Tamoxifen Ebewe yog ib qho tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob. Nws yog siv nyob rau hauv hormonal kho ntawm oncological neoplasms. belongs rau pab pawg ntawm cov tshuaj androgenic. Tamoxifen Ebewe yog tsim nyob rau hauv Austria.
Composition
Cov ntsiab lus ntawm cov khoom lag luam tshuaj no muaj cov ntsiab lus tseem ceeb - tamoxifen citrate (40, 30, 20 lossis 10 mg ib ntsiav tshuaj). Nws yog tsim nyob rau hauv contour hlwb ntawm 10 ntsiav tshuaj, muab tso rau hauv cartons ntawm 10 pieces.
1 ntsiav tshuaj muaj:
- tamoxifen citrate;
- lactose;
- magnesium stearate;
- starch;
- cellulose;
- colloidal silicon dioxide.
Cov ntsiav tshuaj yog puag ncig, xim dawb, nrog tus ntoo khaub lig sib faib zawj ntawm ib sab.
tshuaj muaj txiaj ntsig
Cov khoom xyaw nquag amoxifen yog cov tshuaj tiv thaiv estrogen tsis-steroidal uas tseem muaj cov khoom tsis muaj zog estrogenic. NwsCov nyhuv antitumor yog raws li lub peev xwm los thaiv cov tshuaj estrogen receptors.
Tamoxifen thiab nws cov metabolites sib tw nrog estradiol es tsis txhob khi rau cytoplasmic estrogen receptors hauv lub mis, qhov chaw mos, uterine, anterior pituitary, thiab neoplasms nrog siab concentration ntawm estrogen receptors. Tamoxifen tsis txhawb kev tsim cov DNA hauv cov nucleus, tab sis inhibits cell division, uas ua rau muaj kev cuam tshuam ntawm cov kab mob pathological thiab kev puas tsuaj.
YPharmacokinetics
Tom qab noj tamoxifen yog nqus tau zoo. Qhov siab tshaj plaws hauv cov ntshav tshwm sim kwv yees li 4-7 teev tom qab noj ib zaug. Qhov sib npaug ntawm cov khoom nquag hauv cov ntshav, raws li txoj cai, tau mus txog tom qab 3 lub lis piam ntawm kev siv. Nws mus los ntawm cov txheej txheem ntawm cov metabolism hauv lub siab nrog kev tsim ntawm ntau yam tshuaj. Kev tso tawm ntawm lub cev muaj ob theem xwm txheej nrog thawj ib nrab ntawm lub neej ntawm 7 mus rau 13 teev, ua raws li lub davhlau ya nyob twg ib nrab hnub ntawm 7 hnub. Cov tshuaj no yog excreted mas nyob rau hauv daim ntawv ntawm conjugates, nrog quav thiab nyob rau hauv me me nrog zis.
tshuaj qhia rau kev siv cov tshuaj no
Cov tshuaj no tsuas yog siv rau cov tsos mob thaum ntxov ntawm mob qog noj ntshav. Cov tsos mob ntawm tus kab mob no yog:
- tsim nyob rau hauv lub caj pas seals hauvhauv siab;
- retraction lossis thickening ntawm lub txiv mis;
- tshwm sim ntawm "txiv qaub tev" dhau ntawm kev ua kom pom tseeb;
- liab ntawm daim tawv nqaij;
- kev sib koom ua ke ntawm axillary thiab retrosternal lymph nodes;
- tsis sib npaug ntawm qhov loj ntawm ib lub mis;
- tshwm sim ntawm qhov mob syndrome;
- mis deformity;
- puffiness;
- kev tso tawm ntawm lub txiv mis (xws li ntshav);
- kub nce;
- kev qaug zog;
- poob ceeb thawj;
- kiv taub hau.
x
Ntxiv rau, cov tshuaj "Tamoxifen-Ebewe" tau muab tshuaj rau cov kab mob hauv qab no:
- estrogen-dependent cancer mis rau txiv neej;
- zes qe menyuam, endometrial, mob raum;
- melanoma;
- cov nqaij mos sarcoma nrog estrogen receptor qog;
- mob qog noj ntshav prostate nrog rau lwm yam tshuaj.
Contraindications rau kev siv cov tshuaj no
Tamoxifen-Ebewe yog contraindicated nyob rau hauv cov ntaub ntawv hauv qab no:
- rhiab rau tamoxifen lossis lwm cov khoom xyaw ntawm cov khoom;
- lactation, cev xeeb tub.
Nrog ceev faj, cov tshuaj no tau sau rau lub raum tsis ua haujlwm, ntshav qab zib mellitus, kab mob qhov muag (cataracts), cov hlab ntsha sib sib zog nqus thiab cov kab mob thromboembolic (nrog rau keeb kwm), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia.
ModeDosing and how to take this drug
Txhawm rau ua tiav cov txiaj ntsig zoo tshaj plaws ntawm cov cim qhia ntxov ntawm mob qog noj ntshav mis, cov kev pom zoo rau cov tshuaj no yog 20 mus rau 40 mg ntawm qhov ncauj txhua hnub hauv chav kawm ntev. Yog tias cov tsos mob ntawm qhov kev loj hlob ntawm cov txheej txheem pathological tshwm sim, cov tshuaj raug tso tseg.
Tshuaj tsis tas yuav zom, ntxuav nrog dej me me, ib zaug thaum sawv ntxov lossis muab faib ua ob koob.
Cov teebmeem ntawm "Tamoxifen Ebewe"
Thaum lub sijhawm kho tamoxifen, cov kev mob tshwm sim cuam tshuam nrog nws cov teebmeem antiestrogenic muaj ntau, uas tshwm sim lawv tus kheej li paroxysmal kev xav ntawm tshav kub (kub flashes), qhov chaw mos los yog los ntshav, khaus ntawm qhov chaw mos, alopecia, mob hauv qhov chaw mob., hnyav nce lub cev, ossalgia. Cov kev phiv tshwm sim hauv qab no yog qhov tsis tshua muaj tshwm sim:
- dej tuav;
- nausea;
- anorexia;
- ntua;
- quav quav;
- faus;
- xeev kev nyuaj siab;
- tsis meej;
- cephalgia;
- kiv taub hau;
- nce pw tsaug zog;
- hyperthermia;
- pob khaus;
- kev ua txhaum ntawm qhov pom kev ua haujlwm;
- retinopathy;
- Yretrobulbar neuritis.
Thaum pib ntawm kev kho mob, tej zaum yuav muaj qhov tshwm sim ntawm tus kab mob hauv zos - nce qhov loj ntawm cov nqaij mos neoplasms, uasQee zaum nrog rau qhov mob hnyav ntawm erythema hauv thaj chaw cuam tshuam thiab thaj chaw nyob ib sab - uas feem ntau daws tau hauv 14 hnub.
Qhov yuav tshwm sim ntawm kev txhim kho thromboembolism thiab thrombophlebitis kuj tuaj yeem nce ntxiv. Qee lub sij hawm, thrombocytopenia thiab leukopenia tuaj yeem tshwm sim, nrog rau kev nce hauv daim siab enzymes, qee zaum nrog rau lub siab ua haujlwm tsis zoo, xws li fatty infiltration, kab mob siab thiab cholestasis.
Qee cov neeg mob uas muaj pob txha metastases tau ntsib cov tsos mob ntawm hypercalcemia thaum pib kho. Tamoxifen tuaj yeem ua rau amenorrhea lossis ua rau kev coj khaub ncaws tsis xwm yeem nyob rau lub sijhawm ua ntej cev xeeb tub, nrog rau kev rov qab tsim cov cystic formations ntawm zes qe menyuam.
Nrog kev kho mob ntev nrog cov khoom siv tshuaj no, kev hloov pauv hauv endometrial xws li hyperplasia, polyps thiab, qee zaus, mob qog noj ntshav endometrial, uterine fibroma, kuj tuaj yeem tshwm sim.
Reviews about "Tamoxifen Ebewe"
Muaj qee qhov kev tshuaj xyuas ntawm cov tshuaj no hauv cov vev xaib kho mob, thiab qhov no yog vim qhov tseeb tias cov kab mob oncological tsis tshwm sim hauv tib neeg ntau zaus, tshwj xeeb tshaj yog vim cov tshuaj no tsis tas yuav tshuaj rau lawv.
Los ntawm cov ntaub ntawv ntawm ob peb qhov kev tshuaj xyuas, peb tuaj yeem txiav txim siab tias Tamoxifen-Ebewe tsis yog ib txwm siv tau, tab sis tsuas yog kwv yees li ib nrab ntawm nws qhov kev siv. Cov neeg mob qhia tias muaj kev zam zoo rau qhov kev kho no. Hauv ntau ntawm lawv, kev loj hlob ntawm pathological neoplasm thaum khoraug tshem tawm, lwm tus tsis muaj qhov cuam tshuam no, thiab cov neeg no tau muab tshuaj kho lwm yam.
