Tsis yog-Steroidal Anti-Inflammatory Drugs (NSAIDs) tuav txoj haujlwm muaj zog hauv khw muag tshuaj thoob ntiaj teb. Cov txheej txheem ntawm cov teebmeem no muaj antipyretic, anti-inflammatory thiab analgesic teebmeem rau tib neeg lub cev. Ib qho ntawm cov tshuaj no yog Ibuprom. Cov lus qhia tswj nws raws li kev kho mob zoo heev rau ntau yam kab mob.
Pharmacodynamics ntawm cov tshuaj
"Ibupro" yog ib qho derivative ntawm phenylpropionic acid. Cov txheej txheem ntawm kev cuam tshuam yog raws li kev tawm tsam ntawm kev ua haujlwm ntawm COX (ib qho enzyme, prostaglandins precursor, uas nyob rau hauv lem predominate nyob rau hauv cov txheej txheem ntawm pathogenesis, kev loj hlob ntawm mob thiab kub taub hau). Ntxiv mus, cov tshuaj yog tus yam ntxwv los ntawm kev tsis xaiv inhibition ntawm cyclooxygenase, piv txwv li "Ibuprom" sib npaug inhibits kev ua ntawm ob isoforms ntawm no enzyme - COX-1 thiab COX-2.
Cov tshuaj loog ntawm cov tshuaj "Ibuprom" cov lus qhia rau kev sivua rau ob lub mechanisms - peripheral thiab central. Thawj tus manifests nws tus kheej indirectly los ntawm inhibition ntawm cov txheej txheem ntawm prostaglandin ntau lawm. Kev cuam tshuam ntawm lub tshuab thib ob (nruab nrab) yog txhawm rau txhawm rau tsim cov tib yam prostaglandins nyob rau hauv nruab nrab thiab peripheral cheeb tsam ntawm NS. Vim qhov txo qis hauv lipid physiologically active tshuaj tam sim no nyob rau hauv lub tsom ntawm o, rhiab heev ntawm kev xaav ntawm tshuaj stimuli los ntawm receptors txo. Nyob rau hauv lub hypothalamus nyob rau hauv nruab nrab ntawm lub thermoregulation, kev tawm tsam ntawm prostaglandin synthesis ua rau txo qis hauv lub cev kub thaum lub sij hawm ua npaws.
Ntxiv rau, Ibuprom ntsiav tshuaj (cov lus qhia rau cov tshuaj muaj cov ntaub ntawv zoo li no) inhibit platelet aggregation (gluing) rau qee qhov.
Kev sib xyaw thiab kev tsim cov khoom siv tshuaj
Ibuprofen yog cov khoom xyaw tseem ceeb ntawm Ibuprom. Raws li cov khoom pabcuam, crospovidone, silicon dioxide, polyethylene glycol thiab lwm yam tshuaj (gelatin, starch, zaub roj, sucrose, thiab lwm yam) tuaj yeem hu ua.
Muaj ntau ntau hom tshuaj uas muab rau cov neeg siv khoom. Cov tshuaj tuaj yeem ntim rau hauv ib lub hnab, hauv lub raj mis polyvinyl (50 ntsiav tshuaj) lossis hauv hlwv.
Nyob ntawm qhov ntim ntawm cov khoom tseem ceeb hauv cov tshuaj, lawv tham txog Ibuprom (200 mg ntawm ibuprofen hauv ib ntsiav tshuaj) lossis tshuaj Ibuprom Max (400 mg ntawm ibuprofen). Txawm li cas los xij, tsis yog txhua yam. Hais txog ntau yam xws li "Ibupro Sprint Caps", cov lus qhia qhia tias cov tshuaj yog tsim nyob rau hauvcapsules nrog ib koob ntawm 200 mg ntawm cov khoom tseem ceeb hauv txhua. "Ibupro Extra" kuj tseem muaj rau cov neeg mob hauv cov tshuaj ntsiav, qhov ntim ntawm cov khoom tseem ceeb hauv txhua qhov yog 400 mg. Txog Ibuprom Sinus, cov lus qhia hais tias ib ntsiav tshuaj muaj 200 mg ntawm ibuprofen thiab 30 mg ntawm pseudoephedrine hydrochloride.
Cov lus qhia rau kev siv
Cov lus piav qhia ntawm txhua tus tsos mob thaum tau txais txiaj ntsig zoo, muaj cov lus qhia rau cov tshuaj xws li Ibuprom ntsiav tshuaj. Cov tshuaj muaj pes tsawg leeg (analogues ntawm cov tshuaj nrog tib yam active tshuaj yuav muaj kwv yees li tib yam nyhuv) qhia hais tias cov tshuaj yuav muab ib tug zoo tshwm sim nyob rau hauv kev kho mob ntawm cov kab mob xws li tej inflammatory-degenerative teeb meem nyob rau hauv lub qaum thiab pob qij txha. Kev mob caj dab (rheumatoid, rheumatic, psoriatic), osteoarthritis, ankylosing spondylitis yuav tsis yog qhov zam. "Ibuprom" yog tshuaj rau o ntawm cov ntaub so ntswg mos thiab musculoskeletal system tshwm sim los ntawm kev raug mob, nrog radiculitis, bursitis, tendinitis. Tsis tas li ntawd, cov tshuaj muaj peev xwm daws tau qhov mob taub hau thiab mob hniav, nrog neuralgia, myalgia, nrog mob mob hauv cov kab mob sib kis thiab mob ntawm lub ntsws sab saud. Cov neeg ua haujlwm kho mob tau ua raws li kev teem caij ntawm "Ibupro" nyob rau hauv cov mob febrile kom txo tau lub cev kub, nrog rau qhov mob me me los yog nruab nrab nruab nrab thiab tsis paub meej keeb kwm.
"Ibupro Max" cov lus qhia rau kev siv pom zoo kom noj thaum muaj cov tsos mob zoo ib yam, thaum yuav tsum tau txhaj tshuaj ntxiv. "Ibuprom Ntxiv"tseem yuav siv tau rau cov tsos mob no.
"Ibuprom Sinus" (lub ntsiab lus nrog "Ibuprom Sprint Caps") feem ntau yog muab tshuaj los muab tshuaj tua kab mob, tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob, nrog rau txo qhov o ntawm qhov ntswg mucosa thiab nws cov kab mob paranasal sinuses. Ntawd yog, cov tshuaj yuav ua tau zoo hauv cov tsos mob ntawm kev mob khaub thuas, mob ua pa nyuaj thiab mob khaub thuas, nrog rau mob taub hau, mob caj pas thiab cov leeg, lub cev kub thiab o ntawm cov mucous daim nyias nyias ntawm lub qhov ntswg thiab paranasal sinuses.
Muaj peev xwm siv tau
"Ibuprom" (cov ntsiav tshuaj) cov lus qhia rau kev siv pom zoo kom muab tshuaj rau tus kheej rau txhua tus neeg mob, nyob ntawm qhov mob hnyav ntawm kev kho mob tshwm sim ntawm tus kab mob. Cov txheej txheem tswj hwm kev noj cov tshuaj no yog ib koob ntawm 200 txog 800 mg nrog zaus ntawm 3-4 zaug hauv ib hnub. Rau cov neeg mob me, qhov ntau npaum li cas yog xaiv nyob ntawm qhov hnyav ntawm lub cev - 20-40 mg ib kilogram ntawm qhov hnyav (qhov no yog qhov ntim txhua hnub), muab faib ua ob peb koob tshuaj txhua hnub. Cov kev kho mob feem ntau kav li ntawm 2 mus rau 3 lub lis piam. Qhov siab tshaj plaws pub rau ib hnub rau tus neeg mob laus yog 2.4 g. Nws tau noj thaum lub sijhawm lossis tom qab noj mov thiab ntxuav nrog dej me me. Nws yog qhov tsis tsim nyog los faib cov ntsiav tshuaj rau hauv ntu.
"Ibupro Max" yog noj tsis hais zaub mov, thiab koj yuav tsum haus dej kom txaus. Nws yog qhov tsis tsim nyog los tsoo cov ntsiav tshuaj rau hauv qhov chaw.
Raws li Ibuprom Sprint Caps, rau cov neeg mob hnub nyoog tshaj 12 xyoos, ib koob tshuajyog 1-2 tsiav tshuaj txhua 4-6 teev. Noj thaum noj mov lossis tom qab noj mov. Rau cov neeg laus, tsis tas yuav tsum tau xaiv cov koob tshuaj tshwj xeeb, tshwj tsis yog cov lus hais tsis txaus ntawm kev ua haujlwm ntawm lub raum thiab lub siab.
"Ibupro Extra" cov lus qhia pom zoo kom noj 1 ntsiav tshuaj txhua 4 teev (peb tab tom tham txog cov neeg mob hnub nyoog 12 xyoos), tab sis tsis pub ntau tshaj 3 ntsiav tshuaj thaum nruab hnub. Cov tshuaj yog noj tom qab noj mov, tsis txhob zom. Rau cov neeg mob laus, tsis tas yuav xaiv qhov koob tshuaj tshwj xeeb.
"Ibupro Sinus" noj 1-2 ntsiav tshuaj ua ntej noj mov thiab ntxuav nrog dej. Ntau zaus - txhua 4-6 teev. Qhov nyiaj pub tshaj txhua hnub yog 6 ntsiav tshuaj.
Contraindications rau noj Ibuprom tshuaj
"Ibupro" (cov ntsiav tshuaj) cov lus qhia rau kev siv txwv tsis pub cov neeg uas muaj qhov tsis haum rau ibuprofen lossis ib qho kev pabcuam ntawm cov tshuaj. Nws yog tsis tsim nyog los sau tshuaj rau cov neeg mob uas raug mob ntawm lub plab zom mov ntawm ib tug erosive-ulcerative xwm (tshwj xeeb tshaj yog nyob rau hauv lub mob theem). Kev kho nrog Ibuprom kuj tseem raug txwv nyob rau hauv lub xub ntiag ntawm cov tshuaj aspirin triad thiab hauv qee cov kab mob ntawm lub paj hlwb. Kev sib txawv hauv kev ua haujlwm ntawm cov kab mob hematopoietic kuj yog lub hauv paus rau kev tsis kam siv txhua txoj kev los ntawm pawg NSAID. Nws tsis yog siv los sau cov tshuaj no rau cov neeg mob uas muaj mob hnyav hauv kev ua haujlwm ntawm lub raum thiab lub siab.
Txoj haujlwm tsis raug thiabKev siv "Ibuprom" ua ke nrog lwm cov tshuaj los ntawm pab pawg ntawm nonsteroidal.
Raws li cov tshuaj "Ibuprom Max", cov lus qhia rau kev siv txwv tsis pub noj ntsiav tshuaj rau cov teeb meem tib yam li "Ibuprom" nws tus kheej.
"Ibuprom Ntxiv", tshwj tsis yog rau tag nrho cov contraindications saum toj no, tsis raug sau tseg yog tias cov neeg mob muaj hemorrhagic diathesis, nrog rau lub plawv tsis txaus. Tsis tas li ntawd, tsis txhob noj cov tshuaj no yog tias koj lub cev qhuav dej vim ntuav, raws plab, lossis haus dej tsis txaus.
Cov tshuaj "Ibupro Sinus" muaj tag nrho cov saum toj no contraindications. Tsis tas li ntawd, nws tsis yog siv rau bronchial hawb pob, ntshav qab zib mellitus, nrog nce qib ntawm cov thyroid hormones (hyperthyroidism). Contraindication yog muaj nyob rau hauv cov neeg mob ntawm pheochromocytoma (neoplasms nyob rau hauv cov ntaub so ntswg ntawm lub qog adrenal), hyperplasia (adenoma) ntawm lub qog prostate.
Neegative manifestations
Ibuprom tau zam li cas? Cov lus qhia muaj cov ntaub ntawv hais txog qhov muaj peev xwm tsim tau qee qhov kev mob tshwm sim los ntawm cov kab ke sib txawv thiab cov khoom nruab nrog cev thaum noj cov tshuaj no. Cov tshuaj tiv thaiv ntau tshaj plaws rau kev siv NSAID no yog pom los ntawm txoj hnyuv. Cov neeg mob qhia xeev siab, ntuav, mob epigastric, kev loj hlob ntawm anorexia thiab ulcerative erosive lesions ntawm mucous daim nyias nyias ntawm lub plab zom mov.
Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb, mob taub hau, kiv taub hau, ntxhov siab, sib txawv hauv cov txheej txheem ntawm kev pw tsaug zog thiab pom kev pom feem ntau pom. Tej yam tshwm sim los ntawm cov kab mob hematopoietic thaum noj cov tshuaj rau lub sijhawm ntev - anemia, thrombocytopenia, agranulocytosis.
Ntau yam tshuaj tsis haum rau Ibuprom tuaj yeem ua tau. Cov ntsiav tshuaj (cov lus qhia muaj cov ntaub ntawv zoo li no) tuaj yeem ua rau cov tsos mob ntawm pob khaus, kev loj hlob ntawm Quincke's edema. Muaj tsawg zaus, aseptic meningitis yuav tshwm sim (cov neeg uas muaj kab mob autoimmune feem ntau raug rau cov tshuaj tiv thaiv), bronchospastic syndrome. Raws li kev tshwm sim hauv zos, cov neeg mob qhia txog qhov kub thiab txias ntawm daim tawv nqaij, hyperemia.
"Ibupro Sinus", ntxiv rau tag nrho cov saum toj no, tuaj yeem ua rau ua tsis taus pa, tachycardia, ntshav siab, hyperhidrosis.
Ntau tshaj qhov tso cai koob tshuaj: qhov tshwm sim
Nyob rau hauv cov ntaub ntawv ntawm ib tug overdose ntawm cov tshuaj xws li Ibuprom thiab Ibuprom Max, cov lus qhia rau kev siv qhia txog kev loj hlob ntawm xeev siab thiab ntuav, mob nyob rau hauv lub epigastrium. Tsis tas li ntawd nyob rau hauv cov xwm txheej zoo li no, qaug zog tuaj yeem tshwm sim, mob taub hau thiab kiv taub hau tuaj yeem hnov, txo qis hauv cov ntshav siab thiab kev txhim kho ntawm arrhythmias. Hauv qhov xwm txheej hnyav, cov tsos mob ntawm metabolic acidosis tshwm sim, tsis nco qab nrog kev ua pa tsis zoo yuav tshwm sim.
Nyob rau hauv cov xwm txheej zoo li no, kev ua pa sai sai thiab kho cov tsos mob raug pom zoo. Qhov ncauj noj ntawm enterosorbents yog xyaum. Cov kab mob convulsive raug tshem tawm nrog kev pab ntawm Diazepam, Lorazepam.
Nyob rau hauv rooj plaub ntawm overdose ntawm Ibuprom Sprint Caps, ntxiv rau tag nrho cov saum toj no,muaj peev xwm ntawm disorientation, convulsions, coma. Muaj peev xwm ua rau lub siab ua haujlwm tsis zoo. Hauv cov neeg mob uas muaj mob hawb pob bronchial, cov kab mob yuav ua rau mob hnyav dua.
Kev siv Ibuprom Sinus ntev tuaj yeem ua rau muaj kev hloov pauv hauv cov ntshav, xws li hemolytic anemia (ua kom tawg ntawm cov qe ntshav liab), granulocytopenia (txo qis ntawm cov granulocytes), thrombocytopenia (qis hauv platelets).
Kuv yuav tsum xyuam xim rau dab tsi?
"Ibupro" cov lus qhia pom zoo kom ceev faj rau cov neeg uas muaj kab mob sib kis ntawm daim siab, raum, mob plawv tsis ua haujlwm. Yog tias tus neeg mob muaj cov tsos mob dyspeptic ua ntej pib kho, lossis tus neeg mob tau txais kev phais, kev kho nrog Ibuprom kuj tseem yuav tau pib nrog ceev faj. Lub xub ntiag nyob rau hauv lub anamnesis ntawm cov ntaub ntawv hais txog los ntshav ntawm tej xwm, hais txog cov kab mob ntawm lub digestive ib ntsuj av, kev tsis haum tshuaj tshwm sim cuam tshuam nrog kev kho mob ntawm non-steroidal anti-inflammatory tshuaj, kuj yuav tsum yog ib qho laj thawj rau kev ceev faj rau tus neeg mob tus mob.
Txhawm rau zam qhov tsis txaus siab xav tsis thoob, nws yog qhov tsim nyog nyob rau hauv tus txheej txheem ntawm kev siv Ibuprom los saib xyuas cov haujlwm ntawm ob lub raum thiab daim siab, cov ntshav peripheral.
Ob leeg "Ibupro" thiab "Ibuprom Max" cov lus qhia tsis pom zoo siv hauv peb lub hlis twg ntawm cev xeeb tub. Hauv 1st thiab 2nd trimesters, kev siv cov NSAID no tsuas yog muaj txiaj ntsig yog tias qhov kev xav tau zoo rau leej niam ntau dua qhov tshwm sim tsis zoo raume nyuam.
Ibuprofen, cov khoom tseem ceeb ntawm Ibuprom, tau tawm hauv cov kua mis me me, yog li nws tuaj yeem siv thaum lactation los txo qhov mob thiab kub taub hau. Txawm li cas los xij, yog tias muaj lus nug txog kev kho mob mus sij hawm ntev nrog Ibuprom lossis xav tau koob tshuaj ntau, koj yuav tsum tham nrog koj tus kws kho mob cov lus nug txog kev tsis pub niam mis.
Kev siv "Ibupro Sinus" thaum cev xeeb tub thiab pub niam mis feem ntau yog contraindicated.
Kev sib tham nrog lwm yam tshuaj
Txhua daim ntawv ntawm "Ibuprom" ("Ibuprom Max", "Ibuprom Sprint Caps", "Ibuprom Ntxiv") cov lus qhia rau kev siv txwv tsis pub noj ua ke nrog cov tshuaj tiv thaiv ntshav siab thiab diuretics xws li furosemide, hydrochlorothiazide, txij li lawv cov txiaj ntsig kho tej zaum yuav raug txo kom tsawg.
Kev siv Ibuprom nyob rau hauv tandem nrog antiplatelet thiab xaiv serotonin inhibitors ua rau muaj kev pheej hmoo ntawm kev tsim GI los ntshav. Tsis tas li ntawd, NSAID no tuaj yeem nce cov ntsiab lus ntawm glycosides hauv cov ntshav plasma thiab, yog li, ua rau lub plawv tsis ua haujlwm. "Ibuprom" yuav txhim khu cov nyhuv ntawm anticoagulants ntawm tib neeg lub cev. Vim li no, nws yog ib qho tseem ceeb kom saib xyuas cov ntshav txhaws tsis tu ncua, vim ibuprofen txo qis platelet aggregation.
Thaum siv ua ke nrog lithium npaj thiab Methotrexate, qib ntawm cov tshuaj no hauvntshav ntshav. Tandem nrog cyclosporine yuav ua rau nephrotoxicity tom kawg.
Kev sib xyaw ntawm "Ibuprom" nrog cov kev npaj digitalis (digitalis) tuaj yeem ua rau kev loj hlob ntawm plawv arrhythmias. Koj yuav tsum tsis txhob noj cov tshuaj NSAID no nrog acetylsalicylic acid (aspirin), vim tias muaj peev xwm ua rau muaj kev phiv tsis zoo.
Kev sib xyaw ntawm quinolone cov tshuaj tua kab mob thiab txhua NSAIDs (xws li Ibuprom) ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob convulsive. Thiab kev sib xyaw nrog cov tshuaj xws li Zinovudine ua rau muaj kev pheej hmoo ntawm kev tsim hemarthrosis thiab hematomas hauv cov neeg mob HIV.
Cov neeg mob cov kev xav txog cov tshuaj
Nonsteroidal PVAs yog cov tshuaj loj uas feem ntau muaj ntau yam teebmeem. Yog li ntawd, cov neeg mob tshuaj xyuas ntawm cov nyiaj no yeej ib txwm zoo thiab tsis zoo. Ibuprom yog tsis muaj kev zam.
Feem coob ntawm cov neeg siv tshuaj txaus siab rau nws cov txiaj ntsig. Mob sai sai thiab ntev lawv tsis nco txog lawv tus kheej. Cov tshuaj tau ua pov thawj nws tus kheej zoo rau mob khaub thuas, mob taub hau thiab myositis, nrog myalgia thiab neuralgia.
Tib lub sijhawm, muaj cov neeg mob uas tsis txaus siab rau cov nyhuv ntawm cov tshuaj "Ibuprom". Cov lus qhia tshaj tawm txoj kev loj hlob sai ntawm cov nyhuv ntawm cov tshuaj loog, tab sis ntau tus neeg tau txais kev pab tsis hnov qhov cuam tshuam ntawm cov tshuaj no txhua. Tsis tas li ntawd, ntau tus neeg yws yws txog qhov tshwm sim tsis zoo nyob rau hauv daim ntawv ntawm xeev siab thiab mob taub hau.
Pab pawg neeg coob txausyws tias "Ibuprom" tsis tau tshem tawm cov hniav tag. Txawm hais tias nyob rau hauv cov ntaub ntawv no nws tsis yog yuav tsum tau hais tias cov tshuaj yog phem. Qhov tseeb yog tias, piv txwv li, nrog mob pulpitis, tsis muaj tshuaj tua kab mob yuav pab tau, tsuas yog txhaj tshuaj ncaj qha rau hauv cov pos hniav. Thaum mob hniav, Ibuprom yog lub sijhawm mus ntsib kws kho hniav sai li sai tau yam tsis muaj qhov mob hnyav.
Txawm li cas los xij, NSAIDs yog ib tiam tshiab ntawm cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob uas muaj txiaj ntsig zoo hauv ntau yam kab mob. Nov yog kev xav ntawm cov neeg siv khoom feem ntau thiab cov kws kho mob.
