"Valacyclovir Canon" yog ib qho kev txhim kho zoo tshaj plaws hauv kev lag luam tshuaj niaj hnub. Cov kws paub txog virologists tau sim coj mus rau hauv tus account kiag li txhua yam uas tsim nyog los tiv thaiv ntau yam kab mob los ntawm cov kab mob. Cov tshuaj no yog ib qho kev hloov zoo rau cov tshuaj nrov Acyclovir.
Cov tshuaj
"Valacyclovir Canon" yog muag nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj-coated zaj duab xis. Cov khoom xyaw tseem ceeb yog valaciclovir hydrochloride. Cov khoom siv pabcuam kuj tseem siv tau:
- Povidone K90.
- Polysorb.
- YCrospovidonum.
- Magnesium ntsev ntawm stearic acid.
- MCC.
Lub plhaub siv zaj duab xis muaj titanium dioxide, polysorbate, macrogol. Cov ntsiav tshuaj raug muag hauv pob ntawm 6 thiab 10.
Txoj Cai Ua Haujlwm
Tshuaj "Valacyclovir Canon"belongs rau qeb ntawm antivirals. Twb tau tom qab thawj zaug kev tswj hwm qhov ncauj, cov khoom tseem ceeb tau hloov mus rau hauv cov metabolite acyclovir. Cov tshuaj no muaj zog inhibitory zog tiv thaiv cytomegalovirus, herpes, varicella-zoster, qaib pox. Cov tshuaj no inhibits zus tau tej cov DNA ntawm tus kab mob, vim hais tias ntawm nws cov qauv yog maj mam rhuav tshem thiab nws tsis mus multiply. Hauv qhov xwm txheej zoo li no, txoj kev tuag ntawm tus kab mob yog qhov tsis tuaj yeem.
Thaum siv qhov ncauj, "Valacyclovir Canon" yog nqus tau zoo los ntawm txoj hnyuv. Ib lub siab enzyme hloov nws mus rau hauv ob yam khoom - valine thiab acyclovir. Hauv cov neeg noj qab haus huv, qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav ntshav tau pom 2 teev tom qab noj 500 mg. Qhov ntsuas ntsuas tau nyob hauv thaj tsam ntawm 10 txog 36 µmol / ml. Yog tias koj siv 1 g ntawm cov tshuaj ib zaug, nws qhov kawg bioavailability yuav sib npaug li 50%, tsis hais txog kev noj zaub mov. Cov ntsiab lus siab tshaj plaws ntawm cov tshuaj hauv cov ntshav plasma yog tsau rau peb teev, tom qab ntawd nws maj mam txo qis.
Nyob rau hauv cov neeg mob uas lub raum ua haujlwm ib txwm muaj, ib nrab lub neej tsis pub ntau tshaj peb teev. Ntau tshaj 85% ntawm cov tshuaj tau tawm hauv cov zis li acyclovir. Yog tias tus neeg mob yav dhau los tau kuaj pom tias muaj lub raum tsis zoo, qhov tshwm sim ib nrab ntawm lub neej yuav yog 15 teev lossis ntau dua.
Txhawm rau kom muaj txiaj ntsig zoo ntawm cov tshuaj, cov tshuaj pleev thiab tshuaj pleev nrog acyclovir nquag siv. Hauv qhov xwm txheej zoo li no, tus nqi ntawm cov khoom tseem ceeb tuaj yeem ncav cuag60% qhab nia, tab sis tsuas yog nyob rau ntawm qhov chaw ntawm daim ntawv thov ntawm cov khoom. Cov tshuaj yog npaj rau kev kho mob ntawm qhov chaw mos, qhov ncauj, thiab herpes zoster. Cov tshuaj tiv thaiv kev rov qab los, muaj teeb meem, thiab tseem yuav pab tshem tawm cov pob liab liab uas tshwm sim sai sai.
Nws tsim nyog sau cia tias cov kab mob tsis muaj lawv lub hlwb, yog vim li cas lawv maj mam nkag mus rau hauv tib neeg DNA thiab siv cov khoom siv roj ntsha rau lawv tus kheej. Tom qab ntawd, tus kab mob cell ntawm tus neeg mob lub cev tsis ua nws lub luag haujlwm tseem ceeb. Tias yog vim li cas herpes hu ua tus kab mob intracellular. Yuav rov tsim dua tshiab, tus kab mob no xav tau "tus tswv tsev" txhawm rau txhim kho tsis muaj kev tswj hwm thiab kis mus rau qhov chaw tshiab.
Kev qhia
Hauv cov lus qhia rau "Valacyclovir Canon", cov tuam txhab tau qhia tias cov tshuaj yog npaj rau kev kho thiab tiv thaiv cov kab mob hauv qab no:
- Herpes zoster.
- Tshwj xeeb txo qis kev pheej hmoo kis tus kab mob txaus ntshai rau tus khub kev sib deev.
- Herpes ntawm daim di ncauj (lub hu ua "txias" ntawm daim di ncauj thiab nyob rau hauv lub periodontal cheeb tsam).
- Kev tiv thaiv zoo ntawm cytomegalovirus kab mob thaum lub sijhawm ua haujlwm intracavitary (qhov no kuj siv tau rau kev hloov pauv).
- theem pib thiab rov tshwm sim ntawm qhov chaw mos herpes.
- Kev tiv thaiv kab mob ntawm qhov chaw mos.
YContraindications
Cov tshuaj "Valacyclovir Canon" raug txwv rau cov neeg mob uas tau muajCov kab mob hauv qab no tau kuaj pom:
- kab mob HIV. Cov tshuaj tsis zoo cuam tshuam rau tus neeg mob lub cev yog tias cov ntsiab lus ntawm CD4-lymphocytes tsawg dua 100/µl.
- Hypersensitivity ntawm lub cev rau cov khoom ntawm cov tshuaj.
Cov tshuaj tsis yog tshuaj rau cov menyuam yaus hnub nyoog qis dua 12 xyoos uas muaj tus kab mob cytomegalovirus. Txij li cov kws tshaj lij tsis tau tshawb fawb txog cov txiaj ntsig ntawm cov tshuaj hauv lub cev ntawm cov poj niam cev xeeb tub, tsuas yog kws kho mob tuaj yeem sau tshuaj.
Cov lus qhia rau kev siv
"Valacyclovir Canon" hauv cov ntsiav tshuaj yog noj hauv qhov ncauj, ua ntej lossis tom qab noj mov. Cov koob tshuaj zoo tshaj plaws yog xaiv los ntawm cov kws kho mob tshwj xeeb ntawm tus kheej, vim nws txhua tus nyob ntawm daim duab kho mob. Kev kho yuav tsum tau pib li ntawm ob hnub ntawm thawj cov tsos mob ntawm tus kab mob (mob, kub hnyiab, khaus, pob khaus).
Kev kho mob nyob ntawm tus kab mob kuaj:
- Primary genital herpes. Noj 1 g 2 zaug ib hnub twg. Kev kho mob kav 10 hnub.
- Labial herpes. Thaum sawv ntxov thiab yav tsaus ntuj, noj 2 g ntawm cov tshuaj. Lub sijhawm kho yog txiav txim los ntawm tus kws kho mob.
- Recurrent genital herpes in HIV. Txhawm rau txo qhov kev pheej hmoo ntawm kev sib kis ntawm pathology mus rau tus khub kev sib deev, nws raug nquahu kom haus 0.5 g 1 zaug hauv ib hnub.
- YClassic herpes. Thaum sawv ntxov thiab yav tsaus ntuj, noj 0.5 g ntawm cov tshuaj. Kev kho mob kav 2 lub lis piam.
- Recurrent genital herpes. Rau peb hnub, noj 0.5 g ntawm "Valacyclovir Canon" 2 zaug hauv ib hnub.
- kab mob sib kis. Rau qhov kev kho mob siab tshaj plawsNws yog ib qho tsim nyog yuav tsum noj txhua 8 teev 1 g ntawm cov tshuaj. Kev kho yog tsim rau 1 lub lis piam.
- Yog tus neeg mob tau hemodialysis, ces koj tuaj yeem noj cov tshuaj tsuas yog tom qab tus txheej txheem.
- Kev tiv thaiv zoo ntawm tus kab mob cytomegalovirus tom qab kev hloov pauv hauv nruab nrog cev tau zoo suav nrog kev siv 2 g ntawm cov tshuaj 4 zaug hauv ib hnub. Kev kho mob yuav tsum kav ntev li 3 lub hlis.
Nyob raum tsis ua haujlwm, qhov kev noj zaub mov zoo tau teeb tsa raws li qhov ntsuas ntawm creatinine tshem tawm. Ntau qhov kev tshuaj xyuas ntawm "Valacyclovir Canon" qhia tau hais tias nws yog qhov zoo dua tsis txhob noj nws tus kheej, vim qhov no yog fraught nrog kev tsis zoo ntawm kev noj qab haus huv. Txhawm rau zam qhov tshwm sim tsis zoo, tus neeg mob yuav tsum sab laj nrog nws tus kws kho mob.
kev tawm tsam tsis zoo
Ntau qhov kev tshuaj xyuas ntawm "Valacyclovir Canon" qhia tias kev tsis zoo ntawm kev noj qab haus huv yog qhov tsawg heev. Tsuas yog yog tias tus neeg mob tshaj qhov tso cai ntau npaum li cas los yog tsis kawm tag nrho cov contraindications, ces qhov no yog fraught nrog rau cov nram qab no tsis zoo tshwm sim:
- Kev txhim kho ntawm lub raum tsis ua haujlwm. Tus neeg mob yuav hnov cov tshuaj tiv thaiv ntxiv rau hnub ci, ua pa luv. Thrombocytopenia tsis txiav txim tawm.
- plab hnyuv: ntuav, xeev siab, raws plab, tsis qab los noj mov, kab mob siab, nce siab enzyme ntau ntau, thiab mob plab, uas tuaj yeem tawm mus rau sab nraub qaum.
- Kev tsis haum tshuaj: khaus, tawm pob, urticaria, anaphylacticpoob siab, angioedema, aplastic anemia, vasculitis, lub plawv dhia tsis zoo, ua npaws, lub cev qhuav dej, nce ntshav siab, qaug zog heev.
- Central nervous system: kiv taub hau, tsis tu ncua nervous nro, impaired kev sib koom tes, coma, hallucinations, kev nyuaj siab.
Muaj analogues
"Valacyclovir Canon" yog qhov ua tau zoo, tab sis qee zaum, cov neeg mob yuav tsum hloov cov tshuaj no. Cov analogues nrov tshaj plaws suav nrog:
- V altrex.
- Valmik.
- Vatsireks. Cov tshuaj sai sai ua rau cov kab mob kis thiab tshem tawm qhov mob.
Cov kws tshaj lij ceeb toom tias "Valacyclovir Canon" muaj tsawg kawg yog ob yam tshuaj uas muaj cov ntsiab lus zoo sib xws - cov no yog "V altrex" thiab "Acyclovir". Qhov sib txawv tseem ceeb ntawm cov tshuaj no yog raws li hauv qab no:
- "V altrex" muaj cov qauv yooj yim, vim nws tuaj yeem nyob hauv tus neeg mob lub cev tau ntev, txo cov koob tshuaj ntau. Ntau tus neeg mob xaiv cov tshuaj no vim muaj ntau hom tshuaj: ampoules, cream, ntsiav tshuaj.
- "Acyclovir" tom qab nkag mus rau hauv lub cev tiv thaiv kev kis tus kabmob mus rau lub cell noj qab haus huv. Thaum kawg, nyob rau hauv daim ntawv ntawm cov khoom lwj, nws raug tso tawm los ntawm ob lub raum nrog cov zis.
Yog tus neeg mob txiav txim siab seb yuav ua li cas "Valacyclovir" txawv ntawm "Valacyclovir Canon", ces koj yuav tsum xav txog tias thawj cov tshuaj.ncaj qha cuam tshuam tus kab mob herpes, maj mam rhuav tshem nws thiab tiv thaiv tus kab mob txaus ntshai los ntawm kev loj hlob ntxiv. Ua tsaug rau qhov no, tus neeg mob tuaj yeem tiv nrog pathology sai sai. Cov kws tshaj lij tau ua pov thawj tias tsis muaj qhov sib txawv tseem ceeb ntawm "Valacyclovir Canon" thiab "Valacyclovir". Ob qho tshuaj yog siv ob qho tib si rau kev sib ntaus sib tua tawm tsam herpes thiab tiv thaiv kab mob kis.
Kev Tiv Thaiv
Cov kws kho mob sau cov tshuaj nrog ceev faj hauv cov xwm txheej hauv qab no:
- Lub cev qhuav dej tseem ceeb.
- Kev mob lub siab lossis lub raum tsis ua haujlwm.
- cev xeeb tub thiab pub niam mis.
- Tus neeg mob tshaj 60.
- Kev kho mob nrog tshuaj nephrotoxic.
Nws yog ib qho tseem ceeb uas yuav tsum tau coj mus rau hauv tus account qhov chaw kho mob ntawm tus neeg mob thiab qhov tshwj xeeb ntawm cov kev mob tshwm sim ntawm "Valacyclovir Canon" thaum ntsuas tus neeg mob lub peev xwm tsav tsheb. Cov tshuaj tuaj yeem cuam tshuam rau kev puas siab puas ntsws, uas yog qhov tseem ceeb heev thaum ua haujlwm nrog cov txheej txheem uas yuav tsum tau muaj cov tshuaj tiv thaiv psychomotor ceev.
Kev sib tham nrog lwm cov tshuaj
Txij li "Valacyclovir Canon" tau ua tiav los ntawm ob lub raum los ntawm kev tso tawm cov channel, lwm cov tshuaj yuav tiv thaiv nws qhov kev tso tawm ruaj khov ntawm lub cev. "Mycophenolate" nce qhov concentration ntawm cov tshuaj nyob rau hauv tus neeg mob cov ntshav plasma. Tacrolimus thiab Cyclosporine nce load ntawm lub raum ob peb zaug.
Cov lus qhia tshwj xeeb
Cov neeg lub cev qhuav dej thiab cov neeg laus laus thaum lub sijhawm kho yuav tsum nce cov kua dej ntau ntxiv, vim tias muaj kev pheej hmoo ntawm kev mob raum tsis ua haujlwm. Txhawm rau kom muaj txiaj ntsig zoo dua tiv thaiv qhov chaw mos herpes, nws yog qhov tsim nyog kom tsis txhob muaj kev sib deev, vim tias cov tshuaj tsis tuaj yeem siv los ua ib txoj hauv kev los tshem tawm qhov tseeb ntawm kev kis tus kab mob txaus ntshai.
Kev siv tshuaj ntev ntev hauv cov koob tshuaj ntau hauv cov xwm txheej uas muaj kev tiv thaiv kab mob tiv thaiv kab mob (tshuaj kho cov kab mob HIV, pob txha pob txha lossis hloov lub raum) yog fraught nrog kev loj hlob ntawm thrombocytopenic purpura txaus ntshai thiab hemolytic uremic syndrome. Cov txiaj ntsig tuag tsis suav nrog. Yog tias muaj kev phiv tshwm sim los ntawm lub hauv nruab nrab lub paj hlwb, cov tshuaj yuav tsum tau muab tso tseg.
Siv thaum cev xeeb tub thiab pub niam mis
Valacyclovir Canon tau sau nrog ceev faj rau pawg neeg mob no. Cov lus qhia rau kev siv tsuas yog coj mus rau hauv tus account tsuas yog tias qhov kev cia siab kho tau zoo tshaj qhov muaj feem cuam tshuam rau tus menyuam hauv plab. Cov ntaub ntawv sau tseg los ntawm cov kws kho mob gynecologist tsis pom tias muaj kev nce ntxiv ntawm kev yug menyuam.
Cov tshuaj acyclovir yog cov tshuaj metabolite tseem ceeb ntawm cov tshuaj, uas tau tso tawm dawb hauv cov kua mis. Tias yog vim li cas lub sij hawm ntawm kev kho mob ntawm tus me nyuam yuav tsum tau pauv mus rau cov khoom sib tov.
