Kab mob plawv thiab cov hlab ntsha feem ntau ua rau tuag taus. Ischemia ntawm cov leeg plawv tshwm sim, raws li txoj cai, hauv cov neeg laus thiab cov neeg laus. Cov ntshav tsis txaus rau lub plawv cov leeg yog qhov ua rau muaj tus kab mob.
Txoj kev ua neej ntawm tus neeg, muaj tus cwj pwm tsis zoo, noj zaub mov zoo thiab tsis muaj lub cev ua si ua lub luag haujlwm tseem ceeb. Kev kho mob yuav tsum muaj kev sib koom ua ke. Ntau tus kws kho mob tau sau tshuaj Verapamil hauv nws cov khoom xyaw. Cov lus qhia thiab analogues yuav tham ntxiv.
Hom tshuaj thiab cov khoom sib xyaw
Verapamil muaj nyob rau hauv cov ntawv hauv qab no:
- cov ntsiav tshuaj.
- Txoj kev txhaj tshuaj.
- Dragee.
Lub ntsiab ntawm cov tshuaj yog verapamil hydrochloride. Cov tshuaj sib txawv tuaj yeem muaj qhov sib txawv ntawm cov tshuaj nquag:
- Cov ntsiav tshuaj coated muaj40 mg thiab 80 mg ntawm cov khoom xyaw nquag. Cov khoom xyaw ntxiv: Magnesium Stearate, Starch, Calcium Phosphate, Hydroxypropyl Methylcellulose, Butylhydroxyanisole, Gelatin, Purified Talc, Methylparaben, Indigo Carmine.
- Kev daws rau kev txhaj tshuaj ("Verapamil" hauv ampoules), 2 ml txhua.
- Long-acting ntsiav tshuaj muaj 240 mg ntawm cov tshuaj nquag.
- Dragee muaj nyob rau hauv 40 mg thiab 80 mg.
Drug action
Cov khoom xyaw tseem ceeb, verapamil, yog calcium channel blocker. Txo qhov xav tau ntawm lub plawv cov leeg rau oxygen. Lub automatism ntawm lub sinus node yog inhibited.
Cov tshuaj muaj antiarrhythmic, antianginal thiab antihypertensive zog.
Lub neej ib nrab ntawm daim ntawv ntsiav tshuaj yog 3 mus rau 7 teev, nrog rau kev siv nws rov qab los ntawm 4 mus rau 12 teev. Lub active tshuaj yog metabolized nyob rau hauv lub siab. Ntau tshaj 90% ntawm cov active tshuaj yog absorbed. 90% ntawm verapamil khi rau plasma proteins.
Assigned to
txhais tau tias hauv cov ntsiav tshuaj raug tshuaj yog tias kuaj tau:
- ntshav siab.
- ISB.
- Stable angina thiab Prinzmetal's angina.
- Irregular heart rhythm.
Tshuaj nyob rau hauv daim ntawv kua rau kev txhaj tshuaj txhaj yog pom zoo rau:
- Hypertensive crisis.
- Tachycardias.
- mob plawv tsis txaus.
- Ventricular arrhythmias.
- Flicker thiab atrial flutter.
Hauv txhua qhov tshwj xeeb, lwm cov tshuaj yuav ua haujlwm zoo dua Verapamil, tab sis tsuas yog tus kws kho mob tuaj koom yuav tsum ua raws li lub sijhawm teem tseg. Xav txog thaum tsis siv txoj kev kho.
leej twg yuav tsum tsis txhob noj tshuaj
Nws yog qhov tsim nyog teev cov laj thawj vim li cas koj yuav tsum tsis kam noj Verapamil:
- mob plawv tsis ua hauj lwm.
- ntshav siab.
- YHypertrophic cardiomyopathy.
- Bradycardia.
- Sab laug ventricular obstruction.
- YGalactosemia.
- YLactase deficiency.
- YGlucose-galactose malabsorption.
- Sinoatrial blockade.
- Atrioventricular thaiv 2-3 degree.
- Atrial fibrillation thiab flutter.
- Duchenne muscular dystrophy.
- Teeb meem hauv siab thiab raum.
Kev kho mob nrog cov tshuaj no yuav tsum tau tso tseg ua ntej kev phais.
Verapamil ntsiav tshuaj tsis yog tshuaj rau cov menyuam yaus hnub nyoog qis dua 5 xyoos, vim nws tsis paub tias cov tshuaj muaj kev nyab xeeb npaum li cas rau lub hnub nyoog no.
Cov poj niam cev xeeb tub thiab lactating tsis pom zoo siv tshuaj. Tab sis kev kho yog ua tau yog tias cov txiaj ntsig zoo dua qhov txaus ntshai. Cov tshuaj nquag nkag mus rau hauv cov mis nyuj, yog li nws yog qhov zoo dua los hloov tus menyuam mus rau kev pub mis rau lub sijhawm kho.
Cov neeg mob uas muaj qhov tsis haum rau Verapamil cov khoom yuav tsum tsis txhob noj.
Thaum ua haujlwm nrog cov tshuab txaus ntshai thiabThaum tsav tsheb "Verapamil" yuav tsum tsis txhob noj. Yog tias koj yuav tsum siv cov tshuaj, koj yuav tsum tsis txhob tsav tsheb thiab los ntawm kev ua haujlwm uas yuav tsum tau muaj kev saib xyuas siab.
Txoj kev siv cov ntsiav tshuaj
Tablets "Verapamil", cov lus qhia qhia qhov no, yog npaj rau kev siv qhov ncauj. Koj tuaj yeem haus tau txhua lub sijhawm, tsis hais noj mov. Cov ntsiav tshuaj yuav tsum tsis txhob chew los yog crushed. Thaum nqos tau tag nrho, nws yuav tsum tau ntxuav nrog dej txaus.
Cov koob tshuaj thiab kev kho mob yog muab los ntawm tus kws kho mob tshwj xeeb rau txhua tus neeg mob ntawm tus kheej. Nrog rau kev siv cov tshuaj ntev, nws yog ib qho tsim nyog los saib xyuas kev ua haujlwm ntawm lub siab.
Cov tshuaj pom zoo rau qee yam kab mob yuav tsum tau muab:
- Rau angina pectoris thiab arrhythmias, 80-120 mg 3 zaug ib hnub yog pom zoo.
- Nrog ntshav siab - 80 mg 3 zaug hauv ib hnub. Thaum tsis muaj qhov xav tau, qhov ntau npaum li cas tom qab 7 hnub ntawm kev tswj hwm tuaj yeem nce ntxiv.
- Daim ntawv ntev ntawm cov tshuaj yog noj ntawm 240 mg ib hnub twg. Cov koob tshuaj tuaj yeem muab faib ua ob koob ntawm 120 mg. Thaum lub sij hawm, nws maj mam txo. Lub sijhawm nruab nrab ntawm kev noj cov ntsiav tshuaj txuas ntxiv nrog ob koob tshuaj yuav tsum yog 12 teev.
- Nrog qhov hnyav me me, nws raug pom zoo nyob rau theem pib kom siv tsis pub ntau tshaj 40 mg 3 zaug hauv ib hnub. Qhov koob tshuaj no kuj tau sau tseg rau cov neeg mob laus, nrog rau cov neeg ua haujlwm tsis zoo.kab mob xws li lub siab thiab lub raum. Maj mam, qhov koob tshuaj tuaj yeem nce ntxiv yog tias qhov kev xav tau tsis ua tiav.
Qhov siab tshaj plaws ntawm "Verapamil" yog txiav txim siab - nws yog 480 mg ib hnub.
Kev siv tshuaj txhaj tshuaj
"Verapamil" nyob rau hauv daim ntawv ntawm kev daws yog siv parenterally. Kev txhaj tshuaj intravenously, tuaj yeem ua rau infusion.
Rau infusions, cov tshuaj tau npaj ua ke nrog 5% qabzib lossis 9% sodium chloride tov. Kev taw qhia yuav tsum tau qeeb kom tsis pub ntau tshaj 10 mg ntawm cov tshuaj nquag ntawm cov tshuaj nkag mus rau hauv lub cev hauv 1 teev. Txoj kev kho mob yog kws kho mob sau.
Cia peb saib qee qhov pom zoo txhaj tshuaj txhaj tshuaj ntawm cov cuab yeej kho mob:
- Rau supraventricular tachycardia, 2-4 ml raug pom zoo. Kev txhaj tshuaj yuav tsum tau qeeb thiab kav ntev li 2 feeb. Yog tias qhov kev xav tau tsis tuaj tom qab 20-30 feeb, tom qab ntawd muab tshuaj thib ob ntawm cov tshuaj.
- Thaum muaj kev kub ntxhov siab, cov tshuaj raug pom zoo ntawm tus nqi ntawm 0.05-0.1 mg / kg ntawm lub cev hnyav. Taw qhia rau hauv cov leeg maj mam. Thaum tsis muaj qhov xav tau tom qab 30-60 feeb, koj tuaj yeem nkag mus rau cov tshuaj zaum ob.
Cov koob tshuaj ntau tshaj plaws ntawm Verapamil yog 100 mg ib hnub.
Thaum txhaj tshuaj rau hauv cov hlab ntsha, koj yuav tsum tau saib xyuas tus neeg mob cov ntshav siab thiab lub plawv ua haujlwm tas li.
Txoj kev noj tshuaj rau menyuam yaus
Verapamil yog tshuaj rau cov menyuam yaus uas muaj arrhythmia thiab ntshav siab.
Recommendedsiv cov tshuaj hauv cov ntsiav tshuaj hauv cov tshuaj hauv qab no:
- menyuam yaus hnub nyoog 5 xyoos txog 60 mg ib hnub;
- hnub nyoog 6 txog 14 - 60-360 mg ib hnub.
Yog tus menyuam muaj hnub nyoog qis dua 5 xyoos, nws raug nquahu kom txhaj rau hauv cov leeg:
- menyuam yaus txog 1 xyoos 0.75-2 mg.
- ntawm ib mus rau tsib xyoos, qhov koob tshuaj yog 2-3 mg.
Koj tuaj yeem suav qhov xav tau ntawm cov tshuaj raws li qhov hnyav ntawm tus menyuam. Rau kev txhaj tshuaj, nws yog 0.1-0.3 mg / kg ib lub cev hnyav. Qhov koob tshuaj loj tshaj plaws rau cov menyuam yaus yog 5 mg Verapamil.
Yog tias tom qab kev tswj hwm ntawm cov tshuaj, qhov kev xav tau tsis ua tiav, koj tuaj yeem nkag mus rau ib koob thib ob tom qab 30-60 feeb.
Verapamil phiv
Nws tsim nyog sau cia tias muaj qhov tsis zoo rau lub cev thaum noj tshuaj.
Cov kab mob plawv tuaj yeem teb rau cov tshuaj raws li hauv qab no:
- ntshav siab yuav poob ntau.
- Lub plawv dhia yuav cuam tshuam.
- Ib angina nres yuav tsim.
- Lub plawv yuav nce.
- Muaj peev xwm sinoatrial lossis atrioventricular block.
Muaj kev pheej hmoo:
- Kev mob plawv tsis ua hauj lwm.
- Short-term tsis nco qab.
- mob plawv mob plawv.
Cov kev mob tshwm sim ntawm "Verapamil" kuj tau qhia:
- Ntaus.
- ntuav.
- Qhia los yog raws plab.
- cov pos hniav.
- Dryness ntawm qhov ncauj mucosakab noj hniav.
- Hyperbilirubinemia.
- Npaj siab ua haujlwm.
Y Tam sim no, nrog rau kev siv ntev ntawm "Verapamil" nws cov tshuaj lom rau lub siab hlwb yuav nce.
Cov kev mob tshwm sim yog ib txwm rau "Verapamil" raws li hauv qab no:
- Headache attacks.
- kiv taub hau.
- Txhawj xeeb.
- Impaired cerebral ncig.
- Teeb meem nrog kev pom thiab hnov lus.
- Tinnitus.
- poob teeb meem.
- Paresthesias.
- Tshem.
- Extrapyramidal ntshawv siab.
Genito-urinary system thiab cov kab mob ua me nyuam:
- Tsis ua raws li kev coj khaub ncaws.
- nquag tso zis.
- Erectile dysfunction.
- Gynecomastia.
Cov tsos mob tsis zoo los ntawm lwm lub cev thiab lub cev:
- pob khaus.
- Pigmentation ntawm daim tawv nqaij.
- Alopecia.
- Bronchoconstriction.
- Quicke's edema.
- YQhov tsos ntawm hematomas.
- mob leeg, myalgia.
Cov kev mob tshwm sim kuj tshwm sim thaum noj nrog lwm cov tshuaj.
Kev sib tham nrog lwm yam tshuaj
Tshuaj, ua ke nrog qhov cuam tshuam ntawm "Verapamil" yog txhim kho:
- Neuroleptics.
- Tricyclic antidepressants.
Tshuaj uas ua kom cov concentration ntawm cov tshuaj nquag hauv plasma:
- "Cimetidine".
- Ritonavir.
- Indinavir.
Kev sib xyaw nrog "Verapamil" ntawm cov tshuaj hauv qab no nce ntxivCov tsos mob tsis zoo ntawm lub plawv thiab cov hlab ntsha:
- Kev nqus tshuaj loog.
- Beta-adrenergic blockers.
- Radiocontrast media.
- blockers ntawm neuromuscular kis tau tus mob.
- "Flecainide" (cov tshuaj tiv thaiv kab mob).
Kev siv cov tshuaj saum toj no ua ke tsuas yog ua tau raws li kev saib xyuas nruj ntawm tus kws kho mob.
"Verapamil" nce qhov cuam tshuam rau lub cev:
- tshuaj tiv thaiv hypertensive;
- tshuaj los so cov leeg nqaij.
Plasma concentrations ntawm cov tshuaj hauv qab no nce ntxiv thaum siv ua ke nrog Verapamil:
- YCyclosporin.
- YCarbamazepine.
- Tacrolimus.
- YColchicine.
- Serotonin receptor inhibitors.
- YMacrolides.
- Hlub glycosides.
kev hloov kho koob tshuaj yog xav tau hauv cov kev sib xyaw no.
Cov txiaj ntsig kho ntawm "Verapamil" tsis muaj zog thaum siv ua ke:
- nrog calcium;
- cholecalciferol;
- inducers ntawm microsomal daim siab enzymes.
Verapamil qeeb tshem tawm:
- YPropranolol;
- "Phenobarbital";
- Metoprolol;
- YRifampicin.
Koj tsis tuaj yeem siv "Verapamil" ua ke:
- nrog hoob 1-3 antiarrhythmics;
- Y"Disopyramide".
Kev siv cov tshuaj no tsuas yog ua tau 48 teev tom qab noj Verapamil.
Ua ke nrog "Quinidine" tus neeg mob tuaj yeemtxo ntshav siab heev.
Kev hloov kho koob tshuaj ntawm Simvastatin yog xav tau thaum siv ua ke nrog Verapamil.
Hloov pauv ntawm cov tshuaj pharmacokinetic tuaj yeem ua tau thaum noj cov tshuaj uas cuam tshuam rau cov ntshav plasma proteins.
kua txiv Grapefruit nce qhov nqus ntawm "Verapamil" rau hauv lub cev.
Intensifies negative effect of cawv rau lub cev, yog li nws yog qhov zoo dua kom nyob deb ntawm nws thaum lub sij hawm kho.
Nws tsim nyog them nqi rau cov kev mob tshwm sim ntawm Verapamil thaum noj lwm yam tshuaj nrog nws.
Drug overdose tsos mob thiab kev kho mob
Nws yog qhov tsim nyog los piav qhia cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm Verapamil:
- Lub plawv tsis ua hauj lwm.
- txo qis ntshav siab.
- Asystole.
- Atrioventricular block.
Thaum muaj qhov tshwm sim hnyav, nws raug nquahu kom ua cov haujlwm hauv qab no:
- plab lavage.
- Tau enterosorbents.
- Laxatives.
- Control ua pa, mem tes, ECG thiab ntshav siab.
- Kev tshuaj inotropic ntawm tus kws kho mob qhov kev txiav txim siab.
Muaj peev xwm siv cov pacemakers. Hemodialysis nrog kev noj tshuaj ntau dhau ntawm "Verapamil" tsis zoo.
Analogues ntawm cov tshuaj
Cov tshuaj tsis yog ib txwm tsim nyog vim muaj cov khoom sib xyaw ua ke. Nws yog ib qho tseem ceeb heev uas yuav tau kawm cov lus qhia los ntawm Verapamil. Analogues muaj qhov zoo sib xwskev ua. Cov no suav nrog:
- Ryodipin.
- "Amlodipine".
- Gallopamil.
- Nifedipine.
- Retard.
Nimodipine Nimodipine
Ib yam khoom muaj txiaj ntsig zoo sib xws muaj:
- Caveril.
- Finoptin.
- Lekoptin.
- Isoptin.
Nws yog ib qho tsim nyog los tham txog cov tshuaj "Verapamil" nrog tus kws kho mob. Kev siv cov analogues kuj yuav tsum tau mus ntsib kws kho mob.
Reviews about tshuaj
Cov tshuaj no feem ntau yog muab rau cov ntshav siab thiab arrhythmia. Muaj zoo "Verapamil" tshuaj xyuas. Analogues yuav tsum tsis tshua muaj. Nws muaj cov txiaj ntsig zoo ntawm lub plawv, normalizes ntshav siab, pab nrog angina pectoris. Nws yog ib qho tsim nyog sau cia tias qee cov neeg mob nco txog qhov tshwm sim ntawm cov kev mob tshwm sim thaum noj Verapamil. Kev tshuaj xyuas hais txog qhov ua txhaum cai ntawm cov quav thiab xeev siab, palpitations thiab kiv taub hau. Ntau qhov kev tshuaj xyuas muaj cov ntaub ntawv hais txog mob taub hau thiab pw tsaug zog.
Ntau tus neeg mob pom cov tshuaj zoo heev thiab siv sijhawm ntev. Qhov no yog li cas angina tawm tsam dhau, ntshav siab nce tsawg dua. Kuj tseem nco ntsoov tus nqi pheej yig ntawm "Verapamil". Kev tshuaj xyuas ntawm cov tshuaj analogues hais tias lawv kim dua.
Qee tus neeg mob tsis hnov qhov kev kho mob thaum noj cov tshuaj. Kev taw qhia ntawm cov tshuaj intravenously zoo normalizes ntshav siab thiab lub plawv dhia. Feem ntau rau cov neeg uas muaj ntshav siab heev, yuav tsum tau siv tshuaj "Verapamil" rov qab. Cov lus qhia, tshuaj xyuas nco ntsoov qhov no, muaj cov koob tshuaj pom zoo, yog li koj yuav tsum sab laj nrog kws kho mob ua ntej noj cov tshuaj.
Yog tias muaj teeb meem nrog rau lub siab thiab lub raum, nws yog qhov zoo dua tsis txhob muab cov tshuaj thiab nrhiav kev hloov rau nws. Cov poj niam cev xeeb tub tuaj yeem noj tshuaj kom txo cov suab nrov ntawm lub tsev menyuam thiab nrog tachycardia. Kev siv "Verapamil", cov neeg mob xyuas kom paub meej tias qhov no, nws yuav ua tau zoo yog tias cov tshuaj tau muab los ntawm tus kws kho mob tom qab kuaj tiav. Lub plawv dhia normalizes, tus me nyuam yuav calmer. Qee cov neeg mob tsis muaj zog thiab kiv taub hau thaum noj cov tshuaj. Hauv qhov no, koj yuav tsum tso tseg txoj kev kho thiab nrhiav kev hloov pauv.
Nws tsim nyog sau cia tias koj tsis tas yuav pib noj tshuaj koj tus kheej yam tsis tau sab laj nrog kws kho mob. Kev phiv ntawm "Verapamil" thiab contraindications yuav tsum tau kawm thiab coj mus rau hauv tus account. Nws cov nyhuv nyob ntawm nws.
