Cov tshuaj "Rosuvastatin" tau paub txij li xyoo 2003 thiab tau muab ua IV tiam statin. Nws yog ib qho niaj hnub thiab zoo gamma-methylglutaryl-CoA reductase inhibitor. Cov enzyme no yog lub luag haujlwm rau kev tsim cov roj cholesterol hauv tib neeg lub cev. Nws inhibition ua rau txo qis hauv endogenous cholesterol thiab txo qhov kev pheej hmoo ntawm kev mob plawv.
Ntxiv rau Rosuvastatin, muaj ntau ntau cov chav kawm analogues uas yog ib feem ntawm pawg statin. Cov no yog Simvastatin, Pravastatin, Cerivastatin, Lovastatin, Fluvastatin, Atorvastatin, Pitavastatin. Hais txog kev siv tshuaj kho mob thiab tus nqi txo qis tag nrho thiab cov roj cholesterol tsawg, Rosuvastatin tsuas yog thib ob rau Pitavastatin, uas tseem tsis tau siv dav vim qhov kev tshawb fawb soj ntsuam tsawg dua.
Tam sim noAtorvastatin yog siv ntau dua li lwm cov statins vim qhov tseeb tias nws muaj cov ntaub ntawv tshawb fawb zoo tshaj plaws rau nws cov kev kho mob. Nws thiab nws cov generics kuj tseem pheej yig dua li Rosuvastatin. Tab sis txij li thaum cov nyhuv tom kawg (normalization ntawm lipid profile ntawm cov ntshav plasma) tshwm sim sai dua, ces nws pib siv ntau dua. Qhov no yog ib qho tshuaj zoo tiag tiag uas koj yuav tsum them rau nws tus nqi.
Qhov chaw ntawm Rosuvastatin hauv cov tshuaj khomob
Kev siv Rosuvastatin, txawm hais tias muaj cov chav kawm analogues, yog qhov dav heev. Nws yog txiav txim los ntawm indications thiab txwv los ntawm contraindications. Yuav luag txhua hom hypercholesterolemia thiab cov teeb meem ntawm cov roj metabolism hauv cov rog muaj nyob hauv cov lus qhia. Nyob rau tib lub sijhawm, qhov txo qis hauv atherogenic lipids feem ntau muaj txiaj ntsig zoo rau lub cev. Vim li no, qhov yuav tshwm sim ntawm cov kab mob atherosclerotic raug txo, thiab lub neej expectancy (thiab nws qhov zoo) yog me ntsis ntxiv.
Rozuvastatin tuaj yeem siv ob qho tib si rau kev tiv thaiv kab mob plawv thiab kho lawv. Qhov kawg niche ntawm pharmacotherapy tshwm sim vim qhov inhibition ntawm atherosclerosis txheej txheem thiab stabilization ntawm endothelium tshaj cov quav hniav. Txij li thaum cerebral thiab plawv infarctions tsim vim mob thrombosis ntawm cov hlab ntsha adductor, qhov kev kho mob no yeej pab tiv thaiv cov mob coronary.
Cov lus qhia rau kev siv
Cov lus qhia txuas nrog cov tshuaj "Rozuvastatin"rau kev siv (tsis muaj analogues ntawm cov ntaub ntawv no) muaj ntau qhov nqaim ntawm cov lus qhia rau kev siv. Txawm li cas los xij, nws tsis muaj cov ntaub ntawv rau tus neeg mob tias nws yuav tsum tau txiav txim siab txog cov roj cholesterol ua ntej siv. Nyob rau hauv lub neej yav tom ntej, lawv qhov kev hloov pauv yuav tso cai rau peb los soj ntsuam cov txiaj ntsig ntawm kev kho mob ntawm qhov ntau npaum li cas. Cov lus qhia kuj muaj cov ntaub ntawv hais txog kev ceev faj thiab kev kho mob nta, contraindications thiab feem ntau tshwm sim thiab tseem ceeb phiv.
Cov lus qhia rau kev siv
Ntawm tag nrho cov kab mob cuam tshuam nrog kev nce hauv plasma lipid feem, qee qhov kev kuaj mob tau txheeb pom:
- caj ces heterozygous (tsev neeg) hypercholesterolemia;
- Fredrickson-chaw cais polygenic hypercholesterolemia hom IIa;
- combined dyslipidemia cais los ntawm Fredrickson li IIb;
- homozygous hereditary (tsev neeg) hypercholesterolemia;
- coronary, cerebral lossis lub raum atherosclerosis occluding lub lumen ntawm cov hlab ntsha;
- atherosclerosis ntawm cov hlab ntsha ntawm qis qis, suav nrog Leriche's syndrome;
- hypertriglyceridemia (Fredrickson type IV);
- kho mob myocardial thiab cerebral infarction, pib ntawm lub sijhawm mob;
- tiv thaiv myocardial infarction thiab stroke.
YContraindications
Txhua qhov pheej yig analogue ntawm Rosuvastatin muaj tib tus naj npawb ntawm cov kev mob tshwm sim raws li tus thawj Crestor. Raws li lawv, ib spectrum yog tsimcontraindications uas zoo li no:
- kab mob siab nrog hepatocyte cytolysis syndrome thiab ntau dua peb npaug ntawm kev nce siab hauv transaminase concentration;
- daim siab tsis ua haujlwm, mob siab rau tus menyuam-Pugh qhab nia ntawm 9;
- lub raum tsis ua haujlwm ntev nrog creatinine tshem tawm qis dua 30 ml / min;
- myopathy ntawm ib qho keeb kwm;
- ua xua rau cov khoom ntawm daim ntawv ntau npaum lossis rau Rosuvastatin.
Muaj ib pab pawg ntawm contraindications ntxiv rau 40mg koob:
- lub raum tsis ua haujlwm ntev nrog kev tshem tawm creatinine tsawg kawg 60 ml / min.;
- yuav ua rau myopathies;
- txais tos ib txhij nrog fibrates;
- yuav haus cawv;
- hmoob haiv neeg;
- siv statin thawj zaug.
Txoj kev noj tshuaj
Txhua "Rozuvastatins" yog cov tshuaj, cov analogues uas tau nthuav tawm hauv khw. Thiab, xaiv ib lub npe lag luam, tus neeg mob yuav tsum tau noj cov tshuaj no ntxiv. Qhov ntawd yog, hloov cov tshuaj mus rau lwm qhov yog tsis tsim nyog. Cov tshuaj nws tus kheej yog noj tsis hais zaub mov thiab txhua lub sijhawm ntawm hnub. Muaj cov lus pom zoo sib txawv me ntsis los ntawm cov kws kho mob tshwj xeeb uas yav dhau los ua haujlwm nrog thawj tiam statins. Lawv muaj cov ntaub ntawv hais tias statins yuav tsum tau noj ua ntej pw. Txawm hais tias qhov no tsis yog qhov tseem ceeb, qhov tseem ceeb yog cov tshuaj noj tib lub sijhawm thiab tas li.
Koj yuav tsum tau saib xyuas koj tus kheej tas li thaum noj Rosuvastatin (analogues). Cov lus tawm tswv yim los ntawm cov kws tshaj lij tso cai rau koj los tsim qhov kev pom zoo ntawm kev soj ntsuam. Hauv particular, tom qab tsim muaj cov hypercholesterolemia, koj yuav tsum pib noj cov tshuaj nyob rau hauv ib koob tshuaj. Tom qab 2 lub hlis, kev tswj hwm yog nqa tawm - lipid profile rov ua dua thiab kev ua haujlwm ntawm aminotransferases raug soj ntsuam.
Yog tias muaj qhov normalization ntawm lipid profile ntawm cov ntshav plasma, nws yuav tsum tau noj ntxiv ntawm tib koob tshuaj. Yog tias tag nrho cov roj (cholesterol) tseem siab thiab cov roj cholesterol tsawg tsawg tsawg, yuav tsum tau txhaj tshuaj ntxiv. Yog tias transaminases nce peb zaug, kev tshem tawm ntawm statins yuav tsum tau ua. Nws yuav tsum raug sau tseg tshwj xeeb tshaj yog tias Rosuvastatin muaj qhov tsawg tshaj plaws ua rau cytolysis ntawm tag nrho cov statins. Analogues (Ukraine tseem maj mam txav ntawm Atorvastatin mus rau Rozuvastatin) tsis tshua muaj kev nyab xeeb ntawm chav kawm. Thiab Pitavastatin tseem kawm tsawg tshaj plaws.
Analogues ntawm "Rozuvastatin"
Raws li analogues ntawm Rosuvastatin (Crestor), ntau tshaj 10 cov tshuaj tau muab rau hnub no. Ntawm lawv yog "Akorta", "Mertenil", "Rozart", "Rozistark", "Rozuvastatin Canon", "Rozuvastatin SOTEKS", "Rozuvastatin SZ", "Rozulip", "Rozucard", "Roxera", "Rustor", "Tevastor". Tus nqi ntawm lawv cov kev kho mob txawv, nrog rau kev ua tau zoo. Raws li tus nqi, cov tshuaj no tuaj yeem muab faib uapeb pawg:
- tus nqi qis (los ntawm 250 txog 650 rubles): Rosuvastatin SZ, Rosuvastatin Canon, Akorta, Rosuvastatin SOTEX;
- tus nqi nruab nrab (ntawm 400 txog 900 rubles): "Mertenil", "Rozart", "Roxera", "Rozucard", "Tevastor", "Rozulip";
- tus nqi siab (ntawm 1100 txog 2200 rubles): Crestor.
Kev tshuaj xyuas tus nqi tau ua los ntawm kev sib piv ntawm tus nqi ntawm cov tshuaj, qhov loj ntawm cov tshuaj nquag uas yog 10 mg. Tus nqi ntau yog qhia txog tus nqi ntawm kev kho mob hypocholesterolemic txhua hli. Qhov pheej yig tshaj analogue ntawm "Rozuvastatin" yog tsim los ntawm lub tuam txhab "Northern Star". Rosuvastatin Canon thiab Akorta kuj txawv me ntsis ntawm tus nqi. Lawv tus nqi hloov pauv tsawg kawg nrog cov txiaj ntsig hloov pauv.
Txheej txheem cej luam ntawm pheej yig Crestor generics
YCov tshuaj Rosuvastatin tsim los ntawm Astrazeneca hu ua Crestor. Nws yog thawj cov tshuaj tiv thaiv uas tag nrho lwm tus yuav tsum tau muab piv. Tib yam siv rau kev tshuaj xyuas: cov yam ntxwv ntawm qee yam generic yuav tsum yog raws li nws qhov kev sib piv nrog Crestor. Tab sis vim nws tus nqi siab, ntau tus neeg mob tam sim ntawd pib kho mob hypercholesterolemia nrog pheej yig dua generics.
Cov ntaub ntawv lub hom phiaj hauv kev tshuaj xyuas tsuas yog muab los ntawm cov kws tshaj lij uas feem ntau ntsibKev siv ntawm Rosuvastatin generics thiab thawj Crestor. Thiab cov lus qhia rau kev siv txuas nrog rau kev npaj Rosuvastatin, kev tshuaj xyuas cov neeg mob thiab kev kho mob yuav ua rau lwm tus neeg mob txiav txim siab txog kev xaiv ntawm lub npe lag luam tshwj xeeb.
Kev tshuaj xyuas ntawm Crestor thiab generics
Kev sib piv ntawm "Crestor" tsuas yog ua los ntawm cov kws tshaj lij ntawm All-Lavxias Society of Cardiology. Cov ntaub ntawv no feem ntau luam tawm nyob rau hauv phau ntawv journal Rational Pharmacotherapy hauv Cardiology. Tshwj xeeb, nws kov cov teeb meem ntawm bioequivalence ntawm generics rau Crestor. Raws li cov txiaj ntsig ntawm kev tshawb fawb pharmacoeconomic, nws tau pom tias cov tshuaj "Mertenil", "Rozart", "Roxera", "Rozucard" thiab "Rozulip" yog bioequivalent rau "Crestor".
Qhov no txhais tau hais tias ib qho qhia txog Rosuvastatin analogue muaj cov txiaj ntsig kho zoo ib yam li cov tshuaj qub, muaj tib tus lej thiab qhov mob hnyav. Txog tam sim no, cov tshuaj "Rozuvastatin SZ", "Rozuvastatin Canon", "Rozuvastatin SOTEKS" thiab "Akorta" tsis koom nrog cov kev sim no. Txij li cov kev tshawb fawb statistical no tsis tau txais nyiaj los ntawm cov tuam txhab muag tshuaj, cov ntaub ntawv tau txais yog lub hom phiaj thiab sib haum rau cov yam ntxwv ntawm kev kho mob hypercholesterolemia. Txawm li cas los xij, cov txiaj ntsig tsuas yog rau cov neeg txawv teb chaws xwb.
Tshwj xeeb tshuaj xyuas ntawm pheej yigCov tshuaj "Rosuvastatin"
Niaj hnub pheej yig analogue ntawm Rosuvastatin yuav tsum ua pov thawj nws cov bioequivalence rau Crestor, tom qab ntawd nws tau txais kev hwm ntawm cov kws tshaj lij. Yog tsis muaj kev tshawb fawb txog bioequivalence, cov kws kho mob tsuas tuaj yeem nco ntsoov cov yam ntxwv ntawm daim ntawv thov. Ib qho ntawm lawv yog qhov no: nrog kev siv tas li ntawm pheej yig analogs ntawm Rosuvastatin (cov tshuaj tau teev saum toj no), qhov zaus ntawm cov kev mob tshwm sim yog piv rau qhov pom nrog kev siv cov generics bioequivalent rau Crestor.
Kev hloov pauv hauv cov ntshav plasma ntawm "Rosuvastatin", tshwm sim los ntawm kev siv cov tshuaj ntau npaum li cas nrog cov sib txawv, suav tias yog qhov tsis tseem ceeb hauv qhov no. Yog li ntawd, pheej yig Lavxias teb sab analogue ntawm Rosuvastatin tuaj yeem hloov tau cov tshuaj thawj Crestor thiab nws cov generics rau kev kho mob hypercholesterolemia.
Tus yam ntxwv ntawm kev tshuaj xyuas tus neeg mob
Raws li cov lus tawm tswv yim ntawm cov neeg mob uas qhia lawv cov kev xav txog kev siv tshuaj nrog lawv tus kws kho mob, ntau qhov kev txiav txim siab tuaj yeem paub qhov txawv. Ua ntej, cov neeg mob cov kev txiav txim siab txog qhov zoo ntawm cov tshuaj yog tsis ncaj ncees lawm. Qhov thib ob, vim qhov kev kho mob tsis pom zoo rau tus neeg mob, kev ua raws li kev kho mob tsawg, txawm hais tias kev kho mob yog qhov tsim nyog los tiv thaiv kev pheej hmoo ntawm kev mob plawv. Thib peb, cov neeg mob zoo li hais tawm qhov tseem ceeb ntawm cov kev mob tshwm sim thiab saib tsis taus cov plasma lipid profiles.
