Vasodilators yog ib pawg loj ntawm cov tshuaj uas muaj vasodilating nyhuv. Peripheral vasodilators dilate cov leeg me me thiab cov hlab ntsha los ntawm kev ua haujlwm ntawm cov leeg nqaij ntawm cov hlab ntsha. Vim qhov no, venous inflow mus rau cov nqaij ntshiv, oxygen deficiency hauv myocardium txo. Cov pab pawg no suav nrog cov tshuaj uas cuam tshuam rau qhov chaw deb ntawm cov hlab ntsha.
cov ntaub ntawv dav dav
Vim vim kev noj tshuaj ntawm pab pawg no, cov hlab ntsha dilate, uas txo cov load ntawm lub plawv cov leeg thiab nws xav tau oxygen. Qhov tseeb no tso cai rau lawv siv los ua cov tshuaj antianginal. Peripheral vasodilators yog cov tshuaj uas ua rau cov hlab ntsha tiv taus thiab tau qhia rau kev kho mob ntshav siab. Cov tshuaj no tau pib siv dav hauv lub xyoo pua xeem, lossis ntau dua, hauv tsib caug xyoo. Thaum pib, phentolamamine tau siv los kho lub plawv tsis ua haujlwm, tab sis nws tsis tau siv dav.daim ntawv thov vim muaj coob tus tsis zoo tshwm sim.
Kev siv tshuaj suav nrog hauv pab pawg no yuav tsum tau ua raws li kev saib xyuas ntawm tus kws kho mob uas tuaj koom, vim tias lawv tuaj yeem txo cov ntshav siab, ua rau lub plawv dhia tsis zoo.
Kev faib tawm
Kev faib tawm niaj hnub ntawm peripheral vasodilators yog nyob ntawm kev ua yeeb tshuaj thiab qhov chaw ntawm daim ntawv thov:
- Kev cuam tshuam rau cov hlab ntsha - feem ntau "Hydralazine" thiab "Fentolamine" cuam tshuam rau cov hlab ntsha, thiab "Prazosin" thiab nitrates cuam tshuam rau cov hlab ntsha.
- Alpha-adrenergic receptor blockers - Phentolamine, Droperidol, Prazosin, Nifedipine, Hydralazine.
- Inhibitors ntawm kev hloov enzyme - Enalapril, Captopril. Cov tshuaj txhawb kev hloov pauv ntawm angiotensin 1 mus rau angiotensin 2, thiab kuj ua rau cov leeg du ntawm cov hlab ntsha me.
- Direct effect on vascular du nqaij - Prazosin, Sodium Nitroprusside, nitrates.
Ntxiv rau, cov vasodilators peripheral raug faib ua:
- Venous - Molsidomin, Nitroglycerin.
- Arterial - "Hydralazine", "Fentolamine" "Minoxidil"
- Mixed - Prazosin, Nifedipine, Sodium Nitroprusside, Nitroglycerin thiab Molsidomin.
Los ntawm qhov nrawm ntawm qhov pib ntawm kev kho mob:
- Kev ua tam sim - "Nitroglycerin", "Corvaton" los ntawm kev tso dej, sublingual lossis tshuaj pleev ib ce.
- Ncua - Prazosin, Isosorbide dinitrate, Hydralazine.
Cov lus qhia rau kev siv
Venous vasodilators qhia rau ntau dhau ntawm cov hlab ntsws, lawv yog:
- txo qis hauv lub voj voog me;
- txo qis sab laug ventricular diastolic expansion;
- txo cov ntshav venous mus rau lub plawv;
- txo qis kev siv cov pa oxygen myocardial.
Yog li, cov vasodilators peripheral ntawm pawg pab pawg no tsis ua rau lub plawv dhia, tab sis tsuas yog txo qis (siab) hauv cov hlab ntsws. Cov tshuaj uas muaj feem tseem ceeb ntawm cov hlab ntsha me txo qis tom qab, thaum lawv tsis cuam tshuam rau lub siab hauv cov hlab ntsws, xws li qib ntawm preload tsis hloov. Raws li qhov tshwm sim, myocardial oxygen xav tau txo qis thiab lub plawv tso zis ntau ntxiv. Cov txiaj ntsig tseem ceeb ntawm pawg tshuaj no yog qhov tshwm sim ntawm hypotension thiab nce hauv lub plawv dhia. Muaj nyob rau hauv cov xwm txheej hauv qab no:
- "Hydralazine" - nrog rau lub plawv qis, nrog mob aortic lossis mitral regurgitation.
- "Fentolamine" - rau catecholamine teebmeem rau cov neeg uas muaj pheochromocytoma.
- Dihydropyridines - kho mob ntshav siab.
Tshuaj nrog rau kev cuam tshuam ib txhij ntawm venules thiab arterioles cuam tshuam ua ntej thiab tom qab thauj khoom, yog li lawv tau muab tshuaj rau kev kho mob plawv tsis ua haujlwm. Thiab xws li kev sib xyaw tshwj xeeb xws li Hydralazine + Isosorbide dinitrate, siv hauv kev kho mob plawv.insufficiency, nyob rau hauv ob xyoos ntawm kev nkag mus rau hauv ib tug txo nyob rau hauv txoj kev pheej hmoo ntawm kev tuag.
Pharmacological kev txiav txim ntawm vasodilators
Lub tshuab ua haujlwm ntawm cov vasodilators peripheral txawv, pawg no suav nrog tshuaj:
- blocking alpha-adrenergic receptors;
- Calcium ion antagonists;
- cuam tshuam tus myofibrils ntawm arterioles;
- hloov pauv enzyme inhibitors.
Txawm hais tias muaj qhov sib txawv ntawm kev ua haujlwm, txhua yam tshuaj cuam tshuam rau post- thiab preload ntawm myocardium. Pharmacodynamic cov teebmeem tshwm sim los ntawm kev txo qis hauv cov ntshav mus rau lub plawv vim qhov nce ntawm qhov muaj peev xwm ntawm cov hlab ntsha ntawm lub txaj, thiab feeb cov ntshav ntim, vim qhov nce ntawm lub peev xwm ntawm cov hlab ntsha txuas ntawm autonomic vascular system..
Lub tshuab ua haujlwm ntawm cov tshuaj nrog lub npe thoob ntiaj teb tsis yog "Pentoxifylline"
Cov tsub zuj zuj ntawm cyclic adenosine monophosphate nyob rau hauv cov ntaub so ntswg ntawm cov hlab ntsha ntawm cov leeg nqaij thiab hauv cov ntshav, nrog rau cov inhibition ntawm phosphodiesterase, underlies lub mechanism ntawm kev txiav txim ntawm Pentoxifylline, ib tug peripheral vasodilator, uas yog noj:
- Txhim kho cov tsos mob ntawm kev sib tsoo cerebrovascular los ntawm kev txo tag nrho cov peripheral tsis kam thiab nthuav me ntsis cov hlab ntsha. Qhia me ntsis vasodilating nyhuv.
- inhibits kev sib sau ntawm cov qe ntshav liab thiab platelets, txhawb kev fibrinolysis, txo cov concentration ntawm fibrinogen hauv cov ntshav plasma, txhim kho nws cov viscosity.
Drug«Vazonite»
Yog tshuaj ntev (ntev) ua. Pentoxifylline yog cov tshuaj nquag, uas muaj 600 mg hauv ib daim ntawv noj. Ua tsaug rau kev noj tshuaj "Vazonit 600":
- microcirculation txhim kho hauv qhov chaw ntawm cov ntshav tsis ua haujlwm;
- ntshav fluidity txhim kho vim qhov cuam tshuam ntawm cov qe ntshav liab deformed;
- qhov elasticity ntawm erythrocyte membrane nce;
- nce ntshav viscosity txo;
- platelet aggregation raug thaiv.
Cov tshuaj no nqus tau los ntawm lub plab zom mov. Daim ntawv txuas ntxiv ua rau kom tsis muaj kev cuam tshuam ntawm cov tshuaj nquag mus rau hauv cov hlab ntsha. Qhov siab tshaj plaws nyob rau hauv cov ntshav yog mus txog tom qab peb mus rau plaub teev thiab pheej mus txog li kaum ob teev. Ntau tshaj cuaj caum feem pua ntawm cov hloov pauv pentoxifylline tau tawm los ntawm lub raum.
Cov lus qhia rau kev siv tshuaj nrog INN pentoxifylline
Cov kws kho mob pom zoo Vasonit 600, nrog rau lwm yam tshuaj uas muaj cov khoom xyaw nquag pentoxifylline, raws li cov hauv qab no:
- tsis ua tiav ntawm cov ntshav ntws ntawm ischemic keeb kwm, mob thiab mob ntev.
- Discirculatory thiab atherosclerotic hlwb puas.
- Ua tsis tiav ntawm cov kab mob peripheral tshwm sim tawm tsam keeb kwm ntawm kev mob, nrog rau cov txheej txheem atherosclerotic thiab ntshav qab zib.
- Raws li kev kho mob rau cov txiaj ntsig uas tau tshwm sim tom qab kev sib tsoo cerebrovascular.
- Tsis ua haujlwm ntawm pob ntseg nruab nrab ntawm vascular keeb kwm, uas yog nrog los ntawm kev hnov lus.
- Kev ua txhaum ntawm cov ntshav ncig hauv cov hlab ntsha ntawm qhov muag.
- Cov kab mob trophic tshwm sim los ntawm kev ua tsis tiav ntawm venous thiab arterial microcirculation.
Contraindications thiab phiv ntawm cov tshuaj nrog cov tshuaj nquag pentoxifylline
Raws li cov lus qhia rau kev siv "Pentilin" thiab lwm yam tshuaj nrog INN pentoxifylline, lawv raug txwv tsis pub nkag thaum:
- Hypersensitivity rau pentoxifylline.
- Kev cev xeeb tub.
- Naturally pub.
- YRetinal hemorrhage.
- xiav los ntshav.
- mob myocardial infarction.
- Nyob rau hnub nyoog kaum yim.
Cov teebmeem tshwm sim tuaj yeem tshwm sim los ntawm sab nraud:
- hemostasis thiab kab mob plawv;
- subcutaneous rog thiab tawv nqaij;
- CNS;
- Ydigestive system.
Nrog rau kev tsis haum tshuaj thiab kev hloov pauv hauv qee qhov chaw kuaj mob.
Tshuaj "Agapurin retard"
Cov tshuaj nquag ntawm cov tshuaj no kuj yog pentoxifylline, uas yog 400 mg hauv ib ntsiav tshuaj. Tom qab kev tswj hwm, cov tshuaj nquag tau maj mam tso tawm ntawm daim ntawv ntau npaum thiab nkag mus rau hauv cov hlab ntsha. Ntxiv nrog rau kev txhim kho microcirculation, cov tshuaj muaj cov nyhuv angioprotective. Cov lus qhia rau kev sau tshuaj yog ua txhaum cai:
- qhov muag ncig;
- cerebral ncig (ischemic);
- functional ntsepuab pob ntseg;
- venous thiab peripheral arterial ntshav ntws provoked los ntawm ntshav qab zib mellitus, atherosclerosis;
- trophic los ntawm varicose ulcerative lesions, frostbite, gangrene;
- peripheral arterial thiab venous ncig tshwm sim tawm tsam keeb kwm ntawm cov txheej txheem xws li kis kab mob, ntshav qab zib, atherosclerotic.
Thiab kuj nyob rau hauv angioneuropathy thiab tom qab mob stroke, ob qho tib si hemorrhagic thiab ischemic.
Nyob rau hauv cov tib neeg uas muaj ntshav qab zib mellitus, kev hloov kho ntau npaum li cas ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib feem ntau xav tau. Txwv tsis pub, qhov kev pheej hmoo ntawm hypoglycemia yog siab. Noj tshuaj ob zaug ib hnub nyob rau tib lub sij hawm, nws yog zoo zam. Cov kev phiv tshwm sim tsis tshua muaj.
Tshuaj kho mob nrog INN Vincamine
"Vinoxin MB" muaj kev xaiv vasoregulatory cuam tshuam rau ntawm lub paj hlwb. Vim yog qhov hnyav oxidation ntawm qabzib, nws txhim kho cov metabolism hauv lub hlwb. Kev muab cov pa oxygen rau cov neurons txhim kho. Peripheral tsis kam ntawm cerebral hlab ntsha stabilizes. Tsis tas li ntawd, cov tshuaj tsis cuam tshuam rau lub siab thiab lub raum. Cov kws kho mob pom zoo "Vinoxin MB" kom normalize cerebral ncig thaum muaj kev ua txhaum cai:
- psychic;
- kev tsom xam;
- memory;
- pom thiab hnov ntawm vascular keeb kwm;
- craniocerebral posttraumatic;
- cerebral (tom qab cerebral ischemia);
- thiab lwm tus.
Lub sijhawm ntawm kev kho mob yog xaiv los ntawm tus kws kho mob tus kheej. Nws tsis pom zoo siv rau cov pathologies uas ua rau muaj kev nce hauv intracranial siab, mob stroke, plawv atherosclerosis, nrog rau cov menyuam yaus, cev xeeb tub thiab lactating poj niam. Kev mob tshwm sim me me. Tsis txhob nce koob tshuaj uas koj tus kws kho mob pom zoo. Nrog rau kev siv mus ntev, kev soj ntsuam daim siab yog tsim nyog.
Peripheral tshuaj
Tam sim no, ntau cov tshuaj xaiv tau raug tsim los siv tau zoo rau kev kho mob plawv, nrog rau ntshav siab. Cov hauv qab no yog cov npe tshuaj vasodilator:
- Agapurin.
- "Bencilamane fumarate".
- Duzopharm.
- Qhia.
- Nicegoline.
- Pentamon.
- Pentoxifylline.
- Pentilin.
- Pentomer.
- Radomin.
- Ralofect.
- Sermion.
- Furazolidone thiab lwm yam
Txhua yam tshuaj muaj cov tshuaj sib txawv. Txhawm rau kom ua tiav kev kho mob ntawm pathology, nws yog ib qho tseem ceeb uas yuav tau xaiv txoj kev kho mob. Txhawm rau zam qhov tshwm sim tsis zoo, ua ntej siv cov tshuaj, koj yuav tsum nyeem cov lus qhia rau kev siv thiab ua raws li tag nrho cov lus pom zoo ntawm koj tus kws kho mob.
