Cov tshuaj "Moxifloxacin", cov tshuaj tshuaj uas yuav tau tham tom qab, belongs rau pawg fluoroquinolones. Cov cuab yeej muaj bactericidal, antibacterial nyhuv. Tom ntej no, peb yuav tham txog dab tsi tshuaj "Moxifloxacin" yog. Cov lus qhia rau kev siv, analogues kuj yuav muab rau hauv kab lus.
Effect
Moxifloxacin ua haujlwm li cas? Cov lus piav qhia ntawm cov tshuaj yuav tsum pib nrog cov lus piav qhia ntawm cov txheej txheem ntawm nws cov nyhuv ntawm cov kab mob. Cov nyhuv bactericidal ntawm tus neeg sawv cev yog txuam nrog inhibition (inhibition) ntawm cov kab mob topoisomerases IV thiab II. Qhov no, nyob rau hauv lem, ua rau muaj kev cuam tshuam nyob rau hauv cov txheej txheem ntawm replication, transcription, thiab kho DNA biosynthesis nyob rau hauv microbial hlwb. Qhov tshwm sim yog lawv txoj kev tuag. Tshuaj "Moxifloxacin" cov lus qhia rau kev siv characterizes raws li ib tug dav-spectrum tshuaj tua kab mob.
Txhob Cia Siab
NyobCov tshuaj tua kab mob ntawm cov tshuaj "Moxifloxacin" tsis cuam tshuam los ntawm cov txheej txheem uas ua rau muaj kev tiv thaiv rau tetracyclines, macrolides, aminoglycosides, cephalosporins thiab penicillins. Kuj tsis muaj qhov cuam tshuam cuam tshuam. Txog rau tam sim no, tsis muaj qhov xwm txheej ntawm cov ntshav plasma tau raug txheeb xyuas. Kev tawm tsam rau cov tshuaj "Moxifloxacin" txhim kho qeeb qeeb los ntawm ntau yam kev hloov pauv.
Kev ua haujlwm spectrum
txhais tau tias Moxifloxacin (cov lus qhia rau kev siv - kev lees paub ntawm qhov no) cuam tshuam ntau hom kab mob gram-zoo thiab gram-tsis zoo microbes, cov kab mob acid-ceev ceev, anaerobes, kab mob atypical (mycoplasmas, chlamydia thiab lwm yam), nrog rau. Cov kab mob uas tiv taus macrolide thiab beta-lactam tshuaj tua kab mob.
Thaum noj qhov ncauj, qhov nqus ntawm cov tshuaj "Moxifloxacin" sai thiab yuav luag tiav. Tsis muaj bioavailability rau kev txhaj tshuaj thiab kev tswj qhov ncauj yog li 91%. Thaum noj qhov ncauj (50-1200 mg ib zaug, 600 mg / hnub rau 10 hnub), cov tshuaj pharmacokinetics ntawm cov tshuaj yog linear. Qhov siab tshaj plaws thaum noj 400 mg yog sau tseg tom qab 0.5-4 teev. Thaum siv ib txhij nrog zaub mov, muaj qhov nce ntxiv ntawm lub sijhawm kom ncav cuag Cmax (los ntawm ob teev) thiab nws txo qis li 16%. Lub sij hawm ntawm kev nqus tseem zoo li qub. Txawm li cas los xij, cov ntaub ntawv no tsis cuam tshuam rau kev kho mobtso cai rau koj siv cov tshuaj "Moxifloxacin" tsis hais zaub mov. Tom qab ib qho kev txhaj tshuaj ntawm 400 mg nyob rau ib teev, qhov siab tshaj plaws concentration tau sau tseg thaum kawg ntawm kev txhaj tshuaj.
Kev faib tawm
Hauv peb hnub ntawm kev thov, lub xeev sib npaug tau mus txog. Plasma protein khi yog kwv yees li 45%. Muaj kev faib tawm sai sai ntawm cov tshuaj "Moxifloxacin" hauv lub cev thiab cov ntaub so ntswg. Qhov siab tshaj plaws yog tsim nyob rau hauv lub ntsws cov ntaub so ntswg thiab bronchial mucosa, subcutaneous qauv thiab daim tawv nqaij, qhov ntswg sinuses, thiab inflammatory foci. Hauv cov qaub ncaug thiab cov kua dej interstitial, cov tshuaj muaj nyob rau hauv daim ntawv dawb uas tsis yog khi rau cov proteins. Nws cov concentration ntawm no yog siab dua hauv plasma. Nrog rau qhov no, cov tshuaj muaj nyob rau hauv ntau qhov ntawm lub cev ntawm lub peritoneum, cov ntaub so ntswg ntawm qhov chaw mos ntawm cov poj niam thiab nyob rau hauv lub peritoneal kua.
YMetabolism
Cov tshuaj "Moxifloxacin" (cov lus piav qhia ntawm cov tshuaj hauv cov lus piav qhia muaj cov ntaub ntawv no) tab tom ua biotransformation ntawm theem ob. Kev tshem tawm yog nqa tawm los ntawm ob lub raum thiab cov hnyuv tsis hloov pauv thiab nyob rau hauv daim ntawv ntawm inactive sulfo tebchaw thiab glucuronides. Cov metabolites muaj nyob hauv plasma. Lawv cov concentration yog qis dua li cov khoom qub. Hauv chav kawm ntawm kev tshawb fawb, nws tau ua pov thawj tias cov khoom lwj no tsis muaj qhov tsis zoo rau lub cev.
txhais tau tias "Moxifloxacin": nws yog tshuaj rau dab tsi?
Cov tshuaj tau pom zoo rau cov kab mob inflammatory pathologies hauvcov neeg laus, provoked los ntawm microorganisms uas muaj rhiab heev rau nws. Tshwj xeeb, cov lus qhia muaj xws li exacerbation ntawm mob ntsws ntsws, mob sinusitis, mob ntsws hauv zej zog (ua los ntawm cov kab mob uas muaj ntau yam tsis kam, nrog rau cov tshuaj tua kab mob). Txhais tau hais tias "Moxifloxacin" cov lus qhia rau kev siv pom zoo rau kev kis kab mob ntawm cov nqaij mos thiab tawv nqaij, cov kab mob nyuaj ntawm cov txheej txheem subcutaneous (xws li tus mob ntshav qab zib ko taw) thiab kab mob hauv plab (polymorphic txheej txheem, intraperitoneal abscesses, thiab lwm yam). Cov tshuaj yog muab rau streptococcal pneumonia nrog ntau yam tsis kam mus rau cov tshuaj tua kab mob, nrog rau thaum muaj cov kab mob resistant rau penicillins, ob los yog ntau yam tshuaj los ntawm cov pab pawg neeg thib ob tiam cephalosporins, macrolides, tetracyclines. Cov kev qhia kuj muaj xws li inflammatory lesions nyob rau hauv lub pelvic kabmob ntawm ib tug uncomplicated xwm. Nrog endometritis thiab salpingitis, tus neeg sawv cev hauv nqe lus nug kuj pom zoo (qhov no yog pov thawj los ntawm cov lus qhia rau kev siv txuas nrog Moxifloxacin tshuaj). Qhov muag tee yog tshuaj rau cov kab mob conjunctivitis, provoked los ntawm cov kab mob rhiab heev rau cov tshuaj. Nws tseem yuav tsum tau coj mus rau hauv tus account uas twb muaj lawm cov lus qhia rau kev kho mob ntawm tus kab mob pathologies.
Tshuaj "Moxifloxacin": ntau npaum thiab kev tswj hwm
Cov tshuaj no yog muab rau hauv qhov ncauj (qhov ncauj) thiab tso rau hauv cov hlab ntsha. DurationKev kho mob nrog cov tshuaj "Moxifloxacin", qhov ntau npaum li cas yog 400 mg / hnub, nyob ntawm seb hom pathology thiab nws qhov hnyav, nrog rau cov txiaj ntsig kho tau zoo:
- Exacerbation of chronic bronchitis - 5-10 hnub.
- Kev mob ntsws hauv zej zog - 7-14 hnub ntawm kev kho mob ua ntu zus (cov tshuaj txhaj tshuaj ua raws li kev tswj hwm qhov ncauj).
- Kev poob ntawm cov nqaij mos, tawv nqaij (tsis yooj yim), nrog rau mob sinusitis - 7 hnub.
- Rau cov kab mob hauv lub plab (qhov nyuaj) - 5-14 hnub ntawm kev kho mob.
- Nyob rau hauv qhov mob nyuaj ntawm cov qauv subcutaneous thiab tawv nqaij - 7-21 hnub.
- Nyob rau hauv inflammatory pathologies ntawm lub plab pelvic kabmob - 14 hnub.
Cov ncauj lus kom ntxaws ntxiv muaj nyob hauv cov lus qhia rau kev siv txuas nrog cov tshuaj "Moxifloxacin". Cov ntsiav tshuaj tsis raug tso cai rau zom. Koj yuav tsum haus dej me me.
siv hauv zos
Cov tshuaj "Moxifloxacin" (tej) tuaj yeem muab tshuaj rau cov neeg mob txij li ib xyoos. Raws li kev xyaum qhia, kev txhim kho tshwm sim nyob rau hnub thib tsib. Tom qab ntawd, kev kho mob yuav tsum tau txuas ntxiv rau 2-3 hnub. Cov neeg mob tau instilled rau hauv qhov cuam tshuam qhov muag los ntawm kev poob peb zaug ib hnub twg. Yog tias tsis muaj kev cuam tshuam rau tsib hnub, cov lus nug ntawm qhov tseeb ntawm kev kho lossis kev kuaj mob yuav tsum raug tsa. Lub sijhawm ntawm kev kho mob yog nyob ntawm cov kab mob bacteriological thiab kev kho mob, nrog rau qhov hnyav ntawm pathology.
Cov ntaub ntawv ntxiv txog cov tshuaj infusion
Tshuaj"Moxifloxacin" cov lus qhia rau kev siv tau pom zoo siv hauv ib teev. Hauv qhov no, cov tshuaj tuaj yeem yog ob qho tib si undiluted thiab diluted. Cov tshuaj yog sib xws nrog sodium chloride 0.9%, dej rau txhaj tshuaj, dextrose daws ntawm ib tug concentration ntawm 10% thiab 40%, xylitol 20%, Ringer. Tsuas yog cov kua ntshiab siv xwb. Tom qab dilution, cov tshuaj tseem nyob ruaj khov nyob rau ib hnub ntawm chav tsev kub. Tsis txhob khaws cov khoom hauv lub tub yees. Yog hais tias qhov infusion yog siv nrog rau lwm tus neeg sawv cev, txhua tus ntawm lawv yog muab cais.
Side effects
Raws li kev kho mob nrog cov tshuaj "Moxifloxacin", kev loj hlob ntawm cov kab mob fungal, leukopenia, anemia, thrombocytopenia yog qhov zoo. Qee zaum, thaum kho, muaj kev nce ntxiv hauv lub sijhawm prothrombin, kev hloov pauv hauv thromboplastin concentrations. Hauv qee tus neeg mob, cov tshuaj tuaj yeem ua rau muaj kev tsis haum tshuaj, laryngeal edema, urticaria, anaphylactic shock, khaus, eosinophilia, ua pob liab liab. Muaj tsawg zaus, muaj hyperglycemia, hyperlipidemia, hyperuricemia. Nyob rau hauv tus txheej txheem ntawm kev kho mob, kev puas siab puas ntsws muaj feem yuav. Hauv particular, cov neeg mob yuav muaj kev ntxhov siab, ntxhov siab, kev nyuaj siab, kev xav tsis zoo, kev xav tsis zoo, kev puas siab puas ntsws, nrog rau kev xav tua tus kheej. Cov kev mob tshwm sim feem ntau muaj xws li mob taub hau thiab kiv taub hau, tshee, tsaug zog, tsis meej pem, saj cuam tshuam, pw tsaug zog, thiab tsis meej pem. Qee qhov xwm txheej, tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj, tej zaum yuav muaj kev sib koom ua ke, convulsions,nrog rau ntau yam kev kho mob tshwm sim, hypesthesia, olfactory teeb meem. Ib tug xov tooj ntawm cov neeg mob tau deterioration nyob rau hauv hais lus, mloog, peripheral neuropathy, amnesia, polyneuropathy. Thaum siv tshuaj pleev ib ce, qhov muag pom kev tuaj yeem cuam tshuam txog qhov poob. Txawm li cas los xij, qhov kawg yog suav tias yog lub xeev hloov pauv.
Txoj kev cuam tshuam rau cov hlab plawv
Ntau qhov tsis zoo ntawm kev siv tshuaj "Moxifloxacin" yog qhov ntev ntawm QT-interval hauv cov neeg mob hypokalemia, palpitations, vasodilation, tachycardia. Tsis tshua muaj tshwm sim muaj xws li kub siab thiab hypotension, ventricular tachyarrhythmias, syncope. Lub plawv nres tau tsawg heev. Cov tom kawg yog cov yam ntxwv tseem ceeb ntawm cov neeg uas tau ua rau mob ischemia, bradycardia (kuaj qhov tseem ceeb).
Kev cuam tshuam rau lwm lub cev thiab lub cev
Qee zaum, cov tshuaj tuaj yeem ua rau ua pa luv, suav nrog mob hawb pob. Ib tug xov tooj ntawm cov neeg mob muaj teeb meem nyob rau hauv lub gastrointestinal ib ntsuj av. Tshwj xeeb, thaum kho, xeev siab, ntuav, raws plab, thiab mob plab tshwm sim. Qhov tshwm sim tsis tshua muaj tshwm sim yog poob qab los noj mov, dyspepsia, flatulence, gastroenteritis (tshwj tsis yog erosive), cem quav. Qee cov neeg mob tau kuaj pom tias muaj mob stomatitis, dysphagia, pseudomembranous colitis. Tawm tsam keeb kwm yav dhau los ntawm kev kho mob, kev nce hauv kev ua haujlwm transaminase, lub siab ua haujlwm tsis zoo, thiab kev loj hlob ntawm fulminant kab mob siab, ua rau lub neej ua rau lub siab tsis ua haujlwm, yuav muaj. Tsis tshua muaj, cutaneous bullous lesions tau raug tshaj tawm. Cov tshuaj tiv thaiv kab mob (epidermal toxic necrolysis, Stevens-Jones syndrome). Qee cov neeg mob tau ntsib myalgia, arthralgia, convulsions, nce cov leeg nqaij, tendonitis, cov leeg tsis muaj zog. Nyob rau hauv tsawg zaus, tendon ruptures, mob caj dab, gait cuam tshuam los ntawm kev puas tsuaj rau lub musculoskeletal system yuav raug soj ntsuam. Hauv cov neeg mob tawm tsam keeb kwm yav dhau los ntawm kev siv tshuaj, kuj tseem tuaj yeem muaj kev cuam tshuam hauv kev ua haujlwm ntawm cov zis. Hauv particular, lub cev qhuav dej (ua rau mob raws plab lossis txo qis ntawm cov kua dej), lub raum ua haujlwm tsis zoo, thiab tsis txaus tau sau tseg. Cov kev mob tshwm sim feem ntau muaj xws li tawm hws, tsis mob tshwj xeeb, thiab malaise. Thrombophlebitis los yog phlebitis yuav muaj nyob rau hauv cov hlab ntsha.
Leej twg yog cov tshuaj uas tsis tau sau rau?
Cov tshuaj "Moxifloxacin" muaj cov hauv qab no contraindications:
- Pathology ntawm cov leeg hauv keeb kwm, tsim los ntawm kev kho tshuaj tua kab mob ntawm pawg quinolone.
- Muaj QT ncua sij hawm ntev (tau los yog yug los).
- Electrolyte disorders (tshwj xeeb yog tsis kho hypokalemia).
- Bradycardia (kuaj kho mob tseem ceeb).
- Lub plawv tsis ua haujlwm nrog txo qis ventricular ejection muaj nuj nqi.
- Lub plawv dhia tsis xwm yeem (keeb kwm).
Nyob rau hauv rooj plaub ntawm lactose intolerance, qabzib-galactose malabsorption, lactase tsis txaus, cov tshuaj "Moxifloxacin" kuj tsis pom zoo (cov tshuaj muaj xws li lactose, thiab yog li cov lus hais pathologies suav nrog hauv daim ntawv teev npe). Txoj kev kho tsis tau sau tseg rau cov poj niam cev xeeb tub thiab lactating. Cov ntsiav tshuaj thiab cov tshuaj raug tso cai muab rau cov neeg mob txij li 18 xyoo. Cov tshuaj tsis pom zoo rau kev ua kom tsis haum rau cov khoom.
sijhawm tshwj xeeb
Ceev faj yog xav tau thaum muab tshuaj rau cov neeg mob CNS pathologies uas ua rau muaj kev qaug dab peg. Cov pab pawg muaj kev pheej hmoo suav nrog cov neeg mob uas muaj mob proarrhythmic. Cov no suav nrog, tshwj xeeb, mob ischemia, tshwj xeeb tshaj yog nyob rau hauv cov neeg laus thiab cov poj niam. Tsis tas li ntawd, ceev faj yog pom nyob rau hauv kev kho mob ntawm cov neeg mob cirrhosis ntawm daim siab. Kev kho koob tshuaj yuav tsum tau nyob rau hauv kev kho mob nrog rau cov tshuaj txo cov poov tshuaj.
Xav paub ntxiv
Raws li kev xyaum qhia, cov tshuaj tau txais txiaj ntsig zoo los ntawm ntau tus neeg mob. Cov kws kho mob feem ntau sau cov tshuaj no rau cov kab mob sib kis. Qhov no yog vim qhov tseeb tias cov tshuaj muaj txiaj ntsig zoo tiv thaiv ntau cov kab mob. Txawm li cas los xij, muaj ib txwm muaj kev phiv tshuaj, uas tau ceeb toom los ntawm cov lus qhia rau kev siv txuas nrog Moxifloxacin. Analogues ntawm cov tshuaj, yog tias tsim nyog, yuav tsum tau xaiv los ntawm tus kws kho mob tus kheej. Koj tuaj yeem hloov kho cov tshuaj xws li: Avelox, Vigamox, Rotomox, Moxifur, Moxin thiab lwm yam. Yog tias qhov tshwm sim tsis zoo tshwm sim, qhov ua tsis zoo ntawm tus mob, nrog rau qhov tshwm sim ntawm cov tsos mob uas tsis tau piav qhia hauv cov lus piav qhia, koj yuav tsum sab laj nrog kws kho mob tam sim ntawd. Thaum siv cov tee, tsis txhob cia ntau dhau mus rau hauv qhov muag.tshuaj. Yog tias qhov no tshwm sim, nws yuav tsum tau yaug lawv nrog dej kom sai li sai tau. Nrog rau kev noj tshuaj ntau dhau, muaj kev phiv ntau ntxiv.
Nyob hauv kaw
Cov tshuaj "Moxifloxacin" yog suav tias yog cov tshuaj tua kab mob muaj zog. Hauv qhov no, nws raug nquahu kom tsis txhob ua txhaum cov tshuaj ntawm tus kws kho mob. Tshwj xeeb, qhov no siv rau tus nqi thiab zaus ntawm kev siv tus neeg sawv cev. Tsis txhob tshaj qhov ntau npaum. Kev tswj hwm txoj hlab ntshav yuav tsum tau ua hauv chav tshwj xeeb los ntawm tus neeg tsim nyog uas tuaj yeem muab kev pab yog tias tsim nyog. Koj yuav tsum tsis txhob noj tshuaj rau tus kheej. Yog tias tsis muaj txiaj ntsig ntawm kev kho mob, koj yuav tsum sab laj nrog kws kho mob. Tam sim ntawd ua ntej siv cov tshuaj "Moxifloxacin", koj yuav tsum ua tib zoo nyeem cov lus qhia.
