"Kandesartan": tshuaj xyuas, cov lus qhia rau kev siv, analogues

2024 Tus sau: Curtis Blomfield | [email protected]. Kawg hloov kho: 2024-01-02 05:49

Lub plawv tsis ua hauj lwm (CHF) thiab arterial hypertension (AH) yog teeb meem uas ua rau muaj kev phom sij rau tib neeg. Koj tuaj yeem cawm koj txoj sia, txhim kho koj txoj kev noj qab haus huv nrog kev pab ntawm Candesartan, tab sis koj tsis tuaj yeem txiav txim siab noj cov tshuaj no ntawm koj tus kheej. Ua ntej koj yuav tsum hu rau cov kws kho mob. Yog tias cov kws tshaj lij pom zoo cov tshuaj, txhua yam uas tseem tshuav yog yuav nws thiab nyeem cov lus qhia rau kev siv, tshuaj xyuas txog Candesartan.

Tso tawm daim ntawv thiab cov khoom pov thawj

Cov tshuaj "Candesartan" yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 32, 16 thiab 8 mg. Cov khoom xyaw nquag yog candesartan cilexetil. Cov khoom siv ntxiv - sodium lauryl sulfate, microcrystalline cellulose, pregelatinized starch, low-susstituted hyprolose, sodium croscarmellose, magnesium stearate, lactose monohydrate.

Pharmacokinetics thiab pharmacodynamics

Candesartan cilexetil, thaum noj, yog absorbed hauv plab hnyuv. Thaum cov txheej txheem no, cov tshuaj no hloov pauv. Nws dhau los ua candesartan, uas yog xaiv angiotensin II hom I receptor antagonist (blocker).

Angiotensin II yog ib qho ntawm cov khoom ntawm renin-angiotensin-aldosterone system (RAAS), ib qho tshuaj hormones. Thaum raug AT _{1 -receptors, nws ua rau muaj ntau yam kev cuam tshuam ntawm lub cev - stimulation ntawm cell loj hlob, vasoconstriction (txo ntawm cov hlab ntsha), stimulation ntawm aldosterone ntau lawm, kev tswj dej thiab electrolyte homeostasis.. Yog li, angiotensin II ua lub luag haujlwm tseem ceeb hauv qhov tshwm sim thiab kev loj hlob ntawm CHF, kub siab thiab lwm yam kab mob cuam tshuam nrog lub plawv thiab cov hlab ntsha.}

Candesartan hauv lub cev tsuas yog thaiv AT₁-angiotensin II receptors, tsis cuam tshuam rau cov receptors ntawm lwm cov tshuaj hormones, tsis ua raws li blocker ntawm ion channel uas koom nrog. kev tswj hwm kev ua haujlwm ua los ntawm cov hlab plawv vascular system. Qhov tshwm sim ntawm kev thaiv AT_{1-receptors yog qhov txo qis hauv qib ntawm aldosterone hauv cov ntshav ntshav, qhov nce ntawm koob tshuaj ntawm kev ua haujlwm ntawm angiotensin I, angiotensin II, renin.}

Kev siv Candesartan hauv kev kub siab ua rau poob siab. Cov nyhuv antihypertensive tshwm sim li 2 teev tom qab noj cov tshuaj. Arterial siab pib maj mam txo. Cov tshuaj ua haujlwm ntau tshaj 24 teev. Rau qhov siab tshaj plaws txo cov ntshav siab, kev kho mob ntev nrog cov ntsiav tshuaj hauvtas koob tshuaj. Feem ntau qhov tshwm sim no ua tiav hauv 1 lub hlis txij li pib kho.

Hauv CHF, candesartan pab txo qis tag nrho cov hlab ntsha peripheral tsis kam, capillary siab nyob rau hauv lub ntsws, ua kom cov concentration ntawm angiotensin II hauv cov ntshav plasma thiab renin kev ua, txo cov qib ntawm aldosterone. Ua tsaug rau kev siv Candesartan, qhov zaus ntawm kev mus pw hauv tsev kho mob thiab kev tuag vim tus kab mob no tau txo qis.

Kev txiav txim los ntawm kev tshuaj xyuas ntawm Candesartan, cov ntsiav tshuaj tuaj yeem noj txhua lub sijhawm, tsis hais noj mov. Cov zaub mov tsis cuam tshuam rau bioavailability ntawm cov tshuaj. Cov tshuaj yog excreted feem ntau unchanged los ntawm lub raum thiab cov kua tsib. Nws qhov me me yog metabolized hauv daim siab. Ib nrab-lub neej yog 9 teev. Lub cev tsis khaws cov tshuaj nquag.

Indications thiab contraindications rau kev siv

Kev txiav txim los ntawm cov lus qhia thiab kev tshuaj xyuas, "Kandesartan" raug xaiv:

• nrog ntshav siab, thaum lub siab tshaj 140/90 mm Hg. Art.;
• nrog CHF thiab kev ua haujlwm tsis zoo systolic ua los ntawm sab laug ventricle.

Kev kho mob yuav tsum tsis txhob ua yog tias muaj qhov tsis haum rau cov khoom tseem ceeb lossis cov khoom siv ntxiv.

Kev cev xeeb tub yog lwm qhov kev txwv rau kev siv qhia hauv cov lus qhia. "Candesartan" tuaj yeem cuam tshuam rau tus menyuam hauv plab (piv txwv li, cuam tshuam kev ua haujlwm ntawm lub raum). Yog tias cev xeeb tub tshwm sim, koj yuav tsum tsis txhob noj tshuaj tam sim ntawd thiab sab laj nrog kws kho mob txhawm rau xaiv lwm txoj kev kho. Thaum lub sijhawm pub niam mis, koj yuav tsum tsis txhob haus cov ntsiav tshuaj Candesartan. Nws tsis paub tias cov khoom xyaw nquag ntawm cov tshuaj tuaj yeem nkag mus rau hauv cov kua mis hauv tib neeg lub cev, txij li kev tshawb fawb tib neeg tsis tau ua. Txawm li cas los xij, cov kev sim tau ua rau nas. Cov txiaj ntsig tau pom tias cov khoom nquag ntawm Candesartan tau tawm hauv cov mis nyuj ntawm cov tsiaj.

Daim ntawv teev cov contraindications tsis xaus nrog hypersensitivity, cev xeeb tub thiab pub niam mis. Nws kuj muaj xws li:

• hnub nyoog qis dua 18;
• mob siab ua haujlwm tsis zoo;
• cholestasis;
• glucose-galactose malabsorption syndrome;
• tsis muaj lactase hauv lub cev;
• lactose hypersensitivity.

Ntau yam contraindications cuam tshuam nrog kev siv tib lub sijhawm ntawm lwm cov tshuaj. Hauv cov lus qhia thiab tshuaj xyuas ntawm cov ntsiav tshuaj "Candesartan" tau sau tseg tias cov neeg mob ntshav qab zib mellitus, lub raum tsis ua haujlwm hnyav lossis nruab nrab tsis tuaj yeem ua ke nrog cov tshuaj muaj npe nrog cov tshuaj uas muaj aliskiren hauv lawv cov muaj pes tsawg leeg. Rau cov neeg mob uas mob ntshav qab zib nephropathy, kev sib xyaw ntawm Candesartan thiab angiotensin-hloov enzyme (ACE) inhibitors yog teeb meem.

Leej twg yuav tsum ceev faj noj tshuaj?

Kev tshuaj xyuas txog Candesartan, sau los ntawm cov kws tshaj lij, qhia tias ntau tus neeg mob yuav tsum ceev faj thaum siv cov tshuaj no. Yuav tsum ceev faj:

1. Nrog raum tsis ua haujlwm (mob hnyav). Yog muaj teeb meem li no,Tus neeg mob, cov kws kho mob tshwj xeeb yuav tsum saib xyuas cov qib ntawm cov poov tshuaj thiab creatinine hauv cov ntshav.
2. Nrog stenosis ntawm lub raum cov hlab ntsha. Candesartan tuaj yeem nce ntshav creatinine thiab urea ntau ntau.
3. Rau hemodynamically tseem ceeb mitral thiab / lossis aortic valve stenosis.
4. Rau hypertrophic obstructive cardiomyopathy.
5. Yog koj muaj keeb kwm ntawm kev hloov raum. Nyob rau hauv rooj plaub no, yuav tsum tau ceev faj vim qhov kev kuaj mob tsawg tsawg hauv kev sau tshuaj rau cov neeg uas tau ua haujlwm zoo li no.
6. Thaum kho hemodialysis. Ua tib zoo saib xyuas cov ntshav siab. Thaum lub sij hawm hemodialysis, qhov ntim ntawm cov ntshav plasma txo qis. Vim li no, ntshav siab pib hnov mob heev los thaiv AT receptors_1.
7. Nrog hyperkalemia. Xav tau kev saib xyuas cov poov tshuaj hauv cov ntshav tsis tu ncua.
8. Nrog cov kab mob cerebrovascular ntawm ischemic keeb kwm thiab kab mob plawv. Hauv cov kab mob pathological no, vim kev noj cov tshuaj antihypertensive, ntshav siab tuaj yeem poob qis. Qhov no yog fraught nrog kev loj hlob ntawm mob stroke lossis myocardial infarction.
9. Nrog cov ntshav txo qis.
10. Rau thawj hyperaldosteronism.

Yuav siv li cas rau ntshav siab

Nws raug pom zoo kom pib kho nrog Candesartan nrog qhov tsawg kawg nkaus ntawm 8 mg. Yog tias xav tau kev txo qis ntxiv, ces cov koob tshuaj txhua hnub yuav tsum tau nce mus rau 16 mg. Kev tshuaj xyuas ntawm Candesartan hais tias cov tshuaj muab cov txiaj ntsig siab tshaj plaws hauv 4 lub lis piam. Yog thaum lub sij hawm noj tshuajtxhais tau hais tias lub siab tsis txaus txo, nws yog ib qho tsim nyog yuav tsum tau nce qhov koob tshuaj rau 32 mg ib hnub twg.

Hauv kev tshuaj xyuas, cov neeg mob uas siv tshuaj "Candesartan" nco ntsoov tias kev kho mob muaj qee yam nta:

1. Txawm li cas los xij, Candesartan haus ib hnub ib zaug.
2. Yog tias cov tshuaj tsis txo cov ntshav siab mus rau qhov zoo tshaj plaws, cov kws kho mob tau sau tshuaj ntxiv rau cov neeg mob - thiazide diuretic. Ua tsaug rau cov diuretic, cov tshuaj pharmacological ntawm Candesartan tau txhim kho - lub siab poob ntau dua.
3. Rau cov neeg mob uas mob me mus rau lub raum tsis zoo, thawj koob tshuaj Candesartan yog 4mg.
4. Cov neeg mob uas mob me mus rau nruab nrab kuj tau txais ib koob tshuaj me me ntawm 4mg ib hnub. Yog tias tsim nyog, koob tshuaj yuav nce ntxiv.
5. Nrog 4 mg ib hnub, nws raug nquahu kom pib kho rau hypovolemia (nrog txo cov ntshav ncig).

Yuav siv li cas rau mob plawv tsis ua hauj lwm?

Hauv tus kab mob no, kev kho mob nrog Candesartan pib nrog koob tshuaj 4 mg ib hnub. Yog tias tsim nyog, koob tshuaj tau nce mus rau 32 mg ib hnub, tab sis qhov no tsis ua tam sim. Ua ntej, cov tshuaj siv thawj zaug yog nce 2 zaug. Kev ua ob npaug yog ua nyob rau lub sijhawm tsawg kawg ob lub lis piam.

Hauv kev tshuaj xyuas ntawm Candesartan, cov kws tshaj lij sau tias cov lus qhia ntxiv yuav tsum raug coj mus rau hauv tus account thaum noj tshuaj:

1. koob tshuaj thawj zaug tsis hloov yog tias tus neeg mob ua haujlwm tsis zooob lub raum thiab lub siab. Lub hnub nyoog laus kuj tsis tas yuav hloov koob tshuaj.
2. Candesartan tuaj yeem siv nrog rau lwm yam tshuaj uas siv los kho CHF.
3. Cov menyuam yaus thiab cov tub ntxhais hluas candesartan tsis tau sau tseg, vim tias kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj tsis tau tsim rau cov neeg mob no.

Side effects

Hauv cov lus qhia rau kev siv, tshuaj xyuas ntawm "Candesartan" muaj cov ntaub ntawv hais txog kev phiv. Cov neeg siv tshuaj rau ntshav siab feem ntau ntsib cov tsos mob tsis zoo xws li qaug zog, mob taub hau, kiv taub hau, mob nraub qaum, thiab mob ua pa. Muaj tsawg zaus, kho:

• txo qis ntawm cov leukocytes hauv cov ntshav;
• txo qis ntawm cov neutrophils ncig hauv cov ntshav;
• txo qis hauv qib ntawm granulocytes hauv cov ntshav;
• ntau tshaj qhov qub qib ntawm cov poov tshuaj hauv cov ntshav;
• qis qis ntawm sodium ions hauv ntshav plasma;
• hnoos;
• nausea;
• daim siab ua haujlwm tsis zoo (tej zaum yuav tsim kab mob siab);
• pob khaus;
• tawv nqaij khaus;
• urticaria;
• angioedema;
• mob pob qij txha;
• mob leeg;
• raum tsis ua haujlwm (piv txwv li cov tshuaj tuaj yeem ua rau lub raum tsis ua haujlwm).

Nrog CHF, feem ntau tshaj tawm cov kev mob tshwm sim uas tshwm sim vim kev noj Candesartan yog nce qib ntawm cov poov tshuaj hauv cov ntshav, ua rau lub raum tsis ua haujlwm, thiab txo qis hauv cov ntshav siab. Cov noCov tsos mob feem ntau tshwm sim hauv cov neeg muaj hnub nyoog 70 xyoo, thaum muaj ntshav qab zib mellitus, siv lwm cov tshuaj uas cuam tshuam rau renin-angiotensin-aldosterone system. Tsis tshua muaj, cov neeg mob kuaj tau CHF vim noj Candesartan muaj mob taub hau, kiv taub hau, tsis muaj zog.

Qee tus neeg mob raws plab thaum noj tshuaj. Lawv pib nrhiav cov lus teb rau cov lus nug hauv kev tshuaj xyuas: Candesartan puas ua rau raws plab lossis tsis? Nyob rau hauv cov lus qhia official, xws li ib sab tsos mob tsis qhia. Qhov tshwm sim ntawm raws plab yuav tsis yog los ntawm cov tshuaj, tab sis rau kev noj haus. Txawm li cas los xij, nyob rau hauv txhua rooj plaub, nws raug nquahu kom sab laj nrog kws kho mob.

tshwm sim ntawm kev noj tshuaj ntau dhau

Txij li Candesartan txo qis ntshav siab, nws yog qhov yooj yim los twv tias thaum noj ntau npaum li cas, cov tshuaj pharmacological ntawm cov tshuaj no tau tshaj tawm, kiv taub hau tshwm sim. Nws tsim nyog sau cia tias cov kws kho mob hauv kev tshuaj xyuas ntawm Candesartan piav qhia txog tus neeg mob ntawm kev noj tshuaj ntau dhau. Qee cov neeg mob tau noj txog li 672 mg ntawm candesartan cilexetil. Hauv tag nrho cov xwm txheej no, tib neeg rov zoo. Qhov tshwm sim hnyav tsis tshwm sim, raws li kev kho mob tsim nyog tau muab rau cov neeg mob.

Yog tias koj tsis quav ntsej cov lus pom zoo hauv cov lus qhia thiab noj ntau dhau, koj yuav tsum mus ntsib kws kho mob. Hauv kev tshuaj xyuas ntawm Candesartan, kws kho plawv sau tias qhov kev ntsuas tsim nyog nyob rau hauv rooj plaub ntawm kev noj ntau dhau yog cov tsos mob kho thiab saib xyuas tus neeg mob. Tus neeg mob yuav tsum nyob rau hauv lub supine txoj hauj lwm. Ko taw kawg ntawm lub txajyuav tsum tau tsa. Yog tias tsim nyog, 0.9% kev daws ntawm sodium chloride yog txhaj los ntawm cov hlab ntsha thiab cov tshuaj sympathomimetic raug tshuaj. Tsis muaj cov txheej txheem hemodialysis. Nrog kev pab los ntawm nws, cov tshuaj nquag ntawm cov tshuaj tsis tawm hauv lub cev.

Kev Sib Tham Tshuaj

Ntau tus neeg mob xav paub txog cov lus nug ntawm kev sib raug zoo ntawm Candesartan thiab cawv. Hauv kev tshuaj xyuas, qee tus neeg sau tias koj yuav tsum tsis txhob haus dej cawv, vim lawv tsis zoo rau lub cev. Cov kws tshaj lij lees paub qhov no. Cawv tsis zoo cuam tshuam rau kev ua haujlwm ntawm lub plawv cov leeg thiab ua rau ntshav siab. Vim li no, nws yog qhov zoo dua tsis txhob haus cawv thaum noj Candesartan.

Nws twb tau sau tseg saum toj no tias cov neeg mob ntshav qab zib mellitus, mob hnyav lossis mob raum tsis txaus yuav tsum tsis txhob noj Candesartan nrog aliskiren thiab aliskiren-muaj tshuaj. Lwm tus neeg yuav tsum zam qhov kev sib xyaw ua ke no, vim tias cov tshuaj, sib cuam tshuam, muaj qhov tsis zoo.

Cov neeg mob ntshav qab zib nephropathy yog contraindicated thiab lwm tus neeg tsis pom zoo kom noj ACE inhibitors thiab angiotensin II receptor blockers tib lub sijhawm. Kev sib xyaw ntawm cov tshuaj los ntawm cov pab pawg no tuaj yeem ua rau muaj kev phiv xws li txo cov ntshav siab, lub raum ua haujlwm tsis zoo, thiab nce qib poov tshuaj hauv cov ntshav.

Kev tswj hwm ib txhij ntawm Candesartan thiab lwm yam tshuaj tiv thaiv kab mob ua kom cov nyhuv antihypertensive.

Nrog rau kev siv ua ke ntawm Candesartan thiab lithium npaj, nws yog ib qho tsim nyog los saib xyuas qhov concentration ntawm lithium hauv cov ntshav. Qhov ntsuas notsim nyog vim tias kev teem caij sib koom ua ke ntawm cov tshuaj no tuaj yeem tsim cov tshuaj lom.

Thaum noj cov tshuaj angiotensin II receptor blockers thiab cov tshuaj uas tsis yog-steroidal anti-inflammatory, koj tuaj yeem pom qhov tsis zoo ntawm cov nyhuv antihypertensive. Lwm qhov tshwm sim ntawm kev sib xyaw ntawm cov tshuaj no yog kev ua txhaum ntawm lub raum, qhov tshwm sim ntawm lub raum tsis ua haujlwm, nce qib ntawm cov poov tshuaj hauv cov ntshav. Kev saib xyuas tshwj xeeb raug pom zoo thaum noj cov neeg laus thiab cov neeg uas txo qis cov ntshav ncig.

Kev tshuaj xyuas txog Candesartan los ntawm cov neeg mob thiab kws kho mob: kev tshuaj xyuas ntawm cov tshuaj

Kev ntsuas "Candesartan", cov kws tshaj lij hais tias cov tshuaj muaj tus nqi me me. Nyob rau tib lub sijhawm, nws muab cov txiaj ntsig zoo. Piv rau lwm cov angiotensin II receptor blockers, candesartan muaj cov nyhuv antihypertensive, txo cov ntshav siab ntev. Cov tshuaj no zoo heev thaum noj ib hnub ib zaug. Muaj ntau cov kev mob tshwm sim uas tau teev tseg hauv cov lus qhia, tab sis ib feem tseem ceeb ntawm lawv tshwm sim tsis tshua muaj. Feem ntau, Candesartan tau txais txiaj ntsig zoo los ntawm tib neeg.

Cov kws kho plawv hauv kev tshuaj xyuas ntawm Candesartan nco ntsoov tias cov tshuaj tau ua tib zoo kawm. Cov txiaj ntsig tau pom tias cov nyhuv antihypertensive kav ntev txog 36 teev. Qhov no yog ib qho tseem ceeb ntxiv ntawm cov tshuaj, vim tsis yog txhua tus neeg tuaj yeem noj tshuaj raws sijhawm. Piv txwv li, ib tug neeg yuav tsis khoom, ib tug neeg yuav hnov qab. Vim qhov kev ua haujlwm ntev nyob rau hauv qhov sib txawv ntawm cov koob tshuaj,muaj ntshav siab poob qis, txo txoj kev pheej hmoo mob stroke.

Cov neeg mob hauv kev tshuaj xyuas ntawm Candesartan sau hauv paus tias cov tshuaj pab tau tiag tiag, txhim kho lawv txoj kev noj qab haus huv, thiab tsis ua rau muaj cov tsos mob tsis txaus ntseeg. Qee cov neeg tom qab noj cov tshuaj tau ntsib kiv taub hau, poob qis hauv cov ntshav siab. Hauv cov xwm txheej zoo li no, nws yuav tsum tau sab laj nrog kws kho mob, vim tias yuav tsum tau hloov cov koob tshuaj. Nrog hypersensitivity tshwm sim, Candesartan raug tso tseg. Hloov chaw, tus kws kho mob yuav sau ib co analogue uas tsim nyog.

Zimilar drug

Daim ntawv teev cov analogues ntawm Candesartan yog qhov dav heev. Hauv kev tshuaj xyuas, piv txwv li, qee cov neeg hais txog Hyposart. Cov tshuaj no yog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, nyob rau hauv uas lub active tshuaj yog candesartan. Yog li, "Hyposart" yog tag nrho cov analogue ntawm "Candesartan" nrog tib cov lus qhia thiab contraindications rau kev siv, noj tshuaj. Lwm cov piv txwv tag nrho yog Atakand, Ordiss.

"Aprovel" - tshuaj nyob rau hauv daim ntawv ntsiav tshuaj, nosological analogue ntawm "Candesartan". Kev tshuaj xyuas thiab cov lus qhia qhia tias cov khoom tseem ceeb yog irbesartan. Cov tshuaj no yog ib qho kev xaiv blocker ntawm hom II angiotensin receptors AT₁. Irbesartan thaiv cov teebmeem physiological ntawm cov tshuaj hormones, uas tau paub los ntawm AT _{1receptors. Qhov kev txiav txim ntawm cov khoom tseem ceeb no tso cai rau kev siv cov tshuaj "Aprovel" hauv arterial hypertension (raws li hauvmonotherapy, thiab ua ke nrog lwm yam tshuaj tiv thaiv hypertensive) thiab nrog nephropathy kuaj pom hauv cov neeg mob ntshav siab, hom 2 mob ntshav qab zib mellitus (rau qhov qhia tau hais tias, Aprovel yog ib qho ntawm cov ntsiab lus ntawm kev kho mob ntshav siab). Cov koob tshuaj pom zoo:}

1. Nyob rau hauv arterial hypertension, thawj koob tshuaj yog 150 mg 1 zaug ib hnub twg. Yog tias tsim nyog, tus kws kho mob yuav sau ntau dua - txog 300 mg 1 zaug hauv ib hnub.
2. Rau nephropathy, qhov kev saib xyuas zoo dua yog 300 mg ib hnub ib zaug.

Telzap yog lwm qhov nosological analogue ntawm Candesartan. Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob thiab cov lus qhia tau hais tias cov tshuaj tseem ceeb yog telmisartan, ib qho tshwj xeeb angiotensin II receptor antagonist (hom AT _{1). Cov lus qhia rau kev siv tshuaj yog qhov tseem ceeb ntawm kev kub siab thiab txo qis hauv kev tuag thiab qhov tshwm sim ntawm cov kab mob plawv hauv 2 pawg neeg mob:}

• nrog cov kab mob plawv ntawm atherothrombotic keeb kwm (piv txwv li, mob stroke, kab mob plawv);
• nrog hom 2 mob ntshav qab zib mellitus nrog lub hom phiaj kev puas tsuaj rau lub cev.

"Telzap" rau kev mob ntshav siab yog sau rau ntawm koob tshuaj 1 ntsiav tshuaj (40 mg) 1 zaug hauv ib hnub. Qee cov neeg mob kuj tau txais txiaj ntsig los ntawm qhov txo qis ntawm 20 mg ib hnub. Yog tias tsim nyog, koob tshuaj tuaj yeem nce mus rau qhov siab tshaj plaws - txog 80 mg 1 zaug hauv ib hnub. Nrog rau qhov qhia tau hais tias kev txo qis hauv kev tuag thiab qhov tshwm sim ntawm cov kab mob plawv, cov koob tshuaj yog 80 mg 1 zaug hauv ib hnub.

Koj tuaj yeem pom cov ntaub ntawv tseem ceeb hauv cov lus qhia thiab tshuaj xyuas txog Candesartan, tab sis koj yuav tsum tsis txhob cia siab rau nws xwb. Hais txog kev noj tshuaj, kev noj tshuaj ib txhij, yuav tsum tau mus ntsib kws kho mob kom tsis txhob ua mob rau koj txoj kev noj qab haus huv thiab tsis ua rau koj txoj kev noj qab nyob zoo.