Tetracycline tshuaj tua kab mob yog ib pawg tshuaj loj heev. Cov tshuaj muaj cov qauv tshuaj zoo sib xws. Nws yuav tsum tau muab sau tseg tias cov nyiaj no yog nyob rau hauv ib qho ntawm cov thawj qhov chaw ntawm cov tshuaj nrog ib tug dav spectrum ntawm kev ua si.
Tetracycline tshuaj tua kab mob. Description
Tshuaj nyob rau hauv pab pawg no muaj kev nyuaj siab rau kev yug me nyuam thiab kev loj hlob ntawm gram-negative, gram-positive bacteria, rods (acid-resistant), cov kab mob loj, thiab lwm yam microbes. Cov qeb suav nrog cov tshuaj xws li Chlortetracycline Hydrochloride, Oxytetracycline Hydrochloride, Tetracycline thiab lwm yam. Kev tshawb fawb tshuaj tau pib xyoo 1948. Vim muaj qee qhov teeb meem hauv kev npaj cov tshuaj hluavtaws, niaj hnub no lawv tsim siv biosynthesis. Tag nrho cov tshuaj tua kab mob tetracycline yog amphoteric nyob rau hauv cov xwm. Lawv lub ntsiab zoo yog vim yog pawg dimethylamino. Lub acidic zog ntawm cov tshuaj yog vim phenolic hydroxyl nyob rau hauv D-ring.
Ua amphoteric, compounds dissolve nyob rau hauvacids thiab alkalis tsim cov ntsev. Lawv, nyob rau hauv lem, undergo hydrolysis nyob rau hauv aqueous daws. Cov kua qaub ntau ntxiv tiv thaiv cov txheej txheem hydrolysis, nrog rau cov nag lossis daus ntawm lub hauv paus.
Tag nrho cov tshuaj tetracycline muaj spectra zoo ib yam. Hauv cov molecules, phenolic hydroxyl ua rau cov xim hloov thaum cuam tshuam nrog ferric chloride (3). Tetracycline tshuaj tua kab mob yog decomposed los ntawm alkali los tsim isotetracyclines. Nyob rau hauv lem, qhov no yog nrog los ntawm ib tug nce nyob rau hauv staining. Cov tshuaj tiv thaiv ntawm cov xwm txheej dav dav yog cov yam ntxwv ntawm tag nrho cov tshuaj tetracycline. Nws muaj peev xwm paub qhov txawv ntawm cov tshuaj los ntawm ib leeg vim muaj qhov sib txawv ntawm qhov sib txawv ntawm cov tshuaj sulfuric acid (tseem ceeb). Nyob rau hauv cov ntaub ntawv no, tsim cov tebchaw xim rau txhua tetracycline nyob rau hauv nws cov xim tshwj xeeb tshwm sim. Yog li, piv txwv li, rau ib tug, ib tug liab doog-liab tint tshwm, rau lwm yam - liab doog. Ib qho ntawm cov yam ntxwv tshwj xeeb yog lub peev xwm ntawm cov tshuaj fluoresce nyob rau hauv lub zog ntawm UV teeb. Qhov no feem ntau yog siv los ua pov thawj ntawm lawv qhov tseeb.
tshuaj muaj txiaj ntsig ntawm tetracycline
Cov tshuaj no muaj ntau yam kev ua haujlwm. Nws cov nyhuv bacteriostatic tshwm sim vim qhov inhibition ntawm protein synthesis ntawm cov kab mob pathogenic. Cov kev ua ntawm cov tshuaj yog manifested txheeb ze rau gram-zoo aerobic microbes, nrog rau cov hom uas tsim penicillinase. Cov tshuaj kuj cuam tshuam rau cov kab mob gram-tsis zoo. Qhia tsis kam rau cov tshuaj me meCov kab mob, feem ntau cov kab mob thiab lwm yam kab mob.
Qee txoj cai rau noj tshuaj tua kab mob. Cov tshuaj tiv thaiv tsis zoo
Nws raug nquahu kom siv tshuaj ntawm koob tshuaj 0.3 grams hauv thawj ob hnub, 0.2 grams tsib zaug hauv hnub tom qab. Nrog kab mob gonorrhea (subacute thiab mob tsis yooj yim), 5 g raug muab rau cov chav kawm, nrog rau lwm cov ntaub ntawv - 10 txhua. Nws raug nquahu kom noj cov tshuaj ua ntej lossis thaum noj mov. Tawm tsam keeb kwm yav dhau los ntawm kev siv, plab zom mov, ntuav, xeev siab, yuav muaj.
