Txhua xyoo tus naj npawb ntawm cov neeg mob ua xua hauv ntiaj teb tau nce ntxiv. Nyob rau hauv ib qho kev mob siab los muab kev nplij siab thiab lub neej ib txwm muaj rau cov neeg uas muaj qhov tsis haum rau qee yam khoom, cov tuam txhab tshuaj tsim cov tshuaj tiv thaiv kev ua xua. Yog li, piv txwv li, cov tshuaj "Desal" yog ib qho tshuaj tiv thaiv zoo heev, nws tau pom zoo siv los ntawm cov neeg laus thiab cov menyuam yaus, nws tsis muaj contraindications thiab phiv.
Vim li cas Desal hu ua tshuaj tiv thaiv kab mob?
Raws li cov lus qhia rau kev siv Desal syrup, nws lub ntsiab kom zoo dua yog lub peev xwm los thaiv H1 receptors uas ntxiab histamine. Qhov no pab tiv thaiv kev ua xua lossis txo qis kev ua haujlwm ntawm nws kis.
Cov khoom xyaw tseem ceeb yog desloratadine. Tsis tas li ntawd, cov muaj pes tsawg leeg muaj cov khoom pabcuam uas tsis ua mob rau lub cev.
Raws li kev tshuaj xyuas thiab cov lus qhia rau kev siv, cov tshuaj "Desal" tsis tsim cov nyhuv sedative, uas txhais tau hais tias nws tsim nyog rau cov neeg uas ua lub neej nquag lossis koom nrog cov haujlwm nyuaj uas yuav tsum muaj qhov siab tshaj plaws ntawm kev ua neej. ua yeeb yam. Hauv cov khw muag tshuaj niaj hnub no, cov tshuaj tuaj yeem pom hauv cov ntaub ntawv hauv qab no:
- tshuaj;
- syrup.
Pharmacokinetics: nqus thiab faib
Kev lees txais cov tshuaj nyob rau hauv daim ntawv ntawm kev daws yog tib yam li cov tshuaj hauv cov ntsiav tshuaj, cov ntsiab lus ntawm cov tshuaj nquag yog zoo ib yam.
Tom qab kev tswj hwm qhov ncauj, cov khoom xyaw nquag yog nqus tau zoo los ntawm txoj hnyuv. Hauv cov ntshav plasma, nws tuaj yeem txiav txim siab tom qab ib nrab teev lossis ib teev. Qhov siab tshaj plaws concentration yog mus txog tom qab 3 teev. Bioavailability yog txiav txim los ntawm tus nqi ntawm koob tshuaj ntawm 5 thiab 20 milligrams.
Kev sib txuas lus nrog cov ntshav protein ntau ntawm 85-90%. Qhov nruab nrab ntawm kev kho mob yog 14 hnub. Lub degree ntawm tsub zuj zuj ntawm desloratadine yog ncaj qha nyob ntawm tus nqi ntawm ib nrab-lub neej thiab zaus ntawm kev siv. Thaum kawm cov koob tshuaj suav rau ib koob tshuaj (7.5 milligrams), tsis muaj kev cuam tshuam ntawm cov zaub mov ntawm kev faib cov tshuaj nquag. Cov tshuaj tsis nkag mus rau hauv cov ntshav-hlwb barrier.
Metabolism thiab excretion
Nws tsis yog tus neeg tuag tes tuag taw ntawm CYP2D6 isoenzymes hauv vitro thiab CYP3A4 hauv vivo thiab tsis yog inhibitor lossis substrate ntawm P-glycoprotein. Nws yog nquag faib nyob rau hauv daim siab los ntawm hydroxylation nrog zus tau tej cov 3-hydroxydesloratadine, uas yog tom qab glucuronized.
Raws li cov lus qhia rau kev siv tshuaj "Desal" (syrup), lub thermal theem ntawm ib nrab-lub neej yog los ntawm 27 mus rau 30 teev. Tsis pub ntau tshaj 2% ntawm cov khoom nquag tawm los ntawm lub raum, me ntsis ntxiv los ntawm txoj hnyuv - 7%.
Vim li cas Desal thiaj li nrov?
Cov tshuaj tiv thaiv kab mob tau txais txiaj ntsig ntau thiab xav tau ntawm cov pej xeem ntawm cov hnub nyoog sib txawv thiab kev sib raug zoo vim nws cov ntaub ntawv ceev ntawm kev ua. Tus neeg mob yuav hnov qhov txiaj ntsig zoo hauv ib nrab teev tom qab noj thawj zaug. Cov tshuaj tsw qab zoo thiab muaj kev tiv thaiv zoo los ntawm feem ntau cov neeg ua xua. Yog tias koj kawm txog cov nqi tshuaj xyuas thiab cov lus qhia rau kev siv Desal syrup, koj tuaj yeem nkag siab tias tus nqi kev ywj pheej sib haum xeeb nrog cov khoom siv tshuaj zoo heev. Los ntawm txoj kev, noj cov tshuaj, koj tsis tuaj yeem ua raws li kev noj haus. Cov tshuaj tsis nkag mus los ntawm BBB teeb meem, yog li ntawd, nws tsis ua rau khaus lossis, ntawm qhov tsis sib xws, inhibit lub paj hlwb.
Cov lus qhia rau kev siv
Cov kws kho mob tshwj xeeb hauv kev ua xua qhia cov tshuaj piav qhia hauv cov xwm txheej hauv qab no:
- Rhinitis vim kev mob siab.
- Urticaria ntawm txawv qhov hnyav.
Tus nqi -yam tseem ceeb
Kev tshuaj xyuas txog cov lus qhia rau kev siv thiab tus nqi ntawm Desal txhawb nqa. Yuav kom yuav cov tshuaj, nyob rau hauv ntau cheeb tsam ntawm Lavxias teb sab Federation, koj yuav tau them los ntawm 200 mus rau 300 rubles. Yog tias koj xaj nws hauv ib lub khw muag tshuaj hauv online, tus nqi yuav poob ntau dua.
Yog tias peb kos qhov piv txwv nrog lwm cov tshuaj tiv thaiv kab mob, peb tuaj yeem xaus lus tias Desal yog ib qho pheej yig tshaj plaws.
Tom qab ntsuas cov npe ntawm qhov zoo ntawm cov tshuaj, peb tuaj yeem txiav txim siab tias kev tshem tawm kev ua xua nrog nws yuav ceev, xis nyob thiab zoo.
Cov lus qhia rau kev siv thiab ntau npaum li cas
Kev piav qhia thiab cov lus qhia rau kev siv cov tshuaj Desal hais tias nws yuav tsum tau noj ntawm qhov ncauj, tsis hais txog kev noj zaub mov.
Cov neeg laus thiab cov tub ntxhais hluas feem ntau yog muab 5 mg lossis 10 ml ntawm cov tshuaj ib hnub.
Cov menyuam yaus hnub nyoog kawm ntawv (6-12 xyoos) yuav tsum haus 2.5 mg lossis 5 ml ib hnub.
Cov menyuam mos hnub nyoog qis dua tsib xyoos tsuas yog noj 1.25 mg lossis 2.5 ml ib hnub xwb.
Hauv kev kho mob sib kis (seasonal) allergic rhinitis, thaum nws cov tsos mob tshwm sim tsawg kawg plaub zaug hauv ib xyoos lossis plaub hnub dhau los lossis ntau dua, tus neeg mob cov keeb kwm kho mob thiab cov yam ntxwv ntawm nws lub cev yuav tsum raug coj mus rau hauv tus account. Thaum cov tsos mob tseem ceeb ntawm hypersensitivity tau ploj mus, cov tshuaj yuav tsum tau txiav tawm, nrog rau kev txhim kho ntawm rov ua tsis taus pa, kev kho mob tuaj yeem ua tau.repeat.
Yog tias mob rhinitis tsis tu ncua, piv txwv li, kev ua xua tshwm sim rau ib tus neeg thoob plaws hauv lub xyoo, nws raug nquahu kom noj cov tshuaj txhua lub sijhawm ntawm kev sib cuag nrog qhov khaus.
kev tawm tsam tsis zoo
Nyob rau hauv cov lus qhia rau kev siv cov ntsiav tshuaj thiab syrup "Desal" muaj ib daim ntawv teev cov kev phiv ntawm lub cev rau cov tshuaj.
Los ntawm ib sab ntawm lub paj hlwb: hauv cov menyuam yaus hnub nyoog qis dua ob xyoos - insomnia, mob taub hau; tsawg zaus - tsaug zog, kiv taub hau, pw tsaug zog cuam tshuam, convulsions, hyperactivity.
Mental disorders: tsis tshua muaj heev - hallucinations.
Rau ib feem ntawm txoj hnyuv: ib qho tshwm sim yog overdrying ntawm qhov ncauj mucosa, raws plab (feem ntau tshwm sim rau cov menyuam yaus hnub nyoog qis dua 2 xyoos), tsis tshua muaj - xeev siab, ntuav, mob spasmodic hauv plab plab, dyspepsia.
Los ntawm sab ntawm lub siab: tsis tshua muaj neeg - palpitations, tachycardia; nrog rau qhov tsis paub zaus - ncua ntawm QT lub sijhawm.
Los ntawm ib sab ntawm daim siab thiab cov kabmob ntawm cov kab mob excretory: tsis tshua muaj - nce qib ntawm bilirubin, nce kev ua haujlwm ntawm daim siab thiab lub raum enzymes, kab mob siab; nrog qhov tsis paub ntau zaus - jaundice.
Nyob rau hauv cov lus qhia rau kev siv Desal syrup, kuj muaj kev phiv los ntawm cov epidermis thiab cov ntaub so ntswg subcutaneous. Photosensitivity yuav tshwm sim nrog tsis paub zaus.
Ntawm ib feem ntawm locomotor system, cov leeg nqaij thiab cov nqaij sib txuas: myalgia - tshwm sim nws tus kheej tsis tshua muaj.
Cov kab mob dav dav: muaj ntau zaus (hauv cov menyuam yaus hnub nyoog qis dua 2 xyoos) - kub taub hau, dhia nrawm nrawm, tsawg zaus -anaphylaxis, ua tsis taus pa, urticaria, pruritus, tawm pob, angioedema.
Contraindications rau kev siv tshuaj
Raws li cov lus qhia rau kev siv tshuaj "Desal", cov npe ntawm contraindications rau nws siv yog txwv. Txawm li cas los xij, txhua tus neeg mob yuav tsum nyeem nws ua ntej noj thawj koob:
- nce susceptibility rau lub ntsiab lossis pab pawg ntawm cov tshuaj;
- Y cev xeeb tub thiab lactation;
- menyuam mos, qis dua 1 xyoos;
- kab mob sib kis (fructose intolerance, sucrose deficiency hauv lub cev).
Ntau tshaj
9-10 npaug ntawm koob tshuaj pom zoo (45-50mg) tsis ua rau cov tsos mob tseem ceeb.
Yog tias koj yuam kev noj cov tshuaj ntau, koj yuav tsum tau ntsuas kev kub ntxhov hauv lub plab zom mov thiab noj charcoal, thiab tam sim ntawd mus rau tsev kho mob.
Cov lus qhia rau cov poj niam cev xeeb tub thiab lactating
Cov kws tshaj lij hauv kev kho mob qog noj ntshav tsis pom zoo kom noj tshuaj rau cov poj niam cev xeeb tub. Txog hnub no, cov txiaj ntsig ntawm nws cov khoom tseem ceeb ntawm tus menyuam hauv plab tsis tau kawm.
Kev tshawb fawb soj ntsuam tau pom tias desloratadine tau tawm hauv cov kua mis. Cov tshuaj yog contraindicated nyob rau hauv lactating cov poj niam.
Txoj kev cuam tshuam nrog lwm pawg tshuaj
Nyob rau hauv cov lus qhia rau kev sivsyrup "Dezal" qhia tau hais tias thaum ua ke nrog lwm pab pawg neeg ntawm cov tshuaj, tsis muaj kev soj ntsuam tseem ceeb tshwm sim. Peb tab tom tham txog Ketoconazole, Fluoxetine, Erythromycin.
Kev noj zaub mov ib txhij lossis kua txiv kab ntxwv tsis cuam tshuam rau kev noj tshuaj.
Txawm hais tias muaj ethanol nyob rau hauv cov muaj pes tsawg leeg, desloratadine tsis muaj kev cuam tshuam rau hauv nruab nrab paj hlwb. Tab sis nrog kev siv tom qab sau npe, cov xwm txheej ntawm cawv intolerance tau raug kaw. Yog li ntawd, haus cawv thaum noj desloratadine yuav tsum zam.
Kev muaj peev xwm cuam tshuam rau kev tswj hwm kev thauj mus los thiab cov txheej txheem
Nyob rau hauv cov xwm txheej niaj hnub no, nws yog ib qho teeb meem heev rau tus neeg ua txhaum txoj haujlwm niaj hnub tsis khoom. Yog tias nws muaj kev tsis haum tshuaj, nws yog ib qho tseem ceeb kom tshem tawm nws cov tsos mob tsis zoo. Tsis tas li, cov tshuaj yuav tsum tsis txhob ua rau qaug zog thiab qaug zog.
Txawm hais tias tus nqi qis, cov lus qhia rau kev siv Desal syrup qhia tias nws muaj kev nyab xeeb, tsis tsim cov nyhuv sedative. Cov tshuaj tsis cuam tshuam rau qhov ceev ntawm cov tshuaj tiv thaiv psychomotor yog pom tias cov koob tshuaj raug pom zoo.
Cov lus qhia tshwj xeeb
Cov neeg mob uas muaj teeb meem rau lub raum hnyav tau qhia kom noj tshuaj kom ceev faj lossis raws li tus kws kho mob saib xyuas.
Nyob rau hauv cov menyuam yaus hnub nyoog qis dua ob xyoos, thaum kuaj qhov sib txawv ntawm qhov tsis haum thiabLwm hom rhinitis yuav nyuaj. Ib qho xwm txheej tseem ceeb rau kev kuaj mob yog kev txheeb xyuas ntawm foci ntawm kev kis kab mob lossis kev txawv txav ntawm cov kab mob ua pa sab saud, kev kuaj mob tob tob, cov ncauj lus ntxaws ntxaws, kuaj hauv chav kuaj thiab kuaj kab mob dermatological.
Nyob rau hauv pab pawg menyuam yaus ntawm cov neeg mob thiab 6-7% ntawm cov neeg laus, tsis muaj peev xwm los metabolize desloratadine tau tshwm sim. Li no, qhov raug ntau dua hauv pawg neeg mob no.
Kev kuaj kuaj pom tseeb lossis tsis lees paub qhov ua tau zoo ntawm desloratadine hauv kev kis tus kabmob rhinitis tsis tau ua.
Sib piv nrog analogues
Raws li cov lus qhia rau kev siv Desal syrup rau cov menyuam yaus thiab cov neeg laus, peb tuaj yeem txiav txim siab tias Loratadin yog qhov sib npaug sib npaug. Cov khoom xyaw tseem ceeb, loratadine, yuav pab tau sai sai nrog cov tsos mob ntawm kev tsis haum tshuaj nyob rau hauv cov ntaub ntawv ntawm intolerance rau cov neeg mob nrog desloratadine, uas tau lees paub los ntawm cov neeg mob xyuas. Cov tshuaj kuj muaj nyob rau hauv ob daim ntawv - ntsiav tshuaj thiab tshuaj, siv los ntawm cov neeg mob laus dua 2 xyoos. Nyob rau hauv cov nqe lus ntawm tus nqi, Loratadin yog pheej yig dua Desal, tab sis ho surpasses nws nyob rau hauv cov nqe lus ntawm daim ntawv teev cov kev phiv. Yog li ntawd, nws yog qhov zoo dua tsis kam siv nws rau kev kho menyuam yaus.
Cov lus qhia rau kev siv syrup-analogue "Desal" rau cov menyuam yaus - "Erius" - qhia txog cov khoom muaj txiaj ntsig zoo sib xws hauv ob cov tshuaj no. Cov tshuaj muaj nyob rau hauv ob hom - ntsiav tshuaj thiab syrup, contraindicatedpab pawg neeg mob raum tsis txaus.
Klaritin analogue paub nyob rau hauv kev lag luam hauv tsev muaj cov khoom xyaw nquag loratadine. Hais txog kev tso tawm cov ntaub ntawv thiab txoj kev tswj hwm, nws zoo ib yam li Desal. Raws li kev saib xyuas nruj ntawm tus kws kho mob, nws raug tso cai los ntawm cov poj niam cev xeeb tub.
"Lordestin" muaj cov khoom xyaw zoo sib xws, tab sis tsuas yog muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Qhov no tseem ceeb txwv lub voj voog ntawm cov neeg mob uas tau tso cai noj tshuaj - cov neeg laus thiab cov menyuam yaus hnub nyoog qis dua 12 xyoos. Raws li contraindications, phiv thiab cov ntaub ntawv ntawm overdose, cov tshuaj zoo sib xws, yog li lawv tuaj yeem hloov tau yooj yim nrog ib leeg.
Txhua xyoo muaj ntau thiab ntau dua analogues ntawm "Desal". Nrog cov tsos mob tshiab lossis ua rau muaj kev ua xua rau qhov hnyav, cov kws tshaj lij pom zoo kom hloov cov tshuaj, tab sis nws yog qhov zoo dua kom tso cov kev xaiv ntawm kev kho rau tus kws kho mob tshwj xeeb.
Peb tshuaj xyuas seb cov tshuaj "Desal" yog dab tsi. Cov lus qhia, tshuaj xyuas thiab tus nqi yog tag nrho cov ntsiab lus tseem ceeb uas tib neeg feem ntau nyiam mloog. Tab sis peb xav ceeb toom rau cov neeg nyeem ib zaug ntxiv tias nws tsis pom zoo rau kev kho tus kheej, tshwj xeeb tshaj yog thaum muaj tus kab mob xws li kev ua xua. Koj tuaj yeem ua phem rau koj tus kheej thiab cov neeg koj hlub ntau dua. Thaum muaj mob me ntsis, nrhiav kev pab kho mob.
