Cortisone yog ib qho tseem ceeb heev steroid hormone secreted los ntawm cov qog adrenal. Glucocorticoid activates lub synthesis ntawm carbohydrates los ntawm cov protein, suppresses lymphoid plab hnyuv siab raum, hloov cov txheej txheem metabolic, tsub kom lub cev tiv thaiv kev ntxhov siab. Kev lag luam kws tshuaj tau tsim ib qho analogue rau tib neeg cov tshuaj hormones - cortisone acetate. Cov tshuaj yog ib qho zoo hluavtaws corticosteroid.
yam ntxwv, muaj pes tsawg leeg thiab tso tawm daim ntawv
Cortisone yog ib qho glucocorticosteroid nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb ntawm crystalline hmoov, tsw tsw thiab tsis zoo soluble hauv dej thiab ethanol. Nws zoo ib yam hauv cov qauv tshuaj rau cortisol thiab suav tias yog nws cov khoom lag luam metabolic tsis ua haujlwm. Tus neeg sawv cev yog siv qhov ncauj, parenterally, externally. Cov tshuaj nquag ntawm cov tshuaj yog cortisone acetate. Cov neeg tsim khoom tsim cov tshuaj hauv qab no:
- ntsiav tshuaj muaj 25 thiab 50 mg ntawm cov tshuaj nquag, 80 daim hauv ib lub thawvntim.
- Kev ncua 2.5% hauv vials ntawm 5 lossis 10 ml, 10 daim ib pob. Cov ntsiab lus ntawm cov tshuaj nquag yog 0.025 g ib 1.0 ml.
Cortisone-muaj cov tshuaj pleev kuj tseem yog cov tshuaj glucocorticoids, tab sis muaj cov nyhuv tshuaj nqaim dua. Cov cuab yeej muaj anti-allergic thiab hauv zos anti-inflammatory kev txiav txim. Cov tshuaj nquag ntawm cov tshuaj pleev yog hydrocortisone acetate, uas, zoo li cortisone, yog cov tshuaj steroid uas tsim los ntawm adrenal cortex. Ntawm cov excipients, cov tshuaj muaj xws li propylene glycol - hnyav, glucite - thickener, povidone - enterosorbent, sodium chloride - detoxifier.
tshuaj muaj txiaj ntsig
Glucocorticoid muaj kev tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kev ua xua, txo lub cev rhiab heev.
Cov tshuaj tiv thaiv kab mob yog vim muaj kev cuam tshuam ntawm kev tsim ntawm 2-lysophospholipid thiab fatty acid. Qhov no ua rau inhibition ntawm kev sib txuas ntawm prostaglandins, txo qis hauv kev tso tawm cov proteins uas txhawb kev sib sau ntawm platelets, malignant cells, thiab leukocytes.
Anti-allergic action yog txiav txim siab los ntawm kev ruaj khov ntawm daim nyias nyias ntawm lub cell organoid, uas tswj cov acidic ib puag ncig thiab tiv thaiv kev tso tawm thaum lub sij hawm lysis ntawm cov hlwb uas muaj kev puas tsuaj thiab koom nrog kev hloov cov qauv ntawm cov ntaub so ntswg nyob rau hauv qhov chaw uas muaj kev tsis haum tshuaj tshwm sim.
Immunosuppressive zog yog txuam nrog kev txo qis ntawm cov hlwb uas muaj peev xwm paub txog cov tshuaj tiv thaiv thiab muab cov lus teb tiv thaiv. ib yam liinhibition ntawm cell proliferation nrog kev hloov ntawm lymphocytes mus rau hauv blasts, txo tus naj npawb ntawm cov tshuaj nquag nrog immunoregulatory thiab mediator nta.
Cortisone acetate nce poov tshuaj tso tawm thiab sodium tuav, uas ua rau txo qis hauv cov dej tawm ntawm lub cev. Stimulates enzymes uas yog lub luag hauj lwm rau cov metabolism hauv, ua kom cov ntshav qabzib ntau ntau, nce protein synthesis.
Kev qhia
Raws li cov lus qhia rau kev siv cortisone acetate yog tshuaj rau cov kab mob hauv qab no:
- kab mob endocrine tshwm sim los ntawm qhov tsis muaj peev xwm ntawm cov qog adrenal los tsim cov tshuaj hormones txaus (Addison tus kab mob).
- Hypocortisolism tom qab ua tiav kev phais tshem tawm ntawm cov qog adrenal.
- Kev cuam tshuam ntawm lub caj pas pituitary anterior.
- Kev mob tshwm sim ntawm adrenal cortex.
- kab mob Rheumatic.
- Hemolytic anemia.
- YAtopic dermatitis.
- Kev tsis haum tshuaj.
- Bronchial airway obstruction.
- kis kab mob mononucleosis.
- Hepatitis of viral genesis.
- daim ntawv hnyav ntawm vascular insufficiency (collapse).
- Kev cuam tshuam ntawm lub cev hloov kho rau kev raug mob (shock).
Cov ntaub ntawv ntawm cortisone rau kev siv sab nraud yog siv hauv ophthalmology los kho qhov mob ntawm lub cev ntawm qhov muag. Cov tshuaj pleev tau raug sau tseg kom tsis txhob muaj cov txheej txheem tiv thaiv kab mob thiab hloov kho, txo qhov o thiab khaus.
Contraindications rau cortisoneAcetate
Nov yog cov tshuaj noj thiab muaj cov npe zoo heev ntawm kev noj qab haus huv uas tsis pom zoo siv.
- Ntaus rhiab heev rau cov khoom ntawm cov tshuaj.
- kab mob sib kis.
- kab mob sib kis ntawm ntau yam keeb kwm.
- Lub sijhawm ua ntej thiab tom qab txhaj tshuaj tiv thaiv (8 lub lis piam ua ntej txhaj tshuaj thiab 2 tom qab).
- AIDS thiab HIV.
- Peptic ulcer.
- Kev mob plab ntawm txoj hlab pas.
- mob plab.
- Intestinal anastomosis.
- Ib tug kab mob mob ntev ntawm cov kab mob hauv ob sab phlu (ulcerative colitis).
- YDiverticulitis.
- mob plawv mob plawv.
- Hypertension.
- Dyslipidemia.
- Cushing's disease.
- rau lub raum thiab lub siab tsis ua haujlwm.
- III-IV theem ntawm kev rog.
Kev siv tshuaj yog ua raws li kev saib xyuas ntawm tus kws kho mob uas tau sau tseg. Raws li kev saib xyuas tshwj xeeb yog cov neeg mob cirrhosis ntawm daim siab, nrog rau lub sijhawm ntev tsis muaj cov thyroid hormones. Nrog rau cov kab mob no, cov nyhuv ntawm cov tshuaj yuav nce ntxiv thiab yuav tsum tau kho cov tshuaj.
Yog tus neeg mob uas tau txais kev kho mob nrog cov tshuaj uas muaj cortisone tsis ntev los no tau ntsib nrog cov neeg mob herpes, kab mob qhua pias, amoebiasis, tuberculosis, ces yuav tsum tau ceeb toom rau tus kws kho mob txog qhov no.
Kev siv cov ntsiav tshuaj thiab kev ncua: ntau npaum li cas
Kev siv tus kheej ntawm cov tshuaj muaj qhov lojtxaus ntshai rau kev noj qab haus huv, cov tshuaj yuav tsum tsuas yog coj los ntawm tus kws kho mob tshwj xeeb thiab nyob rau hauv nws kev saib xyuas.
Cov koob tshuaj yog xam tus kheej nyob ntawm tus neeg mob tus mob, pathology thiab nws cov chav kawm. Kev noj txhua hnub ntawm Cortisone ntsiav tshuaj raws li cov lus qhia yuav tsum tsis pub tshaj 300 mg. Thawj koob tshuaj yog 10-20 mg ib zaug mus txog 4 zaug hauv ib hnub. Raws li qhov hnyav ntawm pathology, tus nqi ntawm cov tshuaj nce ntxiv, tab sis ib koob tshuaj rau cov neeg laus yuav tsum tsis pub tshaj 150 mg. Raws li kev noj qab haus huv zoo dua, cov koob tshuaj maj mam txo kom tsawg.
Rau cov menyuam yaus, cov tshuaj tau sau rau hauv qhov me me, qhov ntau npaum li cas nyob ntawm lub hnub nyoog ntawm tus neeg mob me - los ntawm 12 txog 25 mg ib zaug.
Kev ncua yog siv intramuscularly lossis rau hauv kab noj hniav ntawm cov pob qij txha. Lub ampoule yog shaken thiab cov ntsiab lus yog txhaj tob rau hauv lub pob tw los ntawm 50 mus rau 300 mg ib zaug. Qhov koob tshuaj txhua hnub yog 1000-1500 mg. Kev suav cov tshuaj rau cov menyuam yaus nyob ntawm qhov hnyav ntawm tus menyuam: qhov koob tshuaj uas tsim nyog tshaj plaws yog 6-9 mg rau 1 kg ntawm lub cev hnyav.
Kev tswj hwm hauv cov hlab ntsha yog ua tiav ntawm 5-25 mg ib zaug txhua 7 hnub. Hoob kawm 3-5 lub lis piam.
Cortisone tshuaj pleev: cov lus qhia rau kev siv
Tshuaj rau kev siv sab nraud muaj cov tshuaj tiv thaiv hauv zos, tiv thaiv edematous. Cortisone ointment yog siv rau hauv ib txheej nyias mus rau thaj tsam ntawm daim tawv nqaij 2-3 zaug hauv ib hnub. Txhawm rau txhim kho cov txiaj ntsig kho mob, occlusive hnav khaub ncaws yog siv los kaw qhov chaw mob. DurationKev kho yog nyob ntawm tus yam ntxwv, qhov hnyav ntawm pathology thiab kev ua haujlwm ntawm kev kho mob. Lub sijhawm ntawm chav kawm feem ntau yog los ntawm ib mus rau ob lub lis piam, nrog rau cov txheej txheem kab mob tsis tu ncua, kev kho tuaj yeem nce mus txog 20 hnub.
Kev siv tshuaj pleev rau cov menyuam yaus muaj peev xwm txij li ob xyoos. Kev ntsuas uas txhim kho qhov nqus ntawm glucocorticoid tsis suav nrog.
Cortisone thaum cev xeeb tub thiab lactation
Tsis muaj kev tshawb fawb txaus ntawm kev siv corticosteroids thaum cev xeeb tub thiab lactation. Cov ntsiav tshuaj Cortisone yog cov tshuaj steroid, tab sis lawv tsis muaj estrogenic (tsim los ntawm zes qe menyuam follicular apparatus) los yog progestogenic (tsim los ntawm fetal placenta) kev ua. Glucocorticosteroids tswj homeostasis. Txawm li cas los xij, thaum cev xeeb tub, cov poj niam raug pom ntau dua rau cov teeb meem kev ntxhov siab, uas ua rau muaj adrenal secretion ntau dua. Cov qib cortisone siab ua rau muaj ntshav siab, uas tuaj yeem ua rau nchuav menyuam.
Cov tshuaj siv tau thaum cev xeeb tub nkaus xwb yog tias qhov txiaj ntsig zoo dua qhov kev pheej hmoo ntawm kev phiv. Yog tias txawm tias muaj me me ntawm kev ua phem rau tus menyuam hauv plab, ces kev kho mob zoo li no suav tias yog qhov tsis tsim nyog thiab tseem txaus ntshai. Yog hais tias ib tug poj niam nyob rau hauv txoj hauj lwm coj cortisone, ces cov me nyuam yug los yuav tsum tau ua tib zoo saib xyuas vim muaj peev xwm hypofunction ntawm cov qog adrenal.
Thaum lactation nws kuj zoo dua kom tsis txhob sivtshuaj vim lub fact tias nws yog secreted rau hauv cov mis nyuj. Yog tias muaj qhov xav tau ceev ceev los siv cov tshuaj corticosteroid, nws yog qhov zoo dua kom tsis txhob pub niam mis.
Side effects
Qhov zaus ntawm kev tsim thiab kev nthuav tawm ntawm cov teebmeem tsis zoo nyob ntawm lub sijhawm ntawm kev siv, ntau npaum li cas thiab ua raws li kev hloov pauv hauv lub sijhawm teem tseg.
- Rau ib feem ntawm cov kab mob endocrine tom qab noj cortisone acetate, steroid ntshav qab zib mellitus, kev ua haujlwm ntawm adrenal, Itsenko-Cushing's syndrome, thiab ncua kev sib deev hauv cov menyuam yaus tuaj yeem pom.
- Cov txheej txheem metabolic: hypocalcemia, hypernatremia, tawm hws, hnyav nce, reflex convulsive leeg contraction, qaug zog, tsis muaj zog.
- Cov kab mob plawv: arrhythmia, sinus atherosclerosis (bradycardia), ntshav siab, thrombophilia, kev loj hlob ntawm lub plawv tsis ua hauj lwm.
- CNS thiab lub cev hnov qab: ua rau tsis nco qab los ntawm kev tsis meej pem mus rau coma (delirium), tsis muaj peev xwm taug kev hauv qhov chaw, hnov lus zoo, euphoria, ua rau lub siab hloov pauv mus rau txhua qhov kev taw qhia, paranoia, ntxhov siab, nquag insomnia, pib mob taub hau, nce ntxiv. intraocular siab, txav ntawm lub qhov muag - bulging ob lub qhov muag (exophthalmos).
- Musculoskeletal system: osteoporosis, nqaij atrophy, steroid myopathy.
- Y Digestive system: pancreatitis, o ntawm txoj hlab pas nrog cov tsos ntawm erosions thiab ulcers, flatulence, xeev siab,ntuav.
- Kev tsis haum tshuaj.
- pob txuv.
- Nyob ntawm daim tawv nqaij.
Kev Tiv Thaiv
Kev ntsuas ntshav siab yuav tsum tau kuaj xyuas thaum kho.
Raws li cov lus qhia, cortisone acetate yuav tsum tau muab rau cov menyuam yaus tsuas yog rau cov lus qhia tseeb thiab ua tib zoo saib xyuas los ntawm kws kho mob. Nrog rau kev kho mob mus sij hawm ntev, nws yog ib qho tsim nyog los saib xyuas qhov kev loj hlob ntawm kev loj hlob thiab kev loj hlob. Yog hais tias tus me nyuam tau ntsib nrog cov neeg mob uas muaj kab mob qhua pias los yog qhua pias, cov tshuaj immunoglobulins tshwj xeeb raug muab rau kev tiv thaiv.
Tau tshuaj maj maj maj mam txo cov koob tshuaj, txhawm rau kom tsis txhob tsim cov tsos mob tshem tawm.
Kev sib tham nrog lwm yam tshuaj
Cov khoom kho mob ntawm ntau yam tshuaj hauv kev sib cuam tshuam ntawm cortisone acetate yuav txawv nyob ntawm hom tshuaj.
- Glucocorticosteroid txhim kho cov khoom zoo ntawm cov tshuaj tiv thaiv coagulants (cov tshuaj uas txo cov ntshav txhaws), cov tshuaj tiv thaiv kab mob (cov tshuaj tiv thaiv ntshav txhaws.
- Ua kom cov kev mob tshwm sim ntawm NSAIDs, steroid poj niam txiv neej cov tshuaj hormones (estrogens), cardiac glycosides, steroid anabolics, tshuaj tua kab mob Amphotericin B, cystic tshuaj L-asparaginase.
- Txo cov txiaj ntsig ntawm hypoglycemic (glucose txo qis), tshuaj tiv thaiv ntshav siab thiab diuretics (diuretics).
- Derivatives ntawm barbituric acid txo cov txiaj ntsig ntawm cortisone.
hnub tas sij hawm thiab cov cai cia
Raws li cov lus qhia "Cortisone" hauvCov ntsiav tshuaj tau khaws cia rau 5 xyoos txij li hnub tsim khoom hauv qhov chaw tsaus ntawm t + 25 ° C. Lub txee lub neej ntawm cov tshuaj pleev thiab tshem tawm yog 3 xyoos, lawv yuav tsum tau khaws cia ntawm qhov kub ntawm + 15 ° C. Tsis txhob khov cov khoom rau kev siv sab nraud.
Reviews
Kev tshuaj xyuas txog cov kws kho mob cortisone tsuas yog qhov zoo xwb. Cov kws kho mob tau ntev thiab ua tiav siv cov hluavtaws corticosteroid. Nyob rau hauv lawv lub tswv yim, qhov tshwm sim tsis zoo tsuas yog vim tsis ua raws li cov lus pom zoo kho mob.
Kev tshuaj xyuas los ntawm cov neeg mob tsis zoo vim muaj kev phiv. Qee cov neeg mob yws ntawm mob taub hau, xeev siab, tsis hnov tsw ntawm cov khoom noj thaum lub sijhawm kho. Cov neeg mob muaj kev zoo siab heev tom qab qhov kawg ntawm kev kho mob. Tab sis cov kws kho mob hais tias qhov no feem ntau yog qhov tshwm sim ntawm qhov tseeb tias tus neeg tau zoo lawm.
Analogues
Cov analogs tseem ceeb ntawm cortisone acetate thiab hydrocortisone yog Akortin, Dexamethasone, Metipred, Canison ntxiv. Kuj tseem siv tau yog "Avamys", "Betaderm", "Alteson", "Rinocorten", "Cirtodrin".
