Arterial hypertension yog kab mob ntawm ntau lab tus tib neeg niaj hnub no. Tau ntau xyoo, ntau pua cov tshuaj tau raug tsim tawm uas tuaj yeem daws tau sai thiab ntev los daws cov teeb meem ntawm kev dhia hauv cov ntshav siab, qhov txaus ntshai tshaj plaws uas yog kev kub ntxhov siab, uas tuaj yeem ua rau hemorrhagic stroke sai heev thiab tuaj yeem ua rau tuag taus. tus neeg. Hmoov tsis zoo, txhua yam khoom uas tuaj yeem kho tau peb tuaj yeem ua mob rau peb hauv ib txoj kev lossis lwm qhov. Qhov no yog qhov tseeb tshwj xeeb ntawm cov tshuaj, tshwj xeeb tshaj yog cov tshuaj "Valz", cuam tshuam rau lub cev tag nrho. Yog li ntawd, qee zaum nws yuav tsum xaiv qhov analogue ntawm "Valz" yog tias nws tsis haum rau txhua txoj kev.
Kev piav qhia
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm oval biconvex zaj duab xis-coated ntsiav tshuaj nrog sab txaus ntshai thiab V kos rau ntawm ib tug nto. Cov xim nyob ntawm cov ntsiab lus ntawm cov tshuaj nquag. Daj qhia tias muaj 40 lossis 160 mg ntawm valsartan, thiab paj yeeb sib raug rau 80 mg ntawm cov khoom xyaw nquag.
Cov khoom pabcuam suav nrog lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, povidone K29-32, talc thiab silicon dioxide.colloidal.
Pharmacological pawg
Cov tshuaj "Valz" yog hais txog cov vasodilators peripheral, uas yog, los ntawm kev nthuav cov hlab ntsha, nws ua rau txo qis ntshav siab. Cov nyhuv no yog vim muaj cov tshuaj nquag - valsartan, uas yog ib qho tshwj xeeb blocker ntawm AT1 angiotensin II receptors, uas tsis inhibit ACE, tsis cuam tshuam rau tag nrho cov ntshav cholesterol, qabzib, uric acid thiab triglyceride ntau ntau.
Cov nyhuv thawj zaug tshwm sim 2 teev tom qab siv tshuaj, ncav cuag cov txiaj ntsig siab tshaj plaws tom qab 4-6 teev. Cov nyhuv kho tau tuaj yeem kav ntev dua 24 teev. Kev noj cov ntsiav tshuaj tsis tu ncua ua rau cov ntshav siab tsis tu ncua tom qab 2-4 lub lis piam. Yog tias nws tsim nyog yuav tsum tsis txhob noj tshuaj sai sai, tsis muaj kev tshem tawm syndrome.
Mechanism of action
Tom qab kev tswj hwm qhov ncauj, kev nqus sai ntawm cov tshuaj nquag tshwm sim tawm tsam keeb kwm ntawm ntau qib kev nqus. Qhov taw qhia ntawm bioavailability nyob rau hauv qhov nruab nrab ntawm theem ntawm 23%. Tom qab kev tswj hwm qhov ncauj, nws khi rau cov ntshav plasma protein los ntawm yuav luag 97%. Ua ib qho angiotensin II antagonist, cov tshuaj nquag ua rau kev nthuav dav ntawm phab ntsa ntawm cov hlab ntsha, uas ua rau txo cov ntshav siab hauv nws. Cov tshuaj tau ua tiav siv cov txheej txheem enzyme tshwj xeeb rau 9 teev, tom qab ntawd nws tawm 70% los ntawm txoj hnyuv thiab 30% los ntawm cov zis hauv daim ntawv hloov me ntsis.
Ib koob tshuaj ib hnub ua rau ntau heevme ntsis tsub zuj zuj ntawm cov active tshuaj nyob rau hauv lub cev.
Cov lus qhia rau kev siv
Cov tshuaj "Valz N", cov analogues uas tau sau tseg rau cov kab mob zoo sib xws, yog siv:
• rau ntshav siab;
• mob plawv tsis ua hauj lwm ua ib feem ntawm kev kho mob nyuaj;
• tom qab mob myocardial infarction (tseem nyob nruab nrab ntawm 12 teev thiab 10 hnub), nyuaj los ntawm qhov tshwm sim ntawm sab laug ventricular tsis ua haujlwm, systolic tsis ua haujlwm ntawm sab laug ventricle tiv thaiv keeb kwm yav dhau los ntawm qib hemodynamics ruaj khov.
YContraindications
Analogues ntawm cov tshuaj "Valz", zoo li nws tus kheej, tsis siv:
- nrog rau qhov tsis txaus siab rau cov khoom xyaw lossis cov khoom ntxiv;
- nrog rau kev ua txhaum ntawm daim siab (tshwj xeeb tshaj yog nrog kev loj hlob ntawm cholestasis lossis biliary cirrhosis);
- nrog ntau yam sib txawv hauv kev ua haujlwm ntawm lub raum;
- ntawm ntau theem ntawm cev xeeb tub thiab thaum pub niam mis;
- hauv cov menyuam yaus hnub nyoog qis dua 18;
- galactosemia vim malabsorption ntawm galactose thiab lactose intolerance.
Cov ntshav siab qis, qis qis ntawm cov poov tshuaj thiab sodium hauv lub cev, ob sab lub raum hlab ntsha stenosis, aortic thiab mitral stenosis, cardiomyopathy thiab thawj hyperaldosteronism yuav tsum tau ceev faj siv Valz. Lavxias teb sab analogues kuj muaj daim ntawv thov nta, uas yuav tsum tau tshwj xeeb cov lus qhia los muab kev kho mob zoo.
Side effect
Zoo li txhua yam kev kho mob, Valz tuaj yeem ua rau muaj ntau yam tsis zoo los ntawm ntau lub cev:
- qhov txawv txav hauv kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha tuaj yeem tshwm sim raws li orthostatic hypotension, vasculitis tsis tshua tsim, qee zaum los ntshav tshwm sim;
- nquag nquag, muaj cov kab mob hauv lub ntsws ua rau hnoos reflex;
- tej zaum yuav muaj raws plab thiab mob plab;
- cov teebmeem tsis zoo ntawm lub paj hlwb tuaj yeem tshwm sim raws li kiv taub hau, kiv taub hau, insomnia, qee zaum neuralgia lossis mob taub hau;
- neutropenia thiab qee zaum thrombocytopenia;
- txhim kho kev tsis haum tshuaj;
- mob nraub qaum lossis mob leeg, nrog rau mob caj dab thiab myalgia;
- ntau zaus cov tshuaj pab ua rau lub cev tsis muaj zog tiv thaiv, uas ua rau nws yooj yim rau kev kis kab mob (sinusitis, pharyngitis, conjunctivitis);
- tsis tshua muaj qhov xav tias nkees nkees, asthenia, edema tshwm sim.
Qhov tshwm sim ntawm cov teebmeem no yuav xav tau kev sab laj nrog kws kho mob txhawm rau xaiv cov tshuaj analogue "Valz".
Noj cov ntsiav tshuaj los ntawm qhov ncauj nrog cov kua dej txaus, tsis hais noj mov. Qhov ntau npaum li cas nyob ntawm qhov laj thawj ntawm kev siv, txij li cov tshuaj "Valz N", analogues ntawm "Valsacor", "Valsartan", "Valz" thiab lwm tus tuaj yeem siv tsis yog rau kev mob ntshav siab xwb.
Txhawm rau txo cov ntshav siab, cov ntsiav tshuaj tau muab tshuaj ntawm ib koob ntawm 80mg (ib zaug thiab txhua hnub tib lub sijhawm). Cov nyhuv kho nyob rau tib lub sijhawm maj mam nce thaum thawj ob lub lis piam, mus txog qhov tshwm sim loj tshaj plaws tom qab kawm txhua hli. Yog tias qhov koob tshuaj no tsis pab, koj tuaj yeem nce mus rau 160 mg ib hnub, ntxiv kev kho mob nrog diuretics kom ua tau zoo dua. Cov analogue ntawm "Valza" - cov tshuaj "Valz N" - tsis xav tau xws li ib tug ua ke, txij li thaum nws twb muaj, ntxiv rau lub active tivthaiv ntawm valsartan, diuretic hydrochlorothiazide.
Nrog rau txoj kev loj hlob ntawm lub plawv tsis ua hauj lwm (CHF), kev kho mob pib nrog koob tshuaj 40 mg, muab tshuaj 2 zaug hauv ib hnub. Yog tias qhov kev xav tau tsis pom, tus neeg mob raug xa mus rau "Valz 80" - ib qho analogue ntawm cov tshuaj "Valz 40", nrog rau kev noj ob zaug ib hnub (qhov siab tshaj plaws - txog 320 mg hauv ob koob). Nws kuj tseem tuaj yeem ua ke nrog lwm cov tshuaj uas tsim los kom kov yeej lub plawv tsis ua haujlwm.
Nrog keeb kwm ntawm myocardial infarction nrog cov ntshav ntws ruaj khov, kev kho valsartan tuaj yeem pib li ntawm 12 teev tom qab kev kho mob hnyav. Nyob rau tib lub sijhawm, ib nrab ntawm Valz 40 ntsiav tshuaj tau muab tshuaj rau thaum sawv ntxov thiab yav tsaus ntuj, maj mam nce (ntau ntau lub lis piam) mus rau koob tshuaj 160 mg ob zaug ib hnub, dhau los ntawm ntau npaum li cas ntawm 40 thiab 80 mg, feem. Nyob rau tib lub sijhawm, lawv raug coj los ntawm tus neeg mob tus mob, theem ntawm kev zam ntawm cov tshuaj. Kev hloov pauv mus rau qhov koob tshuaj ntawm 80 mg yog ua los ntawm qhov kawg ntawm lub lim tiam thib ob ntawm kev kho mob, ncav cuag ib koob ntawm 160 mg ntawm cov tshuaj nquag thaum kawg ntawm peb lub hlis ntawm kev kho.
Cov neeg mob uas muaj lub raum tsis ua haujlwm, tab sis nrog CC ntau dua 10ml / min, kev hloov koob tshuaj tsis ua. Rau cov neeg mob uas mob me thiab nruab nrab lub siab ua haujlwm tsis zoo (tsis muaj cholestasis, nyob rau hauv lub xub ntiag ntawm cov tshuaj "Valz", Lavxias teb sab analogues, nrog rau cov neeg txawv teb chaws, tsis tau sau ntawv), qhov tso cai noj tshuaj txhua hnub ntawm cov tshuaj no yog siv txog 80 mg. ntawm lub active ingredient.
Daim ntawv thov nta
Vim tias cov tshuaj no muaj contraindications txaus thiab cov kev mob tshwm sim, nws yuav tsum tau siv nrog ceev faj, ua raws li tag nrho cov kws kho mob cov lus pom zoo thiab ua raws li cov lus qhia nruj me ntsis, tshwj xeeb tshaj yog tias muaj kev sib txawv hauv kev ua haujlwm ntawm lwm yam kabmob thiab lub cev.
Yog tias tus neeg mob muaj cov lus tsis txaus sodium, ua ke nrog kev txo qis hauv BCC (uas yuav tshwm sim vim kev noj cov tshuaj diuretics ntau), kev kho mob nrog Valz N (analogue ntawm Valz) tuaj yeem ua rau muaj kev tshaj tawm. poob rau hauv cov ntshav siab twb nyob rau thaum pib ntawm kev kho mob, uas yuav ua rau tsis zoo rau tus neeg mob txoj kev noj qab haus huv. Txhawm rau kom tsis txhob muaj qhov cuam tshuam nrog qhov teeb meem zoo sib xws, nws yog ib qho tsim nyog los kho cov qib ntawm electrolytes thiab lawv qhov sib piv hauv lub cev ua ntej siv cov khoom no.
Nrog rau kev nce siab ntawm hom renovascular, kev ntsuas tsis tu ncua ntawm qib urea thiab creatinine yog qhov yuav tsum tau ua.
Kev sib koom ua ke ntawm cov tshuaj uas muaj cov poov tshuaj lossis nws cov ntsev, nrog rau cov tshuaj muaj feem xyuam nrog cov tshuaj potassium-sparing diuretics, yuav tsum tau saib xyuas tas li ntawm cov ntshav plasma potassium.
Kev siv cov tshuaj "Valz 160", analogues uas tsis tau sau rau tus kab mob no, rau kev kho mob ntawm cov neeg mob nrog CHF, tej zaum yuavua rau poob ntshav siab, uas yuav tsum tau saib xyuas nws cov ntsuas.
Rau cov neeg mob uas raug kev txom nyem los ntawm unilateral los yog ob sab lub raum hlab ntsha stenosis, yuav tsum tau ntsuas cov ntshav urea nitrogen thiab creatinine tsis tu ncua.
Thaum kho nrog cov tshuaj no, koj yuav tsum tau ceev faj txog kev tsav tsheb thiab lwm yam dej num uas cuam tshuam nrog kev nce siab thiab nrawm ntawm cov tshuaj tiv thaiv.
Siv thaum cev xeeb tub thiab lactation
Kev siv cov ntsiav tshuaj Valz thaum nqa lossis pub niam mis yog qhov tsis txaus ntseeg kiag li. Qhov no yog vim qhov tseeb tias kev tshawb fawb txog kev cuam tshuam ntawm valsartan ntawm tus menyuam hauv plab tsis tau ua. Txawm li cas los xij, muaj cov lus qhia tias vim qhov peculiarities ntawm fetal raum perfusion, uas nyob ntawm qhov tsim ntawm renin-angiotensin system, uas pib ua haujlwm tsuas yog los ntawm lub peb hlis ntuj kawg ntawm cev xeeb tub, nkag mus rau hauv cov hlab ntsha ntawm lub embryo. yog nrog los ntawm kev cuam tshuam tsis zoo rau nws, tshwj xeeb tshaj yog thaum lub sijhawm thib ob thiab thib peb trimester. Yog li ntawd, kev tsim kho qhov tseeb ntawm cev xeeb tub yog qhov qhia txog kev tshem tawm ntawm kev kho mob nrog Valz. Analogues, tshuaj xyuas ntawm cov kev kho mob uas zoo, yuav tsum tau xaiv tshwj xeeb tshaj yog los ntawm ib tug kws kho mob rau cov poj niam nyob rau hauv txawv gestation lub sij hawm. Kev kho kom zoo yuav tso cai, tsis ua mob rau tus menyuam hauv plab, los pab tus neeg mob kov yeej cov teeb meem uas tau tshwm sim.
Kev tshawb fawb txog kev nkag mus ntawm cov khoom xyaw nquag rau hauv cov kua mis niam kuj tseem tsis tau ua, yog li, nyob rau hauv cov xwm txheej yuav tsum tau muab tshuajCov tshuaj uas txo cov ntshav siab thaum lub sij hawm lactation, yuav tsum tau xaiv ntawm kev tso tseg kev kho mob thiab txwv tsis pub pub niam mis.
Ntau tshaj
Tshaj li qhov siab tshaj plaws uas tau tso cai lossis ua ke tsis raug ntawm ntau hom tshuaj tuaj yeem ua rau muaj kev noj ntau dhau ntawm cov tshuaj no. Tus mob no tshwm sim los ntawm kev txo qis hauv cov ntshav siab, nce mus txog qhov tsis nco qab thiab qaug zog.
Kev kho mob muaj lub plab zom mov, noj kom txaus ntawm cov tshuaj tua hluav taws xob, lossis kev tswj hwm txoj hlab ntshav ntawm 0.9% sodium chloride tov.
Kev sib tham nrog lwm yam tshuaj
Kev siv tshuaj "Valz", cov analogues uas muaj cov txheej txheem zoo sib xws, yuav tsum tau ua tib zoo saib xyuas thaum muab tshuaj ntawm lwm pawg kws tshuaj.
Cov tshuaj los ntawm pab pawg ntawm cov tshuaj potassium-sparing diuretics, nrog rau kev npaj cov poov tshuaj, nws cov ntsev, cov neeg ua haujlwm uas nce qib ntawm cov kab mob no hauv cov ntshav plasma (piv txwv li, Heparin) tuaj yeem ua rau hyperkalemia.
Kev sib koom ua ke ntawm lwm cov tshuaj tiv thaiv kab mob siab lossis tshuaj diuretics txhim kho cov nyhuv qis ntawm Valz. Nws cov analogues kuj muaj kev cuam tshuam zoo sib xws.
Kev tshuaj xyuas cov tshuaj tsis-steroidal tshuaj tiv thaiv kab mob tuaj yeem ua rau tsis muaj zog tiv thaiv kab mob.
Kev sib koom ua ke ntawm ACE inhibitors thiab cov tshuaj muaj lithium tuaj yeem ua rau rov qab nce ntxiv hauv cov ntsiab lus ntawm cov kab no hauv cov ntshav plasma, mus txog.kev txhim kho cov txheej txheem tshuaj lom.
Analogues rau lub ntsiab tivthaiv
Qhia rau koj paub tias muaj pes tsawg leeg muaj nyob hauv cov tshuaj "Valz", cov lus qhia rau kev siv. Nws cov analogues raws li qhov kev ntsuas no, uas muaj cov txiaj ntsig zoo sib xws ntawm lub cev - Valsafors (Lub Tebchaws Yelemees), Valaar, Valsakor (Slovenia), Valsartan (Switzerland), Diovan (Switzerland), Tareg (Switzerland) ntsiav tshuaj), Nortivan (Hungary), Valsartan Zentiva (Czech koom pheej), Tantordio (India). Lub hom phiaj ntawm kev cuam tshuam ntawm cov tshuaj no yog renin-angiotensin system.
Tshuaj "Valz": ib qho analogue ntawm cov ntsiav tshuaj hauv pawg kws tshuaj
Cov tshuaj no yog los ntawm angiotensin II receptor blockers, raws li koj tuaj yeem xaiv cov tshuaj nrog cov txheej txheem zoo sib xws ntawm kev ua thiab cov nyhuv. Txog rau tam sim no, ntau cov analogues ntawm cov tshuaj no tau tsim, feem ntau yog los ntawm cov tuam txhab txawv teb chaws.
Ntau cov tshuaj tau tsim los ntawm cov tshuaj losartan, qee zaum ua ke nrog diuretic hypothiazide. Cov no yog Cozaar, Gizaar, Lorista, Lozap Plus, Vazotenz thiab Prozartan npaj.
Tshuaj "Valz" yog ib qho analogue ntawm cov ntsiav tshuaj "Divan", "Co-Divan", "Exforge", "Valsacor" hais txog cov khoom xyaw nquag valsartan.
Cov khoom xyaw nquag eprosartan yog ib feem ntawm kev npaj "Teveten" thiab "Teveten plus".
Cov tshuaj telmisartan muaj nyob hauv Micardis thiab Micardis Plus.
Cov tshuaj irbersartan yog ib feem ntawm cov tshuaj "Aprovel", uas yog qhov tseem ceeb thoob ntiaj teb.
PraparatValz N: Lavxias teb sab counterparts
Ntawm cov tshuaj hauv tsev uas koom nrog pawg kws tshuaj no, ib tus tuaj yeem paub qhov txawv ntawm cov tshuaj tiv thaiv hypertensive "Angiakand", uas muaj candesartan ua cov khoom xyaw nquag. Cov tshuaj no yog tsim nyob rau hauv Moscow los ntawm lub tuam txhab Canonpharma. Koj tuaj yeem yuav nws ntawm tus nqi ntawm 400 txog 700 rubles, nyob ntawm cov ntsiab lus ntawm cov khoom xyaw nquag thiab cov ntsiav tshuaj hauv pob.
Lwm tus neeg sawv cev ntawm lub khw muag tshuaj Lavxias yog Bloktran, raws li kev txiav txim ntawm cov tshuaj losartan. Tsim los ntawm Pharmstandard hauv Kursk. Hauv khw muag tshuaj, nws tuaj yeem yuav hauv 150-200 rubles ib pob.
Cov tshuaj no (analogous rau "Valza") thiab tag nrho lwm yam zoo li nws muaj cov txiaj ntsig zoo sib xws thiab kev ua haujlwm siab, uas tso cai rau peb pom zoo kom siv los txo cov ntshav siab. Tus nqi ntawm cov tshuaj "Bloktran" yuav zoo li ntxim nyiam, tab sis koj tsis tuaj yeem ua raws li koj txoj kev xaiv nkaus xwb ntawm tus nqi, koj yuav tsum coj mus rau hauv tus account qhov ua tau zoo ntawm cov tshuaj, muaj kev phiv thiab ntau lwm yam, yog li kev xaiv yuav tsum yog. tso siab rau tus kws tshaj lij.
Yog li, pawg kws tshuaj ntawm cov tshuaj vasodilators tau pom tias muaj txiaj ntsig zoo hauv kev txo cov ntshav siab tiv thaiv keeb kwm yav dhau los ntawm feem pua ntawm cov kev mob tshwm sim tsawg. Qhov zoo ntawm cov tshuaj "Valz" thiab nws cov analogues kuj suav nrog qhov tsis muaj kev tshem tawm cov tsos mob, muaj peev xwm noj cov ntsiav tshuaj ib hnub nkaus xwb (zoo dua nyob rau tib lub sijhawm), tsis muaj cov lus tshaj tawm.action.
