Hauv kab lus, peb yuav txiav txim siab cov lus qhia siv rau Eufillin ntsiav tshuaj.
Nws yuav tsum raug sau tseg tam sim ntawd tias cov tshuaj zoo li no tshem tawm cov hnoos qeev nrog cov hnoos qhuav qhuav, tab sis tsis ncaj qha kho hnoos, tsuas yog txo tus neeg mob ib ntus xwb. Lub sijhawm no yog qhov tsim nyog kom txog thaum qhov kev txiav txim ntawm lwm yam tshuaj pib. Ua tsaug rau Eufillin, tus neeg mob tuaj yeem ua pa thiab tsis hnov mob. Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj, nws cov txiaj ntsig zoo thiab cov tsos mob tshwm sim yuav raug piav qhia meej hauv kab lus no.
tshuaj kho mob
Raws li cov lus qhia rau cov ntsiav tshuaj Eufillin, vim tias cov tshuaj muaj txiaj ntsig zoo ntawm cov tshuaj, cov leeg nqaij bronchial so, mucociliary clearance nce, kev ua haujlwm ntawm diaphragm contraction yog stimulated, thiab kev ua haujlwm ntawm tsis tsuas yog ua pa, tab sis kuj ua haujlwm. Cov leeg nqaij intercostal tau txo qis.
Ntxiv rau, qhov kev txiav txim ntawm cov tshuaj txhawb lub chaw ua pa, ua rau nws rhiab heev rau cov pa roj carbon dioxide, nrog rau kev txhim kho qhov cua ntawm alveoli.
Kev ua pa ua pa rov zoo li qub raws li kev siv tshuajtxhais tau hais tias, ua kom cov pa oxygen saturation ntawm cov ntshav thiab yog li txo cov ntsiab lus ntawm carbon dioxide nyob rau hauv nws.
Ntxiv rau, cov tshuaj txhawb zog ntawm cov tshuaj yog nyob rau hauv kev ua haujlwm ntawm lub plawv, ua kom lub plawv dhia thiab ua rau cov ntshav coronary thiab myocardial oxygen xav tau. Lub vascular tone ntawm daim tawv nqaij, hlwb thiab ob lub raum raug txo.
Tsis tas li ntawd, qhov cuam tshuam ntawm cov tshuaj Eufillin suav nrog:
- muab venodilating peripheral nkaus;
- txo qis hauv cov hlab ntsws;
- txo qis hauv pulmonary vascular resistance;
- nce ntshav ntws mus rau ob lub raum;
- Muab cov nyhuv me ntsis diuretic;
- inhibition ntawm platelet aggregation;
- nthuav tawm ntawm biliary extrahepatic tract;
- ntxiv dag zog rau erythrocyte deformation;
- txo qis hauv cov ntshav txhaws thiab normalization ntawm microcirculation;
- epileptogenic nyhuv ntawm koob tshuaj ntau;
- nce acidity ntawm cov kua txiv hmab txiv ntoo vim yog cov nyhuv tocolytic ntawm tus neeg sawv cev.
Tshuaj pharmacokinetics
Thaum cov tshuaj "Eufilin" nkag mus rau hauv tus neeg mob lub cev, nws tau nqus tag nrho thiab sai sai. Lub bioavailability index nyob rau hauv feem pua yog 90-100. Tus nqi ntawm kev nqus tuaj yeem cuam tshuam los ntawm cov khoom noj, tab sis tsis yog los ntawm ntim. Qhov ua tau zoo tshaj plaws ntawm kev noj tshuaj yog ua tiav hauv ob teev.
Cov tshuaj muaj peev xwm nkag mus rau hauv tus poj niam lub mis rau kwv yees likaum feem pua ntawm tag nrho cov koob tshuaj thiab los ntawm cov placental barrier, qhov twg nws cov concentration yog ho ntau dua li cov plasma niam.
Rau qhov tshwm sim ntawm bronchodilating cov cim qhia ntawm cov tshuaj nquag ntawm cov tshuaj, nws cov ntsiab lus ntawm 10-20 micrograms ib milliliter yog txaus. Cov concentrations siab dua ntawm nws ua rau muaj kuab lom. Interestingly, qhov txo qis ntawm cov tshuaj hauv cov ntshav, qhov ua tau zoo ntawm excitation ntawm qhov chaw ua pa yog pom tau.
Cov tshuaj yog metabolized feem ntau hauv daim siab, ib nrab-lub neej nyob ntawm tus neeg mob. Nws qhov kev tso tawm tshwm sim nrog kev pab ntawm lub raum.
Cov tshuaj no siv thaum twg?
Kev siv cov ntsiav tshuaj Eufillin yog qhov tsim nyog rau kev kho mob ntawm cov neeg mob uas muaj ntau yam kab mob uas yuav tsum tau siv cov tshuaj bronchodilator:
- bronchial obstructive syndrome;
- bronchial hawb pob;
- pulmonary emphysema;
- kab mob obstructive pulmonary;
- obstructive chronic bronchitis;
- cor pulmonale syndrome;
- pw tsaug zog apnea hmo ntuj;
- pulmonary hypertension.
Txoj cai noj tshuaj
Pills "Eufillin" tau noj qhov ncauj. Koj tuaj yeem haus peb zaug ib hnub, 0.15 grams. Cov tshuaj yuav tsum tau noj tom qab noj mov thiab ntxuav nrog dej huv. Thaum menyuam yaus, nws raug tso cai noj cov tshuaj plaub zaug, xya milligrams ib kilogram ntawm qhov hnyav. Cov chav kho mob nrog kev pab ntawm cov ntsiav tshuaj yog txiav txim los ntawm tus kws kho mob tshwj xeeb. Nws tuaj yeem kav ntev li ob peb hnub mus rau ob lub hlis.
Contraindications rau cov tshuaj no
Eufillin ntsiav tshuaj tsis tuaj yeem muab tshuaj rau hauv cov xwm txheej uas tus neeg mob muaj kev nkag siab ntau dhau rau cov tshuaj ntawm cov tshuaj, tshwj xeeb tshaj yog rau nws cov khoom nquag.
Tsis tas li ntawd, cov tshuaj yog contraindicated yog tias tus neeg mob muaj ntau qhov kev kuaj mob:
- mob vwm;
- exacerbation ntawm ulcer pathology ntawm duodenum thiab plab;
- gastritis (yog tias acidity siab);
- hypotension lossis mob siab heev;
- hemorrhagic type stroke;
- tachyarrhythmia;
- ntshav nyob rau hauv lub retina ntawm lub cev ntawm lub zeem muag;
- Cov menyuam yaus hnub nyoog qis dua peb xyoos.
Kev ceev faj hauv kev siv cov ntsiav tshuaj Eufillin yuav tsum muaj nyob rau hauv cov xwm txheej hauv qab no:
- nrog rau kev mob plawv tsis txaus (nyob rau theem mob ntawm angina pectoris, myocardial infarction);
- nrog rau cov vascular atherosclerosis;
- rau obstructive hypertrophic cardiomyopathy;
- nyob rau hauv thaum yau;
- in advanced xyoo;
- nrog nquag ventricular extrasystoles;
- thaum cev xeeb tub;
- nrog kev npaj siab heev;
- nrog gastroesophageal reflux;
- nrog raum thiab lub siab tsis ua haujlwm;
- nrog rau lub sijhawm ntev hyperthermia;
- nrog rwj kab mob ntawm duodenum thiab plab;
- nrog kev tswj tsis tau thyrotoxicosis thiab hypothyroidism;
- rau ntshav los ntawm plab hnyuv.
Tseeb ntawm kev siv tshuaj ntau dhau
Yog tias tus neeg mob haus cov ntsiav tshuaj Eufillin ntau dhau, yuav muaj teeb meem txaus ntshai. Nws yog ib qho tsim nyog yuav tsum tau mus rau qhov chaw kho mob raws sijhawm thiab ntxuav lub plab. Tus kws kho mob uas tuaj koom yuav tsum qhia tam sim ntawd tag nrho cov tsos mob tsis zoo. Ntawm lawv yog cov hauv qab no:
- poob qab los;
- ntuav;
- mob plab;
- gastric los ntshav;
- mob plab plab;
- nrawm nrawm;
- kev txaus siab ntawm tus neeg mob;
- insomnia;
- ntsej muag liab;
- pom kev ntshai thiab kev ntxhov siab;
- pib qaug dab peg thiab pib mob qaug dab peg;
- tsis nco qab los ntawm tus neeg;
- txo qis ntshav siab;
- ntshai lub teeb thiab kiv taub hau.
kho hnoos nrog Eufillin
Ntau zaus, thaum hnoos, cov kws kho mob tshwj xeeb tau muab tshuaj kho rau cov neeg mob nrog kev pab ntawm "Eupyllin". Ua tsaug rau nws, bronchi nthuav dav sai, thiab ua pa zoo tuaj. Kev tawm tsam thiab kev hawb pob pathological yuav dhau mus. Tab sis nws tsis pom zoo kom kho tus hnoos me me nrog cov tshuaj muaj zog zoo li no. "Eufillin" raug sau tshwj xeeb los ntawm tus kws kho mob, yog tias muaj kev tawm tsam hnyav.
Yog tus neeg mob hnoos heev thiab hnoos qeev, ces nws raug tso cai haus cov tshuaj peb zaug hauv ib hnub. Hauv qhov no, yuav tsum muaj sijhawm rau 6 teev nyob nruab nrab ntawm txhua koob tshuaj.
Kev sib cuam tshuam ntawm cov tshuaj no nrog lwm cov tshuaj
Raws li cov lus qhia rau kev siv rau cov ntsiav tshuaj hnoos Eufillin, yog tias koj ib txhij noj cov tshuaj nrog mineralocorticosteroids, glucocorticosteroids, beta-adrenergic stimulants, tshuaj rau cov tshuaj loog, Xanthine thiab cov tshuaj uas txhawb lub hauv nruab nrab lub paj hlwb, nws muaj peev xwm ua tau. ua rau muaj qhov tshwm sim tsis zoo.
Kev siv cov tshuaj tiv thaiv kab mob thiab cov tshuaj enterosorbents yuav txo qhov nqus ntawm cov khoom tseem ceeb ntawm Eufillin.
Kev kho nrog aminoglutethimide, isoniazid, rifampicin, sulfinpyrazone, phenobarbital, carbamazepine, phenytoin, moracizin thiab estrogen-muaj cov tshuaj tiv thaiv qhov ncauj ua rau kom tshem tawm ntawm cov khoom tseem ceeb ntawm cov tshuaj, thiab qhov no yuav ua rau kom cov tshuaj tiv thaiv kab mob ntau ntxiv. dosage.
Kev sib xyaw ntawm cov tshuaj macrolide, allopurinol, verapamil, lincomycin, ticlopidine, cimetidine, thiabendazole, isoprenaline, propafenone, enoxacin, mexiletin, disulfiram, methotrexate, fluoroquinolonamine, recombinant interferon (vascobinant) thiab ntau npaum li cas. Tus kab mob khaub thuas yuav tsum tau txo qhov koob tshuaj "Eupyllin", vim tias cov tshuaj no ua rau kom muaj zog ntawm nws cov cawv.
Eufillin ntsiav tshuaj hnoos, thaum siv ib txhij nrog cov tshuaj diuretics thiab beta-adrenergic stimulants, ua kom cov txiaj ntsig ntawm cov nyiaj no. Txo qhov ua tau zoo los ntawm kev sivpom thaum ua ke nrog lithium npaj thiab beta-blockers.
Anti-antispasmodics ua haujlwm ua ke zoo kawg nkaus, uas tsis tuaj yeem hais txog lwm yam xanthine derivatives, uas tsis pom zoo kom siv ib txhij nrog tshuaj.
Qhov no tau lees paub los ntawm cov lus qhia rau cov ntsiav tshuaj hnoos Eufillin.
Analogues ntawm "Eupyllin"
txhais tau tias thaum kho tuaj yeem hloov nrog cov tshuaj uas zoo sib xws hauv lawv cov tshuaj nquag thiab muaj pes tsawg leeg. Cov no suav nrog cov hauv qab no:
- "Eufillin Darnitsa";
- "Aminophylline Eskom";
- Eufillin tshuaj rau kev txhaj tshuaj 2, 4%;
- "Aminophylline".
Tshuaj xyuas txog cov ntsiav tshuaj "Eufillin"
Kev tshuaj xyuas ntawm cov tshuaj "Eufillin" feem ntau yog qhov zoo. Cov neeg uas tau siv nws txaus siab rau qhov ceev ntawm qhov kev txiav txim thiab qhov ua tau zoo ntawm cov tshuaj hauv kev tshem tawm ua tsis taus pa thiab ua pa yooj yim. Ntau tus neeg mob siv nws los tshem tawm edema, thiab tsuas yog ib daim ntawv teev cov kev mob tshwm sim hauv qee qhov kev tiv thaiv kev nrhiav tau ntawm cov tshuaj no. Txawm li cas los xij, tus nqi pheej yig ntawm cov tshuaj no thiab muaj peev xwm siv tau los ntawm ntau pawg ntawm cov neeg mob tseem yog qhov tseem ceeb hauv kev nyiam nws rau lwm cov tshuaj ntawm ib pab pawg zoo sib xws.
Yog li, "Eufillin" yog lub tsheb thauj neeg mob, feem ntau cawm tau txoj sia ntawm cov neeg uas ua tsis taus pa los ntawm bronchial spasm. Nws plays tib lub luag haujlwm hauv kev ua txhaum ntawm cov ntshav ncig ntawm lub hlwb. Qhov tsuas yog qhov uas tsis tso cai rau kev kho mob ntawm "Eufillin" yog kev ua haujlwm pib ua haujlwm, tom qab ntawdmuaj tus kheej noj tshuaj. Kev kho mob tsuas yog nyob rau hauv kev saib xyuas ntawm kws kho mob.
