawv teem sijhawm hauv qab no:
Rp: Tabulettam Metoclopramidi 0, 01 No. 10
Da. Signa: noj 1 tab. 3 zaug ib hnub rau xeev siab
Rp: Sol. Metoclopramidi 0.5% - 2 ml.
Dtd N 20 in amp.
S: 2 ml IM 3 zaug ib hnub rau kev kho mob plab hnyuv atony
Analogues
Cov tshuaj muaj npe nrov tshaj plaws thiab ntau yam tshuaj analogues"Metoclopramide" yog:
- "Vero-Metoclopramide";
- Metamol;
- "Perinorm";
- Cerucal;
- Metoclopramide-Eskom;
- "Metoclopramide-Vial";
- Raglan.
Tus kws kho mob yuav tsum xaiv qhov hloov pauv.
Price of this tshuaj
Koj tuaj yeem yuav tshuaj txog li 50-80 rubles (lub pob muaj 10 ampoules ntawm cov tshuaj). Cov tshuaj hauv Latin rau cov tshuaj "Metoclopramide" yuav tsum tau nthuav tawm tib lub sijhawm. Tus nqi ntawm cov tshuaj nyob ntawm thaj tsam thiab lub khw muag tshuaj.
Reviews
Cov neeg mob xav txog cov tshuaj no zoo heev, thiab cov kws kho mob nquag siv nws los ua cov tshuaj tiv thaiv kab mob. Cov neeg mob tau txais kev kho mob cytostatic thiab kev kho hluav taws xob qhia tau hais tias cov tshuaj "Metoclopramide" ua tiav pab tshem tawm xeev siab thiab ntuav. Ntau tus neeg mob zam cov tshuaj zoo, lawv tsis yws txog qhov tsis zoo.
Raws li kev siv cov cuab yeej no thaum yau, kev tshuaj xyuas muaj cov ntaub ntawv zoo thiab tsis zoo txog nws. Cov niam txiv thiab cov kws kho mob nco ntsoov tias cov tshuaj no zoo tshem tawm cov tsos mob ntawm xeev siab, tab sis nws ua rau muaj kev phiv ntau, thiab kev pheej hmoo ntawm kev tsim cov teeb meem no ntau dua cov txiaj ntsig. Feem ntau cov tshuaj tiv thaiv rau cov neeg laus thiab menyuam yaus yog kiv taub hau, tsis pom kev pom, tinnitus, thiab cephalalgia. Ntawd yog, cov tsos mob ntawm kev ua txhaum ntawm lub paj hlwb. Cov teeb meem no feem ntau tshwm sim hauvthawj hnub ntawm tshuaj, thiab sai sai ploj.
Cov kws kho mob hauv kev tshuaj xyuas cov tshuaj qhia tias nws yog txwv tsis pub siv cov tshuaj no ntawm lawv tus kheej, yam tsis tau teem sijhawm los ntawm kws kho mob tshwj xeeb. Qhov no yog vim qhov tseeb tias nws feem ntau ua rau lub cev tsis zoo, uas tuaj yeem ua rau muaj teeb meem loj heev.
